Asunto(s)
Cejas , Pestañas , Cabello , Minoxidil , Uso Fuera de lo Indicado , Cuero Cabelludo , Sulfotransferasas , Humanos , Minoxidil/administración & dosificación , Cejas/efectos de los fármacos , Cabello/efectos de los fármacos , Pestañas/efectos de los fármacos , Sulfotransferasas/metabolismo , Femenino , Adulto , MasculinoRESUMEN
BACKGROUND: Eyelashes play a crucial role in self-image and ocular protection. Enhancements to their structure are of both cosmetic and clinical interest. AIMS: To assess the efficacy of a peptide and glycosaminoglycan-based eyelash enhancer serum in improving eyelash structure. PATIENTS/METHODS: This open-label clinical trial involved 30 females aged 25-65. Eyelashes were assessed at baseline (D0), 4 weeks (D28), and 12 weeks (D84) using specialized software and high-resolution imagery. Measurements included lash number, width, length, volume, arc, and angle. RESULTS: At 12 weeks, significant increases were observed in lash length (+8.3%), number (+5%), width (+10.1%), volume (+14.1%), arc (+13.4%), and angle (+28.3%) compared to baseline. Global Eyelash Assessment (GEA) scores significantly improved, and patient treatment satisfaction increased from 73.34% at D28 to 84.33% at D84. No adverse effects were reported. CONCLUSIONS: The eyelash growth enhancer serum demonstrated significant efficacy in improving eyelash structure by Week 12, with early signs of improvement evident by Week 4. The high patient satisfaction levels underscore the perceived effectiveness of the product.
Asunto(s)
Pestañas , Glicosaminoglicanos , Satisfacción del Paciente , Humanos , Femenino , Pestañas/crecimiento & desarrollo , Pestañas/efectos de los fármacos , Persona de Mediana Edad , Adulto , Anciano , Péptidos/administración & dosificación , Resultado del TratamientoRESUMEN
BACKGROUND: Eyelash serums, both prescription and over-the-counter, are gaining popularity for enhancing the appearance of eyelashes through various biologically active molecules. Categorized into prostaglandin analogs and non-prostaglandin analogs, these serums claim increased strength, length, luster, and thickness. Current United States law also requires no efficacy or safety assessments by the Food and Drug Administration before approving products for consumer use, potentially posing health risks for patients seeking over-the-counter eyelash enhancements. AIMS: Our aims include exploring proposed benefits and adverse effects associated with eyelash serums, while providing evidence-based clinical recommendations on their use. We aim to contribute valuable insights to the understanding of eyelash serums and their respective safety considerations. METHODS: The authors conducted a comprehensive electronic search across databases including PubMed, Embase, Cochrane Central, and Google Scholar to evaluate eyelash serum ingredients. Articles were evaluated by two independent researchers for relevance, and the ingredients discussed were analyzed and given clinical recommendations for eyelash serums based off the Oxford Centre for Evidence-Based Medicine. RESULTS: Results highlight bimatoprost's efficacy, supported by numerous studies evaluating safety and adverse effects. Other prostaglandin ingredients show potential benefits, but further studies are encouraged to enhance the understanding of respective safety profiles. While non-prostaglandins ingredients show promising data, more studies are needed due to a lack of formal evidence in eyelash serum use. CONCLUSION: As the cosmeceutical market for eyelash serums is growing, dermatologists need to be knowledgeable about evidence-based information regarding prescription and over-the-counter eyelash serum products before making recommendations to patients.
Asunto(s)
Bimatoprost , Pestañas , Humanos , Pestañas/efectos de los fármacos , Bimatoprost/administración & dosificación , Bimatoprost/efectos adversos , Medicamentos sin Prescripción/efectos adversos , Medicamentos bajo Prescripción/efectos adversos , Prostaglandinas Sintéticas/efectos adversosRESUMEN
BACKGROUND: Intra-arterial chemotherapy is a new retinoblastoma treatment associated with high rates of globe salvage that has been widely adopted for primary treatment of retinoblastoma but is less frequently used as secondary treatment for refractory retinoblastoma. This systematic review aims to summarize the reported outcomes of intra-arterial chemotherapy for refractory retinoblastoma. METHODS: We conducted a systematic review of studies published on PubMed, Medline, and Embase from 2011 to 2021 reporting globe salvage rates following intra-arterial chemotherapy for secondary treatment of refractory retinoblastoma. RESULTS: Our search yielded 316 studies, and 24 met inclusion criteria. The 24 included studies were comprised of 1366 patients and 1757 eyes. Among these, 1184 (67%) eyes received secondary indication treatment, and globe salvage was achieved for 776 of these 1184 eyes (64%). Sixteen studies reported cannulation success rates from 71.8 to 100%. Pooled analysis of subjects revealed 21 patients (2.6%) with metastatic disease and 26 deaths (3%) during study follow-up periods (7-74 months). The most common ocular complications were vitreous hemorrhage (13.2%), loss of eyelashes (12.7%), and periocular edema (10.5%). The most common systemic complications were nausea/vomiting (20.5%), neutropenia (14.1%), fever (8.2%), and bronchospasm (6.2%). CONCLUSIONS: Intra-arterial chemotherapy is associated with high rates of globe salvage and low rates of serious complications in patients with refractory retinoblastoma. Unfortunately, current literature is predominantly comprised of retrospective case studies, and further high-quality evidence is necessary to inform clinical practice.
