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1.
Mycoses ; 67(10): e13804, 2024 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-39438422

RESUMEN

Exophiala dermatitidis is an emerging black fungus that causes pulmonary infections that may be underestimated by conventional culture methods. We encountered one case that initially appeared to be yeast and was misidentified as Rhodotorula spp. using a commercial identification kit. Thus, genetic identification and clinical background investigations were conducted on 46 strains of Rhodotorula spp. The sequences of the internal transcribed spacer and large-subunit RNA genes (D1/D2 regions) of 43 isolates, excluding two environmental isolates and one difficult-to-culture isolate, were determined and genetically identified. Notably, 22 isolates were identified as E. dermatitidis and misidentified as Rhodotorula spp. using the conventional method. Based on the exclusion criteria, the clinical information of 11 patients was retrospectively reviewed. Five cases (definite) had definite exacerbation of pulmonary infections due to E. dermatitidis, and six cases (possible) had undeniable infections. Of the 11 cases of pulmonary infection suggested to be caused by E. dermatitidis, comorbidities included two cases of chronic pulmonary aspergillosis (CPA), three cases of pulmonary non-tuberculous mycobacterial (NTM) infection and one case of pulmonary nocardiosis, suggesting a trend towards simultaneous detection of chronic pulmonary infections. Steroid and immunosuppressive drug use was observed in five cases, and ß-D-glucan elevation was observed in three of five definite cases of pulmonary infections due to E. dermatitidis. The possibility of E. dermatitidis infection should be considered when Rhodotorula spp. are isolated from cultures of airway-derived specimens, and, in addition to CPA and NTM, identification of E. dermatitidis may be important in chronic pulmonary infections.


Asunto(s)
Exophiala , Enfermedades Pulmonares Fúngicas , Feohifomicosis , Rhodotorula , Rhodotorula/aislamiento & purificación , Rhodotorula/genética , Rhodotorula/clasificación , Humanos , Exophiala/genética , Exophiala/aislamiento & purificación , Exophiala/clasificación , Femenino , Masculino , Anciano , Persona de Mediana Edad , Feohifomicosis/microbiología , Feohifomicosis/diagnóstico , Estudios Retrospectivos , Enfermedades Pulmonares Fúngicas/microbiología , Enfermedades Pulmonares Fúngicas/diagnóstico , Errores Diagnósticos , Adulto , ADN de Hongos/genética , Anciano de 80 o más Años , Análisis de Secuencia de ADN , ADN Espaciador Ribosómico/genética
2.
Can Vet J ; 65(8): 758-762, 2024 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-39091472

RESUMEN

A 3-year-old castrated male golden retriever was presented for evaluation of 2 cutaneous masses along the abdominal midline and a 6-month history of progressive lethargy and inappetence. Two years earlier, the dog underwent a gastrotomy to retrieve a foreign object and recovered uneventfully. Fluid aspirated from the lesions was culture-negative for aerobic and anaerobic bacterial growth. Abdominal ultrasound demonstrated a large intra-abdominal mass with apparent communication with the cutaneous lesion, along with gossypiboma from the previous laparotomy. Neoplasia or a sterile abscess were suspected. Exploratory laparotomy was performed and revealed that the intra-abdominal mass was adhered to the abdominal midline and the greater curvature of the stomach. The masses and affected portions of the body wall and stomach were resected and histopathology was consistent with phaeohyphomycosis. Antifungal therapy with voriconazole (6.3 mg/kg, PO, q12h) was initiated. At 1 mo after surgery, all clinical signs had resolved. At 4 and 7 mo after surgery, the dog continued to thrive despite 2 small masses, seen on abdominal ultrasound imaging on the intra-abdominal midline, suggestive of reoccurrence. Continued voriconazole therapy was administered in lieu of further surgical excision. One year after surgery, the masses were no longer present on ultrasonographic evaluation. Phaeohyphomycosis is a rare, opportunistic fungal infection that typically affects the dermis and subcutis of immunocompromised dogs. This is the first report of phaeohyphomycosis in an immunocompetent dog and involving the dermis, subcutis, and abdominal viscera. Key clinical message: This case adds to the very limited literature on phaeohyphomycosis in dogs and illustrates that surgery could be a risk factor for infection, even in dogs with no known underlying disease or immunodeficiency.


