RESUMEN
INTRODUCCIÓN Y OBJETIVO: Los trastornos hipertensivos asociados al embarazo son considerados un problema de salud pública. Se busca describir las características clínicas y desenlaces materno-fetales de las pacientes con esta patología, atendidas en el Hospital Universitario de Santander (HUS) durante el primer semestre de 2017. MÉTODOS: Estudio observacional retrospectivo de corte transversal. Se incluyeron las pacientes en estado de embarazo o puerperio con diagnóstico o sospecha de trastorno hipertensivo; se excluyeron aquellas que no pudieron ser clasificadas o no correspondían a éstos. RESULTADOS: Se analizaron 181 historias clínicas; la edad de las pacientes osciló entre 14 y 44 años; el 43,7% eran primigestantes; el 40,3% tuvo un control prenatal inadecuado y el 27,5% tenía antecedente de trastorno hipertensivo en gestaciones previas. El 75,1% de las pacientes fueron clasificadas como preeclampsia, 18,2% con hipertensión gestacional, 4,4% con hipertensión más preeclampsia sobreagregada y 2,2% con hipertensión crónica. El 16,9% de las pacientes con preeclampsia debutaron antes de la semana 34, de las cuales el 91,3% tenían criterios de severidad; mientras que entre las demás, el 84% presentaron criterios de severidad. CONCLUSIONES: La preeclampsia fue el trastorno hipertensivo más frecuente, predominó la presentación tardía y severa con importantes tasas de complicación maternas y fetales. Mediante la implementación de estrategias de detección temprana y adecuada atención de los trastornos hipertensivos asociados al embarazo podrían mejorarse los desenlaces materno-fetales.
BACKGROUND AND OBJECTIVE: Hypertensive disorders of pregnancy are considered a public health issue. The aim is to describe the clinical features, maternal - fetal outcomes of patients with this disease, who were admitted at the University Hospital of Santander (Bucaramanga, Colombia) during the first half of 2017. METHOD: Cross-sectional retrospective observational study. Patients in pregnancy or puerperium with diagnosis of hypertensive disorder were included; those who could not be classified or did not correspond were excluded. RESULTS: 181 clinical charts were analyzed, the age of the patients ranged between 14 and 44 years, 43.7% were nulliparous, 40.3% had an inadequate prenatal control and 27.5% had history of hypertensive disorder in previous pregnancies. 75.1% were classified as preeclampsia, 18.2% as gestational hypertension, 4.4% as hypertension and superimposed preeclampsia and 2.2% with chronic hypertension; 16.9% of the patients were of an early-onset preeclampsia before week 34, of which 91.3% had criteria of severity; among the others, 84% presented criteria of severity. CONCLUSION: Preeclampsia was the most frequent hypertensive disorder, late and severe presentation prevailed with important maternal and fetal complication rates. Through the implementation of early detection strategies and adequate care of hypertensive disorders associated with pregnancy maternal and fetal outcomes could be improved.
Asunto(s)
Humanos , Femenino , Embarazo , Adolescente , Adulto , Adulto Joven , Hipertensión Inducida en el Embarazo/clasificación , Hipertensión Inducida en el Embarazo/diagnóstico , Hipertensión Inducida en el Embarazo/epidemiología , Preeclampsia/clasificación , Preeclampsia/diagnóstico , Preeclampsia/epidemiología , Resultado del Embarazo , Estudios Transversales , Estudios Retrospectivos , Síndrome HELLP/clasificación , Síndrome HELLP/diagnóstico , Síndrome HELLP/epidemiología , Colombia , Eclampsia/clasificación , Eclampsia/diagnóstico , Eclampsia/epidemiologíaRESUMEN
OBJECTIVE: To determine the prevalence of acute kidney injury (AKI), placental abruption and postpartum hemorrhage in patients with preeclampsia or HELLP syndrome. STUDY DESIGN: A retrospective study of patients with preeclampsia or HELLP syndrome treated at the University of Mississippi Medical Center from January 2000 through December 2010. MAIN OUTCOME MEASURES: Relationships among the obstetric complications of placental abruption, postpartum hemorrhage, and AKI (serum creatinine >107 µmol/L) of women with preeclampsia or HELLP syndrome. Additional analysis was undertaken to explore if there was a correlation between postpartum hemorrhage/placental abruption and the severity of HELLP syndrome according to the Mississippi classification system. RESULTS: Data from 1276 women over 11 years were included in the analysis. 67 of 466 patients (14.4%) with HELLP syndrome and 38 of 810 preeclampsia patients (4.7%) met criteria for AKI. Women with either placental abruption or postpartum hemorrhage had statistically significant increased odds of also having AKI (p < 0.01). Women with HELLP and AKI were also more likely to experience either placental abruption or postpartum hemorrhage. Women with Class 1 HELLP with placental abruption or postpartum hemorrhage were also more likely to have AKI than women with preeclampsia. CONCLUSION: HELLP syndrome, AKI and placental abruption or postpartum hemorrhage appear to be interrelated. AKI occurs more frequently in women with HELLP syndrome with or without associated postpartum hemorrhage and placental abruption.
