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2.
Biomed Res Int ; 2021: 5550267, 2021.
Artículo en Inglés | MEDLINE | ID: mdl-33884263

RESUMEN

We aimed to investigate the oral health of children in terms of the presence of dental caries, periodontal health, halitosis, and dentofacial changes in patients who had adenotonsillar hypertrophy related to mouth breathing and compared these findings with nasal breathing healthy and adenotonsillectomy-operated children. The patient group comprised 40 mouth-breathing children who were diagnosed with adenotonsillar hypertrophy, while the control group consisted of 40 nasal breathing children who had no adenotonsillar hypertrophy. Forty children who had undergone an adenotonsillectomy operation at least 1 year prior to the study were included in the treatment group. Oral examinations of all children were conducted, and the parents were asked about medical and dental anamnesis, demographic parameters, toothbrushing and nutrition habits, oral health-related quality of life (OHRQoL), and symptoms of their children. Demographic parameters, toothbrushing and nutrition habits, and the presence of bad oral habits did not differ between groups (p > 0.05). Adenotonsillectomy is associated with a remarkable improvement in symptoms; however, some symptoms persist in a small number of children. The salivary flow rate, dmft/s, DMFT/S index, plaque, and gingival index scores did not differ between groups (p > 0.05). The patient group showed higher rates of halitosis when compared with the treatment and control groups (p < 0.001). Mouth breathing due to adenotonsillar hypertrophy caused various dentofacial changes and an increase in Class II division 1 malocclusion (p < 0.001). It was shown that adenotonsillar hypertrophy does not negatively affect OHRQoL, it could be a risk factor for dental caries, periodontal diseases, and halitosis, but by ensuring adequate oral health care, it is possible to maintain oral health in children with adenotonsillar hypertrophy. Also, it is recommended that orthodontic treatment should start as soon as possible if it is required. In this context, otorhinolaryngologists, pedodontists, and orthodontists should work as a team in the treatment of children with adenotonsillar hypertrophy.


Asunto(s)
Tonsila Faríngea/patología , Salud Bucal , Tonsila Palatina/patología , Tonsila Faríngea/fisiopatología , Adolescente , Niño , Preescolar , Caries Dental/patología , Oclusión Dental , Índice de Placa Dental , Femenino , Halitosis/complicaciones , Halitosis/patología , Humanos , Hipertrofia , Masculino , Fenómenos Fisiológicos de la Nutrición , Tonsila Palatina/fisiopatología , Índice Periodontal , Cepillado Dental
3.
Qual Life Res ; 29(3): 629-638, 2020 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-31782019

RESUMEN

PURPOSE: Adenoid hypertrophy (AH) is common among young children. Adenoid-based surgery and drug therapy could be applied for symptomatic AH patients, yet the treatment decision is difficult to make due to the diverse cost and efficacy between these two treatments. METHODS: A Markov simulation model was designed to estimate the cost-effectiveness (CE) of the adenoid-based surgery and the drug therapy for symptomatic AH patients. Transition probabilities, costs and utilities were extracted from early researches and expert opinions. Simulations using two set of parameter inputs for China and the USA were performed. Primary outcome was cost per QALY gained over a 6-year period. Deterministic and probabilistic sensitivity analyses were also conducted. RESULTS: The utility for the surgery group and the drug group were 4.10 quality-adjusted life years (QALYs) and 3.58 QALYs, respectively. The cost of the surgery group was more than that of the drug group using model parameters specific to China ($1069.0 vs. $753.7) but was less for the USA ($1994.4 vs. $3977.7). Surgery was dominant over drug therapy when US specific parameters were used. Surgery group had an ICER of $604.0 per QALY when parameters specific to China was used. CONCLUSION: Surgery is cost-effective in the simulations for both China and the USA at WTP thresholds of $9633.1 and $62,517.5, respectively.


Asunto(s)
Tonsila Faríngea/fisiopatología , Hipertrofia/tratamiento farmacológico , Hipertrofia/cirugía , Análisis Costo-Beneficio , Humanos , Cadenas de Markov
4.
Ear Nose Throat J ; 98(5): 279-282, 2019 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-30939913

RESUMEN

The purpose of this article is to differentiate pediatric patients with chronic adenoiditis from those with chronic rhinosinusitis (CRS) based on presenting symptoms. A chart review from a tertiary care facility with pediatric patients who presented with suspected CRS from 2006 to 2014 was identified. We compared patient characteristics, clinical symptoms, duration of symptoms, and past medial history using univariate and multivariate logistic regression models. Based on recent literature, utilizing the computed tomography (CT) score, we identified those children with CRS versus those with chronic adenoiditis. Of the 99 pediatric patients included, 22 patients had diagnosis of adenoiditis and 77 had diagnosis of CRS. When purulent rhinorrhea was present with facial pain, CRS was statistically more prevalent than chronic adenoiditis (P = .017). Symptoms including cough (P = .022), rhinorrhea (P = .27), and facial pressure (P = .98) were not predictive of one diagnosis over the other. Past medical history of asthma or allergy was similar in both groups. Smoke exposure was associated with CT scores >5 (odds ratio 2.4, 95% confidence interval, 0.799-7.182). We conclude that purulent rhinorrhea in the presence of facial pain is more indicative of CRS versus chronic adenoiditis. For all other children, an adenoidectomy without the need for a CT scan can be entertained.


