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OBJECTIVE: This study aimed to assess the public's knowledge of stroke before and after viewing an educational video about stroke risk factors, preventive measures, and alarming signs. METHODS: A single-arm interventional study was conducted in Lebanon using a 3-minute video-based education about stroke. A pre- and post-structured questionnaire compared the level of knowledge about stroke. RESULTS: The study included 685 participants. Knowledge of stroke, risk factors, warning signs, treatment, and preventive measures significantly increased post-educational video sessions. A higher baseline knowledge score was associated with a family history of stroke (Beta = 1.76) and being a healthcare professional (Beta = 3.35). Participants between 25 and 34 years (Beta=-1.39) and those with a high risk of stroke (Beta=-1.03) were significantly associated with a lower knowledge score. CONCLUSION: This study demonstrated the effectiveness of a video-based educational tool to raise awareness about stroke. Short, targeted audio-visual resources using lay language can convey health education messages and influence behavioral changes. The community can benefit from a large-scale educational campaign that targets different socio-economic statuses to enhance knowledge of stroke and save lives.
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Educación en Salud , Conocimientos, Actitudes y Práctica en Salud , Accidente Cerebrovascular , Grabación en Video , Humanos , Líbano , Masculino , Femenino , Adulto , Accidente Cerebrovascular/prevención & control , Persona de Mediana Edad , Educación en Salud/métodos , Encuestas y Cuestionarios , Adulto Joven , Anciano , Adolescente , Factores de RiesgoRESUMEN
BACKGROUND: This study investigates the impact of financial insecurity on the mental well-being and stress levels of parents in Lebanon amid the country's severe economic crisis. The context of Lebanon's economic collapse, coupled with the effects of the COVID-19 pandemic and the Beirut port explosion, has exacerbated financial and psychological distress among the population. This research aims to understand the correlation between financial instability and parental stress, identifying key factors contributing to mental health challenges in this demographic. METHODS: Employing a quantitative research approach, data was collected through an online survey from 785 parents from different backgrounds in Lebanon. The survey incorporated sociodemographic questions, the InCharge Financial Distress/Financial Well-Being Scale (IFDFW), and the Arabic version of the Parental Stress Scale (PSS). Data analysis was conducted using SPSS version 25. RESULTS: Findings showed significant correlations between high levels of parental stress and factors such as age (r = 0.071, p = 0.047) and lower education levels. Notably, refugees residing in Lebanon exhibited higher stress levels compared to Lebanese parents (mean stress score: 51.73 vs. 45.71, p < 0.001). Similarly, employed participants exhibited higher stress levels compared to the nonworking (mean stress score: 46.75 vs. 44.60, p = 0.003). A significant inverse association was found between financial well-being and parental stress (r=-0.216, p < 0.001), emphasizing the profound impact of economic instability on mental health. CONCLUSIONS: This study highlights the adverse effects of financial insecurity on parents' mental health, primarily during a period of economic instability, emphasizing the urgent need for targeted support interventions. These findings contribute to the literature on economic crises and mental health, providing a basis for future research and policy development in similar contexts.
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Recesión Económica , Salud Mental , Padres , Humanos , Líbano , Masculino , Femenino , Adulto , Padres/psicología , Salud Mental/estadística & datos numéricos , Persona de Mediana Edad , Estrés Psicológico/epidemiología , COVID-19/psicología , COVID-19/epidemiología , Encuestas y Cuestionarios , Estrés Financiero/psicología , Adulto JovenRESUMEN
INTRODUCTION: Worldwide, people heavily use chemical-based disinfectants to prevent the spread of COVID-19 with limited or no safety instructions. Awareness about the safe use of chemical-based disinfectants is highly recommended to limit the spread of COVID-19 and to avoid any health risks when misused, especially in developing countries where a poor healthcare system is prominent. Awareness in this context refers to the understanding and knowledge of proper usage, safety protocols and potential health risks associated with chemical disinfectants. Practices refer to the actual behaviours and actions taken when using disinfectants, including frequency of use, methods of application and adherence to safety guidelines. OBJECTIVE: The purpose of this paper is to develop a valid and reliable questionnaire to assess the community level of awareness and practice concerning chemical-based disinfectant use during COVID-19 in Lebanon. DESIGN: The questionnaire was adapted and modified from a previous study held in Iran, in which the questions were generated and developed with content validity ratio and index (CVR and CVI). The study design was divided into the qualitative phase/development of the Disinfectants Use Questionnaire (DUQ) and the quantitative phase/psychometric properties of the DUQ. The questionnaire was subjected to face and content validity tests through expert reviews. Data validation, for 130 participants (80.8% females, 85.5% bachelor's degree and above, 80.8% students and 70.8% aged within 30 years), was examined through psychometric properties at the final stage of the validation. CVI for items (I-CVI), scale-level CVI (S-CVI), universal agreement calculation (S-CVI/UA), S-CVI and the average calculation method (S-CVI/Ave), based on I-CVI and based on proportion relevance, were calculated to determine the content validity. RESULTS: 23 items of the 28-item scale had an I-CVI of 1, and the I-CVI of the remaining five ranged between 0.75 and 0.88. The S-CVI/UA was 0.82 and the S-CVI/Ave was 0.96, which meant that the items were good for the underlying construct. For the psychometric measures, principal axis factoring was performed and the Kaiser-Meyer-Olkin (KMO) measure of sampling adequacy, Bartlett's test, eigenvalues and total variances were quite accepted and satisfactory. CONCLUSION: This study showed that DUQ is a valid and reliable tool for evaluating the community level of awareness and practice concerning chemical-based disinfectant use during COVID-19.