Asunto(s)
Lesión Renal Aguda/fisiopatología , Síndrome HELLP/fisiopatología , Hemólisis/fisiología , Preeclampsia/fisiopatología , Desprendimiento Prematuro de la Placenta/fisiopatología , Adulto , Alanina Transaminasa/sangre , Aspartato Aminotransferasas/sangre , Creatinina/sangre , Femenino , Síndrome HELLP/clasificación , Humanos , Hemorragia Posparto/fisiopatología , Embarazo , Nacimiento Prematuro , Estudios Retrospectivos , Adulto JovenRESUMEN
Hypertensive disorders complicate 5%-10% of pregnancies with increasing incidence mainly due to upward trends in obesity globally. In the last century, several terminologies have been introduced to describe the spectrum of this disease. The current and widely used classification of hypertensive pregnancy disorders was introduced in 1972 and in 1982, but has not been free of controversy and confusion. Unlike other diseases, the existing terminology combines signs and symptoms, but does not describe the underlying pathology of the disease itself. In this commentary, a detailed account is given to vascular disorder of pregnancy (VDP) as an inclusive terminology taking into account the underlying pathology of the disease on affected organs and systems. A simple and uniform classification scheme for VDP is proposed.
Asunto(s)
Eclampsia/clasificación , Síndrome HELLP/clasificación , Hipertensión Inducida en el Embarazo/clasificación , Preeclampsia/clasificación , Complicaciones del Embarazo/clasificación , Terminología como Asunto , Enfermedades Vasculares/clasificación , Femenino , Humanos , EmbarazoRESUMEN
OBJECTIVE: We explored the prevalence of Composite Major Maternal Morbidity (CMMM) for patients with severe preeclampsia (SPRE) and each class or category of HELLP syndrome. METHODS: In a retrospective cohort study from 2000 to 2010, we reviewed maternal charts of patients categorized with complete or partial HELLP syndrome. From 2005 to 2007, the maternal charts for every patient with a diagnosis of SPRE without HELLP syndrome were also evaluated for comparison. The CMMM for each patient group included cardiopulmonary; hematologic/coagulation, central nervous system/visual, hepatic or renal complications. During the study interval patients with class 1 and class 2 HELLP syndrome received Mississippi Protocol management. RESULTS: Four hundred and ninety-five mothers had a form of HELLP syndrome in years 2000-2010; 688 mothers experienced a non-HELLP severe form of preeclampsia during 2005-2007. The prevalence of CMMM for each patient group was: class 1 = 44%; class 2 = 13%; class 3 = 24%; partial HELLP = 20% and SPRE = 18%. CMMM for class 1 HELLP syndrome is significantly higher than all other groups (p < 0.001). CONCLUSIONS: Patients who develop class 1 HELLP syndrome have significantly higher CMMM. Avoiding this most advanced stage of HELLP syndrome and minimizing the development of new MMM becomes a measure of medical management effectiveness and a tool to assess overall quality of care.
