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1.
J Neurodev Disord ; 16(1): 45, 2024 Aug 12.
Artículo en Inglés | MEDLINE | ID: mdl-39135156

RESUMEN

BACKGROUND: Autism spectrum conditions (ASC) and quantitative autistic traits (QATs) are associated with sensory symptoms, which may contribute to anxiety and adversely affect social and cognitive development. Although sensory symptoms can occur across all senses, the relative roles of specific sensory modalities as contributors to the autistic phenotype and to anxiety are not well understood. The objective of this study was to examine which sensory symptoms were most predictive of high anxiety. METHODS: We recruited 257 female primary caregivers of children aged 6 to 11 years (49% girls) to a questionnaire study comprising parent-report measures for classical QATs (social, communicative, and rigid), autism-related sensorimotor symptoms (visual, auditory, tactile, olfactory, gustatory, vestibular, proprioceptive, and motor), and anxiety symptoms. First, Bayesian stochastic search variable selection (SSVS) was used to identify the most probable sensorimotor predictors of specific QATs as well as diagnosed ASC. Then, the selected predictors were used in another SSVS, using anxiety symptoms as a dependent variable, to identify which of the autism-relevant sensorimotor symptoms were most robustly predictive of anxiety. Finally, the effect sizes of anxiety-related sensory symptoms were estimated with linear regressions. RESULTS: We found that auditory symptoms and motor difficulties were most predictive of ASC diagnosis. Developmental motor difficulties were also strongly related to all individual QATs, whereas auditory symptoms were more selectively predictive of rigid traits. Tactile symptoms robustly predicted social interaction QATs, and proprioceptive symptoms predicted communicative QATs. Anxiety outcomes were most strongly predicted by difficulties with auditory and olfactory processing. CONCLUSIONS: The results support the clinical importance of being alert to complaints about sounds and hearing in neurodevelopmental populations, and that auditory processing difficulties may be evaluated as an early marker of poor mental health in children with and without diagnosed autism. Olfactory processing differences appeared to be an anxiety marker less strongly associated with ASC or QATs, while motor difficulties were highly autism-relevant but not equally strongly associated with anxiety outcomes. We suggest that future studies may focus on the mechanisms and consequences of neurodevelopmental central auditory processing dysfunction and its potential relationship to anxiety disorders.


Asunto(s)
Ansiedad , Trastorno del Espectro Autista , Humanos , Femenino , Niño , Masculino , Trastorno del Espectro Autista/complicaciones , Trastorno del Espectro Autista/fisiopatología , Trastornos de la Sensación/etiología , Trastornos de la Sensación/fisiopatología , Trastorno Autístico/complicaciones , Trastorno Autístico/fisiopatología
2.
Occup Ther Int ; 2024: 5921153, 2024.
Artículo en Inglés | MEDLINE | ID: mdl-39055325

RESUMEN

Background: Sensory reactivity (SR) difficulties are characterised by problems regulating an individual's responses to sensory input such that it interferes with occupational performance in daily tasks. South African occupational therapists use assessments developed in the United States to identify SR difficulties in children. These have been found to be inappropriate for the South African context. This study reports on the methodology used to adapt an assessment for use in the Western Cape Province of South Africa. Method: The SPM-2 Child and Preschool caregiver self-report questionnaires and seven tests of the performance-based Evaluation in Ayres Sensory Integration (EASI) that assess SR were identified for adaptation. A qualitative methodology was used to identify challenges using the assessment in a sample of the Western Cape population. Cognitive interviews were conducted with six community members from diverse socioeconomic groupings. Inductive analysis was used to identify and group the emerging themes. The test adaptation was conducted by expert occupational therapists based on these findings. Findings: Challenges were grouped into two themes, namely, language challenges, of which there were three subcategories and inappropriate or threatening assessment tasks. Fifty-three changes were made to the assessment. Conclusion: A detailed methodology was developed to adapt a SR assessment for use in the Western Cape Province. Challenges in using the assessment were elicited primarily from community members rather than professionals.