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COVID-19 , Desinfectantes , Humanos , Líbano , Femenino , COVID-19/prevención & control , Adulto , Encuestas y Cuestionarios , Reproducibilidad de los Resultados , Masculino , Persona de Mediana Edad , Adulto Joven , Psicometría , SARS-CoV-2 , Conocimientos, Actitudes y Práctica en Salud , AdolescenteRESUMEN
INTRODUCTION: Tokophobia is an intense and pathological fear of pregnancy and childbirth. Despite its significance, no research in Lebanon has investigated primary tokophobia within the general population. Nevertheless, it is crucial to assess the attitudes of both women and men, as potential future parents, towards pregnancy and childbirth, particularly during these challenging times for the Lebanese population. Therefore, this study aims to evaluate the psychometric properties of the Tokophobia Severity Scale (TSS) and Fathers' Fear of Childbirth Scale (FFCS) for assessing primary tokophobia among Lebanese nulliparous women and childless men, respectively. METHODS: This cross-sectional investigation encompassed all Lebanese governorates; 651 women and 618 men were recruited via social media platforms, using a snowball sampling technique. The questionnaire included the Tokophobia Severity Scale, the Fathers' Fear of Childbirth Scale, the Patient Health Questionnaire, and the Lebanese Anxiety Scale. RESULTS: Factorial analysis of the TSS in women revealed a three-factor model: concerns related to personal complications (Factor 1), fetal well-being (Factor 2), and outward behavioral responses to fear (Factor 3). The FFCS also yielded a three-factor measurement model: emotional responses during the partner's childbirth (Factor 1), concerns regarding the hospital environment during childbirth (Factor 2), and anxieties surrounding the perinatal health of both the partner and child (Factor 3). Both scales were internally consistent with Cronbach's alpha > 0.9, indicating their reliability. The TSS and FFCS demonstrated statistically significant correlations with measures of anxiety and depression, thus attesting to convergent validity. CONCLUSION: The results of this study provide evidence for the psychometric validity and reliability of the TSS and FFCS scales in Arabic-speaking populations. Given the previously overlooked nature of primary tokophobia in these populations, the availability of these validated instruments can significantly enhance the ability to detect and address this condition, ultimately facilitating the provision of necessary support services.
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Padre , Miedo , Parto , Psicometría , Humanos , Femenino , Psicometría/instrumentación , Líbano , Masculino , Adulto , Parto/psicología , Miedo/psicología , Estudios Transversales , Padre/psicología , Embarazo , Adulto Joven , Encuestas y Cuestionarios/normas , Trastornos Fóbicos/psicología , Trastornos Fóbicos/diagnóstico , Reproducibilidad de los Resultados , Persona de Mediana Edad , AdolescenteRESUMEN
Pharmacogenomics (PGx) is a practice that investigates the link between genetic differences and drug response in patients. This can improve treatment effectiveness and reduce harmful side effects. However, has yet to be adequately realized in developing nations. Three surveys were conducted between November 2022 to March 2023 in Egypt and Lebanon. The first survey assessed availability of PGx testing in different healthcare facilities; the second one assessed knowledge, interest and attitude toward learning about PGx among pharmacists and physicians; and the third one assessed interest in providing PGx education at academic levels. In Egypt, a few of the surveyed healthcare facilities are conducting some form of pharmacogenetic testing. In Lebanon, very few germline pharmacogenomic tests are offered in Greater Beirut's leading hospitals, and no other testing was recorded. PGx education attracts considerable interest, with 34.3% of pharmacists very interested and 48.8% interested. Similarly, 24.8% of total physicians were very interested while 44.8% were interested. Academic professionals in the surveyed institutions in both countries agreed on the need for educational programs in PGx and 78.2% agreed that there were good opportunities for implementing PGx testing. These findings clearly indicate the need to develop and implement educational programs in PGx in the Middle-East.
[Box: see text].