Phéohyphomycose cutanée et viscérale chez un golden retriever immunocompétentUn golden retriever mâle castré de 3 ans a été présenté pour évaluation de 2 masses cutanées le long de la ligne médiane abdominale et d'un historique de léthargie et d'inappétence progressive depuis 6 mois. Deux ans plus tôt, le chien avait subi une gastrotomie pour récupérer un objet étranger et s'était rétabli sans incident. Le liquide aspiré des lésions était négatif en culture pour la croissance bactérienne aérobie et anaérobie. L'échographie abdominale a mis en évidence une masse intra-abdominale importante avec une communication apparente avec la lésion cutanée, ainsi qu'un gossyibome issu de la laparotomie précédente. Un néoplasme ou un abcès stérile ont été suspectés. Une laparotomie exploratoire a été réalisée et a révélé que la masse intra-abdominale adhérait à la ligne médiane abdominale et à la grande courbure de l'estomac. La masse et les parties affectées de la paroi corporelle et de l'estomac ont été réséquées et l'histopathologie était compatible avec une phaeohyphomycose. Un traitement antifongique par voriconazole (6,3 mg/kg, PO, toutes les 12 heures) a été instauré. Un mois après l'intervention chirurgicale, tous les signes cliniques avaient disparu. À 4 et 7 mois après l'intervention chirurgicale, le chien a continué à bien allé malgré 2 petites masses, observées à l'échographie abdominale sur la ligne médiane intra-abdominale, évocatrices d'une réapparition. La poursuite du traitement par le voriconazole a été administrée au lieu d'une nouvelle excision chirurgicale. Un an après l'intervention chirurgicale, les masses n'étaient plus présentes à l'évaluation échographique. La phaeohyphomycose est une infection fongique rare et opportuniste qui affecte généralement le derme et le sous-cutané des chiens immunodéprimés. Il s'agit du premier rapport de phaeohyphomycose chez un chien immunocompétent et impliquant le derme, le tissu sous-cutané et les viscères abdominaux.Message clinique clé :Ce cas s'ajoute à la littérature très limitée sur la phaeohyphomycose chez le chien et illustre que la chirurgie pourrait être un facteur de risque d'infection, même chez les chiens sans maladie sous-jacente ou immunodéficience connue.(Traduit par Dr Serge Messier).


Asunto(s)
Antifúngicos , Enfermedades de los Perros , Feohifomicosis , Animales , Perros , Masculino , Enfermedades de los Perros/microbiología , Enfermedades de los Perros/cirugía , Enfermedades de los Perros/tratamiento farmacológico , Feohifomicosis/veterinaria , Feohifomicosis/tratamiento farmacológico , Feohifomicosis/diagnóstico , Antifúngicos/uso terapéutico , Voriconazol/uso terapéutico , Inmunocompetencia , Dermatomicosis/veterinaria , Dermatomicosis/diagnóstico
3.
Eye Contact Lens ; 50(9): 416-417, 2024 Sep 01.
Artículo en Inglés | MEDLINE | ID: mdl-39028227

RESUMEN

OBJECTIVE: To describe a patient diagnosed with Exophiala jeanselmei keratitis. METHODS: We report a case of a patient who developed infectious keratitis following laser in situ keratomileusis and chronic topical steroid use for approximately six months in both eyes. An atypical infiltrate containing dark pigmentation was noted in the left eye on the initial presentation. During treatment, the infiltrates of the right eye began to exhibit a similar pigmentation. RESULTS: Early treatment with topical antifungals was initiated in the left eye and later in the right eye once culture results returned. Both eyes recovered with good vision after approximately one month. CONCLUSIONS: Patients treated with postoperative topical corticosteroids should be cautioned of potential adverse effects of chronic use and have close follow-up. If infectious keratitis develops, particularly after two weeks, then atypical organisms, such as fungi, should be considered. In addition, our case highlights the significance of recognizing and associating dark-pigmentation with fungal etiologies.


Asunto(s)
Antifúngicos , Exophiala , Infecciones Fúngicas del Ojo , Queratitis , Queratomileusis por Láser In Situ , Adulto , Humanos , Antifúngicos/uso terapéutico , Úlcera de la Córnea/microbiología , Úlcera de la Córnea/tratamiento farmacológico , Úlcera de la Córnea/diagnóstico , Úlcera de la Córnea/etiología , Exophiala/aislamiento & purificación , Infecciones Fúngicas del Ojo/microbiología , Infecciones Fúngicas del Ojo/tratamiento farmacológico , Infecciones Fúngicas del Ojo/diagnóstico , Glucocorticoides/uso terapéutico , Glucocorticoides/administración & dosificación , Queratitis/microbiología , Queratitis/diagnóstico , Queratitis/tratamiento farmacológico , Queratitis/etiología , Queratomileusis por Láser In Situ/efectos adversos , Feohifomicosis/microbiología , Feohifomicosis/diagnóstico , Feohifomicosis/tratamiento farmacológico
4.
J Mycol Med ; 34(3): 101497, 2024 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-38991295

