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1.
Malawi Med J ; 35(1): 70-71, 2023 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-38124695

RESUMEN

We reported on 65 years old patient who has colon cancer and referred to our palliative care center with pain due to enlarging metastatic mass on the dorsal of the right hand. She had swelling and numbness on her jaw. Computed tomography (CT) scan was performed for mandible imaging and two pathologic fractures were detected on the right corpus and right condyle of the mandible. Clinicians should consider possible metastases for terminal stage cancer patients.


Asunto(s)
Neoplasias del Colon , Fracturas Espontáneas , Neoplasias Mandibulares , Femenino , Humanos , Anciano , Neoplasias Mandibulares/diagnóstico por imagen , Neoplasias Mandibulares/patología , Neoplasias Mandibulares/secundario , Fracturas Espontáneas/patología , Mandíbula/patología , Neoplasias del Colon/diagnóstico por imagen , Tomografía Computarizada por Rayos X
2.
Ann R Coll Surg Engl ; 103(8): e264-e265, 2021 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-34464554

RESUMEN

Papillary carcinoma is the most common type of thyroid cancer, accounting for 80-90% of cases. Distant metastasis of papillary thyroid cancer is uncommon, but when it does occur, it is most commonly to the lungs, liver and bone. Bone metastases to the mandible are rarely reported. We present a 68-year-old man who was referred due to a right parotid mass. Appropriate imaging and biopsy revealed a thyroid malignancy with bone metastases. The patient subsequently underwent thyroidectomy, with histology revealing multifocal papillary carcinoma. Radioactive iodine treatment was then commenced to control the metastatic disease.


Asunto(s)
Neoplasias Mandibulares/secundario , Cáncer Papilar Tiroideo/patología , Neoplasias de la Tiroides/patología , Anciano , Humanos , Radioisótopos de Yodo/uso terapéutico , Masculino , Neoplasias Mandibulares/diagnóstico , Cáncer Papilar Tiroideo/terapia , Neoplasias de la Tiroides/terapia , Tiroidectomía
3.
Medicine (Baltimore) ; 100(17): e24399, 2021 Apr 30.
Artículo en Inglés | MEDLINE | ID: mdl-33907087

RESUMEN

ABSTRACT: Neuroblastoma (NB) metastasized into the mandible and spinal extradural region was rarely reported. We present a case with metastatic NB to the mandible and the spinal extradural regions. The patient received chemotherapy using NB 97 regimen and was tumor free after 8 months, but 9 months after the treatment, the patient presented with lower limb paralysis and persistent pain in maxillofacial region as well as swelling in the left mandibular area. Metastasis to the mandible and the spinal extradural regions was diagnosed based on the spinal and maxillofacial magnetic resonance imaging. Radiotherapy with a density of 2 Gy per day was given via a linear accelerator. The total dose of the intraspinal occupying lesion was subject to radiotherapy with a regimen of 30 Gy (10 fractions). For the management of the maxillofacial pain, tumor in the maxillofacial region was subject to a density of 50 Gy (25 fractions). The maxillofacial pain disappeared after a density of 10 Gy and soft tissue tumefaction was eliminated after a density of 50 Gy, and the maxillofacial appearance was much better than before. Finally, the patient died from tumor progression 2 years after diagnosis for NB.


Asunto(s)
Neoplasias de las Glándulas Suprarrenales/patología , Neoplasias Mandibulares/secundario , Neuroblastoma/patología , Neuroblastoma/secundario , Neoplasias de la Columna Vertebral/secundario , Preescolar , Espacio Epidural/patología , Resultado Fatal , Femenino , Humanos , Mandíbula/patología
4.
Pediatr Blood Cancer ; 68(4): e28918, 2021 04.
Artículo en Inglés | MEDLINE | ID: mdl-33507629

