Carols by glow sticks: a retrospective analysis of Poisons Information Centre data.

OBJECTIVE: To win a Christmas hamper. We also devised a study of our most festive seasonal poisoning, to demonstrate how hard we are working while everyone else is partying. DESIGN: Retrospective analysis of the New South Wales Poisons Information Centre database, which we searched for exposures to the substance code "Cyalume light sticks/glow toys" from 1 July 2013 to 30 June 2017. SETTING: A dimly lit basement with a constantly ringing phone. At the other end of the phone was a highly anxious parent and a luminescent child. MAIN OUTCOME MEASURES: Number of glow stick exposures, route of exposures, patient demographics and seasonal trends in exposures. RESULTS: There were 2918 glow stick exposures over the 4-year study period. The vast majority of exposures (94%) were in children aged 14 years and younger. Medical complications were very rare. Glow stick exposures were 4.38 times more likely in December (95% CI, 3.02-6.35; P < 0.001). Statistically significant increases were also observed in October, November, January, February and March. Glow stick exposures were 4.20 times more likely during the holiday period of 1 December to 7 January (95% CI, 3.42-5.15; P < 0.001), 2.52 times more likely over summer (95% CI, 2.12-3.00; P < 0.001), and 1.77 times more likely during school holidays (95% CI, 1.47-2.13; P < 0.001). CONCLUSIONS: This epidemic of poisoning is perhaps due to mass seasonal synaesthesia. The lack of any significant adverse consequences highlights the contribution that 50 years of injury prevention has made to everyone having a Merry Christmas and a Happy New Year.

[Hygiene and the spectral energtic light pattern].

There are considered methodological bases of multicriteria synthesis of a spectral energetic pattern for the evaluation of the excessive share of blue and red light in the spectrum of artificial energy sources. The basis of this methodology is relied upon on the hygienic approach to the spectrum analysis of solar and led light. Relying upon on "photobiological paradox of vision" according to M. A. Ostrovsky, conditions of "melanopsin cross" and mechanisms of adverse impact of light on vision, all the spectral-energy characteristics of solar light were divided into subspaces. The border between them became a spectral energy pattern for the evaluation of artificial sources on the security of their impact on eye and human health according to criteria of the excessive dose of blue or red light. On two examples there was shown the effectiveness and clarity of this estimation with the using of the spectral energetic pattern of light.

[LED LIGHTING AS A FACTOR FOR THE STIMULATION OF THE HORMONE SYSTEM].

There are considered questions of non-visual effects of blue LED light sources on hormonal systems (cortisol, glucose, insulin) providing the high human performance. In modern conditions hygiene strategy for child and adolescent health strategy was shown to be replaced by a strategy of light stimulation of the hormonal profile. There was performed a systematic analysis of the axis "light stimulus-hypothalamus-pituitary-adrenals-cortisol-glucose-insulin". The elevation of the content of cortisol leads to the increase of the glucose level in the blood and the stimulation of the production of insulin, which can, like excessive consumption of food, give rise to irreversible decline in the number of insulin receptors on the cell surface, and thus--to a steady reduction in the ability of cells to utilize glucose, i.e. to type 2 diabetes or its aggravation.

[Visual hygiene in LED lighting. Modern scientific imaginations].

There are considered a classic and modern paradigm of perception of light and its impact on human health. To consider the perception of light as a complex self-organizing synergistic system of compression of information in the process of its sequencing was supposed. This allowed to develop a complex of interrelated measures, which may become the basis for modern hygiene, and determine requirements for the led lamp with biologically adequate spectrum of the light, for which there were obtained patents in Russia, Europe and USA.

[Psychophysiological research of changes of the functional condition of the neuro-psychic sphere of younger schoolchildren during the school day at luminescent and LED lighting in the classroom].

The purpose of the study is to test the hypothesis that the LED lighting (LL) in training class does not have a negative impact on the change in the functional state of the neuro-psychiatric sphere in pupils by the end of the school day, if compared with traditional for schools fluorescent lighting (FL). With the help of specially matched methods for psychophysiological examination there was performed the testing of changes in the functional state of the neuro-psychiatric in pupils during the school day and there was made an analysis of these changes in dependence on the type of lighting the classroom. LL, if compared to FL, was established to lead to a significant weakening of the negative changes of functional lability of the visual analyzer, the power of excitation of the nervous system and cognitive functions, as well as to an increase in positive changes in psychomotorics. The data obtained allow us to recommend the use of LED lighting equipment in modern schools.

The possible ocular hazards of LED dental illumination applications.

