Asunto(s)
Hialohifomicosis/microbiología , Trasplante de Riñón/efectos adversos , Infecciones Oportunistas/microbiología , Trasplante de Páncreas/efectos adversos , Sinusitis/microbiología , Diagnóstico Diferencial , Humanos , Hialohifomicosis/diagnóstico , Hialohifomicosis/inmunología , Hialohifomicosis/terapia , Huésped Inmunocomprometido , Inmunosupresores/efectos adversos , Masculino , Persona de Mediana Edad , Infecciones Oportunistas/diagnóstico , Infecciones Oportunistas/inmunología , Infecciones Oportunistas/terapia , Valor Predictivo de las Pruebas , Sinusitis/diagnóstico , Sinusitis/inmunología , Sinusitis/terapia , Resultado del TratamientoAsunto(s)
Hialohifomicosis/microbiología , Hypocreales/aislamiento & purificación , Huésped Inmunocomprometido/inmunología , Trasplante de Riñón/efectos adversos , Infecciones Oportunistas/microbiología , Anciano , Brazo , Femenino , Humanos , Hialohifomicosis/inmunología , Hialohifomicosis/patología , Hypocreales/inmunología , Fallo Renal Crónico/cirugía , Infecciones Oportunistas/inmunología , Infecciones Oportunistas/patología , Tejido Subcutáneo/microbiología , Tejido Subcutáneo/patologíaRESUMEN
Infection by human T-cell lymphotropic virus (HTLV-1) causes deregulation of the immune system, which makes the infected individuals more susceptible to infectious diseases. Immune deregulation is even more pronounced in HTLV-1 carriers with adult T-cell leukemia/lymphoma (ATLL), which results in frequent opportunistic infections. Hyalohyphomycosis is a rare subcutaneous mycosis which is more commonly associated with immunocompromised patients. We report a case of a HTLV-1-infected man with skin tumors, inguinal lymphadenomegaly, and lymphocytosis. Histopathological examination of skin biopsies revealed a T-cell lymphoma intermingled with a granulomatous process with abscesses and hyaline-septated hyphae. The lymph node showed only a T-cell lymphoma. The patient was diagnosed with acute ATLL and hyalohyphomycosis. He was treated with itraconazole for the subcutaneous mycosis and with chemotherapy for ATLL. A few months later, despite the treatment, he died because of progression of ATLL.
Asunto(s)
Dermatomicosis/inmunología , Infecciones por HTLV-I/inmunología , Virus Linfotrópico T Tipo 1 Humano/inmunología , Hialohifomicosis/inmunología , Huésped Inmunocomprometido , Leucemia-Linfoma de Células T del Adulto/inmunología , Adulto , Antifúngicos/uso terapéutico , Antineoplásicos/uso terapéutico , Biopsia , Dermatomicosis/diagnóstico , Dermatomicosis/tratamiento farmacológico , Dermatomicosis/microbiología , Progresión de la Enfermedad , Resultado Fatal , Infecciones por HTLV-I/diagnóstico , Infecciones por HTLV-I/virología , Virus Linfotrópico T Tipo 1 Humano/aislamiento & purificación , Humanos , Hialohifomicosis/diagnóstico , Hialohifomicosis/tratamiento farmacológico , Hialohifomicosis/microbiología , Leucemia-Linfoma de Células T del Adulto/diagnóstico , Leucemia-Linfoma de Células T del Adulto/tratamiento farmacológico , Leucemia-Linfoma de Células T del Adulto/virología , Masculino , Resultado del TratamientoRESUMEN
Fusarium and Aspergillus species of mold are major causes of corneal infections in the United States and worldwide, resulting in severe visual impairment and blindness. As there is evidence for T cell responses to these pathogenic fungi in infected individuals, we examined the role of IL-17A (IL-17) and IFN-γ in murine models of fungal keratitis. We found that C57BL/6 mice given intratracheal or s.c. immunization of conidia prior to corneal infection exhibited enhanced fungal killing and lower corneal opacity compared with unimmunized mice. Protective immunity was associated with temporal recruitment of IL-17-producing neutrophils and Th17 and Th1 cells and dependent on production of IL-17 but not IFN-γ. Protection was also impaired in neutrophil-depleted and Rag2(-/-) mice. Together, the results of these studies identify an essential role for IL-17-producing neutrophils and Th17 cells in regulating the growth of fungal hyphae and the severity of corneal disease.
