Diagnostic performance in gastric cancer is higher using endocytoscopy with narrow-band imaging than using magnifying endoscopy with narrow-band imaging.

BACKGROUND: For diagnosing gastric cancer, differences in the diagnostic performance between endocytoscopy with narrow-band imaging and magnifying endoscopy with narrow-band imaging have not been reported. We aimed to clarify these differences by analyzing diagnoses made by endoscopists in Japan. METHODS: This single-center retrospective cohort study used 106 cancerous and 106 non-cancerous images obtained via both modalities (total, 424 images) for diagnosis. Sixty-one endoscopists with varying experience levels from 45 institutions were included. Diagnostic accuracy, sensitivity, specificity, and positive and negative predictive values were evaluated to determine the diagnostic performance of each modality and compared using the Mann-Whitney U test. RESULTS: Among all endoscopists, diagnostic accuracy, sensitivity, positive predictive value, and negative predictive value were higher with endocytoscopy with narrow-band imaging than with magnifying endoscopy with narrow-band imaging (percentage [95% confidence interval]: 78.8% [76.4-83.0%] versus 72.2% [69.3-73.6%], p < 0.0001; 82.1% [78.3-85.9%] versus 64.2% [60.4-69.8%], p < 0.0001; 88.7% [82.6-90.7%] versus 78.5% [75.4-85.1%], p = 0.0023; 79.0% [75.3-80.5%] versus 68.5% [66.4-71.6%], p < 0.0001, respectively). In the magnifying endoscopy with narrow-band imaging-trained group, these values were also higher with endocytoscopy with narrow-band imaging than with magnifying endoscopy with narrow-band imaging (p < 0.0001, p = 0.0001, p = 0.0143, and p < 0.0001, respectively). Diagnostic accuracy, sensitivity, and negative predictive value were higher with endocytoscopy with narrow-band imaging than with magnifying endoscopy with narrow-band imaging in the magnifying endoscopy with narrow-band imaging-untrained group (p = 0.0041, p = 0.0049, and p = 0.0098, respectively). CONCLUSIONS: Diagnostic performance was higher using endocytoscopy with narrow-band imaging than using magnifying endoscopy with narrow-band imaging. Our results may help change the technique used to diagnose gastric cancer.

Comparative study of magnifying narrow-band imaging and conventional white light endoscopy in the diagnosis of Helicobacter pylori status after eradication therapy.

Predicting Helicobacter pylori (Hp) status by endoscopic finding would be useful in recent clinical condition that the use of proton-pump inhibitors, anti-platelet, and anti-coagulant have become widespread. We aimed to elucidate the diagnostic accuracy of magnifying narrow-band imaging (M-NBI) endoscopy in distinguishing Hp status in patients with or without history of successful Hp eradication and compare this accuracy to the diagnostic accuracy of conventional white light (WL) endoscopy.Two hundred seven endoscopic examinations before and after Hp eradication were performed in prospective 163 patients. Endoscopic images by using the M-NBI and conventional WL were stored electronically and randomly allocated to 2 readers for evaluation. Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and diagnostic accuracy were assessed by reference to Hp status assessed by conventional clinical test.Sensitivity, specificity, PPV, NPV, and accuracy for predicting Hp status for the conventional WL was 72.2%, 75.5%, 72.2%, 75.5%, and 73.9% for the first reader; 86.6%, 57.3%, 64.1%, 82.9%, and 71.0% for the second reader. On the other hand, sensitivity, specificity, PPV, NPV, and accuracy for predicting Hp status for the M-NBI was 96.9%, 93.6%, 93.1%, 97.1%, and 95.2% for the first reader; 92.8%, 93.6%, 92.8%, 93.6%, and 93.2% for the second reader, respectively. The diagnostic accuracy of M-NBI was significantly higher than that of WL (P < .0001 for both readers). Inter-observer agreement of M-NBI (k = 0.83) was also better than that of WL (k = 0.53).M-NBI was capable of distinguishing Hp status before and after eradication therapy.