The use of high-intensity illumination via Light-Emitting Diode (LED) headlamps is gaining in popularity with dentists and student dentists. Practitioners are using LED headlamps together with magnifying loupes, overhead LED illumination and fiber-optic dental handpieces for long periods of time. Although most manufacturers of these LED illuminators advertise that their devices emit "white" light, these still consist of two spectral bands--the blue spectral band, with its peak at 445 nm, and the green with its peak at 555 nm. While manufacturers suggest that their devices emit "white" light, spectral components of LED lights from different companies are significantly different. Dental headlamp manufacturers strive to create a white LED, and they advertise that this type of light emitted from their product offers bright white-light illumination. However, the manufacturing of a white LED light is done through selection of a white LED-type based on the peak blue strength in combination with the green peak strength and thus creating a beam-forming optic, which determines the beam quality. Some LED illuminators have a strong blue-light component versus the green-light component. Blue-light is highly energized and is close in the color spectrum to ultraviolet-light. The hazards of retinal damage with the use of high-intensity blue-lights has been well-documented. There is limited research regarding the possible ocular hazards of usage of high-intensity illuminating LED devices. Furthermore, the authors have found little research, standards, or guidelines examining the possible safety issues regarding the unique dental practice setting consisting of the combined use of LED illumination systems. Another unexamined component is the effect of high-intensity light reflective glare and magnification back to the practitioner's eyes due to the use of water during dental procedures. Based on the result of Dr. Janet Harrison's observations of beginning dental students in a laboratory setting, the aim of this review is to raise awareness of the potential risk for eye damage when singular or combinations of LED illumination are used.

[Energy saving and LED lamp lighting and human health].

The appearance of new sources of high-intensity with large proportion of blue light in the spectrum revealed new risks of their influence on the function of the eye and human health, especially for children and teenagers. There is an urgent need to reconsider the research methods of vision hygiene in conditions of energy-saving and LED bulbs lighting. On the basis of a systematic approach and knowledge of the newly discovered photosensitive receptors there was built hierarchical model of the interaction of "light environment - the eye - the system of formation of visual images - the hormonal system of the person - his psycho-physiological state." This approach allowed us to develop a range of risk for the negative impact of spectrum on the functions of the eye and human health, as well as to formulate the hygiene requirements for energy-efficient high-intensity light sources.

Eye-safe 2 µm luminescence from thulium-doped silicon.

We report on photoluminescence in the 1.7-2.1 µm range of silicon doped with thulium. This is achieved by the implantation of Tm into silicon that has been codoped with boron to reduce the thermal quenching. At least six strong lines can be distinguished at 80 K; at 300 K, the spectrum is dominated by the main emission at 2 µm. These emissions are attributed to the trivalent Tm(3+) internal transitions between the first excited state and the ground state.

An investigation into the effects of suboptimal viewing conditions in screen-film mammography.

The ability of an observer to detect objects on a radiograph is influenced by the conditions under which the image is viewed. Therefore, to ensure that as much diagnostically relevant information as possible can be extracted from the image, it is important that satisfactory viewing conditions for the task are established and maintained. Factors that are thought to be important are the luminance of the image, glare and ambient light. Together, these factors lead to the formation of reflection on the image, which may degrade the observer's performance. The purpose of this study was to explore, in a systematic manner, the effect of the factors outlined above on the performance of an observer conducting a threshold contrast-detail diameter test. Each factor was investigated separately with attempts made to minimize the confounding effects of other factors. When examined individually, viewing box luminance, ambient light and glare were found to have little effect on the contrast-detail performance of the observers. Reflection was found to have a significant effect, particularly non-uniform reflection, and the magnitude of the effect was related to the contrast degradation factor and reflection modulation. These quantities, which are derived from basic photometric measurements, may be used to develop a protocol to assess viewing conditions in screen-film mammography.

Toxicity of luminescent silica nanoparticles to living cells.

Luminescent nanomaterials can provide high-intensity and photostable luminescent signals when used as labeling materials for the determination of trace amounts of analytes. However, a major concern that has arisen is whether the nanomaterials cause toxic effects in living systems. Here, we address this problem through a systematic investigation of the cytotoxicity and genotoxicity of luminescent silica nanoparticles. These nanoparticles are intensely luminescent labeling materials for ultrasensitive determination of biological samples. The investigation of genotoxicity of the nanomaterials was carried out from two perspectives. First, the integrity of the DNA was examined by detecting DNA base modification, strand breaks, and increased DNA repair activity to recover the damage. Second, different sets of cellular DNAs, including nuclear DNA extracts and the whole genomic DNAs, were examined. Furthermore, to fully assess DNA damage by the nanoparticles, isolated genomic DNAs were directly exposed to the nanoparticles. The cytotoxicity of the nanoparticle was detected by measuring the cell proliferation rate, cell death, and death patterns (necrosis and apoptosis) after the nanoparticle treatments. Results show no significant toxic effects due to the luminescent nanoparticles at the molecular and cellular levels below a concentration of 0.1 mg/mL. Our study indicates that the luminescent silica nanoparticle is a promising labeling reagent for various biomedical applications.