1.
J Clin Pathol
; 74(4): 212-215, 2021 Apr.
Artículo
en Inglés
| MEDLINE
| ID: mdl-32471887
RESUMEN
This is the third in the series of historical articles dealing with developments in clinical pathology. Bence Jones proteins are immunoglobulin light chains found in excessive quantities in urine in multiple myeloma and are believed to be one of the first tumour markers ever discovered . Dr Henry Bence Jones is credited with the discovery of this protein in 1847 that bears his name and he can also be regarded as the first chemical pathologist/clinical chemist. Since then, numerous advances and refinements have been made in the measurement and detection of urine light chain proteins which have resulted in the current sensitive serum free light chain assays used today.
Asunto(s)
Proteína de Bence Jones/historia , Biomarcadores de Tumor/historia , Neoplasias de Células Plasmáticas/historia , Patología Clínica/historia , Proteína de Bence Jones/orina , Biomarcadores de Tumor/orina , Difusión de Innovaciones , Historia del Siglo XIX , Historia del Siglo XX , Historia del Siglo XXI , Humanos , Neoplasias de Células Plasmáticas/diagnóstico , Neoplasias de Células Plasmáticas/orina , Valor Predictivo de las Pruebas , Urinálisis/historia
2.
Hematology Am Soc Hematol Educ Program
; : 297, 2008.
Artículo
en Inglés
| MEDLINE
| ID: mdl-19074099