Asunto(s)
Leiomioma/terapia , Leiomiomatosis/terapia , Neoplasias Uterinas/terapia , Costo de Enfermedad , Femenino , Humanos , Infertilidad Femenina/etiología , Infertilidad Femenina/prevención & control , Leiomioma/etiología , Leiomioma/inmunología , Leiomioma/fisiopatología , Leiomiomatosis/etiología , Leiomiomatosis/inmunología , Leiomiomatosis/fisiopatología , Calidad de Vida , Neoplasias Uterinas/etiología , Neoplasias Uterinas/inmunología , Neoplasias Uterinas/fisiopatologíaAsunto(s)
Leiomioma/terapia , Leiomiomatosis/terapia , Modelos Genéticos , Modelos Inmunológicos , Terapias en Investigación , Neoplasias Uterinas/terapia , Terapia Combinada/tendencias , Costo de Enfermedad , Femenino , Humanos , Leiomioma/genética , Leiomioma/inmunología , Leiomioma/fisiopatología , Leiomiomatosis/genética , Leiomiomatosis/inmunología , Leiomiomatosis/fisiopatología , Terapias en Investigación/tendencias , Neoplasias Uterinas/genética , Neoplasias Uterinas/inmunología , Neoplasias Uterinas/fisiopatologíaAsunto(s)
Activinas/metabolismo , Subunidades beta de Inhibinas/metabolismo , Leiomioma/metabolismo , Leiomiomatosis/metabolismo , Modelos Biológicos , Miometrio/metabolismo , Neoplasias Uterinas/metabolismo , Receptores de Activinas Tipo I/química , Receptores de Activinas Tipo I/metabolismo , Receptores de Activinas Tipo II/química , Receptores de Activinas Tipo II/metabolismo , Transformación Celular Neoplásica , Femenino , Humanos , Leiomioma/inmunología , Leiomioma/patología , Leiomiomatosis/inmunología , Leiomiomatosis/patología , Miometrio/inmunología , Miometrio/patología , Transducción de Señal , Carga Tumoral , Neoplasias Uterinas/inmunología , Neoplasias Uterinas/patologíaRESUMEN
Benign metastasizing leiomyoma (BML) refers to benign pulmonary neoplasm associated with a previous or coincident history of uterine leiomyomata. We report the case of a 56-year-old postmenopausal woman with a 4-year history of multiple benign leiomyomatous lesions in bilateral lungs and the uterus. The tumor cells from the lungs and uterus were focally immunoreactive for HMB-45 antibody and progesterone receptor. Immunoreactivity to HMB-45 is well known in smooth muscle cells of hamartomatous neoplasms, such as angiomyolipoma and lymphangioleiomyomatosis, but has not been reported in BML previously. These features suggest a multifocal hamartomatous histogenesis rather than metastasis in the present case.
Asunto(s)
Leiomiomatosis/diagnóstico , Neoplasias Pulmonares/diagnóstico , Neoplasias Primarias Secundarias/diagnóstico , Antígenos de Neoplasias/análisis , Femenino , Humanos , Leiomiomatosis/química , Leiomiomatosis/inmunología , Neoplasias Pulmonares/química , Neoplasias Pulmonares/inmunología , Neoplasias Pulmonares/secundario , Antígenos Específicos del Melanoma , Persona de Mediana Edad , Proteínas de Neoplasias/análisis , Neoplasias Primarias Secundarias/química , Neoplasias Primarias Secundarias/inmunología , Receptores de Progesterona/análisis , Neoplasias Uterinas/química , Neoplasias Uterinas/inmunología , Neoplasias Uterinas/patologíaRESUMEN
Oesophageal leiomyomatosis and idiopathic eosinophilic oesophagitis are both extremely rare. The former is a diffuse proliferation of smooth muscle in the muscularis propria, whilst the latter is an idiopathic inflammatory condition, thought to be associated with background atopy and characterized by an infiltrate of eosinophils throughout the full thickness of the oesophagus. However, two recent cases of oesophageal leiomyomatosis showed similar full thickness infiltration of the oesophageal wall by eosinophils and this inflammatory cell infiltrate was investigated in conjunction with one case of idiopathic eosinophilic oesophagitis. All three had a similar allergic profile characterized by CD45RO-positive primed T-lymphocytes, EG2-positive (i.e., activated) eosinophils, and tryptasepositive mast cells, together with gene expression for interleukin 4. Previous descriptions of leiomyomatosis describe an association with systemic mastocytosis and urticaria and the possibility that there is a common underlying allergic component to both disorders is raised.