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1.
Skin Res Technol ; 30(9): e70040, 2024 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-39221858

RESUMEN

BACKGROUND: Skin cancer is one of the highly occurring diseases in human life. Early detection and treatment are the prime and necessary points to reduce the malignancy of infections. Deep learning techniques are supplementary tools to assist clinical experts in detecting and localizing skin lesions. Vision transformers (ViT) based on image segmentation classification using multiple classes provide fairly accurate detection and are gaining more popularity due to legitimate multiclass prediction capabilities. MATERIALS AND METHODS: In this research, we propose a new ViT Gradient-Weighted Class Activation Mapping (GradCAM) based architecture named ViT-GradCAM for detecting and classifying skin lesions by spreading ratio on the lesion's surface area. The proposed system is trained and validated using a HAM 10000 dataset by studying seven skin lesions. The database comprises 10 015 dermatoscopic images of varied sizes. The data preprocessing and data augmentation techniques are applied to overcome the class imbalance issues and improve the model's performance. RESULT: The proposed algorithm is based on ViT models that classify the dermatoscopic images into seven classes with an accuracy of 97.28%, precision of 98.51, recall of 95.2%, and an F1 score of 94.6, respectively. The proposed ViT-GradCAM obtains better and more accurate detection and classification than other state-of-the-art deep learning-based skin lesion detection models. The architecture of ViT-GradCAM is extensively visualized to highlight the actual pixels in essential regions associated with skin-specific pathologies. CONCLUSION: This research proposes an alternate solution to overcome the challenges of detecting and classifying skin lesions using ViTs and GradCAM, which play a significant role in detecting and classifying skin lesions accurately rather than relying solely on deep learning models.


Asunto(s)
Algoritmos , Aprendizaje Profundo , Dermoscopía , Neoplasias Cutáneas , Humanos , Dermoscopía/métodos , Neoplasias Cutáneas/diagnóstico por imagen , Neoplasias Cutáneas/clasificación , Neoplasias Cutáneas/patología , Interpretación de Imagen Asistida por Computador/métodos , Bases de Datos Factuales , Piel/diagnóstico por imagen , Piel/patología
2.
Sci Rep ; 14(1): 19036, 2024 08 16.
Artículo en Inglés | MEDLINE | ID: mdl-39152181

RESUMEN

With rising melanoma incidence and mortality, early detection and surgical removal of primary lesions is essential. Multispectral imaging is a new, non-invasive technique that can facilitate skin cancer detection by measuring the reflectance spectra of biological tissues. Currently, incident illumination allows little light to be reflected from deeper skin layers due to high surface reflectance. A pilot study was conducted at the University Hospital Basel to evaluate, whether multispectral imaging with direct light coupling could extract more information from deeper skin layers for more accurate dignity classification of melanocytic lesions. 27 suspicious pigmented lesions from 23 patients were included (6 melanomas, 6 dysplastic nevi, 12 melanocytic nevi, 3 other). Lesions were imaged before excision using a prototype snapshot mosaic multispectral camera with incident and direct illumination with subsequent dignity classification by a pre-trained multispectral image analysis model. Using incident light, a sensitivity of 83.3% and a specificity of 58.8% were achieved compared to dignity as determined by histopathological examination. Direct light coupling resulted in a superior sensitivity of 100% and specificity of 82.4%. Convolutional neural network classification of corresponding red, green, and blue lesion images resulted in 16.7% lower sensitivity (83.3%, 5/6 malignant lesions detected) and 20.9% lower specificity (61.5%) compared to direct light coupling with multispectral image classification. Our results show that incorporating direct light multispectral imaging into the melanoma detection process could potentially increase the accuracy of dignity classification. This newly evaluated illumination method could improve multispectral applications in skin cancer detection. Further larger studies are needed to validate the camera prototype.


Asunto(s)
Melanoma , Nevo Pigmentado , Neoplasias Cutáneas , Humanos , Melanoma/diagnóstico por imagen , Melanoma/clasificación , Melanoma/patología , Melanoma/diagnóstico , Neoplasias Cutáneas/diagnóstico por imagen , Neoplasias Cutáneas/patología , Neoplasias Cutáneas/clasificación , Neoplasias Cutáneas/diagnóstico , Femenino , Nevo Pigmentado/diagnóstico por imagen , Nevo Pigmentado/diagnóstico , Nevo Pigmentado/clasificación , Nevo Pigmentado/patología , Masculino , Persona de Mediana Edad , Adulto , Proyectos Piloto , Anciano , Melanocitos/patología , Iluminación/métodos , Procesamiento de Imagen Asistido por Computador/métodos , Sensibilidad y Especificidad
3.
Sci Rep ; 14(1): 17323, 2024 07 27.
Artículo en Inglés | MEDLINE | ID: mdl-39068205