Asunto(s)
Terapia Ocupacional , Humanos , Sudáfrica , Terapia Ocupacional/métodos , Preescolar , Femenino , Masculino , Niño , Encuestas y Cuestionarios , Trastornos de la Sensación/fisiopatología , Trastornos de la Sensación/diagnóstico , Lenguaje , Evaluación de la Discapacidad
3.
Pediatr Neurol ; 157: 157-166, 2024 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-38924827

RESUMEN

BACKGROUND: To estimate the prevalence of sensory symptoms in people with cerebral palsy (CP) across the lifespan. METHODS: In this cross-sectional study, the self-reported Sensory Processing Scale Inventory (SPS-I) was administered via Research Electronic Data Capture (REDCap) between February 1, 2022, and August 15, 2022, to people with CP or their caregivers enrolled in the online MyCP Community Registry. We determined the association between SPS-I scores and age (Pearson correlation) and functional status as assessed using five validated functional classification systems for CP (analysis of variance [ANOVA]). We hypothesized that sensory symptoms would differ between younger and older individuals with CP. RESULTS: Of 155 responses (28% response rate, age one to 76 years, 34% male), 97% reported at least one bothersome sensory symptom. Total sensory symptoms decreased with age (R2 = 0.12, P < 0.0001), driven by decreases in hyposensitivity symptoms (R2 = 0.32, P < 0.0001), primarily tactile hyposensitivity (R2 = 0.29, P < 0.0001). Sensory symptoms increased with greater functional impairment across all functional domains (ANOVA, P < 0.0001). However, the age-specific decrease in hyposensitivities was most pronounced in people with the greatest gross motor functional impairment (R2 = 0.70, P = 0.0004). CONCLUSION: Our findings suggest that hyposensitivity, primarily tactile sensitivity, decreases with age in people with CP. Future work should assess whether decreased hyposensitivity contributes to other age-related changes in CP like increased pain.


Asunto(s)
Parálisis Cerebral , Humanos , Parálisis Cerebral/fisiopatología , Parálisis Cerebral/complicaciones , Masculino , Femenino , Estudios Transversales , Adulto , Persona de Mediana Edad , Niño , Preescolar , Adulto Joven , Adolescente , Anciano , Lactante , Trastornos de la Sensación/etiología , Trastornos de la Sensación/fisiopatología , Prevalencia
4.
Int Ophthalmol ; 44(1): 270, 2024 Jun 24.
Artículo en Inglés | MEDLINE | ID: mdl-38914919

RESUMEN

PURPOSE: To compare, between Alzheimer's disease (AD) patients and healthy individuals, corneal subbasal nerve plexus (CSNP) parameters and corneal sensitivities. METHODS: Twenty-two patients who were followed up with Alzheimer's disease (Alzheimer's group) and 18 age- and gender-matched healthy individuals (control group) were included in this cross-sectional study. CSNP parameters, including nerve fiber length (NFL), nerve fiber density (NFD), and nerve branch density (NBD), were evaluated using in vivo confocal microscopy. Corneal sensitivity was evaluated using a Cochet-Bonnet esthesiometer. The results were compared between the two groups. RESULTS: In the Alzheimer's group, NFL was 12.2 (2.4) mm/mm2, NFD was 12.5 [3.1] fibers/mm2, and NBD was 29.7 [9.37] branches/mm2. In the control group, NFL was 16.5 (2.0) mm/mm2, NFD was 25.0 [3.13] fibers/mm2, and NBD was 37.5 [10.9] branches/mm2. All three parameters were significantly lower in the Alzheimer's group compared to the control group (p < 0.001, p < 0.001, and p = 0.001, respectively). Similarly, corneal sensitivity was significantly lower in the Alzheimer's group (55.0 [5.0] mm) compared to the control group (60.0 [5.0] mm) (p < 0.001). CONCLUSION: We determined that, in AD, corneal sensitivity decreases significantly, in parallel with the decrease in corneal nerves. Changes in the corneal nerve plexus and a decrease in corneal sensitivity may be used in the early diagnosis and follow-up of AD. In addition, ocular surface problems secondary to these changes should also be kept in mind.


