RESUMEN
Mounting evidence suggests a causal relationship between specific bacterial infections and the development of certain malignancies. In this study, we examined the presence of Porphyromonas gingivalis (P. gingivalis) in oral-digestive tract tumors by immunohistochemistry (IHC) and PCR and analyzed the correlation between P. gingivalis detection and clinicopathological characteristics and prognosis of oral and esophageal carcinoma. The IHC results showed that the positive rates of P. gingivalis were 60.00, 46.00, 20.00, 6.67, and 2.86% in oral, esophagus, cardiac, stomach, and colorectal cancer tissues, respectively. Likewise, PCR results showed rates of 56.00, 42.00, 16.67, 3.33, and 2.86%, respectively. The two methods were consistent, and the kappa value was 0.806, P < 0.001. In addition, P. gingivalis expression was significantly correlated with lymph node metastasis and the clinical stages of oral and esophageal cancer (P < 0.05). The overall survival rate of the P. gingivalis undetected group (86, 50%) was significantly higher than that of the P. gingivalis detected group (57, 14%) for oral and esophageal cancer, respectively. In conclusion, the detection rate of P. gingivalis showed a decreasing trend in oral-digestive tract tumors. Detection with P. gingivalis was associated with poor prognosis for oral and esophageal cancer.
Asunto(s)
Infecciones por Bacteroidaceae/diagnóstico , Infecciones por Bacteroidaceae/epidemiología , Neoplasias Gastrointestinales/complicaciones , Neoplasias de la Boca/complicaciones , Porphyromonas gingivalis/aislamiento & purificación , Infecciones por Bacteroidaceae/etiología , China/epidemiología , Femenino , Estudios de Seguimiento , Neoplasias Gastrointestinales/microbiología , Humanos , Masculino , Persona de Mediana Edad , Neoplasias de la Boca/microbiología , Porphyromonas gingivalis/genética , Pronóstico , Estudios RetrospectivosRESUMEN
Several studies have shown a clear association between periodontal disease and increased risk of cardiovascular disease. Porphyromonas gingivalis (Pg), a key oral pathogen, and its cell surface-expressed gingipains, induce oedema in a zebrafish larvae infection model although the mechanism of these vascular effects is unknown. Here, we aimed to determine whether Pg-induced vascular damage is mediated by gingipains. In vitro, human endothelial cells from different vascular beds were invaded by wild-type (W83) but not gingipain-deficient (ΔK/R-ab) Pg. W83 infection resulted in increased endothelial permeability as well as decreased cell surface abundance of endothelial adhesion molecules PECAM-1 and VE-cadherin compared to infection with ΔK/R-ab. In agreement, when transgenic zebrafish larvae expressing fluorescently labelled PECAM-1 or VE-cadherin were systemically infected with W83 or ΔK/R-ab, a significant reduction in adhesion molecule fluorescence was observed specifically in endothelium proximal to W83 bacteria through a gingipain-dependent mechanism. Furthermore, this was associated with increased vascular permeability in vivo when assessed by dextran leakage microangiography. These data are the first to show that Pg directly mediates vascular damage in vivo by degrading PECAM-1 and VE-cadherin. Our data provide a molecular mechanism by which Pg might contribute to cardiovascular disease.