Asunto(s)
Resistencia a Antineoplásicos , Neoplasias de la Retina/tratamiento farmacológico , Retinoblastoma/tratamiento farmacológico , Terapia Recuperativa/métodos , Antineoplásicos/administración & dosificación , Espasmo Bronquial/inducido químicamente , Carboplatino/administración & dosificación , Edema/inducido químicamente , Pestañas/efectos de los fármacos , Neutropenia Febril/inducido químicamente , Humanos , Infusiones Intraarteriales/efectos adversos , Infusiones Intraarteriales/métodos , Melfalán/administración & dosificación , Metotrexato/administración & dosificación , Náusea/inducido químicamente , Neoplasias de la Retina/mortalidad , Neoplasias de la Retina/radioterapia , Retinoblastoma/mortalidad , Retinoblastoma/radioterapia , Terapia Recuperativa/efectos adversos , Terapia Recuperativa/estadística & datos numéricos , Topotecan/administración & dosificación , Hemorragia Vítrea/inducido químicamente , Vómitos/inducido químicamenteAsunto(s)
Antineoplásicos/efectos adversos , Clorhidrato de Erlotinib/efectos adversos , Pestañas/efectos de los fármacos , Enfermedades de los Párpados/inducido químicamente , Enfermedades del Cabello/inducido químicamente , Neoplasias Pulmonares/tratamiento farmacológico , Anciano , Femenino , HumanosRESUMEN
BACKGROUND: The FDA approved bimatoprost ophthalmic solution 0.03% for treatment of eyelash hypotrichosis in 2008. Consumer concern persists regarding potential side effects of this product. OBJECTIVE: To identify gaps in the safety information associated with the use of prostaglandin eyelash growth products. MATERIALS AND METHODS: Literature searches were performed using PubMed, Embase, and Nexis Uni databases without restriction to publication date, language, or study setting. RESULTS: The literature pertaining to bimatoprost for treatment of eyelash hypotrichosis is dominated by industry-sponsored clinical trials. Study design choices create gaps in our understanding of the clinical safety of these products. CONCLUSION: Because of study design choice, clinical trials of bimatoprost for eyelash growth may have systematically underreported the incidence of drug application discomfort and prostaglandin-associated periorbitopathy. The risk of increased iris pigmentation remains inadequately investigated. Consequently, there is an ongoing need to educate and monitor patients who choose to use these products.
