RESUMEN
The immunotoxic effects of some anthropogenic pollutants on aquatic organisms are among the causes of concern over the presence of these pollutants in the marine environment. The immune system is part of an organism's biological defense necessarily for homeostasis. Thus, the immunotoxicological impacts on aquatic organisms are important to understand the effects of pollutant chemicals in the aquatic ecosystem. When aquatic organisms are exposed to pollutant chemicals with immunotoxicity, it results in poor health. In addition, aquatic organisms are exposed to pathogenic bacteria, viruses, parasites, and fungi. Exposure to pollutant chemicals has reportedly caused aquatic organisms to show various immunotoxic symptoms such as histological changes of lymphoid tissue, changes of immune functionality and the distribution of immune cells, and changes in the resistance of organisms to infection by pathogens. Alterations of immune systems by contaminants can therefore lead to the deaths of individual organisms, increase the general risk of infections by pathogens, and probably decrease the populations of some species. This review introduced the immunotoxicological impact of pollutant chemicals in aquatic organisms, including invertebrates, fish, amphibians, and marine mammals; described typical biomarkers used in aquatic immunotoxicological studies; and then, discussed the current issues on ecological risk assessment and how to address ecological risk assessment through immunotoxicology. Moreover, the usefulness of the population growth rate to estimate the immunotoxicological impact of pollution chemicals was proposed.
Asunto(s)
Organismos Acuáticos/inmunología , Ecosistema , Contaminantes Químicos del Agua/toxicidad , Animales , Organismos Acuáticos/efectos de los fármacosRESUMEN
The scopes related to the interplay between stem cells and the immune system are broad and range from the basic understanding of organism's physiology and ecology to translational studies, further contributing to (eco)toxicology, biotechnology, and medicine as well as regulatory and ethical aspects. Stem cells originate immune cells through hematopoiesis, and the interplay between the two cell types is required in processes like regeneration. In addition, stem and immune cell anomalies directly affect the organism's functions, its ability to cope with environmental changes and, indirectly, its role in ecosystem services. However, stem cells and immune cells continue to be considered parts of two branches of biological research with few interconnections between them. This review aims to bridge these two seemingly disparate disciplines towards much more integrative and transformative approaches with examples deriving mainly from aquatic invertebrates. We discuss the current understanding of cross-disciplinary collaborative and emerging issues, raising novel hypotheses and comments. We also discuss the problems and perspectives of the two disciplines and how to integrate their conceptual frameworks to address basic equations in biology in a new, innovative way.
Asunto(s)
Organismos Acuáticos/inmunología , Sistema Inmunológico/inmunología , Inmunidad Innata , Células Madre/inmunología , Biología de Sistemas , Alergia e Inmunología , Organismos Acuáticos/citología , Organismos Acuáticos/genética , Organismos Acuáticos/metabolismo , Comunicación Celular , Genómica , Sistema Inmunológico/citología , Sistema Inmunológico/metabolismo , Biología Marina , Transducción de Señal , Células Madre/metabolismoRESUMEN
The assumption of near-universal bacterial detection by pattern recognition receptors is a foundation of immunology. The limits of this pattern recognition concept, however, remain undefined. As a test of this hypothesis, we determined whether mammalian cells can recognize bacteria that they have never had the natural opportunity to encounter. These bacteria were cultivated from the deep Pacific Ocean, where the genus Moritella was identified as a common constituent of the culturable microbiota. Most deep-sea bacteria contained cell wall lipopolysaccharide (LPS) structures that were expected to be immunostimulatory, and some deep-sea bacteria activated inflammatory responses from mammalian LPS receptors. However, LPS receptors were unable to detect 80% of deep-sea bacteria examined, with LPS acyl chain length being identified as a potential determinant of immunosilence. The inability of immune receptors to detect most bacteria from a different ecosystem suggests that pattern recognition strategies may be defined locally, not globally.