Asunto(s)
Adenoidectomía/métodos , Tonsila Faríngea , Enfermedades Linfáticas , Rinitis , Sinusitis , Evaluación de Síntomas/métodos , Tonsila Faríngea/diagnóstico por imagen , Tonsila Faríngea/patología , Tonsila Faríngea/fisiopatología , Adolescente , Niño , Preescolar , Enfermedad Crónica , Diagnóstico Diferencial , Dolor Facial/diagnóstico , Dolor Facial/etiología , Femenino , Humanos , Enfermedades Linfáticas/diagnóstico , Enfermedades Linfáticas/epidemiología , Enfermedades Linfáticas/fisiopatología , Masculino , Pediatría/métodos , Pediatría/estadística & datos numéricos , Prevalencia , Rinitis/diagnóstico , Rinitis/epidemiología , Rinitis/fisiopatología , Sinusitis/diagnóstico , Sinusitis/epidemiología , Sinusitis/fisiopatología , Tomografía Computarizada por Rayos X/métodos , Estados Unidos
5.
Med Sci Monit ; 25: 333-340, 2019 Jan 11.
Artículo en Inglés | MEDLINE | ID: mdl-30633736

RESUMEN

BACKGROUND The aim of this study was to determine the efficacy of sublingual administration of Dermatophagoides farinae drops for the treatment of allergic rhinitis (AR) accompanied by adenoid hypertrophy and the effect on immune function in children. MATERIAL AND METHODS Eosinophil counts in peripheral blood before and after treatment were determined; serum levels of immunoglobulin E (IgE), total IgE (T-IgE), immunoglobulin G4 (IgG4), interleukin-2 (IL-2), and interleukin-6 (IL-6) before and after treatment were detected by enzyme-linked immunosorbent assay. RESULTS The total effective rate in the study group was significantly higher than that in the control group (P<0.05). In both the study and control groups, symptom scores, medication scores, eosinophil counts in the peripheral blood, and serum levels of IgE, T-IgE, and IL-6 were significantly lower than those before treatment (P<0.05), while the serum levels of IgG4 and IL-2 were significantly higher than those before treatment (P<0.05). After treatment, symptom scores, medication scores, eosinophil counts in the peripheral blood, and serum levels of IgE, T-IgE, and IL-6 in the study group were significantly lower than those in the control group (P<0.05), while the serum levels of IgG4 and IL-2 were significantly higher in the study group than those in the control group (P<0.05). CONCLUSIONS Sublingual administration of D. farinae drops improved the clinical symptoms of pediatric AR caused by Dermatophagoides mites and improved the immune functions in children.


Asunto(s)
Dermatophagoides farinae/inmunología , Desensibilización Inmunológica/métodos , Rinitis Alérgica/terapia , Tonsila Faríngea/efectos de los fármacos , Tonsila Faríngea/fisiopatología , Administración Sublingual , Animales , Asma/inmunología , Niño , Preescolar , Eosinófilos/efectos de los fármacos , Femenino , Humanos , Inmunoglobulina E/análisis , Inmunoglobulina E/sangre , Inmunoglobulina G/análisis , Inmunoglobulina G/sangre , Interleucina-2/análisis , Interleucina-2/sangre , Interleucina-6/análisis , Interleucina-6/sangre , Masculino , Estudios Retrospectivos , Inmunoterapia Sublingual/métodos , Resultado del Tratamiento
6.
J Craniofac Surg ; 29(4): e381-e384, 2018 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-29498980

RESUMEN

The aim of this study was to evaluate whether pediatric obstructive sleep apnea syndrome (OSAS) secondary to adenoid hypertrophy causes systemic microvascular dysfunction. This is a prospective single-blinded case-control study. As the patient group, 81 patients diagnosed to have OSAS secondary to adenoid hypertrophy at our hospital between January 2016 and May 2016; as the control group, 26 healthy pediatric volunteers who presented to the hospital for health screening were included in this study. Three groups of OSAS patients were defined as mild, moderate, and severe respectively, according to the lateral nasopharynx x-ray. Patients with comorbid diseases were excluded from the study. For microvascular dysfunction, videocapillaroscopic evaluation was performed at the nailfold and capillary density (CD) and postocclusive reactive hyperemia (PORH) values were measured and statistical analysis between the groups was performed. The duration of complaints in all patients with OSAS was at least 6 months and <1 year. CD measurement in the control group and mild, moderate, and severe OSAS group was 94.1 ±â€Š7.9, 96.9 ±â€Š11, 94.7 ±â€Š8.4, and 93.7 ±â€Š9.4, respectively, with no significant difference between the groups (P > 0.05). PORH measurement in the control group and mild, moderate, and severe OSAS group was 95.6 ±â€Š8.6, 97.9 ±â€Š10.1, 96 ±â€Š8.7, and 93.9 ±â€Š9.3, respectively, with no significant difference between the groups (P > 0.05). OSAS secondary to adenoid hypertrophy in pediatric patients was demonstrated to cause no dysfunction in microvascular circulation and carried no cardiovascular risk in the early period.