Asunto(s)
Síndrome HELLP/clasificación , Síndrome HELLP/epidemiología , Índice de Severidad de la Enfermedad , Femenino , Síndrome HELLP/diagnóstico , Humanos , Mississippi/epidemiología , Preeclampsia/diagnóstico , Preeclampsia/epidemiología , Embarazo , Estudios RetrospectivosRESUMEN
Management of pregnancies with human immunodeficiency virus, haemolytic anaemia, elevated liver enzymes, low platelets (HELLP) syndrome, and low platelets presents complexities in investigations and treatments, because these conditions and their treatment affect the mother and baby. Low platelets in severe pre-eclampsia, eclampsia and HELLP syndrome are relatively common, and should be detected early once the diagnosis of pre-eclampsia, HELLP syndrome, or both, are made. The mainstay of treatment is lowering of high blood pressure with rapid-acting antihypertensive agents, prevention of convulsions or further seizures with MgSO(4), use of steroids for fetal lung maturity if necessary, followed by delivery of the baby. The use of high-dose steroids for the rapid recovery of maternal platelet counts is controversial, and should not be used routinely in women with HELLP syndrome. The use of platelet transfusion in women with severe pre-eclampsia, eclampsia and HELLP syndrome is a temporising measure, and should only be justified if the clinical circumstances warrant their use (e.g. before caesarean section when the woman has a low platelet count with evidence of bruising or bleeding from venepuncture sites). Low platelets may be an isolated finding in asymptomatic pregnant women and warrant the offer of a human immunodeficiency virus test, as it may be the first sign of this infection. Isolated low platelets may also indicate gestational thrombocytopaenia or idiothrombocytopaenic purpura. Gestational thrombocytopaenia is a benign condition and a diagnosis of exclusion. All clinicians should be aware that low platelets warrant further investigations because of the above-mentioned issues.
Asunto(s)
Síndrome HELLP/terapia , Infecciones por VIH/complicaciones , Complicaciones Hematológicas del Embarazo/terapia , Trombocitopenia/terapia , Plaquetas/inmunología , Femenino , Síndrome HELLP/clasificación , Síndrome HELLP/diagnóstico , Humanos , Embarazo , Complicaciones Hematológicas del Embarazo/diagnóstico , Trombocitopenia/diagnóstico , Trombocitopenia/etiologíaRESUMEN
OBJECTIVES: To describe magnetic resonance (MR) findings in the liver of stable patients with HELLP syndrome in the puerpuerium. METHODS: A descriptive study was carried out from August 2005 to July 2006, involving a series of 40 postpartum patients admitted to an obstetric intensive therapy unit in IMIP (Instituto Materno Infantil Prof. Fernando Figueira) with diagnosis of HELLP syndrome (complete and partial). Complete HELLP syndrome was defined when all laboratory parameters were present and incomplete when one or more but not all laboratory findings were present. All patients had stable clinical conditions and were evaluated with magnetic resonance of the liver and the main findings were recorded. RESULTS: Average maternal age was 26.8 +/- 6.4 years and gestational age at delivery was 34 +/- 26.8 weeks. The MR imaging was performed between eight and 96 hours after diagnosis of HELLP syndrome (56 +/- 31 h). The most frequent findings were ascitis in 20% (n = 8), pleural effusion in 17.5% and hepatic steatosis in 7.5%. The periportal intensity signal was normal in all cases. Cases of liver infarction and sub-capsular or parenchymatous hematoma were not observed. CONCLUSION: Findings of magnetic resonance imaging of the liver in stable HELLP syndrome postpartum patients were few and unspecific. Severe liver injuries such as parenchymatous or sub-capsular hematoma, entailing life risk were not found. Results do not corroborate the use of magnetic resonance as routine examination for stable patients with HELLP syndrome.
