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1.
F1000Res ; 13: 152, 2024.
Artículo en Inglés | MEDLINE | ID: mdl-38854440

RESUMEN

Background: Managing recalcitrant oral lichen planus (OLP) can be challenging. Laser therapy has been suggested as an alternative to corticosteroids for treatment. Photodynamic therapy (PDT) is a non-invasive technique that enables the removal of lesions without surgery. Photobiomodulation therapy (PBMT) can promote healing and recovery of the lesions. Case presentation: The objective was to treat unresponsive bilateral OLP of the whole buccal mucosae with a combination of PDT and PBMT. Results: A 43-year-old Thai male presented with the severe painful reticular type of OLP of bilateral buccal mucosae involving upper and lower vestibular areas. The lesions were not remitted with either prednisolone systemic steroids or fluocinolone topical corticosteroids. After undergoing ten sessions of PDT with 10% 5-Aminolevulinic acid (5-ALA) in the form of thermoplastic gel and a 635 nm diode laser at 100 to 400 mW with an energy density of 20 to 30 J/cm 2 in continuous wave mode, combined with five interim-sessions of PBMT using a 635 nm diode laser at 200 to 300 mW with an energy density of 6 to 10 J/cm 2 in continuous wave, the patient reported relief of burning sensation beside remission of lesions without any complications. Conclusion: The wide-spreading recalcitrant OLP with burning sensation can be managed by combining PDT and PBMT.


Asunto(s)
Liquen Plano Oral , Terapia por Luz de Baja Intensidad , Mucosa Bucal , Fotoquimioterapia , Humanos , Masculino , Adulto , Fotoquimioterapia/métodos , Liquen Plano Oral/tratamiento farmacológico , Liquen Plano Oral/terapia , Liquen Plano Oral/radioterapia , Liquen Plano Oral/patología , Mucosa Bucal/patología , Terapia por Luz de Baja Intensidad/métodos , Terapia Combinada , Ácido Aminolevulínico/uso terapéutico , Ácido Aminolevulínico/análogos & derivados
3.
Biomolecules ; 13(11)2023 11 13.
Artículo en Inglés | MEDLINE | ID: mdl-38002328

RESUMEN

Oral lichen planus (OLP) is a chronic inflammatory disease that is characterized by the infiltration of T cells into the oral mucosa, causing the apoptosis of basal keratinocytes. OLP is a multifactorial disease of unknown etiology and is not solely caused by the malfunction of a single key gene but rather by various intracellular and extracellular factors. Non-coding RNAs play a critical role in immunological homeostasis and inflammatory response and are found in all cell types and bodily fluids, and their expression is closely regulated to preserve normal physiologies. The dysregulation of non-coding RNAs may be highly implicated in the onset and progression of diverse inflammatory disorders, including OLP. This narrative review summarizes the role of non-coding RNAs in molecular and cellular changes in the oral epithelium during OLP pathogenesis.


Asunto(s)
Liquen Plano Oral , Humanos , Liquen Plano Oral/diagnóstico , Liquen Plano Oral/genética , Liquen Plano Oral/terapia , Queratinocitos/patología , Linfocitos T , Mucosa Bucal/patología , Apoptosis
4.
Zhonghua Kou Qiang Yi Xue Za Zhi ; 58(10): 1083-1090, 2023 Oct 09.
Artículo en Chino | MEDLINE | ID: mdl-37818545

RESUMEN

Proliferative verrucous leukoplakia (PVL) is one of the oral potentially malignant disorders (OPMD) with the highest malignant potential. PVL tends to be easily misdiagnosed owing to the resemblance in clinical manifestations between PVL and other diseases such as oral leukoplakia or oral lichen planus. PVL is considered as a special type of oral leukoplakia by some scholars, which is characterized by its tendency of recurrence and metastasis, along with its high risk of malignant transformation. So far, the accurate clinic diagnosis and management of PVL are still intractable due to the lack of definite histopathological definition, unified diagnostic criteria and effective treatment modalities. This review aims to provide the clinical practitioners with a series of advices on the clinical diagnosis and management of PVL by systematically reviewing the diagnostic logistics, therapeutic strategies, malignant transformation detection based on tremendous relevant data and evidence-based medicine.