Asunto(s)
Tonsila Faríngea/patología , Apnea Obstructiva del Sueño/complicaciones , Enfermedades Vasculares/etiología , Tonsila Faríngea/fisiopatología , Estudios de Casos y Controles , Niño , Femenino , Humanos , Hipertrofia/complicaciones , Masculino , Microcirculación/fisiología , Estudios Prospectivos , Apnea Obstructiva del Sueño/patología , Apnea Obstructiva del Sueño/fisiopatología , Enfermedades Vasculares/complicaciones , Enfermedades Vasculares/patología , Grabación en Video
8.
Medicine (Baltimore) ; 97(4): e9680, 2018 01.
Artículo en Inglés | MEDLINE | ID: mdl-29369187

RESUMEN

The objective of the present study was to investigate the clinical application of magnetic resonance imaging (MRI)-respiratory gating technology for assessing illness severity in children with obstructive sleep apnea hypopnea syndrome (OSAHS).MRI-respiratory gating technology was used to scan the nasopharyngeal cavities of 51 children diagnosed with OSAHS during 6 respiratory phases. Correlations between the ratio of the area of the adenoid to the area of the nasopalatine pharyngeal cavity (Sa/Snp), with the main indexes of polysomnography (PSG), were analyzed. Receiver operator characteristic (ROC) curve and Kappa analysis were used to determine the diagnostic accuracy of Sa/Snp in pediatric OSAHS.The Sa/Snp was positively correlated with the apnea hypopnea index (AHI) (P < .001) and negatively correlated with the lowest oxygen saturation of blood during sleep (LaSO2) (P < .001). ROC analysis in the 6 respiratory phases showed that the area under the curve (AUC) of the Sa/Snp in the end-expiratory phase was the largest (0.992, P < .001), providing a threshold of 69.5% for the diagnosis of severe versus slight-moderate OSAHS in children. Consistency analysis with the AHI showed a diagnosis accordance rate of 96.0% in severe pediatric OSAHS and 96.2% in slight-moderate pediatric OSAHS (Kappa = 0.922, P < .001).Stenosis of the nasopalatine pharyngeal cavity in children with adenoidal hypertrophy was greatest at the end-expiration phase during sleep. The end-expiratory Sa/Snp obtained by a combination of MRI and respiratory gating technology has potential as an important imaging index for diagnosing and evaluating severity in pediatric OSAHS.


Asunto(s)
Imagen por Resonancia Magnética/métodos , Técnicas de Imagen Sincronizada Respiratorias/métodos , Apnea Obstructiva del Sueño/diagnóstico por imagen , Tonsila Faríngea/diagnóstico por imagen , Tonsila Faríngea/fisiopatología , Adolescente , Área Bajo la Curva , Niño , Preescolar , Femenino , Humanos , Masculino , Nasofaringe/diagnóstico por imagen , Nasofaringe/fisiopatología , Polisomnografía , Curva ROC , Respiración , Índice de Severidad de la Enfermedad , Sueño
9.
Otolaryngol Pol ; 73(1): 1-5, 2018 10 01.
Artículo en Inglés | MEDLINE | ID: mdl-30920388

RESUMEN

INTRODUCTION: Adenoids are nasopharyngeal lymphoid tissue with a relevant role in host defence against infection of upper respiratory tract. Nevertheless, adenoids are also a reservoir of microorganisms that can cause infections of upper respiratory tract and otitis particularly in children. OBJECTIVE: Evaluate and compare the association between biofilm assembly on adenoids and the incidence of recurrent infections in a paediatric population submitted to adenoidectomy by either infectious or non-infectious indication. METHODS: Scanning electron microscopy was used to assess biofilms on adenoid surface; biofilm assembly in vitro was monitored by crystal violet assay; antibiotic susceptibility was assessed following EUCAST guidelines; Hinfluenzae capsular typing was performed by PCR. RESULTS: Biofilms were present in 27.4% of adenoid samples and no statistical difference was found between infectious and non-infectious groups. In vitro, the most clinically relevant bacteria, H.influenzae, S.aureus, S.pyogenes, S.pneumoniae and M.catarrhalis, were mostly moderate biofilm assemblers (71.7%). 55.3% of these bacteria were intermediate/resistant to at least one of the tested antibiotics. No association was found between the ability to assemble biofilms in vitro and the presence of biofilms on adenoids nor antibiotic resistance. All H.influenzae were characterized as non-typeable. CONCLUSION: The presence of biofilms on adenoid surface was independent from clinical sample background. Bacterial ability to assemble biofilms in vitro cannot be used to predict biofilm assembly in vivo. The lack of correlation between biofilm formation and infectious respiratory diseases found contributes to question the relevance of biofilms on the pathogenesis of infectious diseases.


