RESUMEN
Systemic lupus erythematosus (SLE) is an autoimmune disease that affects multiple organs and systems. Ocular involvement is estimated to manifest in one-third of individuals with SLE, of which lupus retinopathy and choroidopathy represent the severe subtype accompanied by vision impairment. Advancements in multimodal ophthalmic imaging have allowed ophthalmologists to reveal subclinical microvascular and structural changes in fundus of patients with SLE without ocular manifestations. Both ocular manifestations and subclinical fundus damage have been shown to correlate with SLE disease activity and, in some patients, even precede other systemic injuries as the first presentation of SLE. Moreover, ocular fundus might serve as a window into the state of systemic vasculitis in patients with SLE. Given the similarities of the anatomy, physiological and pathological processes shared among ocular fundus, and other vital organ damage in SLE, such as kidney and brain, it is assumed that ocular fundus involvement has implications in the diagnosis and evaluation of other systemic impairments. Therefore, evaluating the fundus characteristics of patients with SLE not only contributes to the early diagnosis and intervention of potential vision damage, but also holds considerate significance for the evaluation of SLE vasculitis state and prediction of other systemic injuries.
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Fondo de Ojo , Lupus Eritematoso Sistémico , Humanos , Lupus Eritematoso Sistémico/complicaciones , Lupus Eritematoso Sistémico/diagnóstico , Enfermedades de la Retina/etiología , Enfermedades de la Retina/diagnóstico , Enfermedades de la Retina/patología , Enfermedades de la Coroides/etiología , Enfermedades de la Coroides/diagnósticoAsunto(s)
Coroides , Angiografía con Fluoresceína , Desprendimiento de Retina , Epitelio Pigmentado de la Retina , Tomografía de Coherencia Óptica , Humanos , Tomografía de Coherencia Óptica/métodos , Desprendimiento de Retina/diagnóstico , Desprendimiento de Retina/etiología , Desprendimiento de Retina/cirugía , Angiografía con Fluoresceína/métodos , Epitelio Pigmentado de la Retina/patología , Coroides/patología , Coroides/anomalías , Coroides/diagnóstico por imagen , Drusas Retinianas/diagnóstico , Drusas Retinianas/complicaciones , Drusas Retinianas/etiología , Fondo de Ojo , Agudeza Visual , Masculino , Enfermedades de la Coroides/diagnóstico , Enfermedades de la Coroides/etiología , FemeninoRESUMEN
An 84-year-old man presented with decreased right-eye visual acuity. Upon initial examination, the rightand left-eye visual acuities were 0.03 and 1.2, respectively; moreover, the right- and left-eye intraocular pressure was 12 mmHg and 13 mmHg, respectively. Examination revealed a shallow anterior chamber of the right eye, anterior chamber inflammation, vitreous opacity, and marked retinochoroidal detachment. Optical coherence tomography (OCT) revealed retinal detachment (RD) and choroidal folds; moreover, B-scan ultrasonography (B-scan) showed RD as well as thickened sclera with fluid in Tenon's space. Fluorescent fundus angiography revealed hyperfluorescence in the optic disc and vascular hyperpermeability in the right eye. The left eye lacked extra-ocular symptoms or abnormalities. The right ocular axis measured 23.4 mm with no apparent subretinal fluid migration due to positional changes. Accordingly, the patient was diagnosed with panuveitis associated with posterior scleritis and immediately started on 40 mg prednisolone, which improved his symptoms. However, at 3 post-treatment months, choroidal folds were observed and was restarted on 20 mg prednisolone. The choroidal folds subsequently disappeared, with a current visual acuity of 0.3 in the right eye and no recurrence. Our findings indicated the utility of accurate diagnosis of posterior scleritis by B-scan and prompt systemic steroid administration.