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Farmacogenética , Líbano , Humanos , Egipto , Farmacogenética/educación , Encuestas y Cuestionarios , Farmacéuticos , Médicos , Conocimientos, Actitudes y Práctica en Salud , Pruebas de Farmacogenómica/métodos , Necesidades y Demandas de Servicios de Salud , Femenino , MasculinoRESUMEN
INTRODUCTION: Gram-negative bacteremia is a life-threatening infection with high morbidity and mortality. Its incidence is rising worldwide, and treatment has become more challenging due to emerging bacterial resistance. Little data is available on the burden and outcome of such infections in Lebanon. METHODS: We conducted this retrospective study in four Lebanese hospitals. Data on medical conditions and demographics of 2400 patients diagnosed with a bloodstream infection based on a positive blood culture were collected between January 2014 and December 2020. RESULTS: Most bacteremias were caused by Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa and Acinetobacter baumannii, with the more resistant organisms being hospital-acquired. Third-generation cephalosporin and quinolone resistance was steady throughout the study, but carbapenem resistance increased. Mortality with such infections is high, but carbapenem resistance or infection with Pseudomonas or Acinetobacter species were significant risk factors for poor outcomes. CONCLUSION: This is the first multi-center study from Lebanon on gram-negative bacteremia, resistance patterns, and factors associated with a poor outcome. More surveillance is needed to provide data to guide empirical treatment for bacteremia in Lebanon.
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Antibacterianos , Bacteriemia , Bacterias Gramnegativas , Infecciones por Bacterias Gramnegativas , Humanos , Líbano/epidemiología , Bacteriemia/epidemiología , Bacteriemia/microbiología , Bacteriemia/tratamiento farmacológico , Estudios Retrospectivos , Masculino , Femenino , Infecciones por Bacterias Gramnegativas/epidemiología , Infecciones por Bacterias Gramnegativas/microbiología , Infecciones por Bacterias Gramnegativas/tratamiento farmacológico , Persona de Mediana Edad , Antibacterianos/uso terapéutico , Antibacterianos/farmacología , Bacterias Gramnegativas/efectos de los fármacos , Bacterias Gramnegativas/aislamiento & purificación , Anciano , Hospitales/estadística & datos numéricos , Adulto , Infección Hospitalaria/epidemiología , Infección Hospitalaria/microbiología , Pseudomonas aeruginosa/efectos de los fármacos , Pseudomonas aeruginosa/aislamiento & purificación , Pruebas de Sensibilidad Microbiana , Klebsiella pneumoniae/efectos de los fármacos , Klebsiella pneumoniae/aislamiento & purificación , Farmacorresistencia Bacteriana , Anciano de 80 o más Años , Factores de Riesgo , Acinetobacter baumannii/efectos de los fármacos , Acinetobacter baumannii/aislamiento & purificaciónRESUMEN
BACKGROUND: Data on Emotion Dysregulation among youth in Lebanon is scarce. Given that Emotion Dysregulation is associated with psychopathology and has a negative impact on youth outcomes, there is a need to better understand the prevalence, clinical and demographic correlates of Emotion Dysregulation. METHODS: This study is a secondary analysis of the Psychopathology in Children and Adolescents in Lebanon Study which recruited 1517 youth and one parent from a nationally representative sample. Participants completed The Screen for Child Anxiety Related Emotional Disorders, Mood and Feelings Questionnaire, Strengths and Difficulties Questionnaire, Peer Relations Questionnaire, Conflict Behavior Questionnaire (CBQ).Parents completed a sociodemographic questionnaire and the General Health Questionnaire (GHQ). The Strengths and Difficulties Questionnaire-Dysregulation Profile was used to measure Emotion Dysregulation. RESULTS: The prevalence of Emotion Dysregulation was 11.26% among children aged 5 to < 8 years, 9.40% among children aged 8 to < 12 years and 6.60% among those older than 12 years. Emotion Dysregulation was associated with psychopathology across age groups and a number of correlates were identified. In the final regression models, among children aged 5 to < 8 years; Emotion Dysregulation was associated with lower odds of father employment (OR = 0.235;CI[0.078,0.704]). For those aged 8 to < 12 years old, Emotion Dysregulation was associated with acceptable school performance (OR = 2.246,CI[1.209,4.173]) as opposed to a good school performance, having a chronic physical illness (OR = 2.962; CI [1.495,5.867)], and higher parental GHQ scores (OR = 1.034;CI [1.010,10.58)] indicating worse parental mental health. Adolescents aged 12 years and older who screened positive for Emotion Dysregulation were more likely to be younger (OR = 0.688, CI[0.527,0.899]), be a bully (OR = 2.467;CI[1.036,5.875] and to have higher parental CBQ scores (OR = 1.092;CI [1.011,1.180]), indicating worse parent-child conflict. Youth who screened positive for emotion dysregulation were more likely to seek psychiatric care than their counterparts who screen negative for emotion dysregulation. CONCLUSION: Age, school performance, parental mental health, parental conflict, chronic physical illness and bullying emerge as important correlates of Emotion Dysregulation. Findings add to the limited data on Emotion Dysregulation in Lebanon and the region and are a first step towards developing intervention and prevention strategies.