Asunto(s)
Tonsila Faríngea/microbiología , Tonsila Faríngea/fisiopatología , Antibacterianos/uso terapéutico , Biopelículas , Infecciones/diagnóstico , Infecciones/tratamiento farmacológico , Niño , Preescolar , Estudios Transversales , Femenino , Humanos , Lactante , Masculino , Microscopía Electrónica de Rastreo
10.
Int J Pediatr Otorhinolaryngol ; 100: 168-173, 2017 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-28802366

RESUMEN

PURPOSE OF THE STUDY: The aim of the study was to propose "the risk formula" for obstructive sleep apnea in children according to the general and local clinical parameters and findings relevant for obstructive sleep apnea (OSA) severity. The unmet need for this formula arises from the economic burden of polysomnography (device, staff, training, special sleep centers, etc) as the golden standard for the diagnostics. MATERIALS AND METHODS USED: The study was performed from January 2013 until January 2016 in the Sleep Center, Department for Neuroscience, School of Medicine of the University of Split, Department of Pediatrics, University Hospital Split, Croatia and ENT Dept. University Hospital in Split, Croatia. Inclusion criteria were: age > two years, AHI >1 diagnosed by polysomnography. Exclusion criteria were: chronic lung disease, active tonsillitis/pharyngitis at the time of the physical exam and syndromes that affect breathing. All polysomnograms were scored by a qualified sleep technologist and interpreted by two board certified sleep physicians independently. Age, sex, BMI, Mallampati score, tonsillar size and adenoids size were recorded. All statistical calculations were performed using SPSS 20. RESULTS: In total 60 children were included in the study. The median of age was 5 years (range 2-9). There were 19 (32%) girls and 41 (68%) boys. Of all evaluated predictors, there were statistically significant differences in the values of AHI among children with different modified Mallampati score (χ2 = 28.2; p < 0.001), different size of tonsils (χ2 = 25.3; p < 0.001) and different size of adenoids (z = 2.7; p = 0,006) in univariate regression analysis. Strong positive association of AHI with modified Mallampati score (standardized B = 0.51; partial correlation = 0.542, r = 0.631) was found, as well as positive correlation of AHI with tonsillar size (standardized B = 0.246; partial correlation = 0.295,R = 0.489) in the multivariate forward stepwise regression analysis. CONCLUSION: Even though we are aware that PSG is the gold standard for diagnostics of SDB there is a significant financial burden for this diagnostic procedure. That is why there is a necessity for establishing good clinical standards and possible formula for OSA severity evaluation. We propose formula which includes Mallampati score and tonsillar size for OSA -risk calculation in order to perform early therapeutic intervention thereby reducing the risk of long-term negative consequences. We recommend this formula as the screening formula in circumstances where PSG is not available, in cases when the "waiting list" is too long or when a child can not cooperate to perform it. In developing countries like Croatia on time intervention with reduced procedure-associated costs is of the utmost importance.


Asunto(s)
Tonsila Faríngea/fisiopatología , Tonsila Palatina/fisiopatología , Polisomnografía/métodos , Apnea Obstructiva del Sueño/diagnóstico , Niño , Preescolar , Croacia , Femenino , Humanos , Masculino , Estudios Prospectivos
11.
Vestn Otorinolaringol ; 81(5): 73-76, 2016.
Artículo en Ruso | MEDLINE | ID: mdl-27876743

RESUMEN

The available literature data give evidence that viral infection is the main cause underlying the development of inflammatory nasopharyngeal pathology in the children. According to ICD-10, nether acute nor chronic adenoiditis should be considered as a self-consistent nosological entity. Acute adenoiditis is usually regarded as a form of acute nasopharyngitis (J02) or acute respiratory viral infection (J06.9) whereas chronic adenoiditis is commonly referred to as representing other chronic diseases of the tonsils and adenoids (J 35.8). The reactive changes in the nasopharyngeal tonsils begin to be manifested on days 3-5 after the onset of acute respiratory viral infection; thereafter, they persist and gradually disappear within the next 2-3 weeks. In the majority of the cases, acute adenoiditis is actually a physiological reaction of the nasopharyngeal tonsils as the organs of regional mucosal immunity to antigenic stimulation. There is no universally accepted opinion as regards the duration of the inflammatory process which would allow these pathological changes to be considered as turned into chronic ones. This condition is actually not a serious pathology provided it is not associated with the concomitant complications and produces no clinically significant effect on the child's quality of life. Under practical conditions, such children are most frequently treated with the use of irrigation therapy. Taking into account that otorhinolaryngologists all over the world do not consider chronic adenoiditis as an independent nosological entity but distinguish only hypertrophy of adenoid vegetations or chronic rhinosinusitis (in the presence of inflammatory changes in the nasopharynx), it appears correct to speak about chronic adenoiditis provided the clinical manifestations of the disease persist for more than 12 weeks. Based on the predominant etiological component, the viral, bacterial, and allergic forms of nasopharyngeal adenoiditis can be distinguished even though it is rather difficult to actually determine which etiological factor prevails in each concrete case. The aforedescribed situation poses a large number of questions pertaining to the choice of either systemic or topical antibacterial therapy.