Impact on perceived root resorption based on the amount of incisal inclination as determined from conventional panoramic radiography.

INTRODUCTION: Our objective was to measure the impact on perceived root resorption based on the amount of anteroposterior incisal inclination as determined in vitro from conventional panoramic radiography. METHODS: A rapid prototyping model was created to mimic different maxillary and mandibular incisal anteroposterior inclinations. Two titanium beads were placed on the incisors at the apical and incisal edges. Panoramic radiographs were obtained, with the incisors changing relative inclination by 10° increments. The length was measured from the midpoint of the bead on the incisal edge to the midpoint of the bead on the apical edge. By using a length of wire of known size, this value was compared in all images to correct for image magnification. RESULTS: Changes to mandibular incisor anteroposterior inclinations, as either a theoretical proclination or retroclination, resulted in an increase of "apparent" root resorption on a panoramic radiograph. When the maxillary incisors were significantly and severely retroclined, they appeared larger than expected. When the maxillary incisors were mildly retroclined, the length was roughly similar to the theoretical model. When the maxillary incisors were mildly proclined, they appeared shorter than expected. CONCLUSIONS: The foreshortening or forelengthening of incisor root lengths because of incisor inclination vs root resorption cannot be reliably evaluated from panoramic images. The proposed theoretical model helps to understand the direction of the changes produced by the magnification factor. More severe scenarios where either the maxillary or the mandibular teeth are outside the focal trough have not been fully evaluated. The clinical impact of these changes is likely to be questionable.

Precision of dimensional measurements of mandible in different positions on orthopantomogram.

OBJECTIVE: To evaluate the precision of dimensional measurements of the mandible in two different positions on orthopantomogram (OPG) (one with mandibular plane parallel to the floor and the other with Frankfort horizontal plane parallel to the floor) and determine the dimensional reliability. MATERIALS AND METHODS: Anatomical landmarks were used to denote points for measurements on mandible as well as OPG and respective measurements made. Magnification was hence calculated and compared with magnification factor (1.2) listed by the manufacturer. RESULTS: Vertical measurements and anterior horizontal and oblique measurements showed minimal magnification. Posterior horizontal and oblique measurements showed increased magnification. The difference in measurements in the two positions and on comparison with the one given by the manufacturer was statistically significant for posterior horizontal measurements but not for posterior oblique. Horizontal measurements crossing the midline were highly magnified and the difference was statistically significant for the two positions and on comparison to the one given by manufacturer. CONCLUSION: Magnification factor given by the manufacturer is not uniform in all locations and varies with changes in positioning and hence should not be relied upon when accurate measurements are to be made.

Accuracy of volumetric measurement of simulated root resorption lacunas based on cone beam computed tomography.

OBJECTIVES: To evaluate the accuracy of volumetric measurement of simulated root resorption cavities based on cone beam computed tomography (CBCT), in comparison with that of Micro-computed tomography (Micro-CT) which served as the reference. SETTING AND SAMPLE POPULATION: The State Key Laboratory of Oral Diseases at Sichuan University. MATERIAL AND METHODS: Thirty-two bovine teeth were included for standardized CBCT scanning and Micro-CT scanning before and after the simulation of different degrees of root resorption. The teeth were divided into three groups according to the depths of the root resorption cavity (group 1: 0.15, 0.2, 0.3 mm; group 2: 0.6, 1.0 mm; group 3: 1.5, 2.0, 3.0 mm). Each depth included four specimens. Differences in tooth volume before and after simulated root resorption were then calculated from CBCT and Micro-CT scans, respectively. The overall between-method agreement of the measurements was evaluated using the concordance correlation coefficient (CCC). RESULTS: For the first group, the average volume of resorption cavity was 1.07 mm(3) , and the between-method agreement of measurement for the volume changes was low (CCC = 0.098). For the second and third groups, the average volumes of resorption cavities were 3.47 and 6.73 mm(3) respectively, and the between-method agreements were good (CCC = 0.828 and 0.895, respectively). CONCLUSIONS: The accuracy of 3-D quantitative volumetric measurement of simulated root resorption based on CBCT was fairly good in detecting simulated resorption cavities larger than 3.47 mm(3), while it was not sufficient for measuring resorption cavities smaller than 1.07 mm(3) . This method could be applied in future studies of root resorption although further studies are required to improve its accuracy.