Asunto(s)
Panuveítis , Prednisolona , Desprendimiento de Retina , Escleritis , Tomografía de Coherencia Óptica , Agudeza Visual , Humanos , Masculino , Escleritis/etiología , Escleritis/diagnóstico , Escleritis/diagnóstico por imagen , Escleritis/complicaciones , Desprendimiento de Retina/etiología , Desprendimiento de Retina/diagnóstico por imagen , Desprendimiento de Retina/diagnóstico , Anciano de 80 o más Años , Panuveítis/diagnóstico , Panuveítis/etiología , Panuveítis/complicaciones , Prednisolona/administración & dosificación , Resultado del Tratamiento , Angiografía con Fluoresceína/métodos , Coroides/diagnóstico por imagen , Coroides/patología , Enfermedades de la Coroides/etiología , Enfermedades de la Coroides/diagnóstico por imagen , Enfermedades de la Coroides/diagnóstico , Enfermedades de la Coroides/complicacionesRESUMEN
BACKGROUND: Although choroidal thickening was reported as a sign of active inflammation in ocular sarcoidosis, there has been no research on the choroidal changes in non-ocular sarcoidosis (defined as systemic sarcoidosis without overt clinical signs of ocular involvement). Therefore, this study aimed to investigate choroidal structural changes in patients with non-ocular sarcoidosis. METHODS: This retrospective case-control study was conducted at Asan Medical Center, a tertiary referral center. We evaluated 30 eyes with non-ocular sarcoidosis and their age- and spherical equivalent-matched healthy control eyes. The subfoveal choroidal thickness, area ratio (Sattler layer-choriocapillaris complex [SLCC] area to Haller layer [HL] area), and choroidal vascularity index (CVI, luminal area to choroidal area) were analyzed using enhanced depth imaging in optical coherence tomography. Systemic and ocular factors associated with the choroidal thickness were investigated. RESULTS: Compared with the healthy control group, the non-ocular sarcoidosis group had significantly thicker subfoveal choroid (total and all sublayers [SLCC and HL]) and lower area ratio. There were no significant differences in the CVIs at all sublayers between groups. In the non-ocular sarcoidosis group, eyes under oral steroid treatment had thinner choroid than eyes under observation. In the control group, eyes with older age and more myopic spherical equivalent had thinner choroidal thickness. CONCLUSION: Total and all sublayers of the subfoveal choroid were significantly thicker without significant vascularity changes in non-ocular sarcoidosis eyes than in healthy control eyes. The degree of choroidal thickening was disproportionally greater at HL than at SLCC. These characteristic choroidal changes may be the subclinical manifestations in non-ocular sarcoidosis.
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Enfermedades de la Coroides , Coroides , Sarcoidosis , Tomografía de Coherencia Óptica , Humanos , Tomografía de Coherencia Óptica/métodos , Estudios Retrospectivos , Masculino , Femenino , Sarcoidosis/diagnóstico , Sarcoidosis/complicaciones , Sarcoidosis/diagnóstico por imagen , Persona de Mediana Edad , Coroides/patología , Coroides/diagnóstico por imagen , Coroides/irrigación sanguínea , Estudios de Casos y Controles , Enfermedades de la Coroides/diagnóstico , Enfermedades de la Coroides/etiología , Enfermedades de la Coroides/diagnóstico por imagen , Adulto , Anciano , Agudeza VisualAsunto(s)
Enfermedades de la Coroides , Granuloma , Sarcoidosis , Humanos , Sarcoidosis/diagnóstico , Sarcoidosis/complicaciones , Sarcoidosis/patología , Granuloma/diagnóstico , Granuloma/patología , Enfermedades de la Coroides/diagnóstico , Enfermedades de la Coroides/patología , Enfermedades de la Coroides/etiología , Femenino , Masculino , Persona de Mediana EdadRESUMEN
A 65-year-old man presented with decreased visual acuity in the left eye for 1 month. The diagnosis of hemorrhagic retinal detachment (submacular hemorrhage), which was caused by idiopathic polypoid choroidal vasculopathy, was confirmed by the ultra-wide-angle fundus examination, optical coherence tomography, and B-ultrasound. A vitrectomy combined with an ophthalmic surgical robot-assisted retinal puncture and injection was performed. The recombinant tissue plasminogen activator was injected accurately by the ophthalmic surgical robot between the retinal nerve epithelium and retinal pigment epithelium through a micro-injection needle. During the 2-month follow-up, the subretinal hemorrhage was significantly regressive, the visual acuity of the left eye was improved from hand movement to 0.1, and no other complications were observed. (This article was published ahead of print on the official website of Chinese Journal of Ophthalmology on March 15, 2024).