Asunto(s)
Tonsila Faríngea/efectos de los fármacos , Dexametasona/administración & dosificación , Nasofaringitis , Fenilefrina/administración & dosificación , Polimixina B/administración & dosificación , Calidad de Vida , Tonsila Faríngea/patología , Tonsila Faríngea/fisiopatología , Antibacterianos/administración & dosificación , Niño , Combinación de Medicamentos , Monitoreo de Drogas , Femenino , Glucocorticoides/administración & dosificación , Humanos , Masculino , Descongestionantes Nasales/administración & dosificación , Rociadores Nasales , Nasofaringitis/tratamiento farmacológico , Nasofaringitis/etiología , Nasofaringitis/fisiopatología , Nasofaringitis/psicología , Resultado del Tratamiento
12.
Vestn Otorinolaringol ; 81(2): 49-52, 2016.
Artículo en Ruso | MEDLINE | ID: mdl-27213656

RESUMEN

The objective of the present study was to evaluate the influence of an isotonic saline solution containing benzalconium chloride and of a hypertonic seawater solution on the function of ciliary epithelium in the nasal cavity in vitro. To this effect, we investigated the cytological material obtained from 35 children presenting with adenoid tissue hypertrophy. The tissue samples were taken from the nasal cavity by the standard method. A cellular biopsy obtained from each patient was distributed between three tubes that contained isotonic saline solution supplemented by benzalconium chloride (0.1 mg/ml), a hypertonic seawater solution, and a standard physiological saline solution. It was shown that the number of the viable cells in both isotonic solutions was statistically comparable and significantly higher than in the hypertonic solution (p<0.05). The ciliary beat frequency of the cells embedded in the two isotonic solutions was not significantly different but considerably exceeded that in the hypertonic seawater solution (p<0.05). Thus, the present study has demonstrated the absence of the ciliotoxic influence of isotonic saline solution containing benzalconium chloride at a concentration of 0.1 mg/ml and the strong ciliotoxic effect of the hypertonic seawater solution. This finding gives reason to recommend isotonic solutions for the regular application whereas hypertonic solutions can be prescribed only during infectious and/or inflammatory ENT diseases.


Asunto(s)
Tonsila Faríngea , Compuestos de Benzalconio/farmacología , Soluciones Isotónicas/farmacología , Depuración Mucociliar/efectos de los fármacos , Cavidad Nasal , Agua de Mar , Cloruro de Sodio/farmacología , Tonsila Faríngea/patología , Tonsila Faríngea/fisiopatología , Antiinfecciosos Locales/farmacología , Disponibilidad Biológica , Niño , Relación Dosis-Respuesta a Droga , Humanos , Cavidad Nasal/patología , Cavidad Nasal/fisiopatología
13.
Vestn Otorinolaringol ; (4): 39-41, 2014.
Artículo en Ruso | MEDLINE | ID: mdl-25377676

RESUMEN

The objective of the present study was to elucidate the structural and functional mechanisms underlying disturbances of the protective nasolaryngeal barrier with special reference to the following histological and immunohistochemical characteristics of the pharyngeal tonsils (CD4, CD20, CD68, IgA, P53, BCL2, Ki67, TGF-beta) in the children aged 3-6 years and presenting with complicated (n=20) or uncomplicated (n=20) chronic adenoiditis (CA). It was shown that adenoids of the patients with complicated chronic adenoiditis less frequently exhibit markers of active inflammation, such as hyperemia, intraepithelial infiltration, and hemosiderophages. Also, they have the smaller mean area of lymphoid follicles and the number of functional intrafollicular macrophages suggesting impaired immunological reactivity. Lymphoid follicles of the pharyngeal tonsils in the children with uncomplicated chronic adenoiditis show up enhanced density of B-lymphocytes (CD20) and CD69-positive cells which may suggest functional tension. However, density of IgA-producing lymphocytes responsible for the protection of nasolaryngeal mucosa is identical in the patients with complicated and uncomplicated chronic adenoiditis. Taken together with the decreased number of T-helpers (CG4), this finding indicates the compromised immunological response in the children with this pathology. It is concluded that the structural characteristics of pharyngeal tonsils revealed in the present study may provide a basis for the disturbances of congenital and adaptive immunity; moreover, they can serve as the predictors of complications of chronic adenoiditis.


Asunto(s)
Tonsila Faríngea , Otitis Media con Derrame , Tonsilitis , Tonsila Faríngea/inmunología , Tonsila Faríngea/patología , Tonsila Faríngea/fisiopatología , Niño , Enfermedad Crónica , Femenino , Humanos , Masculino , Otitis Media con Derrame/inmunología , Otitis Media con Derrame/patología , Otitis Media con Derrame/fisiopatología , Tonsilitis/inmunología , Tonsilitis/patología , Tonsilitis/fisiopatología
14.
J Craniofac Surg ; 25(4): 1230-5, 2014 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-25006902

RESUMEN

Reliability of acoustic rhinometry (AR) for preoperative diagnosis and decision of surgery in children with adenoid hypertrophy were investigated in this study. Fifty-five children who cannot tolerate nasal endoscopic examination were included. The AR was performed preoperatively and postoperatively 1 month later. The volume of distance between the 6th and 10th centimeters in rhinogram curve was calculated for evaluating the adenoid notch (AN) region. The volume of AN region was compared with each patient's volume of the adenoid tissue removed with adenoidectomy. Whereas the median adenoid specimen volume was 2.0 (1.0-2.0) cm3 in 23 patients with complaint of nasal obstruction, median AN volumes in the rhinogram curve was 2.3 (0.8-5.2) cm3. All children whose preoperative nasopharyngeal volume was 4.2 cm3 or less had increased volume in the area representing the nasopharynx on rhinogram. We found a statistically significant relationship between the AN and the adenoid specimen volume (P = 0.000, r = 0.797). The sensitivity and specificity were found as 61.2% and 95.8%, respectively. We concluded that the children whose preoperative nasopharyngeal volumes were measured as 4.2 cm3 or less by AR could benefit more from adenoidectomy.