RESUMEN

BACKGROUND: Although metastatic involvement of bony sites including cranial bones is common in neuroblastoma (NB), mandibular metastases (MM) are uncommon, and specific outcomes have not been reported upon in the modern therapeutic era. METHODS: In this retrospective study, medical records on patients with MM from NB were reviewed. Statistical analysis was performed using the Kaplan-Meier method. RESULTS: Of 29 patients, nine (31%) had MM at diagnosis, whereas in 20 (69%) MM were first detected at NB relapse at a median time of 26 (6-89) months from diagnosis. Median maximal diameter of lesions was 3 (range 0.8-4.9) cm. MM were unilateral in 83% of patients, with ascending ramus (55%) and mandibular body (38%) being the two most common sites. All patients received systemic chemotherapy, and 26 (93%) patients received radiotherapy to MM. At a median follow-up of 37.3 (24.2-219.5) months, eight of nine patients with MM at diagnosis did not experience mandibular progressive disease. Eighteen of 20 patients with MM at relapse received therapeutic radiotherapy; objective responses were noted in 78%. Seventy-two percent (5/18) had not experienced relapse within the radiation field at a median of 12 (2-276) months postradiotherapy. Dental findings at follow-up after completion of NB therapy included hypodontia, hypocalcification of enamel, and trismus. Median 3-year overall survival in patients with relapsed MM was 51 ± 12% months from relapse. CONCLUSION: MM when detected at diagnosis is associated with a prognosis similar to that for other skeletal metastases of NB. Radiotherapy is effective for control of MM detected both at diagnosis and relapse. Significant dental abnormalities posttherapy warrant regular dental evaluations and appropriate intervention.


Asunto(s)
Mandíbula/patología , Neoplasias Mandibulares/secundario , Neuroblastoma/patología , Adolescente , Adulto , Anodoncia/etiología , Niño , Preescolar , Dentición , Femenino , Humanos , Lactante , Estimación de Kaplan-Meier , Masculino , Mandíbula/efectos de los fármacos , Mandíbula/efectos de la radiación , Neoplasias Mandibulares/tratamiento farmacológico , Neoplasias Mandibulares/patología , Neoplasias Mandibulares/radioterapia , Neuroblastoma/tratamiento farmacológico , Neuroblastoma/radioterapia , Estudios Retrospectivos , Trismo/etiología , Adulto Joven
5.
Head Neck Pathol ; 15(3): 757-768, 2021 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-33394374

RESUMEN

Neuroblastoma is the most common extracranial solid cancer of infancy, occurring mainly in the adrenal gland, with high metastatic potential. However, involvement of the head and neck region is rare. Here, we present two cases of metastatic neuroblastoma of childhood, in which a mandibular swelling was the first sign of disseminated disease. Case 1 describes a 4-year-old boy with a 2-week history of painful swelling in the left mandibular region, body soreness and weakness. Panoramic radiography and computed tomography showed a destructive lesion in the left mandibular ramus. Case 2 describes a 3-year-old boy with a 1-month history of swelling in the right mandibular area. Panoramic radiograph and cone-beam computed tomography showed a destructive lesion in the right body and ramus of the mandible, displacing tooth germs, with the destruction of vestibular and lingual bone cortices. In both cases, microscopic analyses revealed a diffuse proliferation of small, round, and blue cells with hyperchromatic nuclei and scant cytoplasm. While Case 1 was more undifferentiated, Case 2 presented eosinophilic areas suggestive of neuropil. A large immunohistochemical panel was performed, showing expression of neural markers such as CD56, neuron-specific enolase (in Case 2), chromogranin, and synaptophysin. Both lesions presented a high proliferation index (Ki67 > 70% and 80%, respectively). Positron emission tomography-computed tomography revealed ipsilateral adrenal primary lesions in both cases, with multiple bone metastatic lesions. Besides the mandible, multiple sites of the axial and appendicular skeleton were affected. Treatment consisted of induction chemotherapy, adrenalectomy, consolidation chemoradiotherapy, and post-consolidation therapy.