Dimensional accuracy and details of the panoramic cross-sectional tomographic images: an in vitro study.

INTRODUCTION: Transversal slicing system (TSS) of Planmeca PM 2002 CC is a tomographic technique which enables us to take cross-sectional views of jaws. Tomographic imaging modalities are commonly applied to acquire cross-sectional images of the jaws for preimplant assessment of bone. Among the available tomographic imaging modalities, panoramic radiography is the most accessible imaging system. MATERIALS AND METHODS: Study was conducted using 25 mandibles, out of these five were used for linear dimensional accuracy measurement and the rest 20 were utilized to study the details within the mandible. Study was aimed to evaluate dimensional stability in the images using different parameters, such as determination of direction of slice, determination of horizontal and vertical magnification, angular distortion, three dimensional distortion and determination of details. RESULTS: For the direction of slice and for determination of horizontal and vertical magnification change in + 5º to - 5º was in acceptable limit. In determination of details, it was found that there was great discrepancy in readings given by nonradiologist which offset the mean value which was attributed to lack of training for interpretation of the observers. CONCLUSION: 99% of the readings were in the clinically acceptable limits. CLINICAL SIGNIFICANCE: The easy availability, use of routine equipment, the low cost, low radiation dose for cross-sectional radiography make the TSS most preferred modality.

Linear mandibular measurements: comparison between orthopantomograms and lateral cephalograms.

OBJECTIVE: To investigate the reliability of length measurements of the mandible by comparing orthopantomograms (OPTs) with lateral cephalograms. DESIGN: Observational study. SETTING: OPTs and lateral cephalograms were taken of 20 human dry skulls. Four orthodontists and four maxillofacial surgeons located landmarks on all radiographs using a computer program for cephalometric measurements. Intraobserver and interobserver variability in locating landmarks was assessed, as well as positioning of the skulls prior to radiography between the x-ray assistants. Magnification differences between the left and right side of the mandible on the OPT were determined for five skulls. Kappa statistics were used to calculate the intraclass correlation coefficient for intraobserver and interobserver differences. An F test was used to assess differences between methods and between type of observer. RESULTS: No significant differences were found in the magnification factor of the left and right side of the mandible. Compared with a lateral cephalogram, the OPT had comparable reliability in measuring mandibular distances condylion-gonion, gonion-menton, and condylion-menton. No significant differences were observed between the x-ray assistants in taking the OPTs and lateral cephalograms or in repositioning the skulls. Significant differences were found between orthodontists and maxillofacial surgeons for landmark measurements. CONCLUSION: An OPT is as reliable as a lateral cephalogram for linear measurements of the mandible (condylion-gonion, gonion-menton, and condylion-menton).

Results of a survey on digital screening mammography: prevalence, efficiency, and use of ancillary diagnostic AIDS.