Asunto(s)
Tonsila Faríngea/patología , Tonsila Faríngea/fisiopatología , Obstrucción Nasal/diagnóstico , Obstrucción Nasal/fisiopatología , Rinometría Acústica/métodos , Adenoidectomía , Niño , Preescolar , Endoscopía , Femenino , Humanos , Hipertrofia , Masculino , Obstrucción Nasal/cirugía , Reproducibilidad de los Resultados
15.
Int J Pediatr Otorhinolaryngol ; 77(10): 1716-20, 2013 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-23993208

RESUMEN

OBJECTIVES: To evaluate population-based data on incidence of pediatric adenoidectomy and rate of revision surgery. METHODS: A retrospective study of all adenoidectomies in children was performed in the year 2009 in all otolaryngology departments in one federal state, Thuringia, in Germany. Patients' characteristics, preoperative diagnostics and postoperative complications were analyzed. The association between baseline characteristics and the risk of re-adenoidectomy was examined using Kaplan-Meier method with univariate log-rank test, and with a multivariate Cox regression model. Population data were used to calculate age-related annual rates of adenoidectomies. RESULTS: 1939 adenoidectomies were performed in 2009 in Thuringia. 89% were primary cases and 11% of the children already had an adenoidectomy prior to 2009. Immediate re-surgery because of primary hemorrhage was necessary in 0.8% of the cases. Re-adenoidectomy because of recurrent symptoms was needed in 9% of patients after a median interval of 16 months. The univariate analysis showed that the factors age ≤3 years and primary surgery were significantly associated to a higher risk of surgery because of recurrent symptoms The multivariate analysis showed that primary surgery was independently associated with the risk of re-surgery (hazard ratio 1.66; 95% confidence interval 1.01-2.74). The annual adenoidectomy rate was 678/100,000 underage habitants. The incidence was highest between 2 and 4 years of age. CONCLUSIONS: This population based analysis is showing that adenoidectomy is performed country-wide with good results and low risk on important scale in daily routine by otorhinolaryngologists. The risk of re-adenoidectomy seems to be higher than hitherto reported by hospital-based studies.


Asunto(s)
Adenoidectomía/métodos , Adenoidectomía/estadística & datos numéricos , Tonsila Faríngea/cirugía , Complicaciones Posoperatorias/cirugía , Adenoidectomía/efectos adversos , Tonsila Faríngea/fisiopatología , Adolescente , Distribución por Edad , Análisis de Varianza , Niño , Preescolar , Bases de Datos Factuales , Femenino , Estudios de Seguimiento , Alemania , Humanos , Estimación de Kaplan-Meier , Masculino , Análisis Multivariante , Complicaciones Posoperatorias/fisiopatología , Modelos de Riesgos Proporcionales , Recurrencia , Reoperación/estadística & datos numéricos , Estudios Retrospectivos , Medición de Riesgo , Distribución por Sexo , Estadísticas no Paramétricas , Resultado del Tratamiento
16.
Vestn Otorinolaringol ; (2): 65-8, 2013.
Artículo en Ruso | MEDLINE | ID: mdl-23715494

RESUMEN

This study was designed to analyse the effectiveness of combined treatment of chronic adenoiditis in the children with the use of rinorin (Orion, Finland) in comparison with the traditional methods for the management of this condition either combined with irrigation therapy or without it. The results of the study indicate that the application of rinorin enhance the effectiveness of the treatment due to the substantial reduction of the manifestation of clinical symptoms and the frequency of relapses. The patients describe rinorin as a modern convenient-to-use preparation superior to the traditional medicines for the treatment of adenoiditis which improved medication compliance.


Asunto(s)
Tonsila Faríngea/fisiopatología , Cloruro de Calcio/administración & dosificación , Nasofaringitis/terapia , Cloruro de Potasio/administración & dosificación , Cloruro de Sodio/administración & dosificación , Adolescente , Niño , Preescolar , Enfermedad Crónica , Terapia Combinada , Combinación de Medicamentos , Femenino , Humanos , Masculino , Rociadores Nasales , Irrigación Terapéutica , Resultado del Tratamiento
17.
Int J Pediatr Otorhinolaryngol ; 77(5): 717-20, 2013 May.
Artículo en Inglés | MEDLINE | ID: mdl-23434201