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Síntomas Afectivos , Regulación Emocional , Humanos , Líbano/epidemiología , Niño , Masculino , Femenino , Adolescente , Prevalencia , Síntomas Afectivos/epidemiología , Síntomas Afectivos/psicología , Preescolar , Encuestas y CuestionariosRESUMEN
Background: Stress has been shown to be associated with poor nutrition among young women. However, studies around the topic have major limitations in their methodologies and the role of confounding factors within this association remains unclear in the literature. Objective: To investigate the associations between stress and dietary quality/patterns in a culturally diverse population of childbearing-aged women. Methods: A secondary analysis of data from two studies conducted in UK and Lebanon was performed using Structural Equation Modelling (SEM) to explore the role of country context, socio-economic status, and physical variables. Participants were healthy women of childbearing age (n = 493). Variables measured were dietary intake, stress, physical activity, sociodemographic variables, and Body Mass Index. These were included in the SEM analysis to examine the mediating effect of stress. Results: The results showed that, among all variables, only country had a significant effect on dietary quality and patterns through the mediatory effect of stress. Participants from Lebanon were found to have higher stress levels compared to participants from the UK, and this contributed to a lower adherence to a Mediterranean diet. Conclusions: This study shows that for women of childbearing age, having a good diet quality/pattern is dependent on stress levels and country context.
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Dieta , Análisis de Clases Latentes , Estrés Psicológico , Humanos , Femenino , Líbano , Adulto , Reino Unido , Dieta/estadística & datos numéricos , Adulto Joven , Dieta Mediterránea/estadística & datos numéricos , Índice de Masa Corporal , Diversidad Cultural , Ejercicio Físico , Factores Socioeconómicos , Conducta Alimentaria/psicología , AdolescenteRESUMEN
Continuous surveillance and risk assessment of inactivated Coronavirus Disease 2019 (COVID-19)) vaccines provide an understanding of their safety profiles, guide vaccination strategy and public health policy. This study aims to analyze the characteristics and prevalence of officially reported serious adverse events following immunization (AEFIs) with inactivated COVID-19 vaccines by System Organ Class (SOC), age, and sex.To achieve this aim, a retrospective observational study was conducted between February 14th, 2021, and June 30th, 2022. Reported AEFIs were evaluated for data completeness. Causality assessment adhered to the World Health Organization guidelines.Findings revealed that the AEFIs occurrence did not significantly differ between vaccines used (ChAdOx1 vs. BNT162b2), sex, or SOC. The most prevalent AEFIs were vascular disorders (37%), followed by cardiac (25%) and nervous system disorders (14%). The adverse events were predominantly reported post-vaccination with the BNT162b2 vaccine, mainly after the first dose. The mean age was highest for miscellaneous disorders (70 ± 21.7 years) and the lowest for nervous system (46 ± 22 years) and immune system disorders (45 ± 19 years). Age differences were statistically different for vascular disorders (p = 0.003) and immune system disorders (p = 0.012).In conclusion, ongoing surveillance and risk assessment of the vaccine's safety profile is crucial for detecting potential safety signals. Active surveillance of the reported serious AEFIs is highly needed to support evidence-based vaccination strategies and maintain public confidence in immunization programs.
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Vacuna BNT162 , Vacunas contra la COVID-19 , Farmacovigilancia , Humanos , Estudios Retrospectivos , Masculino , Femenino , Persona de Mediana Edad , Anciano , Adulto , Vacunas contra la COVID-19/efectos adversos , Vacunas contra la COVID-19/administración & dosificación , Líbano/epidemiología , Vacuna BNT162/efectos adversos , Adulto Joven , Anciano de 80 o más Años , Sistemas de Registro de Reacción Adversa a Medicamentos/estadística & datos numéricos , Bases de Datos Factuales , COVID-19/prevención & control , COVID-19/epidemiología , Adolescente , ChAdOx1 nCoV-19 , Efectos Colaterales y Reacciones Adversas Relacionados con Medicamentos/epidemiologíaRESUMEN
BACKGROUND AND OBJECTIVE: Nutrition is a basic need for athletes; thus, adequate dietary intake is crucial for maintaining overall health, facilitating training adaptations and boosting athletic performance. Accurate dietary assessment tools are required to minimize the challenges faced by athletes. This study verifies the validity and reproducibility of a 157 item semi-quantitative food frequency questionnaire (FFQ) among Lebanese athletes. This is the only Arabic questionnaire in Lebanon that estimates food consumption for athletes which can also be used in Arabic speaking countries. There has been no previous validated food frequency questionnaire that estimated food consumption for athletes in Lebanon. METHODS: A total of 194 athletes were included in the study to assess the validity of the food frequency questionnaire against four days dietary recalls by comparing the total nutrient intake values from the food frequency questionnaire with the mean values of four 24-hour dietary recalls using Spearman correlation coefficient and Bland Altman plots. In order to measure the reproducibility, the intra class correlation coefficients were calculated by repeating the same food frequency questionnaire after one month. RESULTS: The intra-class correlation coefficient between the two-food frequency questionnaires ranged from average (0.739 for carbohydrates) to good (0.870 for energy (Kcal)), to excellent (0.919 for proteins) concerning macronutrients and ranged from average (0.688 for vitamin D), to excellent (0.952 for vitamin B12), indicating an acceptable reproducibility. Spearman's correlation coefficients of dietary intake estimate from the food frequency questionnaire and the four dietary recalls varied between 0.304 for sodium, 0.469 for magnesium to 0.953 for caloric intake (kcal). Bland-Altman plots illustrated a percentage of agreement ranging between 94.3% for fats to 96.4% for proteins. CONCLUSION: This food frequency questionnaire has a reliable validity and reproducibility to evaluate dietary assessments and is an appropriate tool for future interventions to ensure the adoption of adequate eating strategies by athletes.