Asunto(s)
Infecciones por Bacteroidaceae/etiología , Cardiomegalia/etiología , Edema/etiología , Células Endoteliales/efectos de los fármacos , Cisteína-Endopeptidasas Gingipaínas/toxicidad , Porphyromonas gingivalis/patogenicidad , Animales , Animales Modificados Genéticamente , Antígenos CD/genética , Antígenos CD/metabolismo , Infecciones por Bacteroidaceae/genética , Infecciones por Bacteroidaceae/metabolismo , Infecciones por Bacteroidaceae/patología , Cadherinas/genética , Cadherinas/metabolismo , Permeabilidad Capilar/efectos de los fármacos , Cardiomegalia/genética , Cardiomegalia/metabolismo , Cardiomegalia/patología , Edema/genética , Edema/metabolismo , Edema/patología , Embrión no Mamífero , Células Endoteliales/metabolismo , Células Endoteliales/patología , Angiografía con Fluoresceína , Expresión Génica/efectos de los fármacos , Genes Reporteros , Cisteína-Endopeptidasas Gingipaínas/biosíntesis , Proteínas Fluorescentes Verdes/genética , Proteínas Fluorescentes Verdes/metabolismo , Humanos , Larva/efectos de los fármacos , Larva/microbiología , Molécula-1 de Adhesión Celular Endotelial de Plaqueta/genética , Molécula-1 de Adhesión Celular Endotelial de Plaqueta/metabolismo , Porphyromonas gingivalis/crecimiento & desarrollo , Porphyromonas gingivalis/metabolismo , Cultivo Primario de Células , Transducción de Señal , Pez CebraAsunto(s)
Absceso Abdominal/etiología , Infecciones por Bacteroidaceae/etiología , Coinfección/etiología , Diálisis Peritoneal/efectos adversos , Prevotella/aislamiento & purificación , Infecciones Estreptocócicas/etiología , Streptococcus anginosus/aislamiento & purificación , Anciano de 80 o más Años , Humanos , MasculinoRESUMEN
Chronic periodontitis is characterised by gingival inflammation and alveolar bone loss. A major aetiological agent is Porphyromonas gingivalis, which secretes proteases that activate protease-activated receptor 2 (PAR2 ). PAR2 expressed on oral keratinocytes is activated by proteases released by P. gingivalis, inducing secretion of interleukin 6 (IL-6), and global knockout of PAR2 prevents bone loss and inflammation in a periodontal disease model in mice. To test the hypothesis that PAR2 expressed on gingival keratinocytes is required for periodontal disease pathology, keratinocyte-specific PAR2 -null mice were generated using K14-Cre targeted deletion of the PAR2 gene (F2rl1). These mice were subjected to a model of periodontitis involving placement of a ligature around a tooth, combined with P. gingivalis infection ("Lig + Inf"). The intervention caused a significant 44% decrease in alveolar bone volume (assessed by microcomputed tomography) in wildtype (K14-Cre:F2rl1wt/wt ), but not littermate keratinocyte-specific PAR2 -null (K14-Cre:F2rl1fl/fl ) mice. Keratinocyte-specific ablation of PAR2 prevented the significant Lig + Inf-induced increase (2.8-fold) in the number of osteoclasts in alveolar bone and the significant up-regulation (2.4-4-fold) of the inflammatory markers IL-6, IL-1ß, interferon-γ, myeloperoxidase, and CD11b in gingival tissue. These data suggest that PAR2 expressed on oral epithelial cells is a critical regulator of periodontitis-induced bone loss and will help in designing novel therapies with which to treat the disease.
Asunto(s)
Pérdida de Hueso Alveolar/etiología , Gingivitis/genética , Queratinocitos/metabolismo , Enfermedades Periodontales/etiología , Receptor PAR-2/metabolismo , Pérdida de Hueso Alveolar/genética , Animales , Infecciones por Bacteroidaceae/etiología , Antígeno CD11b/metabolismo , Modelos Animales de Enfermedad , Regulación de la Expresión Génica , Gingivitis/etiología , Interleucina-6/metabolismo , Queratinocitos/patología , Ratones Mutantes , Porphyromonas gingivalis/patogenicidad , Receptor PAR-2/genéticaRESUMEN
BACKGROUND: Fusobacteriae are facultative anaerobic gram-negative bacilli which cause a range of invasive infections, amongst which pyogenic liver abscesses are rare. We describe a case of Fusobacterium nucleatum liver abscess and review the relevant literature. CASE PRESENTATION: A 51-year-old lady presented with a 4-day history of abdominal pain, diarrhoea, fever, rigors, and lethargy. Imaging revealed an abscess which was drained. Cultures of the blood and abscess aspirate grew Fusobacterium nucleatum and Prevotella pleuritidis respectively. She achieved full recovery following treatment. A MEDLINE search was undertaken using free-text and Medical Subject Headings (MeSH), keywords "Fusobacterium" and "Liver abscess". Non-English language reports and cases without confirmed growth of Fusobacterium species were excluded. Additional cases were identified by surveying the references of each report and by using the same keywords in a web-based search. Forty-eight cases were identified, 41 in men. The median age was 42.5, with an interquartile range of 33. F. nucleatum and F. necrophorum were in involved in 22 cases each, and 4 cases were not further speciated. Among cases of F. nucleatum liver abscess, nine were attributed to periodontal disease, four to lower gastrointestinal tract disease, one to Lemierre's Syndrome, and eight were considered cryptogenic. All patients treated made a full recovery. Antimicrobial treatment duration ranged from 2 weeks to 6 months with a median of 6 weeks. CONCLUSION: Fusobacterium nucleatum is an uncommon cause of liver abscess generally associated with good clinical outcomes with contemporary medical and surgical care.