Asunto(s)
Carcinoma Verrugoso , Liquen Plano Oral , Lesiones Precancerosas , Humanos , Leucoplasia Bucal/diagnóstico , Leucoplasia Bucal/terapia , Transformación Celular Neoplásica/patología , Liquen Plano Oral/diagnóstico , Liquen Plano Oral/terapia
5.
Oral Dis ; 29(3): 1269-1281, 2023 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-34953110

RESUMEN

INTRODUCTION: The exposure to amalgam restorations has been reported to bring about altered immunity followed by inflammation and infection. AIMS: This study aimed at identifying whether patients who received restorative or endodontic treatments, or tooth extraction, would have altered odds of developing oral lichen planus (OLP). MATERIAL AND METHODS: In this population-based nested case-control study, 421 cases of OLP and 1,684 controls were included after propensity score matching. Logistic regression was used to estimate the adjusted odds ratio (aOR) of OLP in individuals who had received amalgam and composite resin restorations, root canal therapy, and tooth extraction over a follow-up duration of five years. RESULTS: There were no significantly different odds of OLP for those who underwent either amalgam (aOR = 0.948, 95% CI = 0.853-1.053, p = 0.3170) or resin restorations (aOR = 1.007, 95% CI = 0.978-1.037, p = 0.6557) in both anterior and posterior teeth in an observational period of five  years after restorations. Root canal therapy was associated with significantly lower odds of OLP, with each additional root canal therapy attenuating the risk of OLP at an aOR of 0.771 (95% CI = 0.680-0.874, p = 0.0001) for both anterior (aOR = 0.786, 95% CI = 0.626-0.986, p = 0.0372) and posterior teeth (aOR = 0.762, 95% CI = 0.650-0.893, p = 0.0008). Likewise, each tooth extraction reduced the risk of OLP, with an aOR of 0.846 (95% CI = 0.772-0.927, p = 0.0003), especially for anterior teeth (aOR = 0.733, 95% CI = 0.595-0.904, p = 0.0037). CONCLUSIONS: We reported no significant association between dental restorations and consequent OLP, and significantly lower odds of OLP following both root canal therapy and tooth extraction.


Asunto(s)
Liquen Plano Oral , Humanos , Liquen Plano Oral/terapia , Restauración Dental Permanente/efectos adversos , Estudios de Casos y Controles , Resinas Compuestas , Amalgama Dental/efectos adversos
6.
Zhonghua Kou Qiang Yi Xue Za Zhi ; 57(2): 115-121, 2022 Feb 09.
Artículo en Chino | MEDLINE | ID: mdl-35152645

RESUMEN

Oral lichen planus (OLP) is a chronic and inflammatory oral mucosal disease that commonly affects middle-aged females. Most OLP cases might exhibit such symptom as pain, roughness and other discomfort, and more severe forms may show a high risk of developing oral cancer. Active preventive measure, precise diagnosis and standard therapeutic approach play a vital role in the management and prevention of OLP. This guideline is a revision on the base of trial in 2012, which mainly covers the following 8 aspects: etiology and medical records, clinical manifestations, pathological manifestations, diagnosis, differential diagnosis, laboratory examination, disease treatment and prevention, aiming at providing scientific evidence and guidance for the dental clinicians in diagnose and treatment of OLP.


Asunto(s)
Liquen Plano Oral , Neoplasias de la Boca , Diagnóstico Diferencial , Femenino , Humanos , Liquen Plano Oral/diagnóstico , Liquen Plano Oral/terapia , Persona de Mediana Edad
7.
Clin Oral Investig ; 26(5): 3865-3873, 2022 May.
Artículo en Inglés | MEDLINE | ID: mdl-35013783

RESUMEN

OBJECTIVES: To estimate the economic costs of oral lichen planus (OLP) through a multicenter university hospital-based outpatient study conducted in Italy and Finland. MATERIALS AND METHODS: A multicenter retrospective study was conducted on patients affected by OLP to evaluate the economic cost of managing the disease. Direct costs concerning diagnostic procedures, therapeutic management, and follow-up visits were obtained from clinical records. Statistics was performed with IBM SPSS Statistics. RESULTS: One hundred and eight patients with a confirmed diagnosis of OLP (81 women and 27 men), 58 Italians and 50 Finnish, were enrolled in this study. The mean annual cost was 1087.2 euros per patient. The mean annual cost was higher in Finnish than in Italian cohort (1558.7 euros vs. 680.7 euros-p < 0.05). Within the Italian cohort, the local immunosuppressive therapy group and atrophic and erosive OLP type had a higher cost (p < 0.05). Within the Finnish cohort, the local immunosuppressive therapy group had a higher cost (p < 0.05). CONCLUSIONS: OLP-related costs are very similar to other chronic oral disorders (i.e., periodontitis) with differences between investigated countries. Moreover, patients with more severe clinical features, who need immunosuppressive therapy, are facing more expensive costs. CLINICAL RELEVANCE: In this multicenter cost of illness study, we estimated the direct health care costs of OLP and we found that patients with more severe clinical features, who therefore need symptomatic therapy, are facing more expensive costs.