Asunto(s)
Interacciones Microbiota-Huesped , Microbiota , Receptores de Reconocimiento de Patrones/metabolismo , Agua de Mar/microbiología , Microbiología del Agua , Animales , Organismos Acuáticos/inmunología , Organismos Acuáticos/metabolismo , Biomarcadores , Línea Celular , Interacciones Microbiota-Huesped/genética , Interacciones Microbiota-Huesped/inmunología , Humanos , Ratones , Océanos y Mares , Receptores de Reconocimiento de Patrones/genética , Especificidad de la EspecieRESUMEN
The increasing number of data studies on the biological impact of anthropogenic chemicals in the marine environment, together with the great development of invertebrate immunology, has identified marine bivalves as a key invertebrate group for studies on immunological responses to pollutant exposure. Available data on the effects of contaminants on bivalve immunity, evaluated with different functional and molecular endpoints, underline that individual functional parameters (cellular or humoral) and the expression of selected immune-related genes can distinctly react to different chemicals depending on the conditions of exposure. Therefore, the measurement of a suite of immune biomarkers in hemocytes and hemolymph is needed for the correct evaluation of the overall impact of contaminant exposure on the organism's immunocompetence. Recent advances in -omics technologies are revealing the complexity of the molecular players in the immune response of different bivalve species. Although different -omics represent extremely powerful tools in understanding the impact of pollutants on a key physiological function such as immune defense, the -omics approach has only been utilized in this area of investigation in the last few years. In this work, available information obtained from the application of -omics to evaluate the effects of pollutants on bivalve immunity is summarized. The data shows that the overall knowledge on this subject is still quite limited and that to understand the environmental relevance of any change in immune homeostasis induced by exposure to contaminants, a combination of both functional assays and cutting-edge technology (transcriptomics, proteomics, and metabolomics) is required. In addition, the utilization of metagenomics may explain how the complex interplay between the immune system of bivalves and its associated bacterial communities can be modulated by pollutants, and how this may in turn affect homeostatic processes of the host, host-pathogen interactions, and the increased susceptibility to disease. Integrating different approaches will contribute to knowledge on the mechanism responsible for immune dysfunction induced by pollutants in ecologically and economically relevant bivalve species and further explain their sensitivity to multiple stressors, thus resulting in health or disease.
Asunto(s)
Adaptación Biológica/inmunología , Organismos Acuáticos/inmunología , Exposición a Riesgos Ambientales , Mytilus/inmunología , Contaminación del Agua , Adaptación Biológica/genética , Animales , Organismos Acuáticos/genética , Organismos Acuáticos/metabolismo , Genómica , Metabolómica , Mytilus/genética , Mytilus/metabolismo , Proteómica , Transcriptoma , Contaminación del Agua/efectos adversosRESUMEN
Echinoderms are important marine organisms that live in a wide range from the intertidal zone to the abyssal zone. Members of this phylum are prone to dramatic population fluctuations that may trigger dramatic shifts in ecosystem structure. Despite the extremely complex nature of the marine environment, the immune systems of echinoderms induce a complex innate immune response to prokaryotic and eukaryotic pathogens. Previous studies showed that many echinoderm disease outbreaks were associated with specific bacteria, whereas recent scientific investigations using newly developed technologies revealed the amazing diversity of viruses in seawater. Viruses are potential pathogens of several infectious diseases of marine echinoderms. We reviewed the discovery of viruses in echinoderms and discussed the relationship between viruses and diseases for the first time. We further summarized the research progress of the potential immune-related genes and signal pathways induced by viruses and poly (I:C). Additionally, numbers of studies showed that active substances extracted from echinoderms, or the compounds synthesized from these substances, have significant antihuman virus ability. This result suggests that the active substances derived from echinoderms provide potential antiviral protection for the organism, which may provide future research directions for the antiviral immunity of echinoderms. Thus, this review also collected information on the antiviral activities of biologically active substances from echinoderms, which may pave the way for new trends in antiviral immunity for echinoderms and antiviral drugs in humans.