Asunto(s)
Infecciones por Fusobacterium/etiología , Fusobacterium nucleatum/patogenicidad , Absceso Piógeno Hepático/microbiología , Infecciones por Bacteroidaceae/etiología , Drenaje , Femenino , Infecciones por Fusobacterium/tratamiento farmacológico , Infecciones por Fusobacterium/microbiología , Humanos , Absceso Piógeno Hepático/tratamiento farmacológico , Absceso Piógeno Hepático/etiología , Masculino , Persona de Mediana Edad , Enfermedades Periodontales/microbiología , Prevotella/patogenicidadRESUMEN
An 83-year-old patient suffered a cat bite dorsally to the Achilles tendon. In the further course, he developed an isolated intratendinous abscess of the Achilles tendon, which was surgically revised twice and subsequently healed with antibiotic treatment. In Germany, about 40,000 bite injuries of different origins occur annually. Most of these injuries are cat or dog bites, while human bites are rare. Although the course is often complicated, there are no standard recommendations for treatment. An intratendinous abscess after animal bite injury has not been described in the literature as yet.
Asunto(s)
Absceso/etiología , Tendón Calcáneo/lesiones , Mordeduras y Picaduras/complicaciones , Tendinopatía/etiología , Traumatismos de los Tendones/complicaciones , Absceso/diagnóstico por imagen , Absceso/cirugía , Tendón Calcáneo/diagnóstico por imagen , Tendón Calcáneo/cirugía , Anciano de 80 o más Años , Animales , Infecciones por Bacillaceae/diagnóstico por imagen , Infecciones por Bacillaceae/etiología , Infecciones por Bacillaceae/cirugía , Bacillus , Infecciones por Bacteroidaceae/diagnóstico por imagen , Infecciones por Bacteroidaceae/etiología , Infecciones por Bacteroidaceae/cirugía , Infecciones por Bacteroides/diagnóstico por imagen , Infecciones por Bacteroides/etiología , Infecciones por Bacteroides/cirugía , Mordeduras y Picaduras/diagnóstico por imagen , Mordeduras y Picaduras/cirugía , Ciprofloxacina/uso terapéutico , Terapia Combinada , Humanos , Imagen por Resonancia Magnética , Masculino , Pruebas de Sensibilidad Microbiana , Persona de Mediana Edad , Porphyromonas gingivalis , Reoperación , Tendinopatía/diagnóstico por imagen , Tendinopatía/cirugía , Traumatismos de los Tendones/diagnóstico por imagen , Traumatismos de los Tendones/cirugíaAsunto(s)
Infecciones por Bacteroidaceae/etiología , Infecciones por Campylobacter/etiología , Campylobacter rectus/aislamiento & purificación , Coinfección/microbiología , Infecciones por Fusobacterium/etiología , Fusobacterium necrophorum/aislamiento & purificación , Infecciones por Bacterias Grampositivas/etiología , Meningitis Bacterianas/microbiología , Peptostreptococcus/aislamiento & purificación , Absceso Periodontal/complicaciones , Porphyromonas gingivalis/aislamiento & purificación , Anciano , Antibacterianos/uso terapéutico , Infecciones por Bacteroidaceae/tratamiento farmacológico , Infecciones por Bacteroidaceae/microbiología , Infecciones por Campylobacter/tratamiento farmacológico , Infecciones por Campylobacter/microbiología , Coinfección/tratamiento farmacológico , Terapia Combinada , Drenaje , Quimioterapia Combinada , Resultado Fatal , Femenino , Infecciones por Fusobacterium/tratamiento farmacológico , Infecciones por Fusobacterium/microbiología , Infecciones por Bacterias Grampositivas/tratamiento farmacológico , Infecciones por Bacterias Grampositivas/microbiología , Humanos , Leucocitosis/etiología , Meningitis Bacterianas/tratamiento farmacológico , Meningitis Bacterianas/cirugía , Absceso Periodontal/microbiologíaRESUMEN