Asunto(s)
Bimatoprost/efectos adversos , Pestañas/efectos de los fármacos , Hipotricosis/tratamiento farmacológico , Soluciones Oftálmicas/efectos adversos , Prostaglandinas Sintéticas/efectos adversos , Antihipertensivos/efectos adversos , Pestañas/crecimiento & desarrollo , Humanos , Medicamentos sin Prescripción/efectos adversosAsunto(s)
Antineoplásicos Inmunológicos/efectos adversos , Receptores ErbB/antagonistas & inhibidores , Pestañas/efectos de los fármacos , Hipertricosis/inducido químicamente , Panitumumab/efectos adversos , Neoplasias del Apéndice/tratamiento farmacológico , Resultado Fatal , Femenino , Humanos , Persona de Mediana EdadRESUMEN
OBJECTIVE: To evaluate for relative palpebral and orbital changes after long-term unilateral exposure to prostaglandin analogues (PGAs) in patients with childhood glaucoma. DESIGN: Prospective cross-sectional cohort study. PARTICIPANTS: A total of 29 patients with history of childhood glaucoma, who were treated unilaterally with PGAs for at least 12 months. METHODS: Based on 4 standardized clinical photographs (en face with eyes open, right and left side views with eyes open, and en face with eyes closed), 3 masked expert graders each independently selected the eye they perceived to have received unilateral PGA treatment by physical appearance alone and graded the following features relative to the other eye: (1) ocular (e.g., conjunctival hyperemia, iris heterochromia, and buphthalmos), (2) palpebral (e.g., eyelash trichomegaly, eyelash hypertrichosis, eyelid erythema, eyelid edema, eyelid hyperpigmentation, high upper eyelid crease, upper eyelid ptosis, upper and/or lower eyelid retraction, and eyelid skin atrophy with presence of telangiectasias), and (3) periorbital (e.g., superior sulcus hollowing, proptosis, enophthalmos, hypoglobus, and hyperglobus). An interrater reliability analysis was performed using the Fleiss kappa (κ) statistic to determine consistency among raters. MAIN OUTCOME MEASURES: Frequencies of each feature of prostaglandin-associated periorbitopathy (PAP); group consensus; interrater reliability of selected PGA-treatment laterality. RESULTS: Median unilateral PGA exposure time was 31.7 months (interquartile range: 18.8-44.3 months). Eyelash trichomegaly and hypertrichosis (n = 22, 76%), high upper eyelid crease (n = 20, 69%), upper eyelid ptosis (n = 14, 52%), and superior sulcus hollowing (n = 15, 52%) were the most frequently observed features of PAP in PGA-treated eyes compared with untreated fellow eyes. Most of these changes were mild, but 20% to 30% of patients exhibited moderate eyelash and/or eyelid changes. One patient had severe PAP after long-term unilateral PGA exposure. Group consensus with correctly selected laterality was achieved in all patients. The inter-rater reliability was excellent (κ = 0.815, P < 0.001, 95% confidence interval [0.605, 1.000]). CONCLUSIONS: Mild-to-moderate changes in the ocular adnexa can develop in children and young adults with long-term PGA exposure. Patients and their families should be educated on the possibility of PAP, especially when initiating monocular PGA therapy.
Asunto(s)
Pestañas/efectos de los fármacos , Enfermedades de los Párpados/inducido químicamente , Glaucoma/tratamiento farmacológico , Presión Intraocular/fisiología , Prostaglandinas Sintéticas/efectos adversos , Adolescente , Niño , Estudios Transversales , Pestañas/diagnóstico por imagen , Enfermedades de los Párpados/diagnóstico , Femenino , Glaucoma/fisiopatología , Humanos , Presión Intraocular/efectos de los fármacos , Masculino , Estudios ProspectivosRESUMEN
Purpose: The present study investigated the effects of the antiglaucoma agent and selective E2 receptor agonist omidenepag isopropyl (OMDI) on eyelash growth in comparison with a prostaglandin analog (prostamide receptor agonist) in mice. Methods: Four-week-old female mice (C57BL/6J) were divided into 3 groups of n = 10 each. The groups were administered 3 µL of 0.003% OMDI solution, the vehicle (negative control), or a 0.03% bimatoprost solution (positive control) on the upper eyelids of the right eyes once daily for 14 days. On the 15th day, all animals were euthanized, and the upper eyelids with eyelashes were fixed with 10% neutral formalin. Eyelashes were evaluated for number, length, and thickness using a stereomicroscope. Specimens were then paraffin-embedded and stained with hematoxylin and eosin, followed by microscopic examination to assess eyelash morphology and growth cycle. Results: Eyelash number (143.5 ± 6.7/eyelid), thickness, and percentage of dermal papilla in the anagen phase in the OMDI group were similar to those observed in the vehicle group (eyelash number, 144.2 ± 5.7/eyelid). In contrast, eyelash number (166.7 ± 7.0/eyelid), thickness, and the percentage of dermal papilla in the anagen phase were significantly greater in the bimatoprost group compared with those of the vehicle group. Conclusions: Unlike existing prostaglandin analogs, our findings indicate that OMDI has no effect on eyelash growth in mice, suggesting that it may be a promising antiglaucoma agent with a reduced number of adverse effects.