Asunto(s)
Neoplasias de las Glándulas Suprarrenales/patología , Neoplasias Mandibulares/secundario , Neuroblastoma/secundario , Preescolar , Humanos , Masculino
6.
BMJ Case Rep ; 14(1)2021 Jan 07.
Artículo en Inglés | MEDLINE | ID: mdl-33414122

RESUMEN

Oral cavity is an uncommon site for occurrence of metastasis and usually indicates widespread systemic disease. Primary tumours from the lung most commonly metastasise to oral soft tissues (31.3%) and jaw bones (22%) among men. It is quite challenging to diagnose a solitary metastatic lesion and to determine the site of primary lesion, due to the rarity of these occurrences. This case report describes the jaw bone as a first sign of occult primary lung adenocarcinoma with multiple metastases in 47-year-old man. The patient was treated with the combination of carboplatin and paclitaxel, and has completed two cycles till date with a stable clinical course. Diagnosis of metastatic carcinoma of jaw is very challenging. The pathologist must have knowledge of ancillary techniques along with clinical, radiological and histological correlation to determine the origin of distant primary.


Asunto(s)
Adenocarcinoma del Pulmón/patología , Neoplasias Pulmonares/patología , Neoplasias Mandibulares/secundario , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapéutico , Humanos , Masculino , Neoplasias Mandibulares/tratamiento farmacológico , Persona de Mediana Edad
7.
Oral Oncol ; 116: 105157, 2021 05.
Artículo en Inglés | MEDLINE | ID: mdl-33454219

RESUMEN

A patient suffering from metastatic pancreatobiliary adenocarcinoma was referred to our hospital's stomatology department after a rapidly progressing swelling in the right mandibular angle, trismus and preauricular pain of 3-month duration. A mandible CT scan showed extensive bone rarefaction and a thickening of the contiguous soft tissues that involved the medial masseter and pterygoid muscle. The morphological findings and immunohistochemical profile were compatible with bone metastasis from pancreatic adenocarcinoma. Therefore, palliative treatment was proposed to the patient. Pancreatic cancer metastases to the oral cavity are extremely rare and characterized by its poor prognosis. Herein we describe the ninth case of metastatic spread to the jaw which is also remarkably the longest surviving reported case up to date.


Asunto(s)
Adenocarcinoma , Neoplasias Mandibulares , Neoplasias Pancreáticas , Adenocarcinoma/diagnóstico , Adenocarcinoma/patología , Humanos , Mandíbula , Neoplasias Mandibulares/diagnóstico por imagen , Neoplasias Mandibulares/secundario , Boca , Neoplasias Pancreáticas/diagnóstico , Neoplasias Pancreáticas/patología , Neoplasias Pancreáticas
8.
J Cancer Res Ther ; 16(3): 668-671, 2020.
Artículo en Inglés | MEDLINE | ID: mdl-32719288

RESUMEN

Chordomas are rare tumors which arise from the embryological remnants of the notochord. These tumors can potentially arise from any region within the craniospinal axis and often clinically present as a diagnostic challenge. Chordomas are rare in patients younger than 40 years of age. The most common primary cancers that metastasize to the jaw bones are the ones originating from the breast, lung, kidney adrenal, colo-rectum, or prostate. Mandibular metastasis from a primary chordoma is an extremely rare occurrence with only five prior reports, three originating from primaries in the sacrococcygeal region, one from a lumbar spine primary and the other from a primary arising from the spheno-occipital region. A literature review did not reveal any prior reports of mandibular metastasis at presentation from a clival chordoma. We possibly report the first case of such an unusual clinical scenario in a 7-year-old male child and further discuss the evaluation and management of these rare tumors.


Asunto(s)
Cordoma/patología , Neoplasias de Cabeza y Cuello/secundario , Neoplasias Mandibulares/secundario , Neoplasias de la Base del Cráneo/patología , Biomarcadores de Tumor/metabolismo , Niño , Cordoma/cirugía , Neoplasias de Cabeza y Cuello/cirugía , Humanos , Masculino , Neoplasias Mandibulares/cirugía , Clasificación del Tumor , Neoplasias de la Base del Cráneo/cirugía
9.
Cytogenet Genome Res ; 160(1): 2-10, 2020.
Artículo en Inglés | MEDLINE | ID: mdl-31865307