Porphyromonas gingivalis is a periodontal pathogen strongly associated with loss of attachment and supporting bone for teeth. We have previously shown that the total lipid extract of P. gingivalis inhibits osteoblast differentiation through engagement of Toll-like receptor 2 (TLR2) and that serine dipeptide lipids of P. gingivalis engage both mouse and human TLR2. The purpose of the present investigation was to determine whether these serine lipids inhibit osteoblast differentiation in vitro and in vivo and whether TLR2 engagement is involved. Osteoblasts were obtained from calvaria of wild type or TLR2 knockout mouse pups that also express the Col2.3GFP transgene. Two classes of serine dipeptide lipids, termed Lipid 654 and Lipid 430, were tested. Osteoblast differentiation was monitored by cell GFP fluorescence and osteoblast gene expression and osteoblast function was monitored as von Kossa stained mineral deposits. Osteoblast differentiation and function were evaluated in calvarial cell cultures maintained for 21 days. Lipid 654 significantly inhibited GFP expression, osteoblast gene expression and mineral nodule formation and this inhibition was dependent on TLR2 engagement. Lipid 430 also significantly inhibited GFP expression, osteoblast gene expression and mineral nodule formation but these effects were only partially attributed to engagement of TLR2. More importantly, Lipid 430 stimulated TNF-α and RANKL gene expression in wild type cells but not in TLR2 knockout cells. Finally, osteoblast cultures were observed to hydrolyze Lipid 654 to Lipid 430 and this likely occurs through elevated PLA2 activity in the cultured cells. In conclusion, our results show that serine dipeptide lipids of P. gingivalis inhibit osteoblast differentiation and function at least in part through engagement of TLR2. The Lipid 430 serine class also increased the expression of genes that could increase osteoclast activity. We conclude that Lipid 654 and Lipid 430 have the potential to promote TLR2-dependent bone loss as is reported in experimental periodontitis following oral infection with P. gingivalis. These results also support the conclusion that serine dipeptide lipids are involved in alveolar bone loss in chronic periodontitis.
Asunto(s)
Osteoblastos/microbiología , Osteoblastos/patología , Porphyromonas gingivalis/patogenicidad , Receptor Toll-Like 2/metabolismo , Pérdida de Hueso Alveolar/etiología , Pérdida de Hueso Alveolar/metabolismo , Pérdida de Hueso Alveolar/patología , Animales , Infecciones por Bacteroidaceae/etiología , Infecciones por Bacteroidaceae/metabolismo , Infecciones por Bacteroidaceae/patología , Diferenciación Celular/efectos de los fármacos , Periodontitis Crónica/etiología , Periodontitis Crónica/metabolismo , Periodontitis Crónica/patología , Dipéptidos/metabolismo , Dipéptidos/toxicidad , Humanos , Lipopéptidos/metabolismo , Lipopéptidos/toxicidad , Ratones , Ratones Endogámicos C57BL , Ratones Noqueados , Ratones Transgénicos , Osteoblastos/efectos de los fármacos , Porphyromonas gingivalis/metabolismo , Receptor Toll-Like 2/deficiencia , Receptor Toll-Like 2/genética , Factores de Virulencia/metabolismo , Factores de Virulencia/toxicidadRESUMEN
BACKGROUND: Infections present a major complication of cranioplasty procedures and in many cases removal of the implant material becomes a necessity. Sonication of the artificial implant material has been used during the last years, in order to facilitate better diagnosis of these infections, nevertheless its use in cranial implant infections is still limited. CASE PRESENTATION: A case of a 63-year-old Caucasian male patient who underwent a decompressive craniectomy, due to intracranial hemorrhage, and a consequent cranioplasty using an autogenic bone flap fixed by titanium clamps, is reported. After three unsuccessful cranioplasty efforts to repair a persistent skin defect, removing the bone flap and the titanium clamps was a necessity. Tissue and bone cultures were unable to reveal any microorganism whilst sonication of the removed titanium clamps and consequent culture of the resulting sonication liquid yielded Prevotella disiens and Staphylococcus epidermidis. The patient was treated with daptomycin and metronidazole until discharge and the skin defect was successfully repaired. CONCLUSION: The present case report indicates that the use of the sonication procedure assisted the microbiological diagnosis. This is the first known neurosurgical case of the implementation of the sonication procedure.
