RESUMEN
INTRODUCTION: The use of immune checkpoint inhibitors (ICIs) is gradually increasing; ICIs produce a variety of immune-related adverse events (irAEs), especially ICI-induced hypoadrenocorticism, which can be a lethal complication if treatment is delayed. PATIENT CONCERNS: A 63-year-old man received chemotherapy with pembrolizumab for nonsmall cell lung cancer. He developed drug-induced interstitial pneumonia 366 days after receiving pembrolizumab and was treated with prednisolone. Five hundred thirty-seven days later, he developed drug-induced eosinophilic enteritis, and pembrolizumab was discontinued and prednisolone was continued. After discontinuation of prednisolone, general malaise and edema of the lower extremities appeared, and adrenal insufficiency was suspected. DIAGNOSIS: In blood tests on admission adrenocorticotropic hormone (ACTH) was 2.2 pg/mL and cortisol was 15 µg/dL, with no apparent cortisol deficiency. However, the cortisol circadian rhythm disappeared and remained low throughout the day; a corticotropin-releasing hormone stimulation test showed decreased reactive secretion of ACTH. Pituitary magnetic resonance imaging showed pituitary emptying, suggesting Empty Sella syndrome. INTERVENTIONS AND OUTCOMES: We started hydrocortisone and his symptoms were improved. CONCLUSIONS: The administration of high-dose steroids after ICI administration may mask the symptoms of hypoadrenocorticism as irAEs. Therefore, we should bear in mind the possibility of hypoadrenocorticism when we stop steroid therapy in patients who are treated with steroids after ICI administration.
Asunto(s)
Insuficiencia Suprarrenal , Carcinoma de Pulmón de Células no Pequeñas , Síndrome de Silla Turca Vacía , Neoplasias Pulmonares , Masculino , Humanos , Persona de Mediana Edad , Prednisolona/uso terapéutico , Hidrocortisona , Inhibidores de Puntos de Control Inmunológico/uso terapéutico , Carcinoma de Pulmón de Células no Pequeñas/tratamiento farmacológico , Síndrome de Silla Turca Vacía/inducido químicamente , Neoplasias Pulmonares/tratamiento farmacológico , Insuficiencia Suprarrenal/inducido químicamente , Insuficiencia Suprarrenal/tratamiento farmacológico , Hormona AdrenocorticotrópicaRESUMEN
BACKGROUND: Prolactinomas are typically treated nonsurgically with a dopamine agonist. Once the tumor shrinks, adjacent eloquent structures, such as the optic apparatus, can become skeletonized and herniate into the dilated parasellar space. CASE DESCRIPTION: A 48-year-old man with a prolactin-secreting macroadenoma treated with cabergoline presented with progressive bitemporal hemianopsia. Magnetic resonance imaging showed no recurrence of disease and a stretched optic chiasm herniating into an empty sella. Elevation of the optic chiasm via a transnasal transsphenoidal approach with ALLODERM graft and septal cartilage strut was performed. The patient was discharged home the next day with significant improvement in vision; magnetic resonance imaging showed interval elevation of the optic chiasm. CONCLUSIONS: We review secondary empty sella syndrome and discuss surgical strategies for optic chiasmapexy.