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Atletas , Humanos , Líbano , Masculino , Atletas/estadística & datos numéricos , Femenino , Encuestas y Cuestionarios , Reproducibilidad de los Resultados , Adulto , Adulto Joven , Dieta , Ingestión de Energía , Encuestas sobre Dietas/métodos , Encuestas sobre Dietas/normas , Adolescente , Conducta Alimentaria , Ingestión de AlimentosRESUMEN
Job crafting is the behavior that employees engage in to create personally better fitting work environments, for example, by increasing challenging job demands. To better understand the driving forces behind employees' engagement in job crafting, we investigated implicit and explicit power motives. While implicit motives tend to operate at the unconscious, explicit motives operate at the unconscious level. We focused on power motives, as power is an agentic motive characterized by the need to influence your environment. Although power is relevant to job crafting in its entirety, in this study, we link it to increasing challenging job demands due to its relevance to job control, which falls under the umbrella of power. Using a cross-sectional design, we collected survey data from a sample of Lebanese nurses (N = 360) working in 18 different hospitals across the country. In both implicit and explicit power motive measures, we focused on integrative power that enable people to stay calm and integrate opposition. The results showed that explicit power predicted job crafting (H1) and that implicit power amplified this effect (H2). Furthermore, job crafting mediated the relationship between congruently high power motives and positive work-related outcomes (H3) that were interrelated (H4). Our findings unravel the driving forces behind one of the most important dimensions of job crafting and extend the benefits of motive congruence to work-related outcomes.
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Motivación , Enfermeras y Enfermeros , Humanos , Femenino , Adulto , Masculino , Estudios Transversales , Enfermeras y Enfermeros/psicología , Satisfacción en el Trabajo , Persona de Mediana Edad , Encuestas y Cuestionarios , Poder Psicológico , Lugar de Trabajo/psicología , LíbanoRESUMEN
In Lebanon, the lack of quality data on road traffic injuries (RTIs) led to the implementation of a hospital-based RTI surveillance system by the Ministry of Health in in private and public-run hospitals in the Bekaa governorate. This paper aims to describe the characteristics and severity of RTIs recorded over two years during the pilot phase. It also assesses the strengths and challenges of the surveillance system, highlighting areas for enhancement. The data collected from the Emergency department (ED) was used to conduct a retrospective analysis of population-based injuries hospitalized for road traffic crashes (RTC). Designated focal persons reported injuries weekly using a standardized form, which included demographic and crash-related variables, body lesions, and vital signs. Data were coded per the International Classification of Diseases (ICD-10), entered into Epidata, and analyzed using SPSS. The RTI surveillance system was assessed using Strengths, Weaknesses, Opportunities, and Threats (SWOT) analysis. Over two years, a total of 1576 cases of RTIs were reported. The male-to-female ratio was 2.16 and the majority of RTIs (44.4%) were recorded among those aged between 15 and 29 years old. From 2013 to 2015, a decrease of 0.7% in the revised trauma score (RTS < 4) was recorded. On the contrary, an increase of 3.9% in injury severity score (ISS) that ranged between 15 and 75 was reported. The probability of survival of an injured individual at one month was improved. The hospital-based surveillance system demonstrated strengths in structured data collection and ethical considerations but faced challenges like underreporting, limited coverage, and resource constraints. Recommendations for improvement include enhancing data quality and timely reporting, ultimately supporting evidence-based road safety interventions.