RESUMEN

Skin cancer is a type of cancer disease in which abnormal alterations in skin characteristics can be detected. It can be treated if it is detected early. Many artificial intelligence-based models have been developed for skin cancer detection and classification. Considering the development of numerous models according to various scenarios and selecting the optimum model was rarely considered in previous works. This study aimed to develop various models for skin cancer classification and select the optimum model. Convolutional neural networks (CNNs) in the form of AlexNet, Inception V3, MobileNet V2, and ResNet 50 were used for feature extraction. Feature reduction was carried out using two algorithms of the grey wolf optimizer (GWO) in addition to using the original features. Skin cancer images were classified into four classes based on six machine learning (ML) classifiers. As a result, 51 models were developed with different combinations of CNN algorithms, without GWO algorithms, with two GWO algorithms, and with six ML classifiers. To select the optimum model with the best results, the multicriteria decision-making approach was utilized to rank the alternatives by perimeter similarity (RAPS). Model training and testing were conducted using the International Skin Imaging Collaboration (ISIC) 2017 dataset. Based on nine evaluation metrics and according to the RAPS method, the AlexNet algorithm with a classical GWO yielded the optimum model, achieving a classification accuracy of 94.5%. This work presents the first study on benchmarking skin cancer classification with many models. Feature reduction not only reduces the time spent on training but also improves classification accuracy. The RAPS method has proven its robustness in the problem of selecting the best model for skin cancer classification.


Asunto(s)
Algoritmos , Redes Neurales de la Computación , Neoplasias Cutáneas , Humanos , Neoplasias Cutáneas/clasificación , Neoplasias Cutáneas/patología , Neoplasias Cutáneas/diagnóstico por imagen , Aprendizaje Automático , Piel/patología , Piel/diagnóstico por imagen
4.
Comput Biol Med ; 179: 108851, 2024 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-39004048

RESUMEN

In dermoscopic images, which allow visualization of surface skin structures not visible to the naked eye, lesion shape offers vital insights into skin diseases. In clinically practiced methods, asymmetric lesion shape is one of the criteria for diagnosing Melanoma. Initially, we labeled data for a non-annotated dataset with symmetrical information based on clinical assessments. Subsequently, we propose a supporting technique-a supervised learning image processing algorithm-to analyze the geometrical pattern of lesion shape, aiding non-experts in understanding the criteria of an asymmetric lesion. We then utilize a pre-trained convolutional neural network (CNN) to extract shape, color, and texture features from dermoscopic images for training a multiclass support vector machine (SVM) classifier, outperforming state-of-the-art methods from the literature. In the geometry-based experiment, we achieved a 99.00 % detection rate for dermatological asymmetric lesions. In the CNN-based experiment, the best performance is found 94 % Kappa Score, 95 % Macro F1-score, and 97 % weighted F1-score for classifying lesion shapes (Asymmetric, Half-Symmetric, and Symmetric).


Asunto(s)
Melanoma , Redes Neurales de la Computación , Neoplasias Cutáneas , Máquina de Vectores de Soporte , Humanos , Melanoma/diagnóstico por imagen , Melanoma/patología , Melanoma/clasificación , Neoplasias Cutáneas/diagnóstico por imagen , Neoplasias Cutáneas/patología , Neoplasias Cutáneas/clasificación , Dermoscopía/métodos , Interpretación de Imagen Asistida por Computador/métodos , Algoritmos , Piel/diagnóstico por imagen , Piel/patología
5.
Comput Biol Med ; 178: 108742, 2024 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-38875908

RESUMEN

In recent years, there has been a significant improvement in the accuracy of the classification of pigmented skin lesions using artificial intelligence algorithms. Intelligent analysis and classification systems are significantly superior to visual diagnostic methods used by dermatologists and oncologists. However, the application of such systems in clinical practice is severely limited due to a lack of generalizability and risks of potential misclassification. Successful implementation of artificial intelligence-based tools into clinicopathological practice requires a comprehensive study of the effectiveness and performance of existing models, as well as further promising areas for potential research development. The purpose of this systematic review is to investigate and evaluate the accuracy of artificial intelligence technologies for detecting malignant forms of pigmented skin lesions. For the study, 10,589 scientific research and review articles were selected from electronic scientific publishers, of which 171 articles were included in the presented systematic review. All selected scientific articles are distributed according to the proposed neural network algorithms from machine learning to multimodal intelligent architectures and are described in the corresponding sections of the manuscript. This research aims to explore automated skin cancer recognition systems, from simple machine learning algorithms to multimodal ensemble systems based on advanced encoder-decoder models, visual transformers (ViT), and generative and spiking neural networks. In addition, as a result of the analysis, future directions of research, prospects, and potential for further development of automated neural network systems for classifying pigmented skin lesions are discussed.