Asunto(s)
Síndrome HELLP/patología , Hígado/patología , Periodo Posparto , Adulto , Ascitis/patología , Hígado Graso/patología , Femenino , Edad Gestacional , Síndrome HELLP/clasificación , Síndrome HELLP/cirugía , Humanos , Imagen por Resonancia Magnética , Derrame Pleural/patología , EmbarazoRESUMEN
OBJETIVOS: Descrever os achados hepáticos na ressonância magnética em puérperas estáveis com síndrome HELLP. MÉTODOS: Realizou-se um estudo descritivo, do tipo série de casos, envolvendo 40 puérperas internadas na UTI obstétrica do Instituto Materno Infantil Prof. Fernando Figueira (IMIP), com diagnóstico de síndrome HELLP completa (presentes todas as alterações laboratoriais) e incompleta (uma ou mais alterações laboratoriais, porém sem todos os critérios diagnósticos) no período de agosto de 2005 a julho de 2006. RESULTADOS: A idade média foi de 26,8 ± 6,4 anos, com idade gestacional média no parto de 34 semanas. A ressonância magnética foi realizada entre oito e 96 horas depois do diagnóstico de síndrome HELLP (média de 56 + 31horas). O achado mais freqüente foi ascite em 20 por cento (n = 8), seguindo-se derrame pleural (17,5 por cento) e esteatose hepática (7,5 por cento). A intensidade de sinal periportal foi normal em todos os casos e não se observaram casos de isquemia/infarto hepático ou de hematoma parenquimatoso ou subcapsular. CONCLUSÃO: Os achados da ressonância magnética pós-parto em puérperas estáveis com síndrome HELLP foram inespecíficos e, na presente série, não foram encontradas lesões importantes como hematoma parenquimatoso ou subcapsular, representando risco de vida para a paciente. Os resultados encontrados não corroboram a utilização desse exame de rotina para o seguimento de pacientes com síndrome HELLP.
OBJECTIVES: To describe magnetic resonance (MR) findings in the liver of stable patients with HELLP syndrome in the puerpuerium. METHODS: A descriptive study was carried out from August 2005 to July 2006, involving a series of 40 postpartum patients admitted to an obstetric intensive therapy unit in IMIP (Instituto Materno Infantil Prof. Fernando Figueira) with diagnosis of HELLP syndrome (complete and partial). Complete HELLP syndrome was defined when all laboratory parameters were present and incomplete when one or more but not all laboratory findings were present. All patients had stable clinical conditions and were evaluated with magnetic resonance of the liver and the main findings were recorded. RESULTS: Average maternal age was 26.8 ± 6.4 years and gestational age at delivery was 34 ± 26.8 weeks. The MR imaging was performed between eight and 96 hours after diagnosis of HELLP syndrome (56 ± 31 h). The most frequent findings were ascitis in 20 percent (n = 8), pleural effusion in 17.5 percent and hepatic steatosis in 7.5 percent. The periportal intensity signal was normal in all cases. Cases of liver infarction and sub-capsular or parenchymatous hematoma were not observed. CONCLUSION: Findings of magnetic resonance imaging of the liver in stable HELLP syndrome postpartum patients were few and unspecific. Severe liver injuries such as parenchymatous or sub-capsular hematoma, entailing life risk were not found. Results do not corroborate the use of magnetic resonance as routine examination for stable patients with HELLP syndrome.
Asunto(s)
Adulto , Femenino , Humanos , Embarazo , Síndrome HELLP/patología , Hígado/patología , Periodo Posparto , Ascitis/patología , Hígado Graso/patología , Edad Gestacional , Síndrome HELLP/clasificación , Síndrome HELLP/cirugía , Imagen por Resonancia Magnética , Derrame Pleural/patologíaAsunto(s)
Síndrome HELLP/diagnóstico , Síndrome HELLP/terapia , Enfermería Obstétrica/métodos , Dolor Abdominal/etiología , Adolescente , Cesárea , Urgencias Médicas/enfermería , Femenino , Síndrome HELLP/clasificación , Síndrome HELLP/etiología , Humanos , Rol de la Enfermera , Evaluación en Enfermería/métodos , Atención Perioperativa/métodos , Atención Perioperativa/enfermería , Preeclampsia/etiología , Embarazo , Índice de Severidad de la EnfermedadRESUMEN
A síndrome HELLP é definida pela presença de hemólise, elevação de enzimas hepáticas e trombocitopenia em gestante com toxemia. Sua incidência é estimada em aproximadamente 20 porcento dos casos de pré-eclampsia grave e está associada a grande morbidade materna e perinatal. O diagnóstico laboratorial da síndrome HELLP constitui temática controversa, não havendo consenso tanto quanto aos testes como aos valores a serem utilizados. A conduta das gestantes com síndrome HELLP deve levar em consideração a idade gestacional, a presença de complicações maternas, a vitalidade fetal e as condições do colo uterino. O tratamento ideal, assim como em qualquer caso de toxemia, é o parto. Recentemente, tem-se aventado que a utilização de altas doses de corticóides pode melhorar o desfecho materno, além do já comprovado benefício fetal.