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Enfermedades de la Coroides , Hemorragia Retiniana , Humanos , Masculino , Anciano , Hemorragia Retiniana/etiología , Enfermedades de la Coroides/etiología , Vitrectomía/métodos , Activador de Tejido Plasminógeno/uso terapéutico , Activador de Tejido Plasminógeno/administración & dosificación , Coroides , Agudeza Visual , Punciones , Procedimientos Quirúrgicos Robotizados/métodos , Desprendimiento de Retina/etiología , Retina , Tomografía de Coherencia ÓpticaRESUMEN
INTRODUCTION: Tuberculosis can involve any organ in the body including ocular tissue of which the uveal tissue is most commonly infected. Choroidal involvement ranges from choroidal tubercles to granulomas. This is one of the few cases of a solitary choroidal granuloma with no other systemic symptoms in an immunocompetent child. METHOD: A case report. RESULTS: A 12-year-old female, presented with diminution of vision in the left eye for a month. The anterior segment of her left eye was normal. A fundus examination revealed an isolated orangish-yellow choroidal mass, 4 DD in size, involving the posterior pole with overlying subretinal exudation. CT scan of the thorax showed large pulmonary, cervical and pancreatic lymph nodes, along with lytic lesions of the thoracic vertebrae. Excision biopsy of the cervical lymph nodes showed caseating granulomas with no e/o malignancies on histopathology. The patient was started on anti-tubercular therapy. Six months after the treatment, the lesion had reduced in size and her vision had improved. CONCLUSION: Isolated choroidal tuberculomas can be present in eyes with little associated ocular inflammation and no other symptoms of systemic tuberculosis. High suspicion, early diagnosis and rapid initiation of medication are important for the treatment of ocular and systemic tuberculosis.
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Enfermedades de la Coroides , Tuberculoma , Tuberculosis Ocular , Humanos , Femenino , Niño , Tuberculosis Ocular/diagnóstico , Tuberculosis Ocular/tratamiento farmacológico , Tuberculoma/diagnóstico por imagen , Tuberculoma/tratamiento farmacológico , Granuloma/diagnóstico , Granuloma/tratamiento farmacológico , Granuloma/etiología , Coroides , Enfermedades de la Coroides/diagnóstico , Enfermedades de la Coroides/tratamiento farmacológico , Enfermedades de la Coroides/etiologíaRESUMEN
PURPOSE: To describe a unique indocyanine green angiography (ICGA) feature in sarcoidosis-associated choroidal vasculitis in a 33-year-old woman. METHODS: Case report. RESULTS: A 33-year-old woman with sarcoidosis was referred for the evaluation of blurry vision in both eyes. On ocular examination of both eyes, slit-lamp biomicroscopy and ophthalmoscopy revealed 0.5+ anterior chamber cell, 1+ vitreous cell, and no vitreous haze. Also noted were areas of venous perivascular sheathing and multiple (3-5) inferior snowballs. Fluorescein angiography showed optic disk hyperfluorescence, retinal phlebitis, and hyperfluorescence with late leakage in the periphery (Figure 1). Indocyanine green angiography showed small hypofluorescent spots. Also noted on the ICGA images were multiple, sharp, linear hyperfluorescent areas signifying areas of choroidal vasculitis (Figure 2). The patient was referred to rheumatology for the initiation of immunomodulatory therapy. CONCLUSION: To the best of our knowledge, this ICGA pattern of multiple, sharp, linear hyperfluorescent areas has not been previously described in patients with sarcoidosis. This ICGA pattern represents areas of sarcoidosis associated choroidal vasculitis.