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Accidentes de Tránsito , Servicio de Urgencia en Hospital , Heridas y Lesiones , Humanos , Accidentes de Tránsito/estadística & datos numéricos , Líbano/epidemiología , Femenino , Masculino , Servicio de Urgencia en Hospital/estadística & datos numéricos , Adulto , Adolescente , Persona de Mediana Edad , Adulto Joven , Heridas y Lesiones/epidemiología , Estudios Retrospectivos , Niño , Preescolar , Anciano , Lactante , Puntaje de Gravedad del TraumatismoRESUMEN
OBJECTIVE: To evaluate the effectiveness and safety of tofacitinib in patients with ulcerative colitis (UC) in clinical practice in Lebanon. DESIGN: This was a retrospective cross-sectional study. The data were collected from hospital records. Patients with moderate to severe UC treated with tofacitinib between 2018 and 2021 were included. Patients' demographics, disease-specific characteristics, clinical assessment at three time points (8, 26, and 52 weeks), endoscopic evaluation at 24 weeks, and adverse events were collected. RESULTS: A total of 60 UC patients with a mean duration of disease of 7.9 ± 4.7 years were enrolled. 61.7% of patients had extensive disease, and 58.3% had received ≥ 1 biologic prior to tofacitinib. Clinical remission was reported in 25, 34, and 31 patients (41.7%, 56.7%, and 56.4%) at 8, 26, and 52 weeks respectively. Endoscopic remission (endoscopic Mayo score 0 or 1) was observed in 58.3% of patients at 52 weeks. About one-third of patients (31.7%) stopped tofacitinib at one year, primarily for lack of efficacy or loss of response, with no significant difference between biologics-naïve and experienced patients (24% vs. 37.1% respectively). No serious adverse events or deaths were reported. Adverse events were reported in 3 patients (5.0%) - one C. difficile infection, one case of reversible lymphopenia, and one case of facial acne. No serious adverse events or deaths were noted. On multivariate analysis, biologic-naïve status and reduction or normalization of CRP were associated with clinical remission (OR = 10.87, 95% CI = 1.57, 100, and OR = 78.47, 95% CI = 2.09, 2940.32 respectively), while reduction or normalization of CRP was associated with endoscopic remission at 1 year (OR = 19.03, 95% CI = 1.64, 221.09). CONCLUSION: Tofacitinib was effective in the treatment of moderately severe ulcerative colitis in this real-world cohort in Lebanon. Further, the predictors associated with clinical and endoscopic remissions were found to be biologic-naïve status and reduction in CRP. Observed AEs were consistent with the known safety profile. One of the major limitations of this study is the smaller sample size and the retrospective nature of the study.
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Colitis Ulcerosa , Piperidinas , Pirimidinas , Humanos , Colitis Ulcerosa/tratamiento farmacológico , Pirimidinas/uso terapéutico , Pirimidinas/efectos adversos , Piperidinas/uso terapéutico , Piperidinas/efectos adversos , Masculino , Femenino , Estudios Retrospectivos , Líbano , Adulto , Estudios Transversales , Persona de Mediana Edad , Resultado del Tratamiento , Inducción de Remisión , Índice de Severidad de la Enfermedad , Inhibidores de Proteínas Quinasas/uso terapéutico , Inhibidores de Proteínas Quinasas/efectos adversosRESUMEN
Autism spectrum disorders (ASD) are neurodevelopmental disorders characterized by social, behavioral, and cognitive impairments. Several comorbidities, including gastrointestinal (GI) dysregulations, are frequently reported in ASD children. Although studies in animals have shown the crucial role of the microbiota in key aspects of neurodevelopment, there is currently no consensus on how the alteration of microbial composition affects the pathogenesis of ASD. Moreover, disruption of the gut-brain axis (GBA) has been reported in ASD although with limited studies conducted on the Mediterranean population. In our study, we aimed to investigate gut microbiota composition in Lebanese ASD subjects, their unaffected siblings, and a control group from various regions in Lebanon using the 16 S-rRNA sequencing (NGS). Our study revealed a lower abundance of Turicibacter and a significant enrichment on Proteobacteria in the ASD and siblings' groups compared to the controls, indicating that gut microbiota is probably affected by dietary habits, living conditions together with host genetic factors. The study also showed evidence of changes in the gut microbiome of ASD children compared to their siblings and the unrelated control. Bacteroidetes revealed a lower abundance in the ASD group compared to controls and siblings, conversely, Catenibacterium and Tenericutes revealed an increased abundance in the ASD group. Notably, our study identifies alterations in the abundance of Turicibacter and Catenibacterium in ASD children suggesting a possible link between these bacterial taxa and ASD and contributing to the growing body of evidence linking the microbiome to ASD.
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Trastorno del Espectro Autista , Biomarcadores , Microbioma Gastrointestinal , Humanos , Trastorno del Espectro Autista/microbiología , Microbioma Gastrointestinal/genética , Masculino , Niño , Femenino , ARN Ribosómico 16S/genética , Preescolar , Líbano , Heces/microbiología , Estudios de Casos y Controles , Adolescente , Eje Cerebro-Intestino , HermanosRESUMEN
BACKGROUND: Adequate diet and lifestyle practices are postulated to improve health and enhance wellbeing of cancer survivors. Despite the heavy cancer burden in Lebanon, little is known about the diet quality of survivors. This cross-sectional study assessed the compliance of survivors in remission with the American Cancer Society/American Institute Research Fund (ACS/AICR) diet and physical activity guidelines. METHODS: Cancer survivors in remission for at least 3 months and attending oncology clinics in two referral centers in Beirut, Lebanon were recruited. Adherence to the ACS/AICR was assessed by examining the compliance to guidelines promoting fruits, vegetables and whole grain and discouraging elevated alcohol, meat and energy dense foods intake. Dietary data was assessed through food frequency and lifestyle questionnaires administered face to face and through phone interviews. Anthropometrics, food security and sociodemographic data was also collected. Univariate and bivariate descriptive and logistic regressions were used to determine predictors of adherence rates to the ACS/AICR score. RESULTS: A total of 268 participants were recruited (mean age = 59 ± 23 years, 83% females, 70% breast cancer). Mean time since remission was 3.2 ± 4 years and the majority (72%) had food insecurity. Low physical activity and overweight/obesity were present in 65% and 67% of the survivors, respectively. Median adherence score with the ACS/AICR score was 9.0 out of 15. The majority of survivors had complete adherence to the moderate meat and alcohol consumption guidelines. However, 98% were noncompliant with the whole grains' consumption guidelines. Cancer type, site of recruitment and education were the significant predictors of the ACS/AICR diet adherence score. CONCLUSION: This study highlights the elevated rates of overweight/obesity, physical inactivity and the alarmingly low adherence with the whole grains consumption guideline among cancer survivors in remission. Policy makers ought to use study findings to redirect government subsidization and educational interventions in the country and physicians should stress the importance of adherence to a healthy diet during remission through counseling and timely referral.