Asunto(s)
Femenino , Embarazo , Corticoesteroides/uso terapéutico , Preeclampsia , Complicaciones del Embarazo , Síndrome HELLP/clasificación , Síndrome HELLP/diagnóstico , Síndrome HELLP/epidemiología , Síndrome HELLP/terapia , Técnicas de Laboratorio Clínico , Edad Gestacional , PronósticoRESUMEN
OBJECTIVE: To determine whether specific subtypes of early-onset hypertensive disorders of pregnancy (haemolysis, elevated liver enzymes, low platelets [HELLP] syndrome; severe preeclampsia; eclampsia; and fetal growth restriction) differ in increased prevalences of thrombophilic disorders. DESIGN: Cohort study. SETTING: Two university hospitals in Amsterdam, the Netherlands. POPULATION: 216 patients participating in a randomized clinical trial with severe and early-onset hypertensive disorders of pregnancy. METHODS: More than 3 months after delivery, all patients were invited for a thrombophilia screening protocol, including hereditary thrombophilic disorders (Factor II or V-Leiden mutation, APC-resistance, protein S deficiency), antiphospholipid antibodies (anticardiolipin antibodies and lupus anticoagulant activity), and hyperhomocysteinemia (before and after methionin challenge). Disease expression was classified by HELLP syndrome, severe preeclampsia, or neonatal birth weight ratio below the median (0.65). Univariate and multinomial regression analyses examined the association of disease expression with thrombophilic disorders, and other associated factors (chronic hypertension, smoking, body mass index, positive family history of cardiovascular morbidity, and demographic parameters). MAIN OUTCOME MEASURES: incidence of thrombophilic disorders in different subtypes of disease. RESULTS: Overall prevalence of thrombophilic disorders in 206 (95%) screened women was 36%. Chronic hypertension was present in 32%, and 34% had a positive family history of cardiovascular morbidity. Multinomial regression analysis showed that hereditary thrombophilia was more frequent among women with infants with a birth weight ratio <0.65 than in women with HELLP syndrome or severe preeclampsia (p = 0.01, OR 5.1 (1.5 to 7.3) and OR 3.4 (1.1 to 10.6), respectively). High body mass index was less frequent in women with HELLP syndrome than in those with severe preeclampsia or fetal growth restriction (p = 0.06, OR 0.5 (0.3 to 0.9) and OR 0.4 (0.2 to 1.0), respectively). CONCLUSION: In this population, the high prevalence of thrombophilic factors and chronic hypertension was confirmed. There were small differences between groups. Hereditary thrombophilic disorders were associated with fetal growth restriction but not with type of maternal disease, suggesting an effect on placental function. Maternal body mass index was lower in women with HELLP syndrome.