Asunto(s)
Factores de Restricción Antivirales/inmunología , Organismos Acuáticos/inmunología , Equinodermos/inmunología , Inmunidad Innata/inmunología , Virus/inmunología , Animales , Péptidos Antimicrobianos/inmunología , Péptidos Antimicrobianos/metabolismo , Factores de Restricción Antivirales/genética , Organismos Acuáticos/genética , Organismos Acuáticos/virología , Equinodermos/genética , Equinodermos/virología , Ecosistema , Hemocitos/inmunología , Hemocitos/metabolismo , Hemocitos/virología , Humanos , Inmunidad Humoral/inmunología , Inmunidad Innata/genética , Fagocitosis/inmunología , Virus/crecimiento & desarrollo , Virus/aislamiento & purificaciónRESUMEN
Imaging flow cytometry (IFC) is a powerful tool which combines flow cytometry with digital microscopy to generate quantitative high-throughput imaging data. Despite various advantages of IFC over standard flow cytometry, widespread adoption of this technology for studies in aquatic sciences is limited, probably due to the relatively high equipment cost, complexity of image analysis-based data interpretation and lack of core facilities with trained personnel. Here, we describe the application of IFC to examine phagocytosis of particles including microplastics by cells from aquatic animals. For this purpose, we studied (1) live/dead cell assays and identification of cell types, (2) phagocytosis of degradable and non-degradable particles by Atlantic salmon head kidney cells and (3) the effect of incubation temperature on phagocytosis of degradable particles in three aquatic animals-Atlantic salmon, Nile tilapia, and blue mussel. The usefulness of the developed method was assessed by evaluating the effect of incubation temperature on phagocytosis. Our studies demonstrate that IFC provides significant benefits over standard flow cytometry in phagocytosis measurement by allowing integration of morphometric parameters, especially while identifying cell populations and distinguishing between different types of fluorescent particles and detecting their localization.
Asunto(s)
Organismos Acuáticos/inmunología , Citometría de Flujo/métodos , Leucocitos/inmunología , Microplásticos/metabolismo , Mytilus edulis/inmunología , Imagen Óptica/métodos , Fagocitosis/inmunología , Salmón/inmunología , Tilapia/inmunología , Animales , Biodegradación Ambiental , Células Cultivadas , Riñón Cefálico/citología , TemperaturaRESUMEN
Chitinases play an important role in many biological processes in crustaceans, including molting, digestion, and immunity. In order to further explore the immune defense mechanism of chitinase in Portunus trituberculatus, the PtCht-1 gene was cloned by RACE (rapid-amplification of cDNA ends). This cDNA with a full length of 1910 bp, and an ORF (open reading frame) 1749 bp, coded for 582 amino acid residues and was classified into P. trituberculatus chitinase GH18-group4. It had the typical structural characteristics of GH18 chitinase family. Real-time PCR was used to analyze the expression of PtCht-1 in different tissues, molting stages, after pathogen infection, and low salinity (11). PtCht-1 was expressed in all tissues, with the highest expression in the hepatopancreas. In the hepatopancreas of different molting stages, the expression level decreased successively during post-molt stages (A/B), pre-molt stage (D) and inter-molt stage (C). Under normal circumstances, after artificial infection with WSSV and Vibrio parahaemolyticus, the expression of PtCht-1 in hepatopancreas reached the maximum at 48 h, and in hemolymph at 72 h and 24 h, respectively. Overall PtCht-1 expression was up-regulated compared with the control group. Low salinity stress significantly inhibited the expression of PtCht-1, up to 42 folds. Under low salinity stress, the time when WSSV infection reached the peak was markedly delayed by at least 24 h. The results of this study indicate that PtCht-1, as an immune factor, is likely involved in pathogen defense of P. trituberculatus, the immune function of which may be inhibited to some extent after low salinity stress.