Asunto(s)
Inteligencia Artificial , Redes Neurales de la Computación , Neoplasias Cutáneas , Humanos , Neoplasias Cutáneas/clasificación , Neoplasias Cutáneas/diagnóstico , Neoplasias Cutáneas/patología , Diagnóstico por Computador/métodos , Algoritmos , Aprendizaje Automático
6.
Comput Biol Med ; 178: 108798, 2024 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-38925085

RESUMEN

Skin cancer (SC) significantly impacts many individuals' health all over the globe. Hence, it is imperative to promptly identify and diagnose such conditions at their earliest stages using dermoscopic imaging. Computer-aided diagnosis (CAD) methods relying on deep learning techniques especially convolutional neural networks (CNN) can effectively address this issue with outstanding outcomes. Nevertheless, such black box methodologies lead to a deficiency in confidence as dermatologists are incapable of comprehending and verifying the predictions that were made by these models. This article presents an advanced an explainable artificial intelligence (XAI) based CAD system named "Skin-CAD" which is utilized for the classification of dermoscopic photographs of SC. The system accurately categorises the photographs into two categories: benign or malignant, and further classifies them into seven subclasses of SC. Skin-CAD employs four CNNs of different topologies and deep layers. It gathers features out of a pair of deep layers of every CNN, particularly the final pooling and fully connected layers, rather than merely depending on attributes from a single deep layer. Skin-CAD applies the principal component analysis (PCA) dimensionality reduction approach to minimise the dimensions of pooling layer features. This also reduces the complexity of the training procedure compared to using deep features from a CNN that has a substantial size. Furthermore, it combines the reduced pooling features with the fully connected features of each CNN. Additionally, Skin-CAD integrates the dual-layer features of the four CNNs instead of entirely depending on the features of a single CNN architecture. In the end, it utilizes a feature selection step to determine the most important deep attributes. This helps to decrease the general size of the feature set and streamline the classification process. Predictions are analysed in more depth using the local interpretable model-agnostic explanations (LIME) approach. This method is used to create visual interpretations that align with an already existing viewpoint and adhere to recommended standards for general clarifications. Two benchmark datasets are employed to validate the efficiency of Skin-CAD which are the Skin Cancer: Malignant vs. Benign and HAM10000 datasets. The maximum accuracy achieved using Skin-CAD is 97.2 % and 96.5 % for the Skin Cancer: Malignant vs. Benign and HAM10000 datasets respectively. The findings of Skin-CAD demonstrate its potential to assist professional dermatologists in detecting and classifying SC precisely and quickly.


Asunto(s)
Aprendizaje Profundo , Dermoscopía , Neoplasias Cutáneas , Humanos , Neoplasias Cutáneas/diagnóstico por imagen , Neoplasias Cutáneas/clasificación , Dermoscopía/métodos , Redes Neurales de la Computación , Diagnóstico por Computador/métodos , Interpretación de Imagen Asistida por Computador/métodos
7.
Arch Dermatol Res ; 316(7): 434, 2024 Jun 27.
Artículo en Inglés | MEDLINE | ID: mdl-38935165

RESUMEN

Poor differentiation is strongly associated with poor outcomes in cutaneous squamous cell carcinoma (CSCC). In addition, the National Comprehensive Cancer Network (NCCN) guidelines designate poorly differentiated tumors as "very high risk". Despite its clear prognostic implications, there is no standardized grading system for CSCC differentiation in common use today. CSCC differentiation is graded inconsistently by both dermatopathologists and Mohs surgeons, and reliability studies have demonstrated suboptimal inter- and intra-rater reliability in both of these groups. The absence of a standardized and reliable grading system has impeded the use of differentiation in CSCC staging, despite its apparent correlation with disease outcomes. We performed a comprehensive review of the literature summarizing historical CSCC differentiation grading systems, as well as grading systems in non-cutaneous head and neck SCC as a point of reference. Relevant articles were identified by searching Embase and PubMed, as well as by reviewing reference lists for additional articles and histology textbook excerpts. CSCC grading systems that were identified and summarized include the historical Broders system, the World Health Organization system, the College of American Pathologists' system, and a system described by a 2023 Delphi consensus panel of dermatopathologists.