Asunto(s)
Antibacterianos/uso terapéutico , Infecciones por Bacteroidaceae/diagnóstico , Infecciones por Bacteroidaceae/tratamiento farmacológico , Sonicación , Infecciones Estafilocócicas/diagnóstico , Infecciones Estafilocócicas/tratamiento farmacológico , Infecciones por Bacteroidaceae/etiología , Infecciones por Bacteroidaceae/microbiología , Daptomicina/uso terapéutico , Humanos , Masculino , Metronidazol/uso terapéutico , Persona de Mediana Edad , Prevotella/efectos de los fármacos , Prevotella/crecimiento & desarrollo , Prevotella/aislamiento & purificación , Prótesis e Implantes/microbiología , Procedimientos de Cirugía Plástica/efectos adversos , Cráneo/efectos de los fármacos , Cráneo/microbiología , Cráneo/cirugía , Infecciones Estafilocócicas/etiología , Infecciones Estafilocócicas/microbiología , Staphylococcus epidermidis/efectos de los fármacos , Staphylococcus epidermidis/crecimiento & desarrollo , Staphylococcus epidermidis/aislamiento & purificación , Colgajos Quirúrgicos , Titanio/química , Resultado del TratamientoRESUMEN
It seems that Porphyromanas gingivalis is carcinogenic, because it activates a number of inflammatory immune responses in the host and causes disorders in bacterial clearance mechanisms. There is little information on the prevalence of this bacterium in cancer patients. The aim of this study was to evaluate and compare the prevalence of P. gingivalis in cancer patients by meta-analysis methods.Different databases including PubMed, EMBASE, the Cochrane Library, Scopus, and ISI web of Knowledge were investigated and eight relevant articles published in 2000-2013 were finally analyzed. Data were analyzed by meta-analysis method, fixed effect model. I² statistics were calculated to examine the heterogeneity of papers. The information was analyzed by R and STATA Ver 12.2.A total of 711 people infected with P. gingivalis were included in this study. In total, the prevalence of P. gingivalis was 40.7% (95% CI, 19.3-62.1). The prevalence of P. gingivalis was evaluated in four case-control studies. The results of this study showed that P. gingivalis increased the chance of cancer development and periodontal disease as much as 1.36 times (OR, 1.36; 95%CI, 0.47-3.97).Although there was no significant correlation between P. gingivalis and cancer, this bacterium increased the chance of cancer and periodontal disease and could be considered as a main potential risk factor.
Asunto(s)
Infecciones por Bacteroidaceae/etiología , Neoplasias/etiología , Neoplasias/microbiología , Porphyromonas gingivalis/patogenicidad , Adolescente , Estudios de Casos y Controles , Humanos , Persona de Mediana Edad , Enfermedades Periodontales/etiología , Enfermedades Periodontales/microbiología , Prevalencia , Factores de RiesgoAsunto(s)
Infecciones por Bacteroidaceae/terapia , Enfermedades de la Pulpa Dental/terapia , Infección Focal Dental/terapia , Infecciones por Fusobacterium/terapia , Absceso Periodontal/terapia , Prevotella , Infecciones Estreptocócicas/terapia , Enfermedad Aguda , Infecciones por Bacteroidaceae/diagnóstico , Infecciones por Bacteroidaceae/etiología , Caries Dental/complicaciones , Caries Dental/prevención & control , Enfermedades de la Pulpa Dental/diagnóstico , Enfermedades de la Pulpa Dental/etiología , Infección Focal Dental/diagnóstico , Infección Focal Dental/etiología , Infecciones por Fusobacterium/diagnóstico , Infecciones por Fusobacterium/etiología , Humanos , Absceso Periodontal/diagnóstico , Índice de Severidad de la Enfermedad , Infecciones Estreptocócicas/diagnóstico , Infecciones Estreptocócicas/etiologíaRESUMEN
A wide variety of infections, including bacteria, viruses, fungi and protozoa occur in the immunocompromised condition associated with human immunodeficiency virus type 1 (HIV-1) infection and acquired immunodeficiency syndrome (AIDS). Although these opportunistic infections are believed to arise as an effect of the immunodeficiency, these microbes sometimes promote the disease progression of HIV-1 infection by enhancing viral replication or modulating host immune responses. Here we review the experimental and clinical evidence supporting such causal relationships associated with periodontogenic bacteria. Periodontal disease, caused by subgingival infection with oral anaerobic bacteria, typically Porphyromonas gingivalis (P. gingivalis) belonging to the phylum Bacteroidetes, is found worldwide and is one of the most prevalent microbial diseases of mankind. Emerging evidence implicates the involvement of P. gingivalis infection in the progression of HIV-1 infection. We demonstrate that P. gingivalis can induce HIV-1 reactivation via chromatin modification, and that the bacterial metabolite butyric acid produced in anaerobic conditions is responsible for this effect. These findings suggest that periodontal diseases could act as a risk factor for HIV-1 reactivation in infected individuals and might contribute to AIDS progression. Furthermore, it would imply that prevention and early treatment of periodontitis involving P. gingivalis infection could effectively block further clinical progression of AIDS.