Asunto(s)
Braquiuros/genética , Quitinasas/genética , Sistema Inmunológico , Estrés Fisiológico/inmunología , Animales , Organismos Acuáticos/genética , Organismos Acuáticos/inmunología , Braquiuros/inmunología , Clonación Molecular , Regulación Enzimológica de la Expresión Génica , Filogenia , Salinidad , Alineación de SecuenciaRESUMEN
Vaccine adjuvants help to enhance the immunogenicity of weak antigens. The adjuvant effect of certain substances was noted long ago (the 40s of the last century), and since then a large number of adjuvants belonging to different groups of chemicals have been studied. This review presents research data on the nonspecific action of substances originated from marine organisms, their derivatives and complexes, united by the name 'adjuvants'. There are covered the mechanisms of their action, safety, as well as the practical use of adjuvants derived from marine hydrobionts in medical immunology and veterinary medicine to create modern vaccines that should be non-toxic and efficient. The present review is intended to briefly describe some important achievements in the use of marine resources to solve this important problem.
Asunto(s)
Adyuvantes Inmunológicos , Organismos Acuáticos/inmunología , Vacunas/inmunología , Animales , Antígenos/inmunología , HumanosRESUMEN
Context: CD4+ T lymphocytes are able to differentiate into distinct subtypes according to several immunological scenarios, including T helper (Th)1, Th2, Th17 and regulatory T (Treg) cells. CD4+ T cells are phenotypically flexible and have specific ion channels, such as the nicotinic acetylcholine receptors (nAChR) that could be modulated by peptides produced by marine snails, known as conotoxins. Their effect on T lymphocytes has not been explored and emerging evidence suggests that these peptides may have immunomodulatory activities. Objective: This study investigated the effect of two Californiconus californicus-derived synthetic conotoxins on the proliferation and differentiation of T lymphocyte subpopulations Th1, Th2, Th17 and Treg. Methods: Cells from lymph nodes of BALB/c mice were cultured in the presence of conotoxins cal14.1b and cal14.2c (5.5 µM), during 96 h. Cell proliferation and intracellular cytokine production (IFN-γ, IL-4, IL-17 and IL-10) were analyzed by flow cytometry. Results and Discussion: cal14.1b and cal14.2c increased intracellular IL-10 production in Treg (CD3+CD4+Foxp3+) cells and decreased intracellular IL-17 production (CD3+CD4+) after 72 h of culture. Conotoxins did not show any effect on T cell proliferation nor Th1/Th2 balance. Conclusion: These results suggest that synthetic conotoxins exert immunomodulatory activity, especially by regulating specific functions on T lymphocytes.
Asunto(s)
Linfocitos T CD4-Positivos/inmunología , Conotoxinas/inmunología , Factores de Transcripción Forkhead/inmunología , Factores Inmunológicos/inmunología , Interleucina-10/inmunología , Péptidos/inmunología , Linfocitos T Reguladores/inmunología , Animales , Organismos Acuáticos/inmunología , Diferenciación Celular/inmunología , Proliferación Celular/efectos de los fármacos , Células Cultivadas , Citocinas/inmunología , Activación de Linfocitos/inmunología , Masculino , Ratones , Ratones Endogámicos BALB CRESUMEN
Antibiotic resistance has been increasingly reported for a wide variety of bacteria of clinical significance. This widespread problem constitutes one of the greatest challenges of the twenty-first century. Faced with this issue, clinicians and researchers have been persuaded to design novel strategies in order to try to control pathogenic bacteria. Therefore, the discovery and elucidation of the mechanisms underlying bacterial pathogenesis and intercellular communication have opened new perspectives for the development of alternative approaches. Antipathogenic and/or antivirulence therapies based on the interruption of quorum sensing pathways are one of several such promising strategies aimed at disarming rather than at eradicating bacterial pathogens during the course of colonization and infection. This review describes mechanisms of bacterial communication involved in biofilm formation. An overview of the potential of marine bacteria and their bioactive components as QS inhibitors is further provided.