RESUMEN

OBJECTIVES: We aimed to investigate metabolic parameters in children with adenoid hypertrophy (AH) only or adenotonsillar hypertrophy (ATH) and compare them with healthy controls. METHODS: Forty-four prepubertal children aged 6-12 years who were obstructive symptoms and 16 healthy children were recruited in this study. All children underwent a complete otolaryngologic examination and sleep screening. The patients were divided into three groups according to obstruction type: normal, AH (adenoid grade III or IV, tonsil grade 1 or 2), and ATH (adenoid grade III or IV, tonsil grade 3 or 4). All participants underwent hematologic and biochemical tests including fasting blood glucose, insulin, and plasma lipids. RESULTS: (1) The children with AH and ATH had lower high-density lipoprotein cholesterol (HDL-C), when compared to normal children. (2) The level of HDL-C was negatively correlated with the sum of adenoid and tonsillar size scores and the apnea-hypopnea index (AHI) (r=-0.477, p<0.001 vs. r=-0.548, p<0.001, respectively). There was a modest association between HDL-C and minimal SpO2 (r=0.332, p=0.009). (3) Stepwise multiple regression analysis identified the AHI, triglycerides, and fasting insulin as independent predictors for HDL-C. CONCLUSIONS: Patients with adenoid and tonsil hypertrophy had low HDL-C. HDL-C levels are inversely related to the sum of adenoid and tonsillar size scores and AHI in SDB children. HDL-C may be a sensitive indicator of serum lipids changes in SDB children.


Asunto(s)
Tonsila Faríngea/fisiopatología , Glucemia/análisis , Hipertrofia/sangre , Insulina/sangre , Lípidos/sangre , Tonsila Palatina/fisiopatología , Síndromes de la Apnea del Sueño/sangre , Apnea Obstructiva del Sueño/fisiopatología , Niño , Femenino , Humanos , Masculino , Polisomnografía , Análisis de Regresión
18.
Eur Ann Otorhinolaryngol Head Neck Dis ; 130(2): 67-72, 2013 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-23352732

RESUMEN

INTRODUCTION: Tonsillotomy is an effective treatment for the management of obstructive sleep apnoea syndrome (OSAS) in children with tonsillar hypertrophy and appears to be associated with less pain and postoperative morbidity. OBJECTIVE: To compare postoperative morbidity and short-term and intermediate-term efficacy of radiofrequency tonsillotomy (TT) and bipolar scissors tonsillectomy (TE) in children. PATIENTS AND METHODS: Children with OSAS due to tonsillar hypertrophy were included in a prospective, non-randomized study between February 4, 2008 and March 20, 2010. Exclusion criteria were recurrent tonsillitis (≥ 3 episodes per year), clotting disorders and age less than 2 years. Postoperative complications, efficacy on OSAS, and operating times were evaluated. Pain was evaluated by the Postoperative Pain Measure for Parents score on D0, D1, D7 and D30. RESULTS: One hundred and ninety-three children were included: 105 in the TE group (age: 4.75 ± 2.37 years) and 88 in the TT group (age: 4.88 ± 2.6 years). The pain score was significantly lower in the TT group than in the TE group during the first postoperative week (P<0.05). A significant difference was observed for the secondary postoperative bleeding rate (1 after TT versus 8 after TE). No significant difference was observed between the two techniques in terms of the efficacy on OSAS. At 1 year, the tonsil regrowth rate in the TT group was 4.5%. CONCLUSION: Radiofrequency tonsillotomy is a safe technique for the treatment of obstructive tonsillar hypertrophy in children with good results on OSAS and a reduction of postoperative pain.


Asunto(s)
Tonsila Faríngea/cirugía , Tratamiento de Radiofrecuencia Pulsada , Apnea Obstructiva del Sueño/cirugía , Tonsilectomía/instrumentación , Tonsilectomía/métodos , Tonsila Faríngea/fisiopatología , Distribución de Chi-Cuadrado , Niño , Preescolar , Femenino , Humanos , Hipertrofia , Terapia por Láser , Masculino , Dolor Postoperatorio/prevención & control , Hemorragia Posoperatoria/prevención & control , Estudios Prospectivos , Ronquido/cirugía
19.
Adv Ther ; 29(8): 708-21, 2012 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-22864943

RESUMEN

INTRODUCTION: The aim of this prospective and randomized study was to compare patients who underwent curettage adenoidectomy (CA) or transoral power-assisted endoscopic adenoidectomy (PAEA) performed as isolated procedures by a single surgeon over a period of 7 years. The success of an adenoidectomy has been evaluated by assessing the amount of reduction in the adenoid size and the symptomatic improvement at the sixth postoperative month. METHODS: Patients' nasal airway obstruction was graded by the parents of the patient on a visual analog scale (VAS), with a range from 0 to 10, with grade 10 representing total obstruction. The ratio of the choanal opening obstructed by an adenoid mass was measured and expressed in percentages as representative of the adenoid size. Preoperative and 6-month postoperative adenoid sizes were compared. RESULTS: Fifty-three patients (CA group 27 patients/PAEA group 26 patients) completed the study. In the CA group, VAS score improved from the preoperative score of 8.63 ± 0.88 to the 6-month score of 2.22 ± 1.01 (P < 0.0001); and in the PAEA group, the preoperative VAS score of 8.69 ± 0.84 improved to 2.08 ± 1.05 in the same period (P < 0.0001). No statistical significance was found when VAS score improvements were compared (P = 0.4569). The average ratio of choanal opening obstructed by an adenoid mass improved from the preoperative ratio of 89.41% ± 6.48% to the 6-month ratio of 7.85% ± 2.28% in the CA group; and the preoperative ratio of 90.19% ± 6.95% in the PAEA group improved to 3.65% ± 1.38% after 6 months. The reduction of adenoid size was significantly superior in PAEA than CA (P < 0.0001). The operative time in PAEA was significantly shorter than that in CA (P < 0.0001). CONCLUSION: Although symptomatic improvement at the 6-month follow-up is statistically indifferent, PAEA has been shown to be superior to CA with its superior performance in providing a near-total elimination of the adenoid mass in a shorter operating time.