RESUMEN

Strumae ovarii are neoplasms composed of normal-appearing thyroid tissue that occur within the ovary and rarely spread to extraovarian sites. A unique case of struma ovarii with widespread dissemination detected 48 years after removal of a pelvic dermoid provided the opportunity to reexamine the molecular nature of this form of neoplasm. One tumor, from the heart, consisting of benign thyroid tissue was found to have whole-genome homozygosity. Another tumor from the right mandible composed of malignant-appearing thyroid tissue showed whole-genome homozygosity and a deletion of 7p, presumably the second hit that transformed it into a cancerous tumor. Specimens from 2 other cases of extraovarian struma confined to the abdomen and 8 of 9 cases of intraovarian struma showed genome-wide segmental homozygosity. These findings confirm errors in meiosis as the origin of struma ovarii. The histological and molecular findings further demonstrate that even when outside the ovary, strumae ovarii can behave nonaggressively until they receive a second hit, thereafter behaving like cancer.


Asunto(s)
Carcinoma/genética , Genoma Humano , Meiosis , Neoplasias Ováricas/genética , Estruma Ovárico/genética , Teratoma/genética , Adulto , Anciano , Carcinoma/diagnóstico , Femenino , Eliminación de Gen , Neoplasias Cardíacas/genética , Neoplasias Cardíacas/secundario , Homocigoto , Humanos , Neoplasias Mandibulares/genética , Neoplasias Mandibulares/secundario , Persona de Mediana Edad , Recurrencia Local de Neoplasia , Análisis de Secuencia por Matrices de Oligonucleótidos , Neoplasias Ováricas/diagnóstico , Análisis de Secuencia de ARN , Estruma Ovárico/diagnóstico , Teratoma/diagnóstico , Neoplasias de la Tiroides/genética , Neoplasias de la Tiroides/patología
10.
J Craniofac Surg ; 31(3): e220-e222, 2020.
Artículo en Inglés | MEDLINE | ID: mdl-31688259

RESUMEN

Metastasis from the prostate gland to the mandible is rarely encountered and commonly present with non-specific features like unexplained pain, swelling, and numb chin syndrome. Here we present a case with metastatic prostate adenocarcinoma detected secondary to oral manifestations. Patients present with unexplained facial pain and numbness should alert clinicians to the presence of malignant disease, and appropriate hematological, radiological and or histological investigations should be performed. Thereby, clinicians can prevent the overlook of the first signs of metastasis, accelerate the early diagnosis and positively orientate the prognosis of the disease, especially in a patient without known malignancy.


Asunto(s)
Adenocarcinoma/secundario , Neoplasias Mandibulares/secundario , Neoplasias de la Próstata/patología , Adenocarcinoma/diagnóstico por imagen , Adenocarcinoma/cirugía , Anciano , Humanos , Hipoestesia/etiología , Masculino , Neoplasias Mandibulares/diagnóstico por imagen , Neoplasias Mandibulares/cirugía , Dolor/etiología , Pronóstico , Tomografía Computarizada por Rayos X
12.
J Oral Maxillofac Surg ; 77(11): 2279-2284, 2019 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-31310734

RESUMEN

Medulloblastoma is the most common childhood malignant brain tumor and is considered a minor criterion in the diagnosis of nevoid basal cell carcinoma syndrome (NBCCS). Metastasis of this primitive neuroectodermal tumor is most commonly neuraxial; however, extra-neuraxial metastases have been reported. Extra-neuraxial metastasis to the jaws is a rare occurrence, with only 8 cases previously reported in the literature. The present report documents a unique case of metastatic medulloblastoma to the mandible in a patient with a previous diagnosis of NBCCS.


Asunto(s)
Síndrome del Nevo Basocelular , Carcinoma Basocelular , Neoplasias Mandibulares , Meduloblastoma , Niño , Humanos , Neoplasias Mandibulares/secundario , Meduloblastoma/patología
13.
World Neurosurg ; 129: 349-353, 2019 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-31203066