Asunto(s)
Liquen Plano Oral , Enfermedad Crónica , Costo de Enfermedad , Femenino , Hospitales Universitarios , Humanos , Liquen Plano Oral/terapia , Masculino , Pacientes Ambulatorios , Estudios Retrospectivos
9.
Oral Dis ; 27(8): 2008-2025, 2021 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-34324758

RESUMEN

Patients with oral potentially malignant disorders (OPMDs), including oral leukoplakia and erythroplakia, proliferative verrucous leukoplakia, oral submucous fibrosis, and oral lichen planus/lichenoid lesions, can be challenging to manage. A small proportion will undergo cancer development and determining a patient's cancer risk is key to making management decisions. Yet, our understanding of the natural history of OPMDs has not been fully elucidated, and a precision approach based on the integration of numerous predictive markers has not been validated by prospective studies. Evidence-based health promotion by clinicians and healthcare systems is not embraced universally. Medical and surgical interventions evaluated by rigorous research measuring important endpoints, such as cancer development, mortality, or survival, are difficult and expensive to run. Most of these studies employ non-ideal surrogate endpoints and have deep methodologic flaws. Diagnostic criteria for enrolling research subjects are not uniform, and patients with the highest risk for cancer development comprise small proportions of those enrolled. Few studies explore quality of life and patient preferences. It is time to rethink how we approach the management of these patients, across each OPMD, and considering the healthcare infrastructure and cost-effectiveness. Global networks with well-characterized patient populations with OPMDs and well-designed interventional trials using validated outcome measures are needed.


Asunto(s)
Liquen Plano Oral , Neoplasias de la Boca , Lesiones Precancerosas , Transformación Celular Neoplásica , Humanos , Leucoplasia Bucal/terapia , Liquen Plano Oral/terapia , Mucosa Bucal , Neoplasias de la Boca/terapia , Lesiones Precancerosas/terapia , Estudios Prospectivos , Calidad de Vida
10.
Photodiagnosis Photodyn Ther ; 34: 102255, 2021 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-33727132

RESUMEN

INTRODUCTION: Oral lichen planus (OLP) is a common oral inflammatory condition. Against symptomatic atrophic-erosive OLP, topical steroids, or photobiomodulation (PBM) are deployed. Optical coherence tomography (OCT) provides a real-time, non-invasive, tissue investigation. Aim of this study was to evaluate modifications of OCT pattern in patients with painful atrophic-erosive OLP, before and after treatment with PBM, comparing those results with patients treated with topical steroid. METHODS: Two groups of 20 OLP patients were evaluated. Group A underwent two daily application of 0.05 % clobetasol propionate for 8 weeks; group B was treated with eight weekly PBM sessions using a 980/645 nm diode laser. OCT scans were performed before and after treatment, and six months after end of the proposed protocol. Changes of width of stratified epithelium (EP) and lamina propria (LP) were quantified. RESULTS: After 8-weeks, both groups experienced a significant increase of EP width (p < 0.05), and a significant decrease of LP width (p < 0.05), with Δ-EP in Group A significantly higher than Group B (p = 0.0015); conversely, Δ-LP was not significantly different (p > 0.05). After six months, significant increase of EP width remained only in group B (p = 0.01), with no significant decrease of LP mean width in both groups (p > 0.05). CONCLUSIONS: Increase of EP and decrease of LP might be explained as consequence of clobetasol and PBM ability to promote epithelial healing, and to reduce interface inflammation. When investigated with OCT, clobetasol appears to provide more significant short-term structural changes, whereas PBM might guarantee long-term alterations.