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Antibacterianos/farmacología , Organismos Acuáticos/inmunología , Infecciones Bacterianas/tratamiento farmacológico , Productos Biológicos/uso terapéutico , Percepción de Quorum/efectos de los fármacos , Antibacterianos/uso terapéutico , Organismos Acuáticos/metabolismo , Bacterias/efectos de los fármacos , Bacterias/patogenicidad , Infecciones Bacterianas/microbiología , Biopelículas/efectos de los fármacos , Productos Biológicos/inmunología , Productos Biológicos/metabolismo , Farmacorresistencia Microbiana/efectos de los fármacos , HumanosRESUMEN
The term "acute phase response" (APR) is referred to a nonspecific and complex reaction of an organism that occurs shortly after any tissue damage, such as infection, trauma, neoplasia, inflammation, and stress. The APR can be identified and monitored with some laboratory tests, such as the concentration of several plasma proteins, the acute phase proteins (APPs). The APPs are components of the non-specific innate immune response, and their plasma concentration is proportional to the severity and/or the extent of tissue damage. The evaluation of health status of marine mammals is difficult because the classical clinical signs of illness used for human and domestic animals are difficult to recognize and understand. For this reason, in the past years, several efforts were done to identify laboratory markers of disease in these animals. The APPs have demonstrated their role as early markers of inflammation in veterinary medicine, thus several APPs were tested in marine mammals, such as C-reactive protein (CRP), serum amyloid-A (SAA), and Haptoglobin (Hp). However, the difficulty to extrapolate the knowledge about APPs in one species to another, the lack of specie-specific reagents, the absence of data about negative APPs have hampered their extent use in marine mammals. Herein, the state of art of APPs in marine mammals is reviewed, with particular attention to pre-analytical and analytical factors that should be taken into account in validation and interpretation of APPs assays. Moreover, the current application, potential utility and the future developments of APPs in marine mammals is highlighted and discussed.
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Proteínas de Fase Aguda/inmunología , Proteínas de Fase Aguda/metabolismo , Organismos Acuáticos/inmunología , Organismos Acuáticos/metabolismo , Mamíferos/inmunología , Mamíferos/metabolismo , Proteínas de Fase Aguda/genética , Reacción de Fase Aguda/genética , Reacción de Fase Aguda/inmunología , Reacción de Fase Aguda/metabolismo , Animales , Sistema Inmunológico/inmunología , Sistema Inmunológico/metabolismo , Inmunidad InnataRESUMEN
Peroxiredoxins (Prxs) are a widespread and greatly transcribed family of antioxidant proteins, which rapidly detoxify peroxynitrite, hydrogen peroxide and organic hydroperoxides. The Prxs family members also modulate various physiological functions, including cell growth, differentiation, embryonic development, immune response, apoptosis, lipid metabolism, and cellular homeostasis. In mammals, the physiological functions of Prxs have extensively been studied; however, the knowledge is scanty in their counterpart, aquatic invertebrates. In recent years, substantial progress has been made in our knowledge of Prxs physiological functions in aquatic invertebrates, which has raised interest in defining the contribution of immune responses and removal of reactive oxygen species. In this review, we describe the recent knowledge on the Prxs physiological function in immune responses and DNA protection activity in aquatic invertebrates.