Asunto(s)
Carcinoma de Células Escamosas , Clasificación del Tumor , Neoplasias Cutáneas , Humanos , Neoplasias Cutáneas/patología , Neoplasias Cutáneas/diagnóstico , Neoplasias Cutáneas/clasificación , Carcinoma de Células Escamosas/patología , Carcinoma de Células Escamosas/diagnóstico , Pronóstico , Diferenciación Celular , Reproducibilidad de los Resultados , Estadificación de Neoplasias , Piel/patología , Cirugía de Mohs
8.
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi ; 41(3): 544-551, 2024 Jun 25.
Artículo en Chino | MEDLINE | ID: mdl-38932541

RESUMEN

Skin cancer is a significant public health issue, and computer-aided diagnosis technology can effectively alleviate this burden. Accurate identification of skin lesion types is crucial when employing computer-aided diagnosis. This study proposes a multi-level attention cascaded fusion model based on Swin-T and ConvNeXt. It employed hierarchical Swin-T and ConvNeXt to extract global and local features, respectively, and introduced residual channel attention and spatial attention modules for further feature extraction. Multi-level attention mechanisms were utilized to process multi-scale global and local features. To address the problem of shallow features being lost due to their distance from the classifier, a hierarchical inverted residual fusion module was proposed to dynamically adjust the extracted feature information. Balanced sampling strategies and focal loss were employed to tackle the issue of imbalanced categories of skin lesions. Experimental testing on the ISIC2018 and ISIC2019 datasets yielded accuracy, precision, recall, and F1-Score of 96.01%, 93.67%, 92.65%, and 93.11%, respectively, and 92.79%, 91.52%, 88.90%, and 90.15%, respectively. Compared to Swin-T, the proposed method achieved an accuracy improvement of 3.60% and 1.66%, and compared to ConvNeXt, it achieved an accuracy improvement of 2.87% and 3.45%. The experiments demonstrate that the proposed method accurately classifies skin lesion images, providing a new solution for skin cancer diagnosis.


Asunto(s)
Algoritmos , Diagnóstico por Computador , Neoplasias Cutáneas , Humanos , Neoplasias Cutáneas/patología , Neoplasias Cutáneas/diagnóstico por imagen , Neoplasias Cutáneas/clasificación , Diagnóstico por Computador/métodos , Piel/patología , Interpretación de Imagen Asistida por Computador/métodos
9.
Asian Pac J Cancer Prev ; 25(5): 1795-1802, 2024 May 01.
Artículo en Inglés | MEDLINE | ID: mdl-38809652

RESUMEN

BACKGROUND: Skin cancer diagnosis challenges dermatologists due to its complex visual variations across diagnostic categories. Convolutional neural networks (CNNs), specifically the Efficient Net B0-B7 series, have shown superiority in multiclass skin cancer classification. This study addresses the limitations of visual examination by presenting a tailored preprocessing pipeline designed for Efficient Net models. Leveraging transfer learning with pre-trained ImageNet weights, the research aims to enhance diagnostic accuracy in an imbalanced multiclass classification context. METHODS: The study develops a specialized image preprocessing pipeline involving image scaling, dataset augmentation, and artifact removal tailored to the nuances of Efficient Net models. Using the Efficient Net B0-B7 dataset, transfer learning fine-tunes CNNs with pre-trained ImageNet weights. Rigorous evaluation employs key metrics like Precision, Recall, Accuracy, F1 Score, and Confusion Matrices to assess the impact of transfer learning and fine-tuning on each Efficient Net variant's performance in classifying diverse skin cancer categories. RESULTS: The research showcases the effectiveness of the tailored preprocessing pipeline for Efficient Net models. Transfer learning and fine-tuning significantly enhance the models' ability to discern diverse skin cancer categories. The evaluation of eight Efficient Net models (B0-B7) for skin cancer classification reveals distinct performance patterns across various cancer classes. While the majority class, Benign Kertosis, achieves high accuracy (>87%), challenges arise in accurately classifying Eczema classes. Melanoma, despite its minority representation (2.42% of images), attains an average accuracy of 80.51% across all models. However, suboptimal performance is observed in predicting warts molluscum (90.7%) and psoriasis (84.2%) instances, highlighting the need for targeted improvements in accurately identifying specific skin cancer types. CONCLUSION: The study on skin cancer classification utilizes EfficientNets B0-B7 with transfer learning from ImageNet weights. The pinnacle performance is observed with EfficientNet-B7, achieving a groundbreaking top-1 accuracy of 84.4% and top-5 accuracy of 97.1%. Remarkably efficient, it is 8.4 times smaller than the leading CNN. Detailed per-class classification exactitudes through Confusion Matrices affirm its proficiency, signaling the potential of EfficientNets for precise dermatological image analysis.


Asunto(s)
Redes Neurales de la Computación , Neoplasias Cutáneas , Humanos , Neoplasias Cutáneas/patología , Neoplasias Cutáneas/clasificación , Procesamiento de Imagen Asistido por Computador/métodos , Aprendizaje Profundo
10.
Stud Health Technol Inform ; 314: 183-184, 2024 May 23.
Artículo en Inglés | MEDLINE | ID: mdl-38785028

RESUMEN

Melanoma represents an extremely aggressive type of skin lesion. Despite its high mortality rate, when detected in its initial stage, the projected five-year survival rate is notably high. The advancement of Artificial Intelligence in recent years has facilitated the creation of diverse solutions aimed at assisting medical diagnosis. This proposal presents an architecture for melanoma classification.