Asunto(s)
Enfermedad de Alzheimer , Córnea , Microscopía Confocal , Fibras Nerviosas , Humanos , Femenino , Masculino , Córnea/inervación , Córnea/patología , Estudios Transversales , Enfermedad de Alzheimer/fisiopatología , Anciano , Fibras Nerviosas/patología , Persona de Mediana Edad , Nervio Oftálmico/patología , Trastornos de la Sensación/etiología , Trastornos de la Sensación/fisiopatología , Trastornos de la Sensación/diagnóstico , Anciano de 80 o más Años
5.
Res Dev Disabil ; 149: 104742, 2024 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-38678875

RESUMEN

BACKGROUND: Autistic features and sensory processing difficulties and their phenotypic co-expression with alexithymia share a transdiagnostic vulnerability. In this work, we explored whether the current concept of broad autism phenotype rather translates altered sensory processing (non-specific to autism), meaning that the characteristics of altered sensory processing should be overexpressed among individuals with heightened vulnerability to sensory processing atypicalities (parents of children with sensorial processing disorder, or SPD parents) and individuals with heightened vulnerability to autistic traits (parents of children with autism spectrum disorders, or ASD parents). In addition, the association between altered sensory processing and alexithymia was inspected. METHOD: The Adolescent/Adult Sensory Profile, Autism Spectrum Quotient, and Toronto Alexithymia Scale were completed by 31 parents of children with ASD, 32 parents of children with SPD, and 52 parents of typically developed (TD) children. RESULTS: Extreme sensory patterns were overexpressed both in parents of children with SPD and parents of children with ASD when compared to parents of TD children. In addition, extreme sensory patterns were significantly associated with alexithymia scores. Specifically, sensory avoidance, low registration, and sensory sensitivity were positively correlated with alexithymia. No significant differences were found regarding the proportion of autistic traits and alexithymia between ASD and SPD groups of parents. CONCLUSIONS: These results challenge the specificity of broad autism phenotype and suggest a neurodevelopmental atypicity with roots in altered sensory and emotional processing.


Asunto(s)
Síntomas Afectivos , Trastorno del Espectro Autista , Padres , Humanos , Síntomas Afectivos/fisiopatología , Síntomas Afectivos/psicología , Trastorno del Espectro Autista/psicología , Trastorno del Espectro Autista/fisiopatología , Masculino , Femenino , Padres/psicología , Niño , Adolescente , Adulto , Trastornos de la Sensación/fisiopatología , Trastornos de la Sensación/psicología , Estudios de Casos y Controles , Persona de Mediana Edad
6.
Parkinsonism Relat Disord ; 123: 106074, 2024 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-38579441
7.
Clin Neurophysiol ; 161: 231-241, 2024 May.
Artículo en Inglés | MEDLINE | ID: mdl-38522269

RESUMEN

OBJECTIVE: This study aimed to characterize grasping behavior in static (weight-dependent modulation and stability of control) and dynamic (predictive control) aspects specifically focusing on the relative contribution of sensory and motor deficits to grip force control in patients with chronic stroke. METHODS: Twenty-four chronic stroke patients performed three manipulative tasks: five trials of 5-s grasp-lift-holding, 30-s static holding, and vertical dynamic/cyclic oscillation of holding the object. RESULTS: Exerted static grip force on the paretic side exhibited statistically greater than that on the non-paretic side. Spearman's rank correlation coefficient revealed that the contribution to static grip force control was larger in sensory deficits than in motor deficits. In addition, the sensory deficit is related to the reduced coupling between grip force and load force, suggesting difficulty in predictive control due to the absence of sensory feedback. CONCLUSIONS: Given that grip force control involves predictive feedforward and online feedback control, the evaluation of grip force might be an important and feasible evaluation manner for the assessment of sensorimotor control in patients post-stroke. SIGNIFICANCE: Detailed evaluation of grip force control would help to understand the mechanisms underlying hand dysfunction in stroke patients.


Asunto(s)
Fuerza de la Mano , Accidente Cerebrovascular , Humanos , Fuerza de la Mano/fisiología , Masculino , Femenino , Accidente Cerebrovascular/fisiopatología , Accidente Cerebrovascular/complicaciones , Persona de Mediana Edad , Anciano , Enfermedad Crónica , Adulto , Desempeño Psicomotor/fisiología , Trastornos de la Sensación/fisiopatología , Trastornos de la Sensación/etiología
8.
Autism Res ; 17(4): 775-784