Asunto(s)
Agonistas de Dopamina/efectos adversos , Síndrome de Silla Turca Vacía/diagnóstico por imagen , Ergolinas/efectos adversos , Quiasma Óptico/diagnóstico por imagen , Neoplasias Hipofisarias/tratamiento farmacológico , Prolactinoma/tratamiento farmacológico , Cabergolina , Agonistas de Dopamina/uso terapéutico , Síndrome de Silla Turca Vacía/inducido químicamente , Ergolinas/uso terapéutico , Humanos , Imagen por Resonancia Magnética , Masculino , Persona de Mediana Edad , Procedimientos Neuroquirúrgicos , Quiasma Óptico/cirugía , Resultado del TratamientoAsunto(s)
Ceguera/inducido químicamente , Agonistas de Dopamina/efectos adversos , Agonistas de Dopamina/uso terapéutico , Hernia/inducido químicamente , Síndromes de Compresión Nerviosa/inducido químicamente , Quiasma Óptico/efectos de los fármacos , Enfermedades del Nervio Óptico/inducido químicamente , Neoplasias Hipofisarias/tratamiento farmacológico , Prolactinoma/tratamiento farmacológico , Campos Visuales/efectos de los fármacos , Ceguera/diagnóstico , Ceguera/cirugía , Craneotomía , Síndrome de Silla Turca Vacía/inducido químicamente , Síndrome de Silla Turca Vacía/diagnóstico , Síndrome de Silla Turca Vacía/cirugía , Encefalocele/inducido químicamente , Encefalocele/diagnóstico , Encefalocele/cirugía , Lóbulo Frontal/efectos de los fármacos , Lóbulo Frontal/patología , Lóbulo Frontal/cirugía , Hernia/diagnóstico , Humanos , Imagen por Resonancia Magnética , Masculino , Neoplasia Residual/diagnóstico , Neoplasia Residual/patología , Síndromes de Compresión Nerviosa/diagnóstico , Síndromes de Compresión Nerviosa/cirugía , Degeneración Nerviosa/inducido químicamente , Degeneración Nerviosa/diagnóstico , Degeneración Nerviosa/cirugía , Quiasma Óptico/patología , Quiasma Óptico/cirugía , Nervio Óptico/patología , Nervio Óptico/cirugía , Enfermedades del Nervio Óptico/diagnóstico , Enfermedades del Nervio Óptico/cirugía , Neoplasias Hipofisarias/diagnóstico , Neoplasias Hipofisarias/cirugía , Complicaciones Posoperatorias/diagnóstico , Complicaciones Posoperatorias/patología , Prolactinoma/diagnóstico , Prolactinoma/cirugía , Adherencias Tisulares/inducido químicamente , Adherencias Tisulares/diagnóstico , Adherencias Tisulares/cirugíaRESUMEN
Radiation-induced empty sella (ES) or pituitary atrophy/small pituitary and endocrine impairments, including pituitary and gonadal dysfunction, can manifest decades after radiation and chemotherapy in childhood-onset leukemia patients who received prophylactic cranial irradiation or total body irradiation in preparation for bone marrow transplant. Six childhood-onset leukemia patients (age at diagnosis of leukemia; 2.7-10.2 years) participated in this study. Magnetic resonance imaging (MRI) of the pituitary gland and endocrinological studies were performed 10.5-32.1 years after cranial irradiation. In four of the six patients examined, ES or pituitary atrophy was detected approximately 10.5-19.8 years after cranial irradiation. Four patients had hypogonadism (primary, 3; hypothalamic-pituitary, 1) and one had primary hypothyroidism. We conclude that ES or pituitary atrophy and endocrine impairments can manifest decades after radiation and chemotherapy in childhood-onset leukemia. These patients should, therefore, undergo regular follow-up, including pituitary MRI and hormonal examinations.
Asunto(s)
Efectos Colaterales y Reacciones Adversas Relacionados con Medicamentos , Enfermedades del Sistema Endocrino/etiología , Leucemia/complicaciones , Enfermedades de la Hipófisis/etiología , Radioterapia/efectos adversos , Sobrevivientes , Edad de Inicio , Atrofia/inducido químicamente , Atrofia/etiología , Niño , Preescolar , Síndrome de Silla Turca Vacía/inducido químicamente , Síndrome de Silla Turca Vacía/etiología , Enfermedades del Sistema Endocrino/inducido químicamente , Estudios de Seguimiento , Humanos , Leucemia/tratamiento farmacológico , Leucemia/radioterapia , Imagen por Resonancia Magnética , Enfermedades de la Hipófisis/inducido químicamente , Hipófisis/patologíaRESUMEN
BACKGROUND: The purpose of this study is to demonstrate the added value of intraoperative MRI in treating secondary empty sella syndrome. CASE REPORT: We describe the case of a 66-year-old woman who was diagnosed with a prolactinoma stage IIIb. During treatment with cabergoline she presented with a secondary empty sella syndrome resulting in visual symptoms. We performed intraoperative MRI-guided packing of the secondary empty sella. We explain why this is useful in surgical treatment of secondary empty sella syndrome. CONCLUSION: Intraoperative MRI helps to achieve adequate sellar packing while avoiding insufficient packing as well as overpacking.