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Inmunidad Innata , Invertebrados/inmunología , Peroxirredoxinas/inmunología , Animales , Antioxidantes/metabolismo , Organismos Acuáticos/inmunología , Especies Reactivas de Oxígeno/metabolismoRESUMEN
The use of antibiotics in the feeds of cultivable aquatic animals has been generally practised to reduce infectious diseases as well as to improve the survival and growth. In recent years, many countries ban to aquatic animals due to the use of large amount of antibiotics and chemotherapies, thus alternative novel strategies are need to promote the growth of aquatic animals and control the pathogens. Dietary supplementation of marine-derived polysaccharides (MDPs) is one of the potential substitutes for antibiotics in aquatic animal feeds. Recently, the use of dietary MDPs in the aquaculture animals has been focused with much interest. In aquaculture, MDPs are used as prebiotic substance which is mostly accepted as a nutritional component for improving the growth performance and health conditions. Hence, present review is a comprehensive and an updated collection of available research reports on different MDPs (alginate, fucoidan, carrageenan, laminarin, ulvan, galactan, agar, chitin and chitosan), route of administration, dosage and applications for improving aqua feeds with emphasis on its effects on growth, biochemical indices, immune response, gut microbiota and disease resistance of aquaculture animals. This review describes the sustainability of global aquaculture production by providing a best alternative to harmful antibiotics, thereby meeting the emerging consumer demand for antibiotic-free aquatic food products.
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Adyuvantes Inmunológicos/farmacología , Organismos Acuáticos/efectos de los fármacos , Polisacáridos/farmacología , Alimentación Animal/análisis , Animales , Acuicultura , Organismos Acuáticos/crecimiento & desarrollo , Organismos Acuáticos/inmunología , Dieta/veterinaria , Polisacáridos/administración & dosificación , Prebióticos/administración & dosificaciónRESUMEN
Viruses are important and lethal pathogens that hamper aquatic animals. The result of the battle between host and virus would determine the occurrence of diseases. The host will fight against virus infection with various responses such as innate immunity, adaptive immunity, apoptosis, and so on. On the other hand, the virus also develops numerous strategies such as immune evasion to antagonize host antiviral responses. Here, We review the research advances on virus mediated immune evasions to host responses containing interferon response, NF-κB signaling, apoptosis, and adaptive response, which are executed by viral genes, proteins, and miRNAs from different aquatic animal viruses including Alloherpesviridae, Iridoviridae, Nimaviridae, Birnaviridae, Reoviridae, and Rhabdoviridae. Thus, it will facilitate the understanding of aquatic animal virus mediated immune evasion and potentially benefit the development of novel antiviral applications.
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Organismos Acuáticos/virología , Evasión Inmune , Virus , Animales , Organismos Acuáticos/inmunología , Interacciones Huésped-Patógeno/inmunología , Virosis/inmunología , Virosis/veterinaria , Fenómenos Fisiológicos de los VirusAsunto(s)
Organismos Acuáticos/inmunología , Inmunidad Innata , Micosis/veterinaria , Vertebrados/inmunología , Enfermedades de los Animales/inmunología , Enfermedades de los Animales/microbiología , Enfermedades de los Animales/virología , Animales , Linfocitos B/inmunología , Linfocitos B/metabolismo , Hongos/inmunología , Granulocitos/inmunología , Granulocitos/metabolismo , Interacciones Huésped-Patógeno/inmunología , Vacunación , Virus/inmunologíaRESUMEN
A polyclonal antibody specific to an egg protein of Suminoe oyster Crassostrea ariakensis was previously developed in our laboratory to assess the reproductive life cycle of the oyster. The present study was undertaken to investigate vitellin of C. ariakensis (CAVt). Vitellin is an essential component of egg proteins in marine invertebrates as it provides energy and nutrients to the embryo and larvae. CAVt was purified from eggs of the oyster using ammonium sulfate precipitation followed by affinity chromatography with Concanavalin A-agarose. Native polyacrylamide gel electrophoresis (PAGE) and sodium dodecyl sulfate PAGE showed that CAVt is a high molecular weight [532 kiloDaltons (kDa)] protein, with multiple subunits. Similar to other vitellin proteins, it is a phospholipoglycoprotein composed of phospholipids (12.06%), carbohydrates (mannose, 10.08% or glucose, 9.84%), and alkali-labile phosphates (4.16%). Affinity chromatography, enzyme-linked immunosorbent aasay (ELISA) and western blot analysis revealed that CAVt is only present in the ovary, and two subunits of CAVt (72 and 35 kDa) are believed to be incorporated from the hemolymph into the oocyte. The antibody specific to CAVt (anti-CAVt), raised in rabbit, strongly cross reacted with the egg proteins of oyster species and scallops, suggesting that the antigenic epitopes are highly conserved among species. Our results suggest that the anti-CAVt antibody can be used to develop a tool similar to ELISA or western blotting for investigation of the effect of microorganisms on reproduction as well as the effect of chemicals on the endocrine system in C. ariakensis.