Asunto(s)
Infecciones Oportunistas Relacionadas con el SIDA/inmunología , Síndrome de Inmunodeficiencia Adquirida/inmunología , Infecciones por Bacteroidaceae/inmunología , VIH-1/fisiología , Histonas/inmunología , Periodontitis/inmunología , Porphyromonas gingivalis/fisiología , Infecciones Oportunistas Relacionadas con el SIDA/etiología , Infecciones Oportunistas Relacionadas con el SIDA/microbiología , Síndrome de Inmunodeficiencia Adquirida/complicaciones , Síndrome de Inmunodeficiencia Adquirida/microbiología , Infecciones por Bacteroidaceae/etiología , Infecciones por Bacteroidaceae/microbiología , Progresión de la Enfermedad , Femenino , VIH-1/patogenicidad , Humanos , Masculino , Periodontitis/etiología , Periodontitis/microbiología , Porphyromonas gingivalis/patogenicidad , Activación Viral/inmunología , Latencia del Virus/inmunologíaRESUMEN
We report a case of necrotizing fasciitis in the loin of a 76-year old man with several coexisting or past health issues, including diabetes mellitus, hypertension, alcohol-related liver cirrhosis, gastrectomy for gastric cancer, subarachnoid hemorrhage, normal pressure hydrocephalus, and cerebral infarction. Incision of the necrotizing fasciitis was successful, but it revealed an appendicocutaneous fistula; thus, we performed appendectomy and fistulectomy. We think that the necrotizing fasciitis was caused by appendicitis perforation involving the retroperitoneum, inducing the formation of an appendicocutaneous fistula. Necrotizing fasciitis and appendicocutaneous fistulae are rare complications of appendicitis. Moreover, to our knowledge, this is the first report of fluoroscopic examination demonstrating that a primary appendicocutaneous fistula had caused necrotizing fasciitis. Our search of the literature found 12 cases of necrotizing fasciitis caused by preoperative appendicitis. We discuss the characteristics and findings of these cases.
Asunto(s)
Apendicitis/diagnóstico , Infecciones por Bacteroidaceae/etiología , Fístula Cutánea/diagnóstico , Infecciones por Escherichia coli/etiología , Fascitis Necrotizante/etiología , Infecciones por Bacterias Grampositivas/etiología , Fístula Intestinal/diagnóstico , Anciano , Apendicitis/complicaciones , Infecciones por Bacteroidaceae/diagnóstico , Fístula Cutánea/complicaciones , Infecciones por Escherichia coli/diagnóstico , Fascitis Necrotizante/diagnóstico , Resultado Fatal , Infecciones por Bacterias Grampositivas/diagnóstico , Humanos , Fístula Intestinal/complicaciones , Masculino , Peptostreptococcus/aislamiento & purificación , Prevotella/aislamiento & purificaciónRESUMEN
BACKGROUND: Spondylodiscitis is commonly caused by aerobic bacteria. Of all the spinal infections, anaerobic organisms account for less than 3% and are usually seen in postoperative patients. CASE DESCRIPTION: We report a rare case of spontaneous onset of spondylodiscitis caused by anaerobe Prevotella that led to the diagnosis of serous cystadenofibroma of the ovaries. CONCLUSION: The finding of Prevotella species in musculoskeletal infection should prompt investigation of the genitourinary system.