Asunto(s)
Melanoma , Neoplasias Cutáneas , Melanoma/clasificación , Humanos , Neoplasias Cutáneas/clasificación , Inteligencia Artificial , Diagnóstico por Computador/métodos
11.
Cesk Patol ; 60(1): 49-58, 2024.
Artículo en Inglés | MEDLINE | ID: mdl-38697827

RESUMEN

The section on mesenchymal tumors in 5th edition of WHO classification of skin tumors has undergone several changes, the most important of which, as usual, is the inclusion of newly identified tumor entities, which will be the main focus of this review article. These specifically include three novel cutaneous mesenchymal tumors with melanocytic differentiation, and rearrangements of the CRTC1::TRIM11, ACTIN::MITF, and MITF::CREM genes. In addition, EWSR1::SMAD3-rearranged fibroblastic tumors, superficial CD34-positive fibroblastic tumors, and NTRK-rearranged spindle cell neoplasms were newly included. Of the other changes, only the most important ones will be briefly mentioned.


Asunto(s)
Neoplasias Cutáneas , Organización Mundial de la Salud , Humanos , Neoplasias Cutáneas/genética , Neoplasias Cutáneas/patología , Neoplasias Cutáneas/clasificación
12.
Skin Res Technol ; 30(5): e13607, 2024 May.
Artículo en Inglés | MEDLINE | ID: mdl-38742379

RESUMEN

BACKGROUND: Timely diagnosis plays a critical role in determining melanoma prognosis, prompting the development of deep learning models to aid clinicians. Questions persist regarding the efficacy of clinical images alone or in conjunction with dermoscopy images for model training. This study aims to compare the classification performance for melanoma of three types of CNN models: those trained on clinical images, dermoscopy images, and a combination of paired clinical and dermoscopy images from the same lesion. MATERIALS AND METHODS: We divided 914 image pairs into training, validation, and test sets. Models were built using pre-trained Inception-ResNetV2 convolutional layers for feature extraction, followed by binary classification. Training comprised 20 models per CNN type using sets of random hyperparameters. Best models were chosen based on validation AUC-ROC. RESULTS: Significant AUC-ROC differences were found between clinical versus dermoscopy models (0.661 vs. 0.869, p < 0.001) and clinical versus clinical + dermoscopy models (0.661 vs. 0.822, p = 0.001). Significant sensitivity differences were found between clinical and dermoscopy models (0.513 vs. 0.799, p = 0.01), dermoscopy versus clinical + dermoscopy models (0.799 vs. 1.000, p = 0.02), and clinical versus clinical + dermoscopy models (0.513 vs. 1.000, p < 0.001). Significant specificity differences were found between dermoscopy versus clinical + dermoscopy models (0.800 vs. 0.288, p < 0.001) and clinical versus clinical + dermoscopy models (0.650 vs. 0.288, p < 0.001). CONCLUSION: CNN models trained on dermoscopy images outperformed those relying solely on clinical images under our study conditions. The potential advantages of incorporating paired clinical and dermoscopy images for CNN-based melanoma classification appear less clear based on our findings.


Asunto(s)
Dermoscopía , Melanoma , Redes Neurales de la Computación , Neoplasias Cutáneas , Humanos , Melanoma/diagnóstico por imagen , Melanoma/patología , Melanoma/clasificación , Dermoscopía/métodos , Neoplasias Cutáneas/diagnóstico por imagen , Neoplasias Cutáneas/patología , Neoplasias Cutáneas/clasificación , Aprendizaje Profundo , Sensibilidad y Especificidad , Femenino , Curva ROC , Interpretación de Imagen Asistida por Computador/métodos , Masculino
13.
Sci Rep ; 14(1): 11235, 2024 05 16.
Artículo en Inglés | MEDLINE | ID: mdl-38755202

RESUMEN

Skin cancer is one of the most life-threatening diseases caused by the abnormal growth of the skin cells, when exposed to ultraviolet radiation. Early detection seems to be more crucial for reducing aberrant cell proliferation because the mortality rate is rapidly rising. Although multiple researches are available based on the skin cancer detection, there still exists challenges in improving the accuracy, reducing the computational time and so on. In this research, a novel skin cancer detection is performed using a modified falcon finch deep Convolutional neural network classifier (Modified Falcon finch deep CNN) that efficiently detects the disease with higher efficiency. The usage of modified falcon finch deep CNN classifier effectively analyzed the information relevant to the skin cancer and the errors are also minimized. The inclusion of the falcon finch optimization in the deep CNN classifier is necessary for efficient parameter tuning. This tuning enhanced the robustness and boosted the convergence of the classifier that detects the skin cancer in less stipulated time. The modified falcon finch deep CNN classifier achieved accuracy, sensitivity, and specificity values of 93.59%, 92.14%, and 95.22% regarding k-fold and 96.52%, 96.69%, and 96.54% regarding training percentage, proving more effective than literary works.