Asunto(s)
Adenoidectomía/métodos , Legrado/métodos , Cirugía Endoscópica por Orificios Naturales/métodos , Adenoidectomía/efectos adversos , Tonsila Faríngea/fisiopatología , Tonsila Faríngea/cirugía , Adolescente , Pérdida de Sangre Quirúrgica/fisiopatología , Niño , Preescolar , Legrado/instrumentación , Femenino , Estudios de Seguimiento , Humanos , Hipertrofia/diagnóstico , Hipertrofia/cirugía , Lactante , Masculino , Procedimientos Quirúrgicos Mínimamente Invasivos/efectos adversos , Procedimientos Quirúrgicos Mínimamente Invasivos/métodos , Boca , Cirugía Endoscópica por Orificios Naturales/efectos adversos , Dimensión del Dolor , Dolor Postoperatorio/fisiopatología , Hemorragia Posoperatoria/fisiopatología , Estudios Prospectivos , Medición de Riesgo , Factores de Tiempo , Resultado del Tratamiento
20.
Int. arch. otorhinolaryngol. (Impr.) ; 16(2): 209-216, abr.-jun. 2012. ilus, tab
Artículo en Portugués | LILACS | ID: lil-641630

RESUMEN

Introdução: A hiperplasia de tonsila faríngea é uma das principais causas da respiração oral. O diagnóstico preciso desta alteração é importante para o correto planejamento terapêutico. Em vista disso, estudos têm sido desenvolvidos a fim de fornecer subsídios quanto aos procedimentos que podem ser utilizados para o diagnóstico de obstrução faríngea. Objetivo: Verificar a correlação entre os exames de nasofibrofaringoscopia e cefalometria no diagnóstico de hiperplasia de tonsila faríngea. Método: Estudo transversal, clínico e experimental. Participaram deste estudo 55 crianças, 30 meninas e 25 meninos, com idades entre 7 e 11 anos. As crianças foram submetidas à avaliação nasofibrofaringoscópica e cefalométrica para a determinação do grau de obstrução da nasofaringe. Para verificar a correlação entre esses exames foi utilizado o coeficiente de correlação de Spearman ao nível de significância de 5%. Resultados: Na nasofibrofaringoscopia a maioria das crianças apresentou hiperplasia de tonsila faríngea graus 2 e 3, seguidas de grau 1. Na cefalometria a maior parte das crianças apresentou hiperplasia de tonsilas faríngeas grau 1, seguida de grau 2. Na correlação entre os exames, evidenciou-se correlação regular e positiva. Conclusão: A avaliação da hiperplasia de tonsilas faríngeas pode ser realizada pela nasofibrofaringoscopia e pela cefalometria, pois estes exames apresentam uma relação regular e positiva. No entanto, verificou-se que a cefalometria tende a subestimar o tamanho da tonsila faríngea em relação à nasofibrofaringoscopia...


Introduction: Hyperplasia of the pharyngeal tonsil is one of the main causes of mouth breathing, and accurate diagnosis of this alteration is important for proper therapeutic planning. Therefore, studies have been conducted in order to provide information regarding the procedures that can be used for the diagnosis of pharyngeal obstruction. Objective: To verify the correlation between nasopharyngoscopy and cephalometric examinations in the diagnosis of pharyngeal tonsil hyperplasia. Method: This was a cross-sectional, clinical, experimental, and quantitative study. Fifty-five children took part in this study, 30 girls and 25 boys, aged between 7 and 11 years. The children underwent nasofibropharyngoscopic and cephalometric evaluation to determine the grade of nasopharyngeal obstruction. The Spearman's rank correlation coefficient at the 5% significance level was used to verify the correlation between these exams. Results: In the nasopharyngoscopy evaluation, most children showed grade 2 and 3 hyperplasia of the pharyngeal tonsil, which was followed by grade 1. In the cephalometry assessment, most children showed grade 1 hyperplasia of the pharyngeal tonsil, which was followed by grade 2. A statistically significant regular positive correlation was observed between the exams. Conclusion: It was concluded that the evaluation of the pharyngeal tonsil hyperplasia could be carried out by fiber optic nasopharyngoscopy and cephalometry, as these examinations were regularly correlated. However, it was found that cephalometry tended to underestimate the size of the pharyngeal tonsil relative to nasopharyngoscopy...


Asunto(s)
Humanos , Masculino , Femenino , Niño , Cefalometría , Hiperplasia/diagnóstico , Respiración por la Boca/fisiopatología , Tonsila Faríngea/fisiopatología
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