OBJECTIVE: As the use of full-field digital screening mammography grows rapidly, this study was conducted to determine the time required to interpret digital soft-copy (filmless) mammography compared with conventional film-screen screening mammography and to evaluate radiologists' use of ancillary diagnostic aids when interpreting digital mammography (DM) and conventional film-screen mammography (FSM). MATERIALS AND METHODS: An 18-question survey was sent to 1,703 members of the Society of Breast Imaging, whose e-mail addresses were provided by the society. After subtracting those from whom out-of-office e-mail responses were received and three who wrote back to exclude themselves, there were 1,659 potential participants. Data from the respondents were collected and analyzed by tabulation and cross-tabulation. RESULTS: In total, 396 members of the Society of Breast Imaging completed and returned surveys, for a 23.9% response rate. Of the respondents, 49.0% said that they had access to and interpreted DM. Their estimated average time to read a single digital mammographic study was 2.6 minutes, compared with 2.0 minutes for reading a single film-screen mammographic study. Therefore, the perceived time difference was 0.6 minutes. Magnification was the main ancillary diagnostic aid used in interpreting both DM and FSM: 74.2% of respondents used computer-based magnification at least half the time in interpreting DM, and 90.9% used optical magnification at least half the time in interpreting FSM. Optical magnification was also used by 28.5% of respondents at least half the time in interpreting DM. The respondents also used computer-aided detection frequently: 91.0% and 76.3% of those who had computer-aided detection available said that they used it at least 75% of the time in interpreting DM and FSM, respectively. CONCLUSION: Digital mammography takes longer to interpret than FSM. Radiologists use various ancillary diagnostic aids, but magnification and computer-aided detection are the two most commonly used aids.

A method to calculate angular disparities between object and receptor in "paralleling technique".

OBJECTIVE: To develop an image analysis method for calculation of angular disparities between an object, temporarily equipped with a reference system, and a radiographic receptor. MATERIALS AND METHODS: A mathematical method based on a reference system containing two metallic spheres is developed, allowing calculation of inclination between the inter-spherical axis and the digital image receptor using image features. Experimental evaluation was done in standardized projection geometry for two sphere sizes at four randomly chosen inclinations per size, with each radiograph assessed three times. Truth was assessed threefold from photographs obtained at each inclination. RESULTS: Mean standard deviation between single assessments was 2.6 degrees. Significant differences (P Maloney/Rastogy=0.00) were found between absolute values of truth and calculated values (mean: -0.9 degrees; range: -6.0 degrees; 3.6 degrees), indicating a significant lack of accuracy. CONCLUSIONS: Although so far not sufficiently accurate, the method yields information relevant for correction of distortion in intra-oral radiology.

Film-screen magnification versus electronic magnification and enhancement of digitized contact mammograms in the assessment of subtle microcalcifications.

RATIONALE AND OBJECTIVES: To compare information drawn from magnification mammography with that extracted from electronic magnification, processing, and display of the digitized contact images. METHODS: Contact and magnification images of a mammographic statistical phantom were obtained. The magnification films versus the computer-enhanced, digitized images of the corresponding contact mammograms were separately presented to three observers. Receiver operating characteristic analysis was used to compare lesion detectability. The contact and magnification mammograms of 86 patients with subtle microcalcifications were also studied. The breast imaging reporting and data system (BI-RADS) scheme was used to compare the magnification patient films versus the corresponding digitized contact images. Differences in mammographic assessment were evaluated by using the kappa statistic. The dose to breast tissue from contact and magnification mammography was measured to evaluate dose reduction in instances where magnification mammography was to be avoided. RESULTS: Lesion detectability was found to be similar when either the digitized film image or the magnification hard-copy film was inspected. Interpretation of patient images by inspection of the contact and magnification screen-film mammograms on a view-box was in excellent agreement with that yielded by inspection of the contact image on a view-box and the computer-enhanced, digitized contact image on a display monitor. CONCLUSIONS: Electronic magnification and processing of the digitized contact image may provide valuable information concerning subtle microcalcifications, rendering magnification mammography unnecessary for many patients with such lesions.

[The resolving capacity of systems for the reproduction of x-ray images]. / Razreshaiushchaia sposobnost' sistem vosproizvedeniia rentgenovskikh izobrazhenii.

At digital and film X-ray studies, the geometry of a survey exerts a varying effect on the system's resolution. This may lead to the better quality of digital X-ray image when actual magnification is performed.

[Image quality and radiation exposure in digital mammography with storage phosphor screens in a magnification technic]. / Bildgüte und Strahlenexposition bei der digitalen Mammographie mit Speicherfolien in Vergrösserungstechnik.

