Skin diseases in internationally adopted children.

Internationally adopted children often present diseases contracted in the country of origin. Skin diseases are common in new arrivals, and diagnosis may prove challenging for GPs or even dermatologists if they are inexperienced in the extensive geographic and ethnic diversity of international adoptees. To analyse the frequency and characteristics of skin diseases in international adoptees. In total, 142 adoptees were evaluated for a cross-sectional cohort study. The most frequent diseases observed at arrival were dermatological conditions. Of the adoptees, 70% presented at least one skin disease, of which 57.5% were infectious; Tinea capitis being the most frequent (n = 42). The recovery rate of Tinea capitis was 89% (n = 32/36). Ten cases of scabies were diagnosed. Other diseases included viral skin infection (n = 22), with 16 cases of Molluscum contagiosum and bacterial infection. Skin diseases are very common in internationally adopted children. There is a need for close collaboration between dermatologists and paediatricians to diagnose such infections, as well as clear guidelines to treat them.

Paranormal beliefs of Latvian college students: a Latvian version of the revised paranormal belief scale.

A Latvian version of the Revised Paranormal Belief Scale (RPBS) was completed by 229 Latvian university students. Exploratory and confirmatory factor analyses revealed six relatively independent factors labeled Magical Abilities, Psychokinesis, Traditional Religious Belief, Superstition, Spirit Travel, and Extraordinary Life Forms. Based on the motivational-control model, it was hypothesized that the societal stressors affecting Latvian society during the last 50 yr. have led to a reduced sense of personal control which, in turn, has resulted in increased endorsement of paranormal beliefs to re-establish a sense of control. The motivational-control hypothesis was not supported. Results indicated that (except for Traditional Religious Belief in women), the majority of these students were disbelievers in paranormal phenomena. As hypothesized, Latvian women reported significantly greater paranormal belief than men.

Transnational spaces of care: migrant nurses in Norway.

This article argues that international nurse recruitment from Latvia to Norway is not a win­win situation. The gains and losses of nurse migration are unevenly distributed between sender and receiver countries. On the basis of empirical research and interviews with Latvian nurses and families they left behind, this article argues that nurse migration transforms families and communities and that national health services now become global workplaces. Some decades ago feminist research pointed to the fact that the welfare state was based on a male breadwinner family and women's unpaid production of care work at home. Today this production of unpaid care is "outsourced" from richer to poorer countries and is related to an emergence of transnational spaces of care. International nurse recruitment and global nurse care chains in Norway increasingly provide the labor that prevents the new adult worker model and gender equality politics from being disrupted in times where families are overloaded with elder care loads.

Association studies of candidate genes and cleft lip and palate taking into consideration geographical origin.

Isolated cleft lip and/or palate (CL/CLP) is a complex congenital anomaly with many contributing factors. There are several genes involved in the aetiology of CL/CLP, they are different in selected populations. In a previous study, the mitochondrial haplotypes of Latvian subjects with CL/CLP were characterized. Latvian subjects with CL/CLP have mostly mitochondrial haplogroups U4/U5 compared with the ethnic population of Latvia. The aim of this study was to stratify the results of genotyping based on European mitochondrial DNA (mtDNA) haplotypes. DNA samples from 108 patients with CL/CLP and from 182 unrelated and unaffected individuals selected randomly in Latvia (used as controls) were obtained for investigation. In this study, we analysed the data taking into consideration mitochondrial haplogroups and found that gene associations depended on the genetic origin of the population. The phenotype of patients with non-U haplotypes was associated with markers in wingless-type MMTV integration site family, member 3 (WNT3), collagen, type XI, alpha 2 (COL11A2), and fibroblast growth factor receptor 1 (FGFR1), whereas patients with U4 and U5 haplotypes showed significant association with WNT3 and COL11A2. It is unlikely that mtDNA variants play a direct role in the development of CL/CLP; rather, they may be a surrogate for population substructure and provide a tool to increase homogeneity and statistical power.

Coming of age under Hitler and Stalin: the everyday life of adolescent girls in occupied Latvia.

This article explores the possibility of the continuation of everyday life in occupied Europe through a case study of the lives of twenty-five adolescent girls and young women living in Latvia between 1939 and 1944. Late adolescence is the period in which young women are struggling to establish some degree of independence, especially through leaving the parental home and entering the labour market. These transitions are the conventional markers of adulthood in modern societies. The article explores how occupation by the Soviet Union and the Third Reich affected daily life and the speed and nature of the transition to adulthood.

Who died in the Holocaust? Recovering names from official records.