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Enfermedades de la Coroides , Sarcoidosis , Vasculitis , Femenino , Humanos , Adulto , Verde de Indocianina , Enfermedades de la Coroides/diagnóstico , Enfermedades de la Coroides/etiología , Coroides/irrigación sanguínea , Angiografía con Fluoresceína , Sarcoidosis/complicaciones , Sarcoidosis/diagnóstico , Vasculitis/complicaciones , ColorantesRESUMEN
PURPOSE: To describe a condition with the following features: chronic central serous chorioretinopathy (CCSC), chorioretinal folds, scleral changes (including any of the following flattened or 'squared off' posterior pole, 'T sign', or thickened ocular coats), accompanied by a short axial length and hypermetropia in a series of 7 patients. METHODS: The case notes of 7 patients presenting with a combination of CSC, choroidal folds scleral changes and hypermetropia were reviewed as part of a retrospective case series. Corrected visual acuities, serial refraction, colour imaging, fluorescein and indocyanine green angiography findings, together with B-ultrasound scan features were recorded, with axial length measurements as available (< 23.3 mm was defined as short). RESULTS: The study included 14 eyes of 7 subjects (2 females and 5 males) with a primary presentation of central vision disturbance. All patients showed signs of previous or current episodes of the following features in at least one eye: CSC (5/7 bilateral); choroidal folds (6/7 bilateral), thickening of ocular coats in the 5 in whom this was measured, at least one scleral abnormality on ultrasound in at least one eye. A short axial length at final appointment was recorded in 13/14 eyes. CONCLUSIONS AND RELEVANCE: The combination of CCSC with choroidal folds, hypermetropia with apparent shortening of the eyeball associated with one or more scleral abnormalities such as a flattened or 'squared off 'appearance of the B ultrasound may be a specific ocular condition. The aetiology of this particular combination of posterior segment manifestations is unknown; the choroid could be the primary focus of disease with secondary involvement of the sclera. Alternatively, the features observed may result from a chronic inflammatory process affecting the sclera with secondary effects on the choroid, retinal pigment epithelium and retina. In our case series, the final vision was not significantly different from vision at presentation.
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Coriorretinopatía Serosa Central , Enfermedades de la Coroides , Hiperopía , Masculino , Femenino , Humanos , Coriorretinopatía Serosa Central/diagnóstico , Estudios Retrospectivos , Esclerótica , Angiografía con Fluoresceína/métodos , Verde de Indocianina , Tomografía de Coherencia Óptica/métodos , Coroides , Enfermedades de la Coroides/diagnóstico , Enfermedades de la Coroides/etiologíaRESUMEN
A 64-year-old woman presented with diminution of vision, progressive redness, and dull aching pain in the right eye for 8 months. What would you do next?
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Enfermedades de la Coroides , Efusiones Coroideas , Femenino , Humanos , Anciano , Enfermedades de la Coroides/diagnóstico , Enfermedades de la Coroides/etiología , Coroides , Trastornos de la VisiónRESUMEN
BACKGROUND: We present a case of hypertensive choroidopathy due to malignant hypertension with exudative retinal detachment as a sole finding. We use OCT- angiography for initial diagnosis and report findings from extensive follow up. CASE PRESENTATION: A 51-year-old female with no past medical history, presented to our clinic with painless loss of vision in her left eye. Fundus examination revealed only exudative retinal detachment in her left eye that was confirmed with Optical Coherence Tomography. Fluorescein angiography showed hyperfluorescent spots with leakage in late phases. OCTA manifested a focal dark area in the choriocapillaris slab corresponding to flow signal voids, signifying regions of non-perfusion. Her blood pressure was 220/120 mmHG. Complete blood work -up failed to reveal any other possible etiology. During follow-up period of 9 months blood pressure normalized, patient regained visual function and choriocapillaris perfusion was completely restored. DISCUSSIONS AND CONCLUSIONS: Hypertensive choroidopathy with exudative retinal detachment can be the only sign of malignant hypertension and no pre-existing history of a systemic disease is required in order to become apparent. OCTA reveals areas of non-perfusion at choriocapillaris level, proving that it is an essential tool in the diagnosis and follow up of patients with hypertensive choroidopathy. Finally, we propose that early diagnosis prevents permanent damage of the RPE and leads to complete choroidal remodeling and better visual outcomes.