PURPOSE: Comparison of image quality between digital phosphor storage plate mammography in magnification technique and a conventional film screen system regarding the special aspect of radiation exposure. MATERIALS AND METHODS: Radiograms of a RMI-mammography phantom were acquired using a conventional film screen system and two digital storage plate systems. Additionally, the radiograms of one digital system were post-processed emphasizing contrast and included in the comparison. RESULTS: The detectability of details in storage plate mammographies with magnification technique is almost equal to that of film screen mammographies. Thereby, lower radiation exposures were necessary using the digital systems. CONCLUSIONS: Based on these results, storage plate mammography in magnification technique is used in clinical routine at our institution. The correct parameters in image postprocessing are of elementary importance for detail detectability. Future studies must show, whether the lower radiation exposure in digital radiograms of the breast, revealing much higher background noise, will allow the same detail detectability as film screen mammographies.

[Direct digital magnification mammography with a large-surface detector made of amorphous silicon]. / Direkt digitale Vergrösserungsmammographie mit einem grossflächigen Detektor aus amorphem Silizium.

PURPOSE: To investigate the image quality of a new direct digital mammography system using a large-area amorphous silicon X-ray detector in a phantom study. MATERIALS AND METHODS: The contrast-detail resolution as a function of the tube voltages, the magnification factors and the mean glandular doses were investigated using dedicated test objects. RESULTS: The contrast-detail resolution was significantly improved in comparison with conventional screen-film mammography. Usually, the doses necessary to obtain these high-quality survey mammograms were smaller. CONCLUSIONS: By combining the direct magnification technique and a digital flat panel detector the limited spatial resolution of such image receptors can be overcome. With this direct digital mammography technique, a digital image was directly captured without an intermediate step of optical or mechanical scan.

Characteristics of the Orthopantomograph OP 100.

OBJECTIVE: To investigate empirically the imaging characteristics of the Orthopantomograph OP 100 and compare them to the average form of the dental arch. METHODS: Repeatable radiographs were taken of a lead resolution grid positioned at 1 mm increments along known angular intervals of the projected X-ray beam. Focal trough thickness was determined by visibility of the 1.5 lp mm-1 resolution limits. The path of the effective rotation center was determined using a film positioned at right angles to the slit beam. The vertical magnification and horizontal magnification and distortion index, corrected for the position of the tomographic layer, were calculated using a reference object placed at various resolution limits of the focal trough. The beam projection angle was calculated with respect to the central plane of the focal trough and the average dental arch shape compared with the average proximal contact angle. RESULTS: The maximum resolution observed at the central plane of the focal trough was 5 lp mm-1. The width of the focal trough varied from 17 mm in the anterior region to 44 mm in the posterior region. The path of the effective rotation center was found to translate between three fixed centers of rotation, with the effective anterior projection radius of 24 mm. The vertical magnification factor within the focal trough showed a linear increase along the beam path from 1.24-1.37 and the horizontal magnification varied from 1.01-1.63. The distortion index varied from 0.84-1.24. The beam projection angle increased from 90 degrees anteriorly to 115 degrees in the premolar area with respect to the central plane of the focal trough and from 90 degrees anteriorly to 110 degrees in the premolar area compared with the average dental arch. CONCLUSIONS: The OP 100 provides a focal trough conforming well to the overall geometry of the dental arch and provides adequate spatial resolution.

The effect of image variations on fractal dimension calculations.