Asunto(s)
Liquen Plano Oral , Fotoquimioterapia , Administración Tópica , Antiinflamatorios/uso terapéutico , Glucocorticoides/uso terapéutico , Humanos , Liquen Plano Oral/tratamiento farmacológico , Liquen Plano Oral/terapia , Fotoquimioterapia/métodos , Fármacos Fotosensibilizantes/uso terapéutico , Tomografía de Coherencia Óptica
11.
Oral Dis ; 27(7): 1728-1737, 2021 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-33107655

RESUMEN

OBJECTIVES: In the search for more effective and safe treatment avenues, we investigated cold physical plasma as a new treatment modality for therapy of oral lichen planus (OLP). MATERIAL AND METHODS: Healthy and diseased human mucosal tissue samples with a size of 3 mm in diameter obtained from OLP patients were subjected to plasma treatment ex vivo or were left untreated. Tissue sections were quantified for immune-infiltration of CD4+ , CD8+ , CD45RA+ , and CD45R0+ T cells. Moreover, the tissues' inflammatory profile was assessed by analyzing 12 different cytokines in the surrounding media. RESULTS: A significantly increased infiltrate of CD8+ and CD45-R0+ T cells was detected in OLP tissue samples when compared to healthy tissue. A higher concentration of interleukin (IL) 1ß, IL6, IL8, and granulocyte macrophage-colony stimulating factor (GM-CMF) was detected in OLP samples compared to healthy mucosal tissue. For all cytokines and chemokines investigated, 23 out of 24 comparisons showed a decrease in tendency (significant for IL1ß, IL2, IL10, and GM-CSF) in response to plasma treatment. In ex vivo-treated tissue, a decrease of T-cell infiltrate in OLP lesions compared with healthy tissue was observed. CONCLUSION: Our findings suggest cold physical plasma can be a promising therapeutic option for OLP that requires further validation in vivo.


Asunto(s)
Liquen Plano Oral , Gases em Plasma , Quimiocinas , Citocinas , Humanos , Liquen Plano Oral/terapia , Linfocitos T
13.
Probiotics Antimicrob Proteins ; 12(4): 1340-1348, 2020 12.
Artículo en Inglés | MEDLINE | ID: mdl-32506228

RESUMEN

Oral lichen planus (OLP) is a T cell-mediated common chronic inflammatory mucosal disease, with limited therapies available for long-term use. Previous study showed that ratio of genus Streptococcus decreased significantly in OLP patients when compared with controls. Buccal cotton swab samples of 43 OLP patients and 48 healthy individuals were collected for real-time quantitative polymerase chain reaction (RT-PCR) to investigate relative abundance alteration of Streptococcus salivarius in OLP lesions. Bacterial supernatants of S. salivarius ATCC® BAA-2593™ were collected by centrifugation and added to HSC-3 cells, and quantitative analysis of expression of IL-1ß, IL-6, IL-8, and TNF-α in the HSC-3 cells was determined by RT-PCR. Then, a randomized, non-blinded, controlled study was conducted. Forty patients with symptomatic OLP were randomly allocated into two groups and received topical treatment of 0.1% triamcinolone acetonide dental paste (group A) and S. salivarius K12 lozenge (group B), respectively, for 4 weeks. Sign scores, visual analogue scale (VAS), and adverse reactions were recorded. Relative abundance of S. salivarius in the OLP group was lower than that of control group (P < 0.05). After treated with 0.1% supernatants of S. salivarius ATCC® BAA-2593™, the expression level of IL-6 in the HSC-3 cells significantly reduced (P < 0.001), while IL-1ß, IL-8, and TNF- α showed a decreasing tendency (P > 0.05). There was significant reduction in sign scores and VAS scores in both groups after the 4-week treatment, with no significant difference between two groups. No adverse reaction was observed. S. salivarius might maintain local immune balance by inhibiting the NF-κB pathway. Topical application of Streptococcus salivarius K12 seemed to be effective in treatment of symptomatic OLP, especially with promising potential in long-term use. More detailed clinical studies with long follow-up period and standardized usage/dosage are expected to acquire definite conclusions.