RESUMEN

BACKGROUND: Infants and young children with neuroblastoma (NB) may present with metastases. The primary tumor most commonly originates in the abdomen and metastasizes to lymph nodes, liver, and bone marrow. Infants and young children presenting with multiple skull metastases are rare. METHODS: We present a rare case of a 20-month-old child who presented with metastatic neuroblastoma and multiple skull lesions. The child responded well to induction chemotherapy followed by myeloablative busulfan/melphalan consolidation. RESULTS: The child had substantial tumor reduction after chemotherapy was started. There was a significant decrease in tumor sizes and uptake, as seen in the metaiodobenzylguanidine study. The 6-month follow-up examination showed complete remission, and the remission continues. CONCLUSIONS: Infants and young children with neuroblastoma rarely present with metastatic lesions to the skull. Even large lesions involving the skull base may be successfully treated with chemotherapy. The use of myeloablative busulfan/melphalan consolidation after induction chemotherapy can decrease the overall metastatic tumor burden. Craniofacial specialists should be aware of treatment options for these young children.


Asunto(s)
Neoplasias Mandibulares/secundario , Neuroblastoma/secundario , Neoplasias Craneales/patología , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapéutico , Femenino , Humanos , Lactante , Neoplasias Mandibulares/tratamiento farmacológico , Neuroblastoma/tratamiento farmacológico , Neoplasias Craneales/tratamiento farmacológico
14.
Head Neck ; 41(4): 915-923, 2019 04.
Artículo en Inglés | MEDLINE | ID: mdl-30758110

RESUMEN

BACKGROUND: The clinical degradation rate and strength of biodegradable implant exposed to postoperative radiotherapy (PORT) are unknown. METHODS: A prospective randomized control trial of 40 consecutive mandibulotomy patients randomly divided into titanium and biodegradable cohorts. All patients received PORT. The following parameters were compared: maximal mouth opening, occlusal force, center of force trajectory, occlusal status, radiographic evidence of bony union, mandibular function impairment questionnaire (MFIQ), overall satisfaction score, and complication rates. RESULTS: Both the mandibular function and occlusal status parameter of the biodegradable and the titanium groups were not significantly difference. Biodegradable cohort showed better MFIQ scores (P = .08) and overall satisfaction scores (P = .64) but was not statistically significant. Of note, 40% of patients in the titanium cohort complained of plate palpability/cold intolerance and required plate removal (P = .02); 10% of patients in the titanium cohort developed osteoradionecrosis. CONCLUSION: Biodegradable osteosynthesis is as reliable as titanium osteosynthesis for mandibulotomy fixation. PORT did not increase the complication rate in the biodegradable group.


Asunto(s)
Implantes Absorbibles , Carcinoma de Células Escamosas/patología , Osteotomía Mandibular/métodos , Titanio/uso terapéutico , Neoplasias de la Lengua/patología , Anciano , Carcinoma de Células Escamosas/cirugía , Femenino , Estudios de Seguimiento , Fijación Interna de Fracturas/métodos , Curación de Fractura/fisiología , Humanos , Masculino , Fracturas Mandibulares/diagnóstico por imagen , Fracturas Mandibulares/cirugía , Neoplasias Mandibulares/secundario , Neoplasias Mandibulares/cirugía , Persona de Mediana Edad , Estudios Prospectivos , Medición de Riesgo , Estadísticas no Paramétricas , Neoplasias de la Lengua/cirugía , Resultado del Tratamiento
15.
BMJ Case Rep ; 11(1)2018 Dec 14.
Artículo en Inglés | MEDLINE | ID: mdl-30567274

RESUMEN

We present here a case of a 64-year-old female patient who reported with a complaint of pain in the chin region of 3-month duration. The radiographs revealed an irregular radiolucent lesion in the anterior part of the mandible. An incisional biopsy was carried out and the microscopy showed features of adenocarcinoma. Suspecting a metastatic lesion, the patient was then sent for whole body examination which showed a mass in the lungs. A whole body scan also showed metastasis to other organs such as kidney, gallbladder and vertebrae. This case is unusual in that the patient complained only of a vague jaw pain with no other systemic symptoms even in the presence of widespread disease.