Asunto(s)
Redes Neurales de la Computación , Neoplasias Cutáneas , Neoplasias Cutáneas/diagnóstico , Neoplasias Cutáneas/clasificación , Neoplasias Cutáneas/patología , Humanos , Pinzones , Animales , Masculino , Detección Precoz del Cáncer/métodos , Femenino , Sensibilidad y Especificidad
14.
Cancer Invest ; 42(5): 365-389, 2024 May.
Artículo en Inglés | MEDLINE | ID: mdl-38767503

RESUMEN

Skin cancer can be detected through visual screening and skin analysis based on the biopsy and pathological state of the human body. The survival rate of cancer patients is low, and millions of people are diagnosed annually. By determining the different comparative analyses, the skin malignancy classification is evaluated. Using the Isomap with the vision transformer, we analyze the high-dimensional images with dimensionality reduction. Skin cancer can present with severe cases and life-threatening symptoms. Overall performance evaluation and classification tend to improve the accuracy of the high-dimensional skin lesion dataset when completed. In deep learning methodologies, the distinct phases of skin malignancy classification are determined by its accuracy, specificity, F1 recall, and sensitivity while implementing the classification methodology. A nonlinear dimensionality reduction technique called Isomap preserves the data's underlying nonlinear relationships intact. This is essential for the categorization of skin malignancies, as the features that separate malignant from benign skin lesions may not be linearly separable. Isomap decreases the data's complexity while maintaining its essential characteristics, making it simpler to analyze and explain the findings. High-dimensional datasets for skin lesions have been evaluated and classified more effectively when evaluated and classified using Isomap with the vision transformer.


Asunto(s)
Neoplasias Cutáneas , Humanos , Neoplasias Cutáneas/patología , Neoplasias Cutáneas/clasificación , Neoplasias Cutáneas/diagnóstico , Aprendizaje Profundo , Piel/patología
15.
Comput Biol Med ; 176: 108594, 2024 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-38761501

RESUMEN

Skin cancer is one of the common types of cancer. It spreads quickly and is not easy to detect in the early stages, posing a major threat to human health. In recent years, deep learning methods have attracted widespread attention for skin cancer detection in dermoscopic images. However, training a practical classifier becomes highly challenging due to inter-class similarity and intra-class variation in skin lesion images. To address these problems, we propose a multi-scale fusion structure that combines shallow and deep features for more accurate classification. Simultaneously, we implement three approaches to the problem of class imbalance: class weighting, label smoothing, and resampling. In addition, the HAM10000_RE dataset strips out hair features to demonstrate the role of hair features in the classification process. We demonstrate that the region of interest is the most critical classification feature for the HAM10000_SE dataset, which segments lesion regions. We evaluated the effectiveness of our model using the HAM10000 and ISIC2019 dataset. The results showed that this method performed well in dermoscopic classification tasks, with ACC and AUC of 94.0% and 99.3%, on the HAM10000 dataset and ACC of 89.8% for the ISIC2019 dataset. The overall performance of our model is excellent in comparison to state-of-the-art models.


Asunto(s)
Dermoscopía , Neoplasias Cutáneas , Humanos , Neoplasias Cutáneas/diagnóstico por imagen , Neoplasias Cutáneas/patología , Neoplasias Cutáneas/clasificación , Dermoscopía/métodos , Aprendizaje Profundo , Interpretación de Imagen Asistida por Computador/métodos , Piel/diagnóstico por imagen , Piel/patología , Bases de Datos Factuales , Algoritmos
16.
Curr Oncol Rep ; 26(7): 818-825, 2024 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-38780675

RESUMEN

PURPOSE OF REVIEW: Melanoma in younger individuals has different clinical presentations, histologic characteristics and prognosis from older patients. This review summarizes key differences and important new insights into pediatric and young adult melanoma, as well as recent evolutions in treatment. RECENT FINDINGS: Molecular techniques have improved the classification of melanocytic neoplasms, and are especially useful in the workup of the diagnostically challenging lesions frequent in this age group. Molecular evaluation highlights differences between melanoma and atypical lesions with Spitz-like morphology, and should routinely be incorporated for diagnosing and classifying Spitzoid melanocytic to guide prognostication and treatment. Once diagnosed, the management of bona fide melanoma in children and young adults is largely similar to older patients, while the optimal management of lesions such as atypical Spitz tumors remains uncertain. Increased awareness of the presentation and diagnostic characteristics of melanoma in young individuals will allow earlier detection, and improved diagnostic techniques will allow optimum management without over- or under-treatment.