Asunto(s)
Antiinflamatorios/uso terapéutico , Expresión Génica/efectos de los fármacos , Liquen Plano Oral/terapia , Mucosa Bucal/efectos de los fármacos , Streptococcus salivarius/fisiología , Administración Tópica , Adulto , Anciano , Línea Celular , Femenino , Humanos , Interleucina-1beta/genética , Interleucina-1beta/inmunología , Interleucina-6/genética , Interleucina-6/inmunología , Interleucina-8/genética , Interleucina-8/inmunología , Liquen Plano Oral/genética , Liquen Plano Oral/inmunología , Liquen Plano Oral/patología , Masculino , Persona de Mediana Edad , Mucosa Bucal/inmunología , Mucosa Bucal/patología , FN-kappa B/genética , FN-kappa B/inmunología , Triamcinolona Acetonida/uso terapéutico , Factor de Necrosis Tumoral alfa/genética , Factor de Necrosis Tumoral alfa/inmunología
14.
Eur Rev Med Pharmacol Sci ; 23(18): 8148-8157, 2019 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-31599444

RESUMEN

OBJECTIVE: The aim of this review is to describe the "hot points" of current clinical governance for oral HPV comprising the use of new diagnostic molecular procedures, namely, Pyrosequencing and Next Generation Sequencing. MATERIALS AND METHODS: The data on oral HPV was collected through two levels of research. First for all, we used the canonical medical search engines, PubMed, and Medline, followed by the study of current commercial tools for HPV diagnosis, particularly within commercial companies involved in the molecular procedures for HPV detecting and genotyping. RESULTS: Different medical procedures are now described and used throughout the world in HPV diagnosis and treatment. However, the laboratory methods are often validated and used for genital infections, and, in these cases, data are missing in the literature as regards the clinical approach for oral lesions. CONCLUSIONS: Dental care units are often the front line for a clinical evaluation of a possible HPV lesion in the oral cavity, which means that correct clinical governance could avoid a viral neoplastic progression of this disease with great advantages for the patient. In this case, the problem is due to the difficulty in lesion recognition but also and more especially the absence of correct laboratory diagnosis and subsequent treatment in the clinical course.


Asunto(s)
Enfermedades de la Boca/diagnóstico , Enfermedades de la Boca/terapia , Infecciones por Papillomavirus/diagnóstico , Infecciones por Papillomavirus/terapia , Carcinoma Verrugoso/diagnóstico , Carcinoma Verrugoso/terapia , Carcinoma Verrugoso/virología , Criocirugía , Hiperplasia Epitelial Focal/diagnóstico , Hiperplasia Epitelial Focal/terapia , Hiperplasia Epitelial Focal/virología , Humanos , Terapia por Láser , Leucoplasia Bucal/diagnóstico , Leucoplasia Bucal/terapia , Leucoplasia Bucal/virología , Liquen Plano Oral/diagnóstico , Liquen Plano Oral/terapia , Liquen Plano Oral/virología , Enfermedades de la Boca/virología , Neoplasias de la Boca/diagnóstico , Neoplasias de la Boca/terapia , Neoplasias de la Boca/virología , Papiloma/diagnóstico , Papiloma/terapia , Papiloma/virología , Papillomaviridae/genética , Infecciones por Papillomavirus/virología , Fotoquimioterapia , Carcinoma de Células Escamosas de Cabeza y Cuello/diagnóstico , Carcinoma de Células Escamosas de Cabeza y Cuello/terapia , Carcinoma de Células Escamosas de Cabeza y Cuello/virología , Verrugas/diagnóstico , Verrugas/terapia , Verrugas/virología
15.
Oral Dis ; 25(8): 1954-1963, 2019 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-31478283

RESUMEN

OBJECTIVE: In this study, the effect of photodynamic therapy with topical corticosteroid in oral lichen planus patients was compared. MATERIAL AND METHODS: In this randomized, double-blind clinical trial, eight patients with bilateral oral OLP lesions were recruited. Toluidine blue was applied on the lesions of both sides; a 660-nm diode laser InGaAlP was irradiated for 10 min (power: 25 mW, fluence: 19.23 J/cm2 , probe cross section: 0.78 cm2 ) for three sessions. In the control side of the oral mucosa, only sham laser was used. Follow-up sessions were held on weeks 3 and 7. In week 3, oral paste triamcinolone acetonide 0.1% was prescribed. Response rates were assessed clinically by VAS, Thongprasom sign scoring, clinical severity index, efficacy indices, and the amount of reduction in the size of the lesions. The Mann-Whitney test was used to evaluate the treatment outcomes. RESULTS: In spite of the control side, all scores improved significantly between sessions 0 and 4 for the intervention side. The differences between the changes in almost all scores between sessions 0 and 4 in both the intervention and control sides were significantly considerable (p value < .05). CONCLUSION: Photodynamic therapy can be used as an alternative therapy alongside standard methods or as a new modality for refractory OLP.