Asunto(s)
Adenocarcinoma del Pulmón/patología , Carcinoma de Células Renales/secundario , Dolor Facial/patología , Neoplasias de la Vesícula Biliar/secundario , Mandíbula/patología , Neoplasias Mandibulares/secundario , Adenocarcinoma del Pulmón/diagnóstico por imagen , Carcinoma de Células Renales/diagnóstico por imagen , Dolor Facial/diagnóstico por imagen , Dolor Facial/etiología , Femenino , Neoplasias de la Vesícula Biliar/diagnóstico por imagen , Humanos , Mandíbula/diagnóstico por imagen , Neoplasias Mandibulares/diagnóstico por imagen , Persona de Mediana Edad , Tomografía Computarizada por Tomografía de Emisión de Positrones , Pronóstico , Extracción Dental , Imagen de Cuerpo Entero
17.
Vet Comp Oncol ; 16(4): 562-570, 2018 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-29989306

RESUMEN

The diagnostic accuracy of contrast-enhanced CT for detection of cervical lymph node metastasis in dogs is unknown. The purpose of this retrospective, observational, diagnostic accuracy study was to assess the efficacy of CT for detection of mandibular and medial retropharyngeal lymph node metastasis in dogs. Histopathology of dogs with cancer of the head, CT and bilateral mandibular and medial retropharyngeal lymphadenectomy was reviewed. A single radiologist measured lymph nodes to derive short axis width and long-short axis ratios. Two blinded radiologists separately assessed lymph node margins, attenuation and contrast enhancement and each provided a final subjective interpretation of each node site as benign or neoplastic. Where radiologists' opinions differed, a consensus was reached. Sensitivity, specificity and accuracy were calculated for mandibular and medial retropharyngeal sites. Agreement between radiologists was assessed. Fisher's exact test and the Kruskal-Wallis H-test were used to assess associations between variables. Forty-one primary tumours were recorded in 40 dogs. Metastasis to mandibular or retropharyngeal lymph nodes occurred in 16 out of 40 dogs (43/160 nodes). Agreement between radiologists was almost perfect for margination, attenuation and enhancement, strong for interpretation of mandibular lymph node metastasis, and weak for interpretation of medial retropharyngeal lymph node metastasis. Sensitivity of CT was 12.5% and 10.5%, specificity was 91.1% and 96.7%, and accuracy was 67.5% and 76.3% for mandibular and medial retropharyngeal lymph nodes respectively. No individual CT findings were predictive of nodal metastasis. Given the low sensitivity of CT, this modality cannot be relied upon alone for assessment of cervical lymph node metastasis in dogs.


Asunto(s)
Enfermedades de los Perros/diagnóstico por imagen , Neoplasias Mandibulares/veterinaria , Neoplasias de la Boca/veterinaria , Neoplasias Nasales/veterinaria , Neoplasias Faríngeas/veterinaria , Animales , Enfermedades de los Perros/diagnóstico , Enfermedades de los Perros/patología , Perros , Femenino , Metástasis Linfática , Masculino , Neoplasias Mandibulares/diagnóstico , Neoplasias Mandibulares/diagnóstico por imagen , Neoplasias Mandibulares/secundario , Neoplasias de la Boca/diagnóstico , Neoplasias de la Boca/diagnóstico por imagen , Neoplasias de la Boca/patología , Neoplasias Nasales/diagnóstico , Neoplasias Nasales/diagnóstico por imagen , Neoplasias Nasales/patología , Neoplasias Faríngeas/diagnóstico , Neoplasias Faríngeas/diagnóstico por imagen , Neoplasias Faríngeas/secundario , Reproducibilidad de los Resultados , Tomografía Computarizada por Rayos X/veterinaria
18.
BMJ Case Rep ; 20182018 Jun 04.
Artículo en Inglés | MEDLINE | ID: mdl-29866691

RESUMEN

We describe a case of a 70-year-old man presenting with a mandibular metastasis as the first sign of a mucinous adenocarcinoma of the rectum. After 6 months of a protracted toothache, the patient presented with a palpable mandibular mass and trismus, precluding adequate clinical evaluation. A CT scan was performed, and imaging findings suggested an aggressive primary jawbone tumour, most likely an osteosarcoma. However, biopsy and further patient's management proved to be a metastasis. Metastasis to the oral cavity account for only 1%-3% of all malignant oral tumours, and the mandible is the most frequent site. Clinical presentation can be quite variable, and most often a primary malignancy is already known. Jawbone metastases are a sign of disseminated malignant neoplasms, with poor prognosis and usually an indication for palliative therapy.