Asunto(s)
Melanoma , Neoplasias Cutáneas , Humanos , Melanoma/diagnóstico , Melanoma/patología , Melanoma/terapia , Melanoma/clasificación , Niño , Adulto Joven , Neoplasias Cutáneas/diagnóstico , Neoplasias Cutáneas/patología , Neoplasias Cutáneas/terapia , Neoplasias Cutáneas/clasificación , Pronóstico , Adolescente , Adulto , Nevo de Células Epitelioides y Fusiformes/diagnóstico , Nevo de Células Epitelioides y Fusiformes/patología , Nevo de Células Epitelioides y Fusiformes/terapia
17.
Sci Rep ; 14(1): 9336, 2024 04 23.
Artículo en Inglés | MEDLINE | ID: mdl-38653997

RESUMEN

Skin cancer is the most prevalent kind of cancer in people. It is estimated that more than 1 million people get skin cancer every year in the world. The effectiveness of the disease's therapy is significantly impacted by early identification of this illness. Preprocessing is the initial detecting stage in enhancing the quality of skin images by removing undesired background noise and objects. This study aims is to compile preprocessing techniques for skin cancer imaging that are currently accessible. Researchers looking into automated skin cancer diagnosis might use this article as an excellent place to start. The fully convolutional encoder-decoder network and Sparrow search algorithm (FCEDN-SpaSA) are proposed in this study for the segmentation of dermoscopic images. The individual wolf method and the ensemble ghosting technique are integrated to generate a neighbour-based search strategy in SpaSA for stressing the correct balance between navigation and exploitation. The classification procedure is accomplished by using an adaptive CNN technique to discriminate between normal skin and malignant skin lesions suggestive of disease. Our method provides classification accuracies comparable to commonly used incremental learning techniques while using less energy, storage space, memory access, and training time (only network updates with new training samples, no network sharing). In a simulation, the segmentation performance of the proposed technique on the ISBI 2017, ISIC 2018, and PH2 datasets reached accuracies of 95.28%, 95.89%, 92.70%, and 98.78%, respectively, on the same dataset and assessed the classification performance. It is accurate 91.67% of the time. The efficiency of the suggested strategy is demonstrated through comparisons with cutting-edge methodologies.


Asunto(s)
Algoritmos , Dermoscopía , Redes Neurales de la Computación , Neoplasias Cutáneas , Humanos , Neoplasias Cutáneas/diagnóstico , Neoplasias Cutáneas/diagnóstico por imagen , Neoplasias Cutáneas/clasificación , Neoplasias Cutáneas/patología , Dermoscopía/métodos , Procesamiento de Imagen Asistido por Computador/métodos , Interpretación de Imagen Asistida por Computador/métodos , Piel/patología , Piel/diagnóstico por imagen
18.
J Eur Acad Dermatol Venereol ; 38(8): 1491-1503, 2024 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-38581201

RESUMEN

The classification of primary cutaneous lymphomas and lymphoproliferative disorders (LPD) is continuously evolving by integrating novel clinical, pathological and molecular data. Recently two new classifications for haematological malignancies including entities of cutaneous lymphomas were proposed: the 5th edition of the WHO classification of haematolymphoid tumours and the International Consensus Classification (ICC) of mature lymphoid neoplasms. This article provides an overview of the changes introduced in these two classifications compared to the previous WHO classification. The main changes shared by both classifications include the downgrading of CD8+ acral T-cell lymphoma to CD8+ acral T-cell LPD, and the recognition of entities that were previously categorized as provisional and have now been designated as definite types including primary cutaneous small or medium CD4+ T-cell LPD, primary cutaneous gamma/delta T-cell lymphoma, primary cutaneous CD8+ aggressive epidermotropic cytotoxic T-cell lymphoma, Epstein-Barr virus-positive mucocutaneous ulcer. Both classifications consider primary cutaneous marginal zone B-cell clonal neoplasm as an indolent disease but use a different terminology: primary cutaneous marginal zone lymphoma (WHO) and primary cutaneous marginal zone LPD (ICC). The 5th WHO classification further introduces and provides essential and desirable diagnostic criteria for each disease type and includes chapters on reactive B- or T-cell rich lymphoid proliferations formerly referred as cutaneous pseudolymphomas, as well as histiocyte and CD8 T-cell rich LPD in patients with inborn error of immunity. As already emphasized in previous lymphoma classifications, the importance of integrating clinical, histological, phenotypic and molecular features remains the crucial conceptual base for defining cutaneous (and extracutaneous) lymphomas.