The names of most Holocaust victims from Central and East Europe have remained unknown, but can be retrieved from official records, as illustrated here for the town of Liepaja, Latvia. Drawing on thirteen different sources, the authors have recovered the names and fates of about 7,000 of the 7,140 Jews once living there. The main source (5,700 names) is a census conducted during August 1941, the second month of the German occupation. Other sources are victims' lists compiled by Yad Vashem and by the Soviet Extraordinary Commission, house books, police and camp records, telephone and business directories, lists of deportees to the USSR, survivor reports, etc. All sources are incomplete and many are error-ridden, but they usually can be reconciled. Coverage of victims from Liepaja thus has increased from 20% to over 95%. For most victims, accurate data are now available on birth dates and places, prewar and wartime addresses, occupations, etc., permitting analysis of demography, survival patterns, and other trends.

Analysis of the immune status in Latvian Chernobyl clean-up workers with nononcological thyroid diseases.

The aim of the present work was to characterize the immune status of 385 individuals who participated in the 1986-90 clean-up work of the after effects of the Chernobyl nuclear power plant explosion. Fifty-nine Chernobyl clean-up workers developed the most common thyroid diseases; euthyroid nodular and diffuse goiter; 47 healthy blood donors were taken as controls. The levels of immunoglobulins (IgA, IgG and IgM), the numbers of peripheral blood leukocytes, lymphocytes, monocytes, T lymphocytes and their subpopulations (CD3+, CD4+, CD8+), B lymphocytes (CD19+), natural killer (NK) cells (CD16+), classical and alternative pathway activity of complement (CH50, APH50), the C3 split product C3d, and neutrophil phagocytosis were determined in the peripheral blood. We found a significantly decreased number of CD16+ cells (natural killer), of CD4+ and CD8+ T lymphocytes, a reduced neutrophil phagocytic activity as well as a significant complement activation in Chernobyl clean-up workers with and without thyroid diseases when compared with normal levels and those in the control group. In addition, the number of CD3+ and CD4+ cells was significantly higher in patients with nodular goiter when compared with that in patients with diffuse goiter. Levels of IgG and numbers of monocytes were significantly decreased in persons who worked in Chernobyl in 1986 during the first 2 months after the accident (with maximal radiation exposure) but were without correlation to thyroid disorders. Our results clearly reflect an impaired immune system in the Chernobyl clean-up workers even 10-14 years after the nuclear accident.

Retrospective dosimetry for Latvian workers at Chernobyl.

Between 1986 and 1991 approximately 6500 Latvian inhabitants were recruited for clean-up work at the Chernobyl nuclear power plant. Their absorbed doses are usually unknown, because less than half of them had their external exposure officially documented. Clinical investigations show a high morbidity rate for these clean-up workers when compared with that of the general population. In order to understand the causes of their diseases and the impact of ionising radiation, electron spin resonance (ESR) has been used to measure the absorbed doses in human tooth enamel. The doses estimated by ESR were between two and three times higher than previously documented and are in accord with the results of immunological and biological tests. The results may be explained by considering the effects of irradiation caused by long-lived incorporated radionuclides.

Polymorphism at NRAMP1 and D2S1471 loci associated with juvenile rheumatoid arthritis.

OBJECTIVE: To examine the role of NRAMP1 in susceptibility to juvenile rheumatoid arthritis (JRA). METHODS: DNA from 119 JRA patients (72 pauciarticular, 47 polyarticular) and 111 healthy controls from Latvia was genotyped for a functional repeat polymorphism in the promoter of NRAMP1 and a linked (<150 kb) microsatellite D2S1471. The findings were compared with those from HLA-DQ alleles typed previously. Chi-square analyses were performed using the Mantel-Haenszel test and stratification according to pure Latvian or pure Russian descent. Haplotype analysis was performed using the Associate program to implement the expectation-maximization algorithm based on the gene-counting technique. RESULTS: Allele 3 at NRAMP1 conferred increased risk (odds ratios [ORs] 2.26, 2.31, and 2.19; P = 0.0006, 0.003, and 0.019) of disease in the JRA, pauciarticular, and polyarticular patient groups, respectively. Allele 2 conferred protection (OR 0.44, 0.43, and 0.46). Alleles at D2S1471 that conferred susceptibility (6 and 12) or protection (11) did so only when on a haplotype with alleles 3 or 2, respectively, at NRAMP1. Allele 3 at NRAMP1 was additive with HLA-DQ7 for susceptibility (OR 3.71, 3.71, and 4.02), and allele 2 at NRAMP1 was additive with HLA-DQ5 for protection (OR 0.19, 0.08, and 0.12). CONCLUSION: The NRAMP1 allele conferring susceptibility to JRA drives high levels of NRAMP1 expression, while the allele associated with protection drives low levels. These 2 alleles are inversely associated with susceptibility to infectious disease, consistent with their maintenance in populations through balancing selection.