RESUMEN
Despite its uniqueness, the Bargellini multicomponent reaction remains barely known by the most part of chemists. This can be ascribed to the fact that this transformation has not been adequately reviewed in the classic books of named reactions in organic chemistry. Nevertheless, several works on this reaction have been carried out over the years, many of them were written in Italian in the period 1929-1966. In this review article we extensively cover, in a chronological order, the most important applications of the Bargellini reaction reported to date, with the hope that this knowledge-sharing will help chemists to properly use this multicomponent transformation and imagine novel reactivities based on it.
Asunto(s)
Química Orgánica/historia , Descubrimiento de Drogas/historia , Historia del Siglo XX , ItaliaRESUMEN
Endotoxin research in recent years at the molecular level has required chemically synthesized lipid A without contamination by other bioactive components. Total synthesis of Escherichia coli-type lipid A was achieved in the 1980s by the challenging spirits of the scientists at Osaka University, Japan. They clarified the role of lipid A in the immunological activities of endotoxin in collaboration with Japanese and German researchers, based on the friendships that existed between them. This article introduces the great contributions made by three generations of professors, Tetsuo Shiba, Shoichi Kusumoto, and Koichi Fukase, at the Laboratory of Natural Product Chemistry at Osaka University, to the study over four decades of endotoxin.
Asunto(s)
Química Orgánica/historia , Escherichia coli/metabolismo , Lípido A/síntesis química , Choque Séptico/inmunología , Historia del Siglo XX , Historia del Siglo XXI , Cooperación Internacional , Japón , Lípido A/inmunologíaAsunto(s)
Productos Biológicos/síntesis química , Técnicas de Química Sintética/historia , Técnicas de Química Sintética/métodos , Química Orgánica/historia , Bélgica , Materiales Biomiméticos/síntesis química , Cantaridina/síntesis química , Cevanas/síntesis química , Francia , Hormonas Esteroides Gonadales/síntesis química , Historia del Siglo XX , Historia del Siglo XXI , Humanos , Quinina/síntesis química , Esteroides/síntesis química , Estados UnidosAsunto(s)
Bioquímica/historia , Química Orgánica/historia , Antineoplásicos/historia , Coenzimas/química , Coenzimas/metabolismo , Ciclodextrinas/metabolismo , Historia del Siglo XX , Ácidos Hidroxámicos/historia , Tutoría , Biología Molecular/historia , New Jersey , Ciudad de Nueva York , Tiamina/análogos & derivados , Tiamina/química , Tiamina/farmacología , Tiamina Pirofosfato/química , Tiamina Pirofosfato/farmacología , Vorinostat , Derechos de la Mujer/historiaAsunto(s)
Aniversarios y Eventos Especiales , Bioquímica/historia , Investigación Biomédica/historia , Química Orgánica/historia , Reacción de Maillard , Estrés Oxidativo , Envejecimiento , Animales , Bioquímica/métodos , Bioquímica/tendencias , Investigación Biomédica/métodos , Investigación Biomédica/tendencias , Química Orgánica/métodos , Química Orgánica/tendencias , Diabetes Mellitus/inmunología , Diabetes Mellitus/metabolismo , Diabetes Mellitus/fisiopatología , Productos Finales de Glicación Avanzada/metabolismo , Historia del Siglo XX , Historia del Siglo XXI , Humanos , Peroxidación de Lípido , Obesidad/inmunología , Obesidad/metabolismo , Obesidad/fisiopatología , South Carolina , Estados Unidos , VeteranosRESUMEN
The passionate study of the complex and ever-evolving discipline of organic synthesis over more than a four-decade span is certain to elucidate meaningful and significant lessons. Over this period, Amos B. Smith III, the Rhodes-Thompson Professor of Chemistry and Member of the Monell Chemical Senses Center at the University of Pennsylvania, has mentored well over 100 doctoral and masters students, more than 200 postdoctoral associates and numerous undergraduates, in addition to collaborating with a wide spectrum of internationally recognized scholars. His research interests, broadly stated, comprise complex molecule synthesis, the development of new, versatile and highly effective synthetic methods, bioorganic and medicinal chemistry, peptide mimicry chemistry and material science. Each area demands a high level of synthetic design and execution. United by a passion to unlock the secrets of organic synthesis, and perhaps of Nature itself, innumerable lessons have been, and continue to be, learned by the members of the Smith Group. This lead article in a Special Issue of the Journal of Antibiotics affords an opportunity to share some of those lessons learned, albeit a small selection of personal favorites.