Asunto(s)
Bimatoprost/toxicidad , Pestañas/efectos de los fármacos , Glicina/análogos & derivados , Pirazoles/toxicidad , Piridinas/toxicidad , Animales , Antihipertensivos/administración & dosificación , Antihipertensivos/toxicidad , Bimatoprost/administración & dosificación , Pestañas/crecimiento & desarrollo , Femenino , Glicina/administración & dosificación , Glicina/toxicidad , Ratones , Ratones Endogámicos C57BL , Microscopía , Pirazoles/administración & dosificación , Piridinas/administración & dosificación , Subtipo EP2 de Receptores de Prostaglandina E/agonistasAsunto(s)
Bimatoprost/efectos adversos , Hiperpigmentación/inducido químicamente , Iris/efectos de los fármacos , Administración Tópica , Antihipertensivos/administración & dosificación , Antihipertensivos/efectos adversos , Bimatoprost/administración & dosificación , Pestañas/efectos de los fármacos , Femenino , Humanos , Persona de Mediana Edad , Soluciones OftálmicasAsunto(s)
Pestañas/efectos de los fármacos , Trastornos de la Pigmentación/inducido químicamente , Inhibidores de Proteínas Quinasas/efectos adversos , Pirimidinas/efectos adversos , Sulfonamidas/efectos adversos , Carcinoma de Células Renales/tratamiento farmacológico , Carcinoma de Células Renales/patología , Pestañas/patología , Femenino , Humanos , Indazoles , Neoplasias Renales/tratamiento farmacológico , Neoplasias Renales/patología , Persona de Mediana Edad , Inhibidores de Proteínas Quinasas/administración & dosificación , Pirimidinas/administración & dosificación , Sulfonamidas/administración & dosificaciónRESUMEN
Trichomegaly is a known adverse effect of systemic administration of cyclosporine but is less commonly associated with systemic tacrolimus or with topical calcineruin inhibitors. In this report, we describe the first case, to our knowledge, of trichomegaly due to long-term use of topical tacrolimus for periocular vitiligo.
Asunto(s)
Pestañas/efectos de los fármacos , Tacrolimus/efectos adversos , Vitíligo/tratamiento farmacológico , Administración Tópica , Adolescente , Pestañas/anomalías , Dermatosis Facial/diagnóstico , Dermatosis Facial/tratamiento farmacológico , Humanos , Masculino , Enfermedades Raras , Medición de Riesgo , Tacrolimus/uso terapéutico , Vitíligo/diagnósticoRESUMEN
BACKGROUND: Eyelashes have both a protective and an aesthetic function. Hypotrichosis of the eyelashes may negatively influence an individual's self-perception. OBJECTIVE: To evaluate efficacy and safety of topical administration of a new cosmetic preparation containing 15 keto fluprostenol isopropyl ester (80 µgr/mL) for the treatment of idiopathic hypotrichosis of the eyelashes. METHODS: This is a monocentric, double-blind, vehicle-controlled study. Forty patients (18 years) with idiopathic hypotrichosis (GEA 1 or 2), who also exhibit feelings of low confidence, based on the ESQ score, were divided into two groups. Group 1: twenty women treated with once-daily 15 keto fluprostenol isopropyl ester gel and Group 2: twenty women treated only with the vehicle gel. RESULTS: Group 1: The average difference in eyelash length measured at the midpoint of palpebral margins between T0 and T2 for Group 1 was 1633 mm and for Group B was 0.25 (P < 0.0001). Comparing the ESQ questionnaires of Groups 1 and 2 from T0 to T2, only the 80% of the patients of Group 1 declared to dedicate less time to the application of cosmetic mascara, having longer and darker lashes at T2 vs patients of Group 2, of which only 20% reported longer and darker eyelashes at T2. About safety, only one patient of Group 1 experienced sensation of ocular sensation heaviness and headache. No other side effects were referred. CONCLUSIONS: 15 keto fluprostenol isopropyl ester gel was effective in enhancing eyelash growth, with an excellent safety profile.