Asunto(s)
Corticoesteroides/uso terapéutico , Liquen Plano Oral/terapia , Terapia por Luz de Baja Intensidad/métodos , Fotoquimioterapia/métodos , Fármacos Fotosensibilizantes/uso terapéutico , Cloruro de Tolonio/uso terapéutico , Administración Tópica , Corticoesteroides/administración & dosificación , Método Doble Ciego , Femenino , Humanos , Láseres de Semiconductores/uso terapéutico , Masculino , Persona de Mediana Edad , Resultado del Tratamiento
16.
Photobiomodul Photomed Laser Surg ; 37(3): 175-181, 2019 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-31050948

RESUMEN

Objective: The purpose of this study is to evaluate the efficacy of CO2 laser vaporization therapy for oral lichen planus (OLP) refractory to conservative treatments. Methods: The study group comprised 16 patients with clinically and histologically diagnosed OLP. They underwent conservative treatment for 3 months using an adrenal cortex hormone ointment and azulene sulfonate sodium hydrate gargle. Patients who showed no improvement with conservative treatment underwent CO2 laser vaporization therapy (3 W, continuous-wave mode). The assessment was performed using the numerical rating scale (NRS) as a subjective indicator and the Thongprasom sign score (TSS) as an objective indicator of OLP. These two scales were recorded during examinations performed before treatment and then at 7 days, 1, 3, and 6 months, and 1 year after irradiation. Differences between preirradiation and each point of time after irradiation were tested by Wilcoxon's signed-rank tests. Results: Laser irradiation was administered to 9 patients with 11 sites. The NRS score and TSS decreased at all 11 sites (100%) and 10 sites (90.9%) at 1 year after irradiation compared with preirradiation scores. The NRS score and TSS were statistically lower (p < 0.05) at 1 and 3 months (short-term) and 6 months and 1 year (mid-long-term) after irradiation than the preirradiation scores. There were no patients with malignant transformation during the study period. Conclusions: These single-arm clinical trial results show the efficacy of CO2 laser vaporization therapy for OLP refractory to conservative treatment.


Asunto(s)
Terapia por Láser , Láseres de Gas/uso terapéutico , Liquen Plano Oral/terapia , Anciano , Dióxido de Carbono , Femenino , Estudios de Seguimiento , Humanos , Masculino , Persona de Mediana Edad , Método Simple Ciego , Resultado del Tratamiento
17.
Emerg Med Clin North Am ; 37(1): 55-68, 2019 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-30454780

RESUMEN

Soft tissue disorders of the mouth encompass a wide expanse of pathophysiology. This article focuses on the identification, etiology, management, and complications of common infectious processes (candidiasis, dental caries, and herpes labialis), inflammatory lesions (sialolithiasis, oral lichen planus, and aphthous ulcer), and benign entities (bony tori and mucocele).


Asunto(s)
Enfermedades de la Boca/diagnóstico , Candidiasis Bucal/diagnóstico , Candidiasis Bucal/tratamiento farmacológico , Caries Dental/diagnóstico , Caries Dental/terapia , Urgencias Médicas , Herpes Labial/diagnóstico , Herpes Labial/tratamiento farmacológico , Humanos , Leucoplasia Bucal/diagnóstico , Leucoplasia Bucal/terapia , Liquen Plano Oral/diagnóstico , Liquen Plano Oral/terapia , Enfermedades de la Boca/terapia , Mucocele/diagnóstico , Mucocele/terapia , Cálculos de las Glándulas Salivales/diagnóstico , Cálculos de las Glándulas Salivales/terapia , Estomatitis Aftosa/diagnóstico , Estomatitis Aftosa/terapia
18.
Medicine (Baltimore) ; 97(50): e13630, 2018 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-30558050