RESUMEN

Phaeohyphomycoses are infections caused by dark-walled dematiaceous fungi. Alternaria and Curvularia are two genera of dematiaceous molds known to cause invasive fungal rhinosinusitis, particularly in immunocompromised patients. Co-infection with two dematiaceous fungi is rarely reported in the literature. This report describes a case of biopsy proven invasive fungal rhinosinusitis with Alternaria spp. and Curvularia spp. co-infection in a neutropenic host. The infection characteristics, microbiologic findings, and treatment are described.


Asunto(s)
Alternaria , Ascomicetos , Coinfección , Huésped Inmunocomprometido , Neutropenia , Feohifomicosis , Humanos , Feohifomicosis/microbiología , Feohifomicosis/diagnóstico , Feohifomicosis/complicaciones , Feohifomicosis/tratamiento farmacológico , Coinfección/microbiología , Coinfección/diagnóstico , Alternaria/aislamiento & purificación , Neutropenia/complicaciones , Neutropenia/microbiología , Ascomicetos/aislamiento & purificación , Masculino , Alternariosis/microbiología , Alternariosis/complicaciones , Alternariosis/diagnóstico , Antifúngicos/uso terapéutico , Persona de Mediana Edad , Sinusitis/microbiología , Sinusitis/complicaciones , Sinusitis/diagnóstico , Rinitis/microbiología , Rinitis/complicaciones
5.
J Vet Med Sci ; 86(5): 550-554, 2024 May 25.
Artículo en Inglés | MEDLINE | ID: mdl-38631889

RESUMEN

Pus discharge containing black granular materials (1-2 mm in diameter) was found in the abdominal skin of a 13-year-old sterilized female cat. Abdominal ultrasonography revealed a large intra-abdominal mass with abundant blood flow beneath the skin lesion. Laparotomy revealed a large mass that adhered to the spleen and left kidney. Similar small lesions were found in the abdominal wall and mesentery. The masses were surgically removed along with the spleen and kidney. Histopathologically, the mass lesions consisted of granulomas with lesional pigmented fungi, and the cat was diagnosed with phaeohyphomycosis. Uisng genetic analysis, the Exophiala dermatitidis was identified as the causative pathogen.


Asunto(s)
Enfermedades de los Gatos , Exophiala , Feohifomicosis , Animales , Feohifomicosis/veterinaria , Feohifomicosis/microbiología , Feohifomicosis/diagnóstico , Feohifomicosis/patología , Enfermedades de los Gatos/microbiología , Enfermedades de los Gatos/diagnóstico , Enfermedades de los Gatos/patología , Femenino , Gatos , Exophiala/aislamiento & purificación
7.
J Mycol Med ; 34(2): 101467, 2024 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-38432117

RESUMEN

A 3-year-old boy presented with acute headache, vomiting and right focal clonic seizures without history of fever, joint pain or altered sensorium. Neuroimaging showed multifocal contrast enhancing lesions with significant perilesional edema. CECT chest and abdomen showed multiple variable sized nodules in the lungs and hypodense lesion in liver with mesenteric lymphadenopathy. There was persistent eosinophilia with maximum upto 35 %. Liver biopsy and brain biopsy revealed Cladophialophora bantiana. He was treated with IV liposomal amphotericin and voriconazole for 6 weeks with repeat neuroimaging showing more than 50 % resolution of the intracranial lesions. He was transitioned to oral combination of flucytosine and voriconazole. At 14 months follow-up, he remained symptom free with complete radiological resolution of the lesions and no eosinophilia. High suspicion, an aggressive approach in obtaining microbiological diagnosis and timely combination antifungal therapy may give satisfactory outcome without surgery.