Asunto(s)
Síndrome de Silla Turca Vacía/patología , Síndrome de Silla Turca Vacía/cirugía , Ergolinas/efectos adversos , Neoplasias Hipofisarias/tratamiento farmacológico , Prolactinoma/tratamiento farmacológico , Anciano , Cabergolina , Síndrome de Silla Turca Vacía/inducido químicamente , Ergolinas/uso terapéutico , Femenino , Humanos , Imagen por Resonancia Magnética , Resultado del Tratamiento , Campos Visuales/efectos de los fármacosRESUMEN
We report on two cases of patients who developed diabetes insipidus (DI) before acute erythroleukaemia (EL). A brain MRI showed an empty sella turcica in one case and hypothalamo-hypophyseal peduncle damage in the second case. Reduced levels of TGF-beta1 and Vitamin D3, with associated EVI-1 over-expression and karyotypic abnormalities were documented. These two cases show specific chromosomal/molecular alterations in EL with DI. The hypothesis of pituitary involvement in erythroleukemogenesis is discussed.
Asunto(s)
Diabetes Insípida/complicaciones , Síndrome de Silla Turca Vacía/inducido químicamente , Enfermedades Hipotalámicas/complicaciones , Leucemia Eritroblástica Aguda/complicaciones , Hipófisis/patología , Adulto , Colecalciferol/sangre , Aberraciones Cromosómicas , Proteínas de Unión al ADN/genética , Proteínas de Unión al ADN/metabolismo , Diabetes Insípida/diagnóstico , Diabetes Insípida/metabolismo , Síndrome de Silla Turca Vacía/diagnóstico , Síndrome de Silla Turca Vacía/metabolismo , Femenino , Humanos , Enfermedades Hipotalámicas/diagnóstico , Enfermedades Hipotalámicas/metabolismo , Leucemia Eritroblástica Aguda/diagnóstico , Leucemia Eritroblástica Aguda/metabolismo , Proteína del Locus del Complejo MDS1 y EV11 , Imagen por Resonancia Magnética , Masculino , Persona de Mediana Edad , Proto-Oncogenes/genética , Factores de Transcripción/genética , Factores de Transcripción/metabolismo , Factor de Crecimiento Transformador beta1/metabolismoRESUMEN
A symptomatic empty sella developed in a female patient undergoing bromocriptine therapy for microprolactinoma. Placement of a ventriculoperitoneal shunt dramatically improved the symptoms of headache and blurred vision. The post-operative imaging showed resolution of the empty sella. She was able to resume bromocriptine therapy without recurrence of her previous symptoms and give birth to a baby 20 months later. An MRI 44 months after surgery and on bromocriptine therapy showed no recurrence of the empty sella. We conclude that ventriculoperitoneal shunt may be a simple, and durable treatment for drug induced empty sella and allows resumption of bromocriptine therapy for preexisting microprolactinoma.
Asunto(s)
Bromocriptina/efectos adversos , Síndrome de Silla Turca Vacía/inducido químicamente , Síndrome de Silla Turca Vacía/cirugía , Antagonistas de Hormonas/efectos adversos , Adulto , Femenino , Humanos , Imagen por Resonancia Magnética , Neoplasias Hipofisarias/tratamiento farmacológico , Prolactinoma/tratamiento farmacológico , Derivación VentriculoperitonealRESUMEN
The pituitary gland is a hormone-responsive gland and is known to vary in size depending on the hormonal status of the patient and the multifaceted positive and negative feedback hypothalamic-pituitary-gonadal axis. Partial empty sella syndrome with an atrophied pituitary gland is seen in primary neuroendocrinopathies such as growth hormone deficiency, primary hypothyroidism, central diabetes insipidus and hypogonadism. Partial empty sella has also been shown to occur in patients with elevations in intracranial pressure. Secondary partial empty sella syndrome with significant pituitary gland atrophy from negative feedback inhibition of long-term exogenous hormonal use has not been previously reported. We are reporting on a case of partial empty sella syndrome occurring in an elite bodybuilder with a long history of exogenous abuse of growth hormone, testosterone and thyroid hormone. The pathophysiological mechanisms of secondary partial empty sella syndrome from exogenous hormone use and the possibility for elevations in intracranial pressure contributing to this syndrome will be discussed.