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Anticuerpos , Organismos Acuáticos , Ostreidae , Óvulo , Vitelinas , Animales , Anticuerpos/química , Anticuerpos/inmunología , Organismos Acuáticos/química , Organismos Acuáticos/inmunología , Reacciones Cruzadas , Ostreidae/química , Ostreidae/inmunología , Óvulo/química , Óvulo/inmunología , Conejos , Vitelinas/química , Vitelinas/inmunología , Vitelinas/aislamiento & purificaciónRESUMEN
Environmental risk assessment of engineered nanomaterials (ENMs) is an emergent field since nanotechnology industry is rapidly growing due to the interesting physicochemical properties of nanomaterials. Metal-based nanomaterials are among the most rapidly commercialized materials and their toxicity towards aquatic animals has been investigated at different levels of the biological organization. The objective of this synthesis review is to give an overview of the signaling molecules that have a key role in metal-based NM mediated cytotoxicity in both marine and freshwater organisms. Since toxicity of metal-based NMs could be (partly) due to metal dissolution, this review only highlights studies that showed a specific nano-effect. From this bibliographic study, three mechanisms (detoxification, immunomodulation and genotoxicity) have been selected as they represent the major cell defense mechanisms and the most studied ones following ENM exposure. This better understanding of NM-mediated cytotoxicity may provide a sound basis for designing environmentally safer nanomaterials.
Asunto(s)
Apoptosis/efectos de los fármacos , Organismos Acuáticos/efectos de los fármacos , Inmunidad Innata/efectos de los fármacos , Nanopartículas del Metal/toxicidad , Modelos Biológicos , Transducción de Señal/efectos de los fármacos , Contaminantes Químicos del Agua/toxicidad , Animales , Organismos Acuáticos/crecimiento & desarrollo , Organismos Acuáticos/inmunología , Organismos Acuáticos/fisiología , Exposición a Riesgos Ambientales/efectos adversos , Agua Dulce , Regulación del Desarrollo de la Expresión Génica/efectos de los fármacos , Inactivación Metabólica/efectos de los fármacos , Mutágenos/toxicidad , Estrés Oxidativo/efectos de los fármacos , Agua de Mar , Especificidad de la Especie , Teratógenos/toxicidad , Toxicocinética , Xenobióticos/toxicidadRESUMEN
The discovery of antibiotics for the treatment of bacterial infections brought the idea that bacteria would no longer endanger human health. However, bacterial diseases still represent a worldwide treat. The ability of microorganisms to develop resistance, together with the indiscriminate use of antibiotics, is mainly responsible for this situation; thus, resistance has compelled the scientific community to search for novel therapeutics. In this scenario, antimicrobial peptides (AMPs) provide a promising strategy against a wide array of pathogenic microorganisms, being able to act directly as antimicrobial agents but also being important regulators of the innate immune system. This review is an attempt to explore marine AMPs as a rich source of molecules with antimicrobial activity. In fact, the sea is poorly explored in terms of AMPs, but it represents a resource with plentiful antibacterial agents performing their role in a harsh environment. For the application of AMPs in the medical field limitations correlated to their peptide nature, their inactivation by environmental pH, presence of salts, proteases, or other components have to be solved. Thus, these peptides may act as templates for the design of more potent and less toxic compounds.