Asunto(s)
Cosméticos/administración & dosificación , Ésteres/administración & dosificación , Pestañas/efectos de los fármacos , Hipotricosis/tratamiento farmacológico , Prostaglandinas F Sintéticas/administración & dosificación , Crema para la Piel/administración & dosificación , Travoprost/administración & dosificación , Administración Tópica , Adulto , Anciano , Cosméticos/efectos adversos , Método Doble Ciego , Ésteres/efectos adversos , Pestañas/crecimiento & desarrollo , Femenino , Humanos , Hipotricosis/psicología , Persona de Mediana Edad , Satisfacción del Paciente , Autoimagen , Crema para la Piel/efectos adversos , Travoprost/efectos adversos , Travoprost/análogos & derivados , Resultado del TratamientoAsunto(s)
Alopecia Areata/tratamiento farmacológico , Cejas/efectos de los fármacos , Pestañas/efectos de los fármacos , Piperidinas/administración & dosificación , Pirimidinas/administración & dosificación , Pirroles/administración & dosificación , Administración Tópica , Adulto , Alopecia Areata/diagnóstico , Estudios de Cohortes , Femenino , Estudios de Seguimiento , Humanos , Masculino , Persona de Mediana Edad , Estudios Retrospectivos , Medición de Riesgo , Resultado del Tratamiento , Adulto JovenRESUMEN
15-Keto fluprostenol isopropyl ester and 15-keto fluprostenol have demonstrated a stimulatory effect on the growth and thickening of the eyelashes without the disadvantages of the prostaglandin derivatives of the PGF2α group, which have a hydroxyl group at position 15 in their structure. The two 15-ketoderivatives have the same efficacy as the 15-hydroxyl derivatives in allowing the regrowth, lengthening, darkening, or thickening of the eyelashes, but without darkening the edge of the eyelid or coloring the iris, even temporarily.
Asunto(s)
Pestañas/efectos de los fármacos , Pestañas/crecimiento & desarrollo , Luteolíticos/farmacología , Prostaglandinas F Sintéticas/farmacología , Adolescente , Adulto , Anciano , Femenino , Humanos , Masculino , Persona de Mediana Edad , Adulto JovenRESUMEN
PURPOSE: To compare the in vitro antiparasitic effects of MGO™ Manuka honey and tea tree oil against ocular Demodex. METHODS: Fifty-two viable Demodex mites were acquired from the epilated eyelashes of 9 participants with blepharitis and symptomatic dry eye. Viable mites were randomised to one of five treatment groups: cyclodextrin-complexed and uncomplexed Manuka Honey, 100% and 50% tea tree oil, and no treatment. Following treatment application, mite viability was assessed for 240â¯min, based on limb and body movement and/or the development of a crenated/translucent appearance. Kaplan-Meier survival analysis was then performed. RESULTS: The log-rank test demonstrated a significant treatment effect on the survival distribution of Demodex mites (pâ¯<â¯0.001). Bonferroni-corrected post-hoc pairwise analysis showed that all treatments except for uncomplexed honey effected lower survival probabilities than the untreated group (all pâ¯<â¯0.001). Among the four treatments, survival probabilities were lowest with 100% tea tree oil (all pâ¯<â¯0.001), and highest with uncomplexed honey (all pâ¯≤â¯0.001). No difference was observed between complexed honey and 50% tea tree oil (pâ¯=â¯0.81). CONCLUSIONS: The in vitro efficacy of cyclodextrin-complexed Manuka honey was comparable with 50% tea tree oil, an established treatment for ocular Demodex. The findings support future clinical trials investigating the therapeutic effects of complexed honey in demodectic blepharitis patients.
Asunto(s)
Blefaritis/terapia , Infecciones Parasitarias del Ojo/tratamiento farmacológico , Pestañas/parasitología , Miel , Óxido de Magnesio/administración & dosificación , Ácaros/efectos de los fármacos , Aceite de Árbol de Té/administración & dosificación , Administración Tópica , Adulto , Anciano , Animales , Antiinfecciosos Locales/administración & dosificación , Blefaritis/diagnóstico , Blefaritis/parasitología , Infecciones Parasitarias del Ojo/parasitología , Pestañas/efectos de los fármacos , Femenino , Estudios de Seguimiento , Humanos , Masculino , Persona de Mediana Edad , Resultado del Tratamiento , Adulto JovenRESUMEN
PURPOSE: To compare the in vitro anti-demodectic activity of four commercially available dedicated eyelid cleansers (Cliradex® towelette cleanser, Oust™ Demodex® cleanser, Blephadex™ eyelid foam, TheraTears® SteriLid® eyelid cleanser), tea tree oil, undiluted terpinen-4-ol and linalool; and to assess the terpinen-4-ol content of the commercial cleansers and tea tree oil. METHODS: In vitro anti-demodectic efficacy assessment: 93 viable Demodex mites were acquired from the epilated eyelashes of 10 participants, and were randomised to application with one of the four eyelid cleansers, 100% and 50% tea tree oil, undiluted terpinen-4-ol and linalool, or no treatment. Following treatment application, mite viability was assessed for 300 min, based on limb/body movement and/or the development of a crenated/translucent appearance. Kaplan-Meier survival analysis was then performed. MASS SPECTROMETRY ANALYSIS: The absolute concentration of terpinen-4-ol and the relative abundance of linalool in the four eyelid cleansers and tea tree oil were determined. RESULTS: In vitro anti-demodectic efficacy assessment: No significant differences were observed between undiluted tea tree oil, terpinen-4-ol and linalool (all p > 0.05). Although all commercial eyelid cleansers effected lower mite survival probabilities than the untreated group, Cliradex® was the only eyelid cleanser that demonstrated comparable antiparastic activity to 50% tea tree oil (p = 0.36). MASS SPECTROMETRY ANALYSIS: Among the four eyelid cleansers, Cliradex® contained the highest concentration of terpinen-4-ol, while linalool was present in TheraTears® SteriLid® only. CONCLUSIONS: Of the four commercial eyelid cleansers, Cliradex® demonstrated the highest levels of in vitro anti-demodectic activity and terpinen-4-ol content. Undiluted linalool and terpenin-4-ol showed comparable antiparasitic efficacy, and the use of linalool in the management of demodectic blepharitis warrants further investigation.