Asunto(s)
Hipertensión Inducida en el Embarazo/clasificación , Trombofilia/clasificación , Resistencia a la Proteína C Activada/clasificación , Adulto , Anticuerpos Anticardiolipina/sangre , Anticuerpos Antifosfolípidos/sangre , Peso al Nacer , Índice de Masa Corporal , Estudios de Cohortes , Eclampsia/sangre , Eclampsia/clasificación , Factor V/genética , Femenino , Retardo del Crecimiento Fetal/clasificación , Estudios de Seguimiento , Síndrome HELLP/sangre , Síndrome HELLP/clasificación , Humanos , Hiperhomocisteinemia/clasificación , Hipertensión Inducida en el Embarazo/sangre , Recién Nacido , Inhibidor de Coagulación del Lupus/sangre , Mutación/genética , Mutación Puntual/genética , Preeclampsia/sangre , Preeclampsia/clasificación , Embarazo , Deficiencia de Proteína S/clasificación , Protrombina/genética , Fumar , Trombofilia/sangre , Trombofilia/genéticaRESUMEN
OBJECTIVE: To determine the association between adverse maternal/perinatal outcomes and Canadian and U.S. preeclampsia severity criteria. METHODS: Using PIERS data (Preeclampsia Integrated Estimate of RiSk), an international continuous quality improvement project for women hospitalized with preeclampsia, we examined the association between preeclampsia severity criteria and adverse maternal and perinatal outcomes (univariable analysis, Fisher's exact test). Not evaluated were variables performed in <80% of pregnancies (e.g., 24-hour proteinuria). RESULTS: Few of the evaluated variables were associated with adverse maternal (chest pain/dyspnea, thrombocytopenia, 'elevated liver enzymes', HELLP syndrome, and creatinine >110 microM) or perinatal outcomes (dBP >110 mm Hg and suspected abruption) (at p < 0.01). CONCLUSIONS: In the PIERS cohort, most factors used in the Canadian or American classifications of severe preeclampsia do not predict adverse maternal and/or perinatal outcomes. Future classification systems should take this into account.
Asunto(s)
Preeclampsia/clasificación , Resultado del Embarazo , Desprendimiento Prematuro de la Placenta/clasificación , Adulto , Alanina Transaminasa/sangre , Aspartato Aminotransferasas/sangre , Canadá , Dolor en el Pecho/clasificación , Estudios de Cohortes , Creatinina/sangre , Disnea/clasificación , Femenino , Enfermedades Fetales/clasificación , Predicción , Síndrome HELLP/clasificación , Humanos , Recién Nacido , L-Lactato Deshidrogenasa/sangre , Hígado/enzimología , Embarazo , Medición de Riesgo , Índice de Severidad de la Enfermedad , Trombocitopenia/clasificación , Estados UnidosRESUMEN
HELLP (hemolysis, elevated liver enzymes, and low platelet count) syndrome is a severe, life-threatening pregnancy pathology, which occurs in 0.2-0.8% of all pregnancies, and approximately 10% (2-20%) of pregnancies are complicated with severe preeclampsia. This syndrome usually develops in the third trimester of pregnancy in preeclamptic patients, sometimes it occurs in the second trimester of pregnancy, and very rarely HELLP syndrome may develop within 48-72 hours after delivery. Diagnosis is complicated as there are no specific clinical signs, therefore, this syndrome may be confused with other pathologies like acute fatty liver of pregnancy, idiopathic thrombocytopenia, hemolytic uremic syndrome, appendicitis, and etc. The patients with HELLP syndrome should be treated in the tertiary care hospital, where appropriate diagnostics and multidisciplinary help for mother and fetus can be assured. When the syndrome was described for the first time, L. Weinstein recommended prompt delivery as the only possible treatment. Current studies show that conservative treatment of patients with HELLP syndrome is safe, without an increase in morbidity and mortality. That is why now many authors agree that treatment approach should be based on the estimated gestational age and the condition of the mother and fetus.