Asunto(s)
Adenocarcinoma Mucinoso/secundario , Neoplasias Mandibulares/secundario , Neoplasias del Recto/patología , Adenocarcinoma Mucinoso/diagnóstico por imagen , Adenocarcinoma Mucinoso/patología , Anciano , Biopsia , Neoplasias Colorrectales/diagnóstico por imagen , Neoplasias Colorrectales/patología , Humanos , Neoplasias Hepáticas/diagnóstico por imagen , Neoplasias Hepáticas/secundario , Masculino , Neoplasias Mandibulares/diagnóstico por imagen , Neoplasias Mandibulares/patología , Neoplasias del Recto/diagnóstico por imagen , Tomografía Computarizada por Rayos X
19.
BMJ Case Rep ; 20182018 May 14.
Artículo en Inglés | MEDLINE | ID: mdl-29764822

RESUMEN

A 51-year-old woman a known case of stage 2 breast carcinoma in 2006 and underwent left mastectomy performed in the same year presented with bilateral lower limb pain suggestive of spinal pathology, and left chin numbness, both of 2 weeks' duration. Examination revealed left mandibular hypoesthesia without any other sign or symptoms. Orthopantomogram was unremarkable apart from mild alveolar bone expansion at tooth 36 area, which was extracted 3 months earlier. Subsequently, a full-body positron emission tomography contrast enhanced computer tomography revealed hypermetabolic lesions of her axial (excluding skull) and appendicular skeleton. In the head and neck region, left mandibular foramen and oropharynx bilaterally showed increased metabolism suggestive of tumour metastasis. The diagnosis was numb chin syndrome secondary to mandibular metastasis. Apart from supportive treatment, she was started on palliative chemotherapy and radiotherapy. At the time of discharge, there were no active complaints other than the aforementioned hypoesthesia.


Asunto(s)
Mentón , Hipoestesia/etiología , Neoplasias Mandibulares/secundario , Neoplasias de la Mama/patología , Femenino , Foramen Magno/diagnóstico por imagen , Humanos , Neoplasias Mandibulares/diagnóstico por imagen , Neoplasias Mandibulares/patología , Neoplasias Mandibulares/terapia , Persona de Mediana Edad , Tomografía Computarizada por Tomografía de Emisión de Positrones , Radiografía Panorámica
20.
Zhong Nan Da Xue Xue Bao Yi Xue Ban ; 43(3): 337-340, 2018 Mar 28.
Artículo en Chino | MEDLINE | ID: mdl-29701199

RESUMEN

Early diagnosis of malignant lymphoma is often difficult since the clinical manifestation of the lymphoma occurred in the maxillofacial region is very similar to that of the squamous cell carcinoma. When the pathological diagnosis is not clear, the surgeon is easy to misdiagnose and lead to mistreatment. A patient visited the Affiliated Haikou Hospital of Xiangya School of Medicine, Central South Universily for gingival mass with an ipsilateral submaxillary enlargement. The clinical manifestation and preoperative MRI are very prone to squamous cell carcinoma with metastasis, so we did not take a preoperative pathological examination. The gingival mass was surgical removed firstly, but frozen pathological result showed that it was malignant small round cell tumor. Since the patient was diagnosed as high degree malignant of small round cell tumor and the submandibular region have been significantly metastasized, so we carried out the combined radical dissection of gingival, mandible and neck surgery. The postoperative pathological report was malignant lymphoma, suggesting that the patient was a case of misdiagnosis and mistreatment. This article draws lessons from misdiagnosis and provided experience for seeking improvement measures.


Asunto(s)
Carcinoma de Células Escamosas/patología , Errores Diagnósticos , Neoplasias Gingivales/patología , Linfoma/patología , Neoplasias Mandibulares/patología , Disección del Cuello , Neoplasias Gingivales/cirugía , Humanos , Linfoma/cirugía , Neoplasias Mandibulares/secundario , Neoplasias Mandibulares/cirugía
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