Asunto(s)
Blefaritis/tratamiento farmacológico , Infecciones Parasitarias del Ojo/tratamiento farmacológico , Párpados/efectos de los fármacos , Ácaros , Terpenos/farmacología , Administración Tópica , Adulto , Anciano , Animales , Infecciones Parasitarias del Ojo/parasitología , Pestañas/efectos de los fármacos , Pestañas/parasitología , Párpados/parasitología , Femenino , Humanos , Masculino , Persona de Mediana Edad , Resultado del Tratamiento , Adulto JovenAsunto(s)
Infecciones Parasitarias del Ojo/diagnóstico , Pestañas/patología , Enfermedades de los Párpados/diagnóstico , Foliculitis/diagnóstico , Infestaciones por Ácaros/diagnóstico , Ácaros , Anciano , Animales , Antiinfecciosos Locales/uso terapéutico , Infecciones Parasitarias del Ojo/tratamiento farmacológico , Infecciones Parasitarias del Ojo/parasitología , Pestañas/efectos de los fármacos , Pestañas/parasitología , Enfermedades de los Párpados/tratamiento farmacológico , Enfermedades de los Párpados/parasitología , Foliculitis/tratamiento farmacológico , Foliculitis/parasitología , Humanos , Masculino , Infestaciones por Ácaros/tratamiento farmacológico , Infestaciones por Ácaros/parasitología , Aceite de Árbol de Té/uso terapéuticoAsunto(s)
Anticuerpos Monoclonales/efectos adversos , Pestañas/efectos de los fármacos , Enfermedades de los Párpados/inducido químicamente , Anticuerpos Monoclonales/uso terapéutico , Antineoplásicos , Receptores ErbB/antagonistas & inhibidores , Pestañas/diagnóstico por imagen , Enfermedades de los Párpados/diagnóstico , Humanos , Neoplasias Hepáticas/secundario , Neoplasias Hepáticas/terapia , Masculino , Persona de Mediana Edad , PanitumumabRESUMEN
PURPOSE: Eyebrow and eyelash loss (madarosis) is a common and distressing side effect of chemotherapy for which no protective strategies have yet been developed. The purpose of this study was to develop an overview of perceptions and experiences of women undergoing taxane-based treatment for early breast cancer. METHODS: A total of 25 women with a diagnosis of invasive early breast cancer participated in a focus group (n = 5), ages ranging from 35 to 64 (median 50), all had completed therapy with a taxane-based chemotherapy treatment. This focus group used targeted questions to explore participants' perceptions and experience of madarosis during and following chemotherapy and identified issues associated with impact of madarosis on quality of life (QoL). Thematic analysis was conducted to identify important issues experienced by participants. RESULTS: Seven themes emerged from the data: (1) timing of regrowth and permanent changes, (2) meaning/importance of eyebrow/eyelashes, (3) preparedness/information given, (4) impact of the hair loss of self, (5) impact of hair loss on others, (6) physiological side effects of loss of eyebrows/eyelashes, and (7) management of loss of eyebrows/eyelashes. In addition, participants noted physical symptoms of eye irritation during their treatment that they attributed to madarosis. CONCLUSION: This study highlights the significant impact of madarosis on patients, providing the first published analysis of patient's attitude and perception of eyelash and eyebrow loss during chemotherapy. Further research in this area is required and will be benefitted from the development of a dedicated instrument/questionnaire that can capture and measure the impact of madarosis on QoL and allow development of clinical trial strategies.