Asunto(s)
Anfotericina B , Antifúngicos , Ascomicetos , Inmunocompetencia , Feohifomicosis , Humanos , Masculino , Preescolar , Antifúngicos/uso terapéutico , Ascomicetos/aislamiento & purificación , Feohifomicosis/microbiología , Feohifomicosis/diagnóstico , Feohifomicosis/tratamiento farmacológico , Anfotericina B/uso terapéutico , Voriconazol/uso terapéutico , Flucitosina/uso terapéutico , Flucitosina/administración & dosificación
9.
Indian J Pathol Microbiol ; 67(3): 631-633, 2024 Jul 01.
Artículo en Inglés | MEDLINE | ID: mdl-38391321

RESUMEN

ABSTRACT: Fungal infection is a rare condition in immunocompetent individuals, and it is associated with high rates of morbidity and mortality. We report on a case of cutaneous phaeohyphomycosis in healthy 25-year-old man. Based on the clinical findings, the case was first thought to be cervico-facial actinomycosis, but Alternaria was identified on the culture after debridement. Simple surgical excision resulted in the complete cure without administration of systemic antifungals.


Asunto(s)
Alternaria , Cara , Feohifomicosis , Humanos , Masculino , Adulto , Feohifomicosis/diagnóstico , Feohifomicosis/microbiología , Feohifomicosis/tratamiento farmacológico , Feohifomicosis/patología , Alternaria/aislamiento & purificación , Cara/microbiología , Cara/patología , Desbridamiento , Microscopía , Histocitoquímica , Dermatomicosis/diagnóstico , Dermatomicosis/microbiología , Dermatomicosis/patología , Dermatomicosis/tratamiento farmacológico , Inmunocompetencia , Piel/patología , Piel/microbiología
10.
J Infect Chemother ; 30(9): 934-937, 2024 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-38369121

RESUMEN

Phaeohyphomycosis is caused by dematiaceous (pigmented) fungi. Most phaeohyphomycosis is non-invasive infections, however, they can lead to invasive infections, including fungemia and disseminated disease, particularly in severely immunocompromised patients. Invasive phaeohyphomycosis has recently emerged, however, the treatment strategy was not determined because of the intrinsic resistance to antifungals and the lack of clinical experience. Here, we describe a novel case of echinocandin-breakthrough Coniochaeta hoffmannii (Lecythophora hoffmannii) fungemia after hematopoietic stem cell transplantation, which was identified using matrix-assisted laser desorption ionization time-of-flight mass spectrometry and ribosomal RNA sequencing. The patient was a female in her 40s who had acute myeloid leukemia refractory to chemotherapy before progressing to cord blood transplantation. Before developing fungemia, the patient was administered multiple broad-spectrum antibiotics and micafungin for recurrent infections and prophylaxis. Clinical and microbiological responses to liposomal amphotericin B were poor but improved after replacement to voriconazole and engraftment. A literature review of the previously reported cases with C. hoffmannii human infections imply that disruption of the cutaneous/mucosal barrier and the use of antimicrobial agents, both antibiotics and antifungals, could incite C. hoffmannii invasive infections.


Asunto(s)
Antifúngicos , Trasplante de Células Madre de Sangre del Cordón Umbilical , Fungemia , Leucemia Mieloide Aguda , Micafungina , Voriconazol , Humanos , Femenino , Leucemia Mieloide Aguda/complicaciones , Leucemia Mieloide Aguda/tratamiento farmacológico , Leucemia Mieloide Aguda/terapia , Micafungina/uso terapéutico , Micafungina/administración & dosificación , Antifúngicos/uso terapéutico , Voriconazol/uso terapéutico , Voriconazol/administración & dosificación , Fungemia/tratamiento farmacológico , Fungemia/microbiología , Adulto , Trasplante de Células Madre de Sangre del Cordón Umbilical/efectos adversos , Feohifomicosis/tratamiento farmacológico , Feohifomicosis/microbiología , Feohifomicosis/diagnóstico , Huésped Inmunocomprometido , Equinocandinas/uso terapéutico , Equinocandinas/administración & dosificación
12.
Mycoses ; 66(11): 1012-1017, 2023 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-37553547

RESUMEN

Exophiala spinifera is a rare dematiaceous fungus causing cutaneous, subcutaneous and disseminated phaeohyphomycosis (PHM). Standard antifungal therapy for PHM is still uncertain. Here, we report a case of a Chinese male with PHM caused by E. spinifera, who received significant clinical improvement after the treatment with oral itraconazole and terbinafine. With the aim of evaluating the antifungal therapy for PHM caused by E. spinifera, a detailed review was performed.