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Enfermedades de la Coroides , Hipertensión Maligna , Desprendimiento de Retina , Humanos , Femenino , Persona de Mediana Edad , Desprendimiento de Retina/etiología , Desprendimiento de Retina/complicaciones , Hipertensión Maligna/complicaciones , Hipertensión Maligna/diagnóstico , Tomografía de Coherencia Óptica/métodos , Enfermedades de la Coroides/diagnóstico , Enfermedades de la Coroides/etiología , Angiografía con Fluoresceína/métodosRESUMEN
Importance: The primary contributing factor for development of chorioretinal folds during spaceflight is unknown. Characterizing fold types that develop and tracking their progression may provide insight into the pathophysiology of spaceflight-associated neuro-ocular syndrome and elucidate the risk of fold progression for future exploration-class missions exceeding 12 months in duration. Objective: To determine the incidence and presentation of chorioretinal folds in long-duration International Space Station crew members and objectively quantify the progression of choroidal folds during spaceflight. Design, Setting, and Participants: In this retrospective cohort study, optical coherence tomography scans of the optic nerve head and macula of crew members completing long-duration spaceflight missions were obtained on Earth prior to spaceflight and during flight. A panel of experts examined the scans for the qualitative presence of chorioretinal folds. Peripapillary total retinal thickness was calculated to identify eyes with optic disc edema, and choroidal folds were quantified based on surface roughness within macular and peripapillary regions of interest. Interventions or Exposures: Spaceflight missions ranging 6 to 12 months. Main Outcomes and Measures: Incidence of peripapillary wrinkles, retinal folds, and choroidal folds; peripapillary total retinal thickness; and Bruch membrane surface roughness. Results: A total of 36 crew members were analyzed (mean [SD] age, 46 [6] years; 7 [19%] female). Chorioretinal folds were observed in 12 of 72 eyes (17%; 6 crew members). In eyes with early signs of disc edema, 10 of 42 (24%) had choroidal folds, 4 of 42 (10%) had inner retinal folds, and 2 of 42 (5%) had peripapillary wrinkles. Choroidal folds were observed in all eyes with retinal folds and peripapillary wrinkles. Macular choroidal folds developed in 7 of 12 eyes (4 of 6 crew members) with folds and progressed with mission duration; these folds extended into the fovea in 6 eyes. Circumpapillary choroidal folds developed predominantly superior, nasal, and inferior to the optic nerve head and increased in prevalence and severity with mission duration. Conclusions and Relevance: Choroidal folds were the most common fold type to develop during spaceflight; this differs from reports in idiopathic intracranial hypertension, suggesting differences in the mechanisms underlying fold formation. Quantitative measures demonstrate the development and progression of choroidal folds during weightlessness, and these metrics may help to assess the efficacy of spaceflight-associated neuro-ocular syndrome countermeasures.
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Enfermedades de la Coroides , Hipertensión Intracraneal , Enfermedades de la Retina , Vuelo Espacial , Humanos , Femenino , Persona de Mediana Edad , Masculino , Presión Intracraneal/fisiología , Estudios Retrospectivos , Incidencia , Hipertensión Intracraneal/complicaciones , Enfermedades de la Coroides/diagnóstico , Enfermedades de la Coroides/epidemiología , Enfermedades de la Coroides/etiología , Enfermedades de la Retina/diagnóstico , Enfermedades de la Retina/epidemiología , Enfermedades de la Retina/etiologíaAsunto(s)
Enfermedades de la Coroides , Tuberculosis Miliar , Tuberculosis Ocular , Humanos , Tuberculosis Miliar/complicaciones , Tuberculosis Miliar/diagnóstico , Coroides , Enfermedades de la Coroides/etiología , Enfermedades de la Coroides/complicaciones , Granuloma/complicaciones , Tuberculosis Ocular/complicaciones , Tuberculosis Ocular/diagnósticoRESUMEN
INTRODUCTION: Pregnancy may be associated to unique retinal disorders and is associated to worsening of retinal disease that also occurs in non-pregnant females. We report a case of chorioretinopathy caused by pre-eclampsia associated to HELLP (Hemolysis-Elevated-Liver enzymes and Low Platelet count) syndrome. METHODS: Multimodal Imaging features of HELLP syndrome-related hypertensive chorioretinopathy including retinography, Spectral Domain-Optical Coherence Tomography (SD-OCT), Fluorescein angiography (FA), Indocyanine-green angiography (ICG) along with OCT-angiography (OCTA) are presented and discussed. RESULTS: Multimodal imaging and OCTA show both retinal and choroidal involvement by HELLP syndrome, resolved after hypertension treatment. CONCLUSIONS: Multimodal imaging is useful to study HELLP syndrome-related hypertensive chorioretinopathy. Moreover, OCTA is a new technology able to study and follow the circulatory status of the choriocapillaris during the disease.