Asunto(s)
Síndrome HELLP , Adulto , Cesárea , Pruebas Enzimáticas Clínicas , Diagnóstico Diferencial , Femenino , Muerte Fetal/etiología , Edad Gestacional , Glucocorticoides/administración & dosificación , Glucocorticoides/uso terapéutico , Síndrome HELLP/clasificación , Síndrome HELLP/diagnóstico , Síndrome HELLP/tratamiento farmacológico , Síndrome HELLP/epidemiología , Síndrome HELLP/mortalidad , Humanos , Recién Nacido , Inicio del Trabajo de Parto , Hígado/enzimología , Estudios Multicéntricos como Asunto , Parto , Embarazo , Tercer Trimestre del Embarazo , Ensayos Clínicos Controlados Aleatorios como Asunto , Factores de RiesgoRESUMEN
INTRODUCTION: HELLP syndrome (Haemolysis, Elevated Liver enzymes, Low platelet count) is a grave, life threatening form of preeclampsia, which was named by Weinstein in 1982, on the basis of characteristic changes in laboratory findings (haemolysis, elevated level of liver enzymes and thrombocytopenia). OBJECTIVE OF THE STUDY: To assess the rate of maternal complications in HELLP syndrome. MATERIAL AND METHODS: In the past ten years, 107 patients were treated for HELLP syndrome at the Intensive Care Unit (ICU) of the 1st Department of Obstetrics and Gynaecology, Semmelweis University. The authors summed up about their experience with the treatment of patients, with special regard to the typical symptoms of HELLP syndrome, the course of the disease, postpartum maternal complications. RESULTS: The frequency of HELLP syndrome in live births was found to be 0.37%. In 96% of the patients the pregnancy was terminated via Caesarean section. Pulmonary oedema was the most common cardiopulmonary complication (11%) and developed in Mississippi Group I in the majority of the cases (21%). Transfusions had to be given quite frequently; 62% of the patients in the study were transfused using erythrocyte preparations. In persistent or progressive cases in the postpartum period, the elimination (uterine curettage and lavage) of factors responsible for the persistence of the disease (toxic and vasoactive agents in the endometrium) resulted in the recovery of one third of the patients. Maternal thromboembolic complications developed in 11% of the patients, each of them was affected in Mississippi Group I, with the lowest platelet count. CONCLUSIONS: The immediate termination of a pregnancy in which HELLP syndrome emerges may save the patient's life. It is recommended to try and lift foci applying uterine curettage and lavage as the first step, if the mothers' condition persists or progresses after delivery. Its development is accompanied by a significant increase in maternal and fetal morbidity and mortality alike, therefore it is essential for the obstetricians to be familiar with the disease.
Asunto(s)
Síndrome HELLP/fisiopatología , Adulto , Peso al Nacer , Femenino , Síndrome HELLP/clasificación , Humanos , Hungría/epidemiología , Embarazo , Resultado del Embarazo , Segundo Trimestre del Embarazo , Tercer Trimestre del Embarazo , Edema Pulmonar/complicaciones , Edema Pulmonar/epidemiología , Índice de Severidad de la EnfermedadRESUMEN
Antepartum or postpartum HELLP syndrome constitutes an obstetric emergency that requires expert knowledge and management skills. The insidious and variable nature of disease presentation and progression challenges the clinician and complicates consensus on universally accepted diagnostic and classification criteria. A critical review of published research about this variant form of severe preeclampsia, focused primarily on what is known about the pathogenesis of this disorder as it relates to patient experience with corticosteroids for its management, leads to the conclusion that there is maternal-fetal benefit realized when potent glucocorticoids are aggressively used for its treatment. Although acknowledging the need for definitive multicenter trials to better define the limits of benefit and the presence of any maternal or fetal risk, and given an understanding of the nature of the disorder with its potential to cause considerable maternal morbidity and mortality, we recommend for the present that aggressively used potent glucocorticoids constitute the cornerstone of management for patients considered to have HELLP syndrome.
Asunto(s)
Glucocorticoides/uso terapéutico , Síndrome HELLP/tratamiento farmacológico , Femenino , Muerte Fetal/etiología , Feto/efectos de los fármacos , Glucocorticoides/efectos adversos , Síndrome HELLP/clasificación , Síndrome HELLP/diagnóstico , Síndrome HELLP/etiología , Humanos , Mortalidad Materna , Morbilidad , EmbarazoAsunto(s)
Síndrome HELLP/diagnóstico , Síndrome HELLP/terapia , Corticoesteroides/uso terapéutico , Consejo , Parto Obstétrico , Diagnóstico Diferencial , Femenino , Síndrome HELLP/clasificación , Síndrome HELLP/complicaciones , Hematoma/diagnóstico , Hematoma/terapia , Humanos , Hepatopatías/diagnóstico , Hepatopatías/terapia , Periodo Posparto , Embarazo , Rotura/diagnóstico , Rotura/cirugíaRESUMEN
Plasma exchange therapy has been successfully used in selected patients with hemolysis, elevated liver enzymes, and low platelets (HELLP) syndrome who have organ failure or refractory to treatment. There is no prospective study regarding plasma exchange and its effect in HELLP syndrome. The aim of this study was to investigate the effects of early postpartum use of plasma exchange in patients with HELLP syndrome on outcomes. The mortality rate and the recovery times were compared in patients with HELLP syndrome treated with plasma exchange and historic control group of patients treated conservatively. During a 3-year period (between April 2000 and December 2003), 29 consecutive patients with HELLP syndrome were treated with single or multiple plasma exchange by using fresh-frozen plasma at post-partum period. The control group consist of 26 patients with HELLP syndrome treated between 1993 and 1999. Maternal mortality rate was 23.1% in the control group; there was no death in plasma exchange group; and the mortality rate was significantly higher in the control group (p=0.006). The length of stay at the intensive care unit was shorter in the plasma exchange group (p<0.0001). Rapid improvement of the platelet, aspartate aminotransferase, alanine aminotransferase, and lactic dehydrogenase levels were observed in the plasma exchange group. This study showed that postpartum early plasma exchange therapy improves treatment outcomes in patients with severe HELLP syndrome.