RESUMEN

RATIONALE: Biopsy is very important for the diagnosis of oral lichen planus (OLP) on the lips. Traditional Chinese medicine (TCM) can be used to coordinate the whole body, soften and eliminate swellings and masses, and regulate the functions of qi and blood. Therefore, TCM could be an effective and safe treatment for OLP. Wet dressing is particularly important for the treatment of lip diseases. We report on a rare case of OLP on the lower lip. PATIENT CONCERNS: A 38-year-old female patient presenting with a history of recurrent erosion, bleeding, and pain on her lower lip for 10 years. DIAGNOSES: Erosive OLP of the lower lip. INTERVENTIONS: The patient was treated for 4 months using TCM comprising "Qingwen Jiedu Kouyankang granules," total Paeonia glucosides, and a combination of hormones and anti-inflammatory agents applied locally using a wet dressing. OUTCOMES: Lip erosion was improved remarkably after 1 month, and there was no recurrence or aggravation of the condition. The duration of the follow-up period was 5 months. LESSONS: The therapeutics used here were effective and safe for the treatment of OLP and could improve the quality of life in patients with lip erosion. The therapeutics provide new insight into the treatment of OLP on the lip.


Asunto(s)
Vendajes , Glucósidos/administración & dosificación , Liquen Plano Oral , Labio , Medicina Tradicional China/métodos , Paeonia , Adulto , Biopsia/métodos , Medicamentos Herbarios Chinos/administración & dosificación , Femenino , Humanos , Liquen Plano Oral/patología , Liquen Plano Oral/fisiopatología , Liquen Plano Oral/terapia , Labio/efectos de los fármacos , Labio/patología , Fitoquímicos/administración & dosificación , Qi , Resultado del Tratamiento
19.
J Am Acad Dermatol ; 79(5): 807-818, 2018 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-30318137

RESUMEN

Having reviewed the diverse clinical subtypes of lichenoid disease and the postulated molecular basis thereof in the first article in this 2-part continuing medical education series, we discuss herein the existing and emerging treatment strategies in the most common clinical forms of lichenoid inflammation and provide an overview of their pharmacodynamics and evidence base. The scope of this review is not to exhaustively discuss treatment modalities for all lichenoid variants discussed in the previous article of this series. Instead, the focus will be on frequently encountered subtypes of lichen planus and on linking mechanisms of disease with mechanisms of drug action. Future directions and potential avenues for translational research will also be discussed.


Asunto(s)
Corticoesteroides/administración & dosificación , Inmunosupresores/administración & dosificación , Liquen Plano/diagnóstico , Liquen Plano/terapia , Administración Tópica , Inhibidores de la Calcineurina/administración & dosificación , Terapia Combinada , Femenino , Humanos , Liquen Plano Oral/diagnóstico , Liquen Plano Oral/terapia , Erupciones Liquenoides/diagnóstico , Erupciones Liquenoides/terapia , Masculino , Fototerapia/métodos , Pronóstico , Medición de Riesgo , Índice de Severidad de la Enfermedad , Resultado del Tratamiento
20.
J Am Acad Dermatol ; 79(5): 789-804, 2018 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-30318136

RESUMEN

Deriving from the Greek word λειχήν for "tree moss" and the Latin word planus for "planar," lichen planus is a relatively uncommon and heterogeneous cutaneous disorder that typically develops in middle-aged adults. Despite the significant clinical burden associated with the disorder, little well-conducted molecular research has been undertaken, possibly because of heterogeneity impeding consistent and confident phenotyping. The multiple variants of lichenoid disease bear overlapping clinical and pathologic features despite manifesting as distinct clinical disorders. The first article in this 2-part continuing medical education series provides a comprehensive overview of the clinical and pathologic characteristics of cutaneous lichenoid dermatoses and links these manifestations to recent advances in our understanding of the underlying pathobiology of such diseases.


Asunto(s)
Liquen Plano Oral/terapia , Liquen Plano/patología , Erupciones Liquenoides/patología , Enfermedades de la Piel/patología , Adulto , Biopsia con Aguja , Enfermedad Crónica , Progresión de la Enfermedad , Femenino , Humanos , Inmunohistoquímica , Liquen Plano/diagnóstico , Liquen Plano/terapia , Liquen Plano Oral/patología , Liquen Escleroso y Atrófico , Erupciones Liquenoides/diagnóstico , Masculino , Persona de Mediana Edad , Pronóstico , Factores de Riesgo , Índice de Severidad de la Enfermedad , Enfermedades de la Piel/diagnóstico
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