Asunto(s)
Infecciones por Bacteroidaceae/diagnóstico , Cistadenoma Seroso/complicaciones , Discitis/diagnóstico , Discitis/etiología , Neoplasias Ováricas/complicaciones , Prevotella , Anciano , Infecciones por Bacteroidaceae/etiología , Infecciones por Bacteroidaceae/terapia , Cistadenoma Seroso/microbiología , Cistadenoma Seroso/terapia , Discitis/terapia , Femenino , Humanos , Neoplasias Ováricas/microbiología , Neoplasias Ováricas/terapiaAsunto(s)
Embolización Terapéutica/efectos adversos , Endometritis/etiología , Leiomioma/terapia , Infecciones Estreptocócicas/etiología , Streptococcus bovis/aislamiento & purificación , Neoplasias Uterinas/terapia , Infecciones por Bacteroidaceae/etiología , Cuello del Útero/microbiología , Femenino , Infecciones por VIH/complicaciones , Humanos , Histerosalpingografía , Huésped Inmunocomprometido , Persona de Mediana Edad , Prevotella melaninogenica/aislamiento & purificación , Choque Séptico/etiologíaRESUMEN
Liposuction represents the standard surgical treatment of localized fat excess. Some non-plastic-surgery-board-certified practitioners are likely to offer non-invasive alternatives treatments. We report the clinical case of a 14-year-old female patient who followed a Lipectomy treatment. The Lipectomy technique consists in a hypodermic injection of hypotonic solutions in order to obtain an adipocytes lysis by osmotic shock. No PubMed referenced scientific publication is related to the efficacy or the tolerance of this technique. Postoperative evolution was marked by a polymicrobial subcutaneous abscess that needed two surgical evacuations and 10 days of overnight stay in our department. Through this clinical case, we evoke the possible dangers linked to the application of a non-evaluated medical technique and the necessity of establishing an official validation agency related to innovative techniques in aesthetic medicine and surgery.
Asunto(s)
Absceso/etiología , Infecciones por Bacteroidaceae/etiología , Infecciones por Bacterias Grampositivas/etiología , Inyecciones Subcutáneas/efectos adversos , Lipectomía/efectos adversos , Cloruro de Sodio/administración & dosificación , Grasa Subcutánea/cirugía , Absceso/diagnóstico , Absceso/tratamiento farmacológico , Absceso/microbiología , Absceso/cirugía , Adolescente , Antibacterianos/uso terapéutico , Infecciones por Bacteroidaceae/diagnóstico , Infecciones por Bacteroidaceae/tratamiento farmacológico , Infecciones por Bacteroidaceae/cirugía , Drenaje , Femenino , Infecciones por Bacterias Grampositivas/diagnóstico , Infecciones por Bacterias Grampositivas/tratamiento farmacológico , Infecciones por Bacterias Grampositivas/cirugía , Humanos , Soluciones Hipotónicas/administración & dosificación , Lipectomía/métodos , Muslo/patología , Muslo/cirugía , Resultado del TratamientoRESUMEN
This is a case report of septic arthritis of the knee due to Prevotella loescheii, in a patient with advanced arthrosis. Two weeks beforehand he had undergone a dental root extraction without antibiotic prophylaxis. His knee had become inflamed 48 hours after extraction and he was started on ibuprofen and steroid treatment (prescribed by his primary health care doctor). With a provisional diagnosis of septic arthritis, synovial fluid was taken for study. Antimicrobial therapy was commenced with amoxicillin/clavulanic acid and the patient progressed satisfactorily. Prevotella loescheii was identified by anaerobic culture. A site of origin for the infection was never found. Joint infection is generally secondary to haematogenous dissemination of bacteria from habitual sites such as odontogenic locations. We suggest that patients with inflammatory arthropathies should be considered as candidates for antibiotic prophylaxis in oral surgery and invasive dental procedures. We suggest, in these cases, the use of antibiotic with spectrum against aerobic and anaerobic bacteria.