Asunto(s)
Trastornos Linfoproliferativos , Neoplasias Cutáneas , Humanos , Neoplasias Cutáneas/patología , Neoplasias Cutáneas/clasificación , Trastornos Linfoproliferativos/patología , Trastornos Linfoproliferativos/clasificación , Trastornos Linfoproliferativos/diagnóstico , Linfoma Cutáneo de Células T/patología , Linfoma Cutáneo de Células T/clasificación , Linfoma Cutáneo de Células T/diagnóstico , Organización Mundial de la Salud
19.
Diagnosis (Berl) ; 11(3): 283-294, 2024 Aug 01.
Artículo en Inglés | MEDLINE | ID: mdl-38487874

RESUMEN

OBJECTIVES: Early skin cancer diagnosis can save lives; however, traditional methods rely on expert knowledge and can be time-consuming. This calls for automated systems using machine learning and deep learning. However, existing datasets often focus on flat skin surfaces, neglecting more complex cases on organs or with nearby lesions. METHODS: This work addresses this gap by proposing a skin cancer diagnosis methodology using a dataset named ASAN that covers diverse skin cancer cases but suffers from noisy features. To overcome the noisy feature problem, a segmentation dataset named SASAN is introduced, focusing on Region of Interest (ROI) extraction-based classification. This allows models to concentrate on critical areas within the images while ignoring learning the noisy features. RESULTS: Various deep learning segmentation models such as UNet, LinkNet, PSPNet, and FPN were trained on the SASAN dataset to perform segmentation-based ROI extraction. Classification was then performed using the dataset with and without ROI extraction. The results demonstrate that ROI extraction significantly improves the performance of these models in classification. This implies that SASAN is effective in evaluating performance metrics for complex skin cancer cases. CONCLUSIONS: This study highlights the importance of expanding datasets to include challenging scenarios and developing better segmentation methods to enhance automated skin cancer diagnosis. The SASAN dataset serves as a valuable tool for researchers aiming to improve such systems and ultimately contribute to better diagnostic outcomes.


Asunto(s)
Aprendizaje Profundo , Neoplasias Cutáneas , Humanos , Neoplasias Cutáneas/patología , Neoplasias Cutáneas/clasificación , Neoplasias Cutáneas/diagnóstico por imagen , Biopsia , Piel/patología , Piel/diagnóstico por imagen , Procesamiento de Imagen Asistido por Computador/métodos , Aprendizaje Automático , Algoritmos
20.
Microsc Res Tech ; 87(8): 1789-1809, 2024 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-38515433

RESUMEN

Skin cancer is a terrifying disorder that affects all individuals. Due to the significant increase in the rate of melanoma skin cancer, early detection of skin cancer is now more critical than ever before. Malignant melanoma is one of the most serious forms of skin cancer, and it is caused by abnormal melanocyte cell growth. In recent years, skin cancer predictive categorization has become more accurate and predictive due to multiple deep learning algorithms. Malignant melanoma is diagnosed using the Recurrent Convolution Neural Network-Long Short-Term Memory (RCNN-LSTM), which is one of the deep learning classification approaches. Using the International Skin Image Collection and the RCNN-LSTM, the data are categorized and analyzed to gain a better understanding of skin cancer. The method begins with data preprocessing, which prepares the dataset for classification. Additionally, the RCNN is employed to extract the features that are vital to the prediction process. The LSTM is accountable for the final step, classification. There are further factors to examine, such as the precision of 94.60%, the sensitivity of 95.67%, and the F1-score of 95.13%. Other benefits of the suggested study include shorter prediction durations of 95.314, 122.530, and 131.205 s and lower model loss of 0.25%, 0.19%, and 0.15% for input sizes 10, 15, and 20, respectively. Three datasets had a reduced categorization error of 5.11% and an accuracy of 95.42%. In comparison to previous approaches, the work discussed here produces superior outcomes. RESEARCH HIGHLIGHTS: Recurrent convolutional neural network (RCNN) deep learning approach for optimizing time prediction and error classification in early melanoma detection. It extracts a high number of specific features from the skin disease image, making the classification process easier and more accurate. To reduce classification errors in accurately detecting melanoma, context dependency is considered in this work. By accounting for context dependency, the deprivation state is avoided, preventing performance degradation in the model. To minimize melanoma detection model loss, a skin disease image augmentation or regularization process is performed in this work. This strategy improves the accuracy of the model when applied to fresh, previously unobserved data.


Asunto(s)
Aprendizaje Profundo , Detección Precoz del Cáncer , Melanoma , Redes Neurales de la Computación , Neoplasias Cutáneas , Melanoma/diagnóstico , Melanoma/clasificación , Humanos , Neoplasias Cutáneas/clasificación , Neoplasias Cutáneas/diagnóstico , Detección Precoz del Cáncer/métodos , Procesamiento de Imagen Asistido por Computador/métodos , Algoritmos , Melanoma Cutáneo Maligno , Piel/patología
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