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Supervivientes de Cáncer , Política Nutricional , Humanos , Femenino , Líbano , Masculino , Supervivientes de Cáncer/psicología , Supervivientes de Cáncer/estadística & datos numéricos , Persona de Mediana Edad , Estudios Transversales , Adulto , Anciano , Cooperación del Paciente/estadística & datos numéricos , Estados Unidos , American Cancer Society , Neoplasias , Ejercicio Físico , Dieta/estadística & datos numéricos , Adhesión a Directriz/estadística & datos numéricosRESUMEN
On September 17, 2024, at 15:30 local time, thousands of pagers used by members of a specific party group detonated across Lebanon. As a result of the explosions, 2800 were wounded and 12 lost their lives. Almost two-thirds of the injuries were in the face, eyes, or hands. The Lebanese American University Medical Center received 38 injured and admitted 36 patients, 13 of them to the Intensive care unit. A total of 33 patients needed surgeries. All medical and nursing staff were deployed. The health care workers faced major challenges that night: the severity of the injuries and the unprecedented types of injuries with the same pattern, and the urgent need for ophthalmology and orthopedics within the hospital and across the country. Learning from the Pager Explosion, each hospital should perform assessments of their disaster response plan, develop trainings, and conduct regular exercises in preparation for future disasters.
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Explosiones , Humanos , Líbano , Explosiones/estadística & datos numéricos , Masculino , Adulto , Femenino , Planificación en Desastres/métodos , Traumatismos por Explosión/terapiaRESUMEN
The 2019 coronavirus (COVID-19) pandemic and strict quarantine increased the likelihood of mental symptoms and abnormal eating behaviours. This study aimed to assess the magnitude of emotional eating (EE) among nurses working in Lebanese hospitals and its association with mental health. A cross-sectional study was conducted among nurses aged between 18 and 50 years working in Lebanese hospitals during the COVID-19 outbreak and the economic crisis. A total of 303 nurses consented to participate. The mean EE score was 28.56 (±8.11). The results of this study revealed that 53.8% of the nurses reported depression, 58.1% suffered from anxiety and 95.1% experienced either moderate or severe stress. The study concluded that females (ß = 8.112, P = 0.004), non-smokers (ß = -4.732, P = 0.01) and depressed nurses (ß = 0.596, P = 0.046) had a higher tendency towards EE. Additionally, it was found that EE was associated with weight gain (ß = 6.048, P = 0.03) and increased consumption of fried foods (ß = 5.223, P = 0.001). Females experienced more stress (ß = 2.244, P = 0.003) and anxiety (ß = 1.526, P = 0.021) than their male counterparts. With regard to mental health, depression was associated with weight gain (ß = 2.402, P = 0.003) and with lower consumption of healthy foods such as nuts (ß = -1.706, P = 0.009) and dishes prepared with sofrito sauce (ß = -1.378, P = 0.012). These results can help the health authorities to design preparedness plans to ensure proper mental and physical well-being of nurses during any unforeseen emergencies.
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Ansiedad , COVID-19 , Depresión , Emociones , Salud Mental , Humanos , Femenino , Adulto , COVID-19/psicología , COVID-19/epidemiología , Masculino , Estudios Transversales , Líbano , Depresión/epidemiología , Persona de Mediana Edad , Adulto Joven , Enfermeras y Enfermeros/psicología , SARS-CoV-2 , Estrés Psicológico , Conducta Alimentaria , Adolescente , Pandemias , Hospitales , Encuestas y CuestionariosRESUMEN
BACKGROUND: Global research on gender bias has highlighted key trends in discrimination and inequality across various fields, including medicine. In Lebanon, a nation celebrated for its diverse cultural landscape and increasing female representation in medical education, there has been a notable absence of studies exploring gender dynamics in the medical profession. METHODS: To address this gap, we conducted a cross-sectional study using an online survey to explore the Lebanese population's perceptions towards female physicians and the quality of care they provide. RESULTS: The mean age of the study sample (n = 330) was 31.55 ± 10.07 years and included 114 females and 216 males. Most respondents had received care from a female physician. Notably, those who selected female physicians as their family doctors or had female doctors within their immediate family displayed a stronger tendency to engage in annual medical check-ups. While most respondents did not express any preference for the gender of their general practitioner or surgeon, there was a marked preference for female obstetricians/gynecologists, psychiatrists, pediatricians, and dermatologists. This preference was attributed to perceptions of female physicians being particularly compassionate, understanding, and proficient in communication. CONCLUSION: This study represents a groundbreaking contribution to understanding gender perceptions in the Lebanese medical field. It highlights the growing trust and positive regard for female physicians, underscoring the significant role in shaping healthcare experiences and outcomes in Lebanon.