OBJECTIVES: We used digitized dental radiographs of alveolar bone to test the hypothesis that the fractal dimension, as calculated with the program "ImageFractal" was independent of variations in X-ray exposure, beam alignment, and region of interest placement. STUDY DESIGN: The radiographic data set consisted of 72 radiographs digitized with 200 microns pixels. Radiographs were obtained with the use of three time settings and two alignments. Rectangular regions of interest were placed on each digital image over the interdental bone between the mandibular first and second molars on six hemimandibles. Each of six hemimandibles had identical copies of a unique region of interest placed on every image in its series. New regions were made 3 months later. A fractal dimension was computed from each region of interest with the caliper method included in ImageFractal, a public domain program available through National Institutes of Health. The resulting fractal dimensions were evaluated with two repeated measures analysis of variance. RESULTS: No significant differences were found between the fractal dimensions calculated for baseline images and those from overexposed and underexposed images, from images with 4 to 6 degrees of alignment variations, or from repeat regions of interest. CONCLUSION: The results support the hypothesis that fractal dimensions derived from digitized dental radiographs are not affected by variations in exposure or small variations in alignment and imply an absolute region of interest placement may not be necessary. However, caution should be used with the use of the fractal dimension to discriminate among alveolar bone variations until further research is performed.

Analytic isocenter calibration. A new approach for accurate x-ray gantries.

Isocenter calibration transforms cardiac structures in digitized biplane angiograms to absolute dimensions, calculating their radiological magnification and video transformation. Since a scaling device is not required, isocenter calibration yields to more accurate measurements than the widely used reference object calibration. Both isocenter methods reported so far, regarding geometrically inaccurate x-ray gantries, yield to different and complex computational formulas. Since these formulas are hard to understand, isocenter calibration is less widely used. To facilitate the implementation of the isocenter calibration, the basic formulas for accurate x-ray gantries are derived. Shifting virtually one x-ray system onto the other, basic isocenter calibration is derived geometrically in three simple steps. The radiological magnification of an object is illustrated as a ratio of planes. The calculation of all parameters entering the computations is demonstrated geometrically, by use of the isocenter of the x-ray gantry. The derivation gives a clear idea of isocenter calibration. It is simple to derive and facilitates the understanding of the error regarding developments. When geometrical inaccuracies vanish, all formulas become equivalent. However, even if the inaccuracies increase, all methods provide nearly identical results, indicating the robustness of isocenter calibration.

In vitro correlation of intravascular ultrasound and direct magnification radiography for calcified arterial lesions.

RATIONALE AND OBJECTIVES: Intravascular ultrasound (IVUS) is an adjunct to contrast angiography that gives additional information concerning the morphology of the vascular wall. The authors examined the accuracy of intravascular ultrasound (IVUS) in the evaluation of calcified lesions within the abdominal aorta and the iliac artery. METHODS: Forty-nine human specimens (iliac artery, 26; abdominal aorta, 23) were examined using a 20-MHz 6.0-F ultrasound catheter, followed by magnification radiography of the same specimens using a newly developed microfocus x-ray tube. Magnification radiographs and ultrasound images were divided into identical sectors to analyze the morphology of calcified arteriosclerotic lesions. RESULTS: A total of 644 sectors was analyzed. Sensitivity of intravascular sonography was 70%, specificity 53%. Sensitivity strongly depended on the morphology of the calcified lesions. CONCLUSION: The detection of calcified arteriosclerotic lesions by means of IVUS revealed a sensitivity of 70% in an in vitro study using human specimens. However, the specificity of IVUS was only 53%, which is basically a random chance occurrence.

Optimal sampling interval and edge detection algorithm for measurement of blood vessel diameter on a cineangiogram.

RATIONALE AND OBJECTIVES: The authors studied the effects of image magnification and the type of edge detection filter on the precision of measuring blood vessel diameters on coronary angiograms. METHOD: A blood vessel phantom containing five channels of various diameters filled with contrast medium was filmed. The magnifications examined were x4, x10, and x20, and the edge detection filters used were the first derivative, second derivative, composite, and entropy filters. The regression line y = a+bx was introduced, where x represents the nominal diameter and y the diameter measured by the edge-detection filters. Determination criteria were the offset, slope, and residual variance from the regression equation. RESULTS: The best value among three criteria was obtained with a magnification of x10 or x20. The entropy filter gave the best value of slope and residual variance. The composite filter gave the best value of offset. CONCLUSION: The most precise measurement is obtained when the entropy filter and a magnification of x10 or x20 are applied.