Asunto(s)
Anabolizantes/efectos adversos , Síndrome de Silla Turca Vacía/inducido químicamente , Levantamiento de Peso , Adulto , Anabolizantes/administración & dosificación , Retroalimentación , Humanos , Masculino , Autoadministración , Factores de TiempoRESUMEN
Pituitary apoplexy has been reported as a rare complication of dynamic testing used for the study of pituitary functional reserve. In 1993, a diagnosis of non-secreting macroadenoma with moderate functional hyperprolactinaemia was made in a 43-year-old woman. Soon after the start of therapy with bromocriptine up to 5 mg/die, the patient complained of nausea and postural hypotension. As the symptoms persisted even when the dose was reduced to 2.5 mg/die, the patient was transferred to therapy with quinagolide at the dosage of 37.5 microg/die. PRL levels quickly normalized (range 1.4-5.7 ng/ml) as well as menstrual cycles, and no side-effect was reported. In 1995 a sellar magnetic resonance imaging (MRI) showed no shrinkage of the known macroadenoma. In 1996, few hours after a gonadotropin-releasing-hormone (GnRH) test, which showed normal LH and FSH response and with baseline PRL levels in the normal range, the patient started complaining of severe frontal headache, nausea and vomiting. No gross visual defects were present. An emergency computed tomography (CT) showed no evident hemorrhagic infarction in the macroadenoma. The symptoms completely resolved in few days with steroidal and antiemetic therapy. A new MRI performed in 1998 showed a partial empty sella and PRL levels were in the normal range under dopaminergic treatment. The pituitary functional reserve proved normal on dynamic testing. The temporal association between the onset of symptoms and the GnRH test strongly suggests an association between the two events. No evident signs of pituitary apoplexy (either on emergency CT or hormonal evaluation) were detected. The authors suggest that GnRH can cause severe side-effects that mimic pituitary apoplexy without related morphological evidence and that, in our particular case, it can have caused the gradual disappearance of the non-secreting macroadenoma. Moreover, a causal role of the chronic dopaminergic treatment cannot be completely ruled out.
Asunto(s)
Adenoma/metabolismo , Síndrome de Silla Turca Vacía/inducido químicamente , Síndrome de Silla Turca Vacía/diagnóstico , Hormona Liberadora de Gonadotropina/efectos adversos , Apoplejia Hipofisaria/diagnóstico , Pruebas de Función Hipofisaria/efectos adversos , Neoplasias Hipofisarias/metabolismo , Adenoma/patología , Adulto , Diagnóstico Diferencial , Síndrome de Silla Turca Vacía/patología , Femenino , Humanos , Imagen por Resonancia Magnética , Apoplejia Hipofisaria/patología , Neoplasias Hipofisarias/patología , Tomografía Computarizada por Rayos XAsunto(s)
Síndrome de Silla Turca Vacía/complicaciones , Hipopituitarismo/complicaciones , Metilprednisolona/efectos adversos , Metilprednisolona/uso terapéutico , Adulto , Síndrome de Silla Turca Vacía/inducido químicamente , Femenino , Humanos , Hipopituitarismo/inducido químicamente , Lupus Eritematoso Sistémico/tratamiento farmacológico , Masculino , Metilprednisolona/administración & dosificación , Persona de Mediana Edad , Síndrome Nefrótico/tratamiento farmacológicoRESUMEN
A total of 110 patients were examined using magnetic-resonance (MR) tomography of the brain and a special MR myelographic method. An 'empty' sella turcica was diagnosed in 29% of cases. MR tomographic criteria permitting the diagnosis of this condition were defined: a crescent-shaped hypophysis, presence of a low-intensive signal area with a glow phenomenon on MR myelogram, this area being localized intrasellarly. Different clinical variants of the empty sella turcica syndrome are demonstrated, including variants resultant from substitution therapy of thyroid hypofunction, from dopamine agonist therapy for hyperprolactinemic hypogonadism, from radiotherapy of hypophyseal adenoma. Hence, the studies have demonstrated a high efficacy of MR tomography in the diagnosis of empty sella turcica and in dynamic monitoring of patients with various hypothalamohypophyseal dysfunctions over the course of therapy.