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Médicos Mujeres , Sexismo , Humanos , Líbano , Femenino , Masculino , Estudios Transversales , Médicos Mujeres/psicología , Adulto , Actitud del Personal de Salud , Persona de Mediana Edad , Encuestas y Cuestionarios , Adulto JovenRESUMEN
BACKGROUND: Klebsiella pneumoniae is a significant global public health burden, especially in low-income countries and regions with fragile healthcare infrastructures, due to its ability to cause severe infections, increase mortality rates, and its rising antimicrobial resistance. This study aimed to estimate the proportion of multidrug-resistant (MDR) K. pneumoniae infections and identify associated risk factors. METHODS: Data were retrospectively collected from three academic hospitals in Beirut, Lebanon, between January 2021 and September 2023 using a standardized form. Binary logistic regression was used to determine risk factors associated with MDR, extended-spectrum beta-lactamase (ESBL)-producing, and carbapenem-resistant K. pneumoniae (CRKP) infections. RESULTS: Out of 2,655 K. pneumoniae cases, 410 met the inclusion criteria. The primary infection sources were the urinary tract (58.3%) and the respiratory tract (12.4%). Among the isolates, 61% were MDR K. pneumoniae, with 7.3% being extensively drug-resistant, and 0.5% pandrug-resistant. Additionally, 36.8% were ESBL-producing, while 6.3% were CRKP. Predictors significantly associated with MDR K. pneumoniae infections included male sex (adjusted odds ratio [AOR] = 3.46, 95% CI = 1.01-11.86, P = 0.04), recent antibiotics use (AOR = 4.52, 95% CI = 1.65-12.36, P = 0.003), and recent cancer chemotherapy (AOR = 3.43, 95% CI = 1.25-9.42, P = 0.01). ESBL-producing infections were associated with age ≥ 65 years, higher Charlson Comorbidity Index (CCI), and recent antibiotic use. CRKP infections were linked to male sex, prior antibiotic use, and longer hospital stays prior to infection (all P < 0.05). CONCLUSIONS: MDR K. pneumoniae infections are steadily rising in Lebanon, along with an increase in ESBL-producing and CRKP cases. The main risk factors for MDR K. pneumoniae infections were male sex, recent antibiotic use, and cancer chemotherapy. ESBL-producing infections were associated with advanced age, higher CCI, and recent antibiotic use, while CRKP infections were linked to male sex, prior antibiotic use, and prolonged hospital stays. This situation is further exacerbated by inadequate healthcare infrastructure and suboptimal national surveillance. Strengthening local surveillance and implementing effective antibiotic stewardship programs are critical to managing this growing threat..
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Farmacorresistencia Bacteriana Múltiple , Infecciones por Klebsiella , Klebsiella pneumoniae , Humanos , Líbano/epidemiología , Masculino , Infecciones por Klebsiella/epidemiología , Infecciones por Klebsiella/tratamiento farmacológico , Femenino , Klebsiella pneumoniae/aislamiento & purificación , Klebsiella pneumoniae/efectos de los fármacos , Factores de Riesgo , Persona de Mediana Edad , Anciano , Estudios Retrospectivos , Adulto , Antibacterianos/uso terapéutico , Antibacterianos/farmacología , Anciano de 80 o más Años , Adulto JovenRESUMEN
Traditional Lebanese cuisine is based on traditional dishes, where Arabic sweets play an important role in daily consumption. This study focuses on the evaluation of total fibers and trace elements, especially vitamins A, D, E, and C of traditional foods and Arabic sweets commonly consumed in Lebanon by chemical analysis. A total of thirty types of Arabic sweets were chosen from reputable confectionery establishments, while thirty varieties of traditional Lebanese dishes were collected from central kitchens in the main Lebanese governorates. It was discovered that 23% percent of Arabic sweets and 30% of traditional dishes were rich in total dietary fiber. Moreover, Arabic sweets had trace amounts of vitamin A, vitamin E, and vitamin C. In specific sweets, vitamin A content showed variability, with values ranging from 8ug to 15 ug per 100 g of edible portions. Most of the traditional dishes contained traces of vitamin C. However, Tabboula stood out as the only dish that contributed to over 23% of the recommended daily value for vitamin C. Trace amounts of vitamins A, D, E, and C were present in almost all traditional Lebanese foods and Arabic sweets. This study revealed that these foods lack essential micronutrients and total dietary fibers.