Asunto(s)
Exophiala , Feohifomicosis , Masculino , Humanos , Itraconazol/uso terapéutico , Terbinafina/uso terapéutico , Antifúngicos/uso terapéutico , Feohifomicosis/diagnóstico , Feohifomicosis/tratamiento farmacológico , Feohifomicosis/microbiología
13.
Diagn Cytopathol ; 51(12): E338-E341, 2023 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-37602913

RESUMEN

Fine-needle aspiration cytology (FNAC) is often the first-line investigation for detection of any fungal infection. Rhytidhysteron rufulum is an emerging dematiaceous fungus detected as a human pathogen. FNAC combined with molecular techniques helps in the detection of rare fungal species, especially in cases of non-sporulating fungi. We describe the cytomorphologic features of this species in a 62-year immunocompetent male who presented with a localised subcutaneous infection. Molecular studies helped in the final diagnosis.


Asunto(s)
Ascomicetos , Micosis , Feohifomicosis , Humanos , Masculino , Feohifomicosis/diagnóstico , Feohifomicosis/microbiología , Micosis/diagnóstico , Citodiagnóstico
15.
Med Mycol ; 61(6)2023 Jun 05.
Artículo en Inglés | MEDLINE | ID: mdl-37327089

RESUMEN

Central nervous system (CNS) phaeohyphomycosis is a rare and often fatal fungal infection. Our study reported a case series of eight CNS phaeohyphomycosis cases at our institution over the past 20 years. We did not observe the common pattern of risk factors, abscess location, or number of abscesses among them. Most patients were immunocompetent without classic risk factors for fungal infection. Early diagnosis and aggressive management with surgical intervention and prolonged antifungal therapy can lead to a favorable outcome. The study highlights the need for further research to better understand the pathogenesis and optimal management of this challenging rare infection.


Asunto(s)
Feohifomicosis Cerebral , Micosis , Feohifomicosis , Animales , Feohifomicosis/diagnóstico , Feohifomicosis/tratamiento farmacológico , Feohifomicosis/microbiología , Feohifomicosis/veterinaria , Feohifomicosis Cerebral/diagnóstico , Feohifomicosis Cerebral/tratamiento farmacológico , Feohifomicosis Cerebral/veterinaria , Micosis/tratamiento farmacológico , Micosis/veterinaria , Factores de Riesgo , Antifúngicos/uso terapéutico
16.
Int J Infect Dis ; 134: 99-101, 2023 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-37268101

RESUMEN

A woman presented with purulent infiltrating plaques on her hands and arms after a 7-year history of nephrotic syndrome. She was ultimately diagnosed with subcutaneous phaeohyphomycosis, which is caused by Alternaria section Alternaria. The lesions completely resolved after 2 months of antifungal treatment. Interestingly, spores (round-shaped cells) and hyphae were observed in the biopsy and pus specimens, respectively. This case report highlights that distinguishing subcutaneous phaeohyphomycosis from chromoblastomycosis may be difficult if the diagnosis is solely based on pathological findings. It also emphasizes that the parasitic forms of the dematiaceous fungi in immunosuppressed hosts may vary with the site and environment.


Asunto(s)
Cromoblastomicosis , Feohifomicosis , Humanos , Femenino , Feohifomicosis/diagnóstico , Feohifomicosis/tratamiento farmacológico , Feohifomicosis/microbiología , Alternaria , Antifúngicos/uso terapéutico , Cromoblastomicosis/tratamiento farmacológico , Huésped Inmunocomprometido
17.
Methods Mol Biol ; 2667: 159-168, 2023.
Artículo en Inglés | MEDLINE | ID: mdl-37145283

RESUMEN

Infections by dematiaceous fungi especially phaeohyphomycosis are an emerging group of infectious diseases worldwide with a variety of clinical presentations. The mouse model is a useful tool for studying phaeohyphomycosis, which can mimic dematiaceous fungal infections in humans. Our laboratory has successfully constructed a mouse model of subcutaneous phaeohyphomycosis and found significant phenotypic differences between Card9 knockout and wild-type mice, mirroring the increased susceptibility to this infection observed in CARD9-deficient humans. Here we describe construction of the mouse model of subcutaneous phaeohyphomycosis and related experiments. We hope that this chapter can be beneficial for the study of phaeohyphomycosis and facilitate the development of new diagnostic and therapeutic approaches.