Asunto(s)
Síndrome HELLP/terapia , Intercambio Plasmático , Adulto , Femenino , Síndrome HELLP/clasificación , Síndrome HELLP/mortalidad , Humanos , Embarazo , Recuperación de la Función , Tasa de Supervivencia , Factores de TiempoAsunto(s)
Humanos , Femenino , Embarazo , Hígado Graso/cirugía , Hígado Graso/diagnóstico , Hígado Graso/etiología , Hígado Graso/patología , Hígado Graso/terapia , Síndrome HELLP/clasificación , Síndrome HELLP/diagnóstico , Síndrome HELLP/epidemiología , Síndrome HELLP/etiología , Enfermedad Aguda , Diagnóstico Diferencial , Complicaciones del EmbarazoRESUMEN
El síndrome de Hellp, indudablemente trae consigo un incremento de la morbi-mortalidad materno neonatal y debe considerarse por consiguiente como un proceso realmente complejo. Presentamos a continuación un caso de este síndrome, con todas sus características y realizamos una revisión de la literatura.
Asunto(s)
Síndrome HELLP/clasificación , Síndrome HELLP/diagnóstico , Síndrome HELLP/epidemiología , Síndrome HELLP/etiología , Síndrome HELLP/terapiaRESUMEN
Con este artículo se pretenden revisar las características etiológicas, fisiopatológicas y clínicas del sindrome HELLP y presentar la casuística de morbimortalidad encontrada en el Instituto Materno Infantil-IMI de Santafé de Bogotá en el período de tiempo comprendido entre enero de 1997 y diciembre de 1999
Asunto(s)
Mortalidad Materna , Síndrome HELLP/clasificación , Síndrome HELLP/mortalidadRESUMEN
OBJECTIVE: To describe the maternal morbidity and mortality in pregnancies complicated by HELLP Syndrome. STUDY DESIGN: This is a descriptive and prospective study of women with HELLP Syndrome managed at our center from January 1998 through March 2000. Patients are grouped into 3-class system of Mississippi classification. RESULTS: 170 cases were analysed, 156 (92%), ocurred ante partum and 14 (8%) postpartum; 15 cases (9%) developed at < 27 weeks, 112 (66%) between 28 to 36 weeks of gestational age and 43 (25%) at term. Maternal morbidity included acute renal failure (13.5%), abruptio placentae (6.6%), pneumonia (3%), subcapsular liver hematoma (2.3%), pulmonary edema (2.3%), diseminated intravascular coagulopathy (1.7%) and cerebral hemorrhage (1.2%). Maternal mortality was 4.7% (8 patients), 7 deaths ocurred in patients with class I disease and only one with class II HELLP Syndrome. 6 maternal deaths (75%) were associated to eclampsia. Up to 85% of the maternal morbidity and mortality developed with class I disease (platelet nadir < 50,000 mm3. CONCLUSIONS: There is a progressive rise in maternal morbidity and mortality as the pregnancy moves from class III to class I HELLP Syndrome. 75% of maternal mortality was associated with eclampsia. Early diagnosis of this syndrome could improve maternal prognosis and outcome.