Asunto(s)
Artritis Infecciosa/microbiología , Infecciones por Bacteroidaceae/etiología , Articulación de la Rodilla , Prevotella , Extracción Dental/efectos adversos , Anciano , Humanos , MasculinoRESUMEN
PURPOSE: Body piercing has become increasingly prevalent. We describe a case of breast infection with combined mycobacteria and anaerobe following nipple piercing, and review the literature. CASE: A 17-year-old female developed a breast abscess 4 months after nipple piercing. Cultures grew Prevotalla melangenica and Mycobacterium fortuitum. She required drainage and antibiotic treatment. Three months into her treatment she stopped her medications, relapsed, and required drainage. Two months later, on antimycobacteria therapy, her wound is healing. DISCUSSION: Review of the infectious complications of nipple piercing yielded 12 cases, 5 of which had a foreign body. The pathogens isolated (coagulase negative staphylococcus, mycobacteria, streptococcus, anaerobe, and gordonia) are not the usual organisms to be isolated from a breast abscess. This could result from reporting bias or the presence of a foreign body, the nipple ring. The three cases of mycobacteria, in addition to ours, are reviewed. The average age is 22 years. Three to 9 months elapsed between piercing and infection. All cases required drainage. Antimycobacteria therapy was used in three of the four cases for 10 days to 6 months. CONCLUSION: With the increasing prevalence of body piercing, it is important to document and report infections. We describe a breast abscess following nipple piercing with combined anaerobic and a mycobacterial pathogens. This underscores the need for obtaining cultures including anaerobes and mycobacteria.
Asunto(s)
Absceso/microbiología , Perforación del Cuerpo/efectos adversos , Enfermedades de la Mama/etiología , Infecciones por Mycobacterium no Tuberculosas/etiología , Mycobacterium fortuitum/aislamiento & purificación , Absceso/terapia , Adolescente , Antibacterianos/uso terapéutico , Infecciones por Bacteroidaceae/etiología , Infecciones por Bacteroidaceae/microbiología , Infecciones por Bacteroidaceae/terapia , Enfermedades de la Mama/microbiología , Enfermedades de la Mama/terapia , Drenaje , Femenino , Humanos , Infecciones por Mycobacterium no Tuberculosas/microbiología , Infecciones por Mycobacterium no Tuberculosas/terapia , Prevotella melaninogenica/aislamiento & purificaciónRESUMEN
We present a case of a 29-y-old woman with rectocele, cystocele, and uterine prolapse who developed a vaginal infection after the placement of a macroporous polypropylene vaginal mesh. Bacteroides melaninogenicus was isolated from the area of the infection. The exposed parts of the mesh were removed and she received treatment with metronidazole and doxycycline. No recurrence of the infection was noted during 12 months of follow-up. However, the patient continued to avoid intercourse due to severe dyspareunia. Vaginal mesh-related infections represent an emerging type of infection that may complicate reconstructive surgery in patients with pelvic organ prolapse.
Asunto(s)
Infecciones por Bacteroidaceae/patología , Cuerpos Extraños/microbiología , Prevotella melaninogenica/aislamiento & purificación , Mallas Quirúrgicas/microbiología , Prolapso Uterino/cirugía , Adulto , Infecciones por Bacteroidaceae/tratamiento farmacológico , Infecciones por Bacteroidaceae/etiología , Femenino , Humanos , Mallas Quirúrgicas/efectos adversosRESUMEN
BACKGROUND: Squamous intraepithelial lesions are more prevalent in women infected with the human immunodeficiency virus (HIV) compared with immunocompetent women. Loop electrosurgical excision procedure (LEEP) is commonly used to treat squamous intraepithelial lesions because it may be performed as an outpatient procedure with minimal blood loss and a low complication rate. CASE: We report a major infectious post-LEEP complication in an HIV-infected female who had an uneventful LEEP in which a cellulose hemostatic agent was used. Despite the severity of the infection, she was successfully treated with a minor surgical procedure along with broad antibiotic coverage. CONCLUSION: Although a cellulose hemostatic agent contaminated with perineal secretions may have served as a nidus for infection, use of perioperative antibiotics or cervical cleansing should be considered to prevent sepsis in immunocompromised hosts.