Asunto(s)
Feohifomicosis , Humanos , Animales , Ratones , Feohifomicosis/diagnóstico , Feohifomicosis/tratamiento farmacológico , Feohifomicosis/microbiología , Hongos , Antifúngicos/uso terapéutico , Proteínas Adaptadoras de Señalización CARD
18.
Indian J Pathol Microbiol ; 66(2): 314-320, 2023.
Artículo en Inglés | MEDLINE | ID: mdl-37077074

RESUMEN

Objectives: Phaeohyphomycosis refers to infections caused by phaeoid/dematiaceous or darkly pigmented fungi. This study was undertaken to further increase our knowledge about the incidence of phaeohyphomycosis and its causative agents. Materials and Methods: The present study was conducted over a period of one and a half years (January 2018-June 2019) on specimens received from patients with varied clinical manifestations ranging from superficial infections, subcutaneous cysts, pneumonia, brain abscess to a disseminated infection. These specimens were processed in the Department of Microbiology for potassium hydroxide (KOH) examination and culture and in Pathology for cytology/histopathological examination (HPE). All specimens positive on direct examination for dark grey, brown or black fungi were included in the study. Results: A total of 20 specimens were confirmed as phaeohyphomycosis. Most of the patients belonged to the age group of 41 to 50 years. Male: Female ratio was 2.3:1. Trauma was the most common risk factor. Spectra of the isolated fungal pathogens comprised of Bipolaris species, Exophiala species, Curvularia geniculata, Phialemonium species, Daldinia eschscholtzii, Hypoxylon anthochroum, Phaeoacremonium species, Leptosphaerulina australis, Medicopsis romeroi, Lasiodiplodia theobromae, Eutypella species, Chaetomium globosum, Alternaria species, Cladophialophora bantiana and 2 unidentified dematiaceous fungi. Recovery from phaeohyphomycosis was seen in 12 patients, 7 were lost to follow up and one patient succumbed to the illness. Conclusion: Infections caused by phaeoid fungi can no longer be viewed as rare. In fact, phaeohyphomycosis can have myriad of presentations spanning from mild cutaneous infections to fatal brain disease. Therefore, a high index of clinical suspicion is needed to diagnose such infections. The primary treatment modality remains surgical removal of the lesion in cutaneous or subcutaneous infections however disseminated disease with a guarded prognosis requires aggressive management.


Asunto(s)
Encefalopatías , Feohifomicosis , Humanos , Masculino , Femenino , Adulto , Persona de Mediana Edad , Feohifomicosis/diagnóstico , Feohifomicosis/epidemiología , Feohifomicosis/tratamiento farmacológico , Piel/patología , Atención a la Salud , India/epidemiología , Antifúngicos/uso terapéutico
19.
J Infect Chemother ; 29(6): 615-619, 2023 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-36921763

RESUMEN

A 65-year-old Japanese woman repeatedly withdrew and resumed antibiotics against pulmonary non-tuberculous mycobacterial infection caused by Mycobacterium intracellulare for more than 10 years. Although she continued to take medications, her respiratory symptoms and chest computed tomography indicated an enlarged infiltrative shadow in the lingular segment of the left lung that gradually worsened over the course of a year or more. Bronchoscopy was performed and mycobacterial culture of the bronchial lavage fluid was negative, whereas Exophiala dermatitidis was detected. After administration of oral voriconazole was initiated, the productive cough and infiltrative shadow resolved. There are no characteristic physical or imaging findings of E. dermatitidis, and it often mimics other chronic respiratory infections. Thus, when confronting refractory non-tuberculous mycobacterial cases, it might be better to assume other pathogenic microorganisms, including E. dermatitidis, and actively perform bronchoscopy.


Asunto(s)
Exophiala , Feohifomicosis , Neumonía , Humanos , Femenino , Anciano , Feohifomicosis/diagnóstico , Feohifomicosis/tratamiento farmacológico , Feohifomicosis/microbiología , Micobacterias no Tuberculosas , Voriconazol/uso terapéutico , Neumonía/tratamiento farmacológico , Pulmón/diagnóstico por imagen , Pulmón/patología
20.
Cytopathology ; 34(3): 275-278, 2023 05.
Artículo en Inglés | MEDLINE | ID: mdl-36648323

RESUMEN

In this case of phaeohyphomycosis, fine needle aspiration cytology enabled a rapid diagnosis and prompt treatment. This infection is quite prevalent in immunocompromised individuals; however, the Medicopsis romeroi species is a rare causative agent. These cases are associated with inadequate response to standard antifungal therapy and require discussion.


Asunto(s)
Ascomicetos , Mucormicosis , Feohifomicosis , Humanos , Antifúngicos/uso terapéutico , Mucormicosis/diagnóstico , Mucormicosis/tratamiento farmacológico , Feohifomicosis/diagnóstico , Feohifomicosis/tratamiento farmacológico , Femenino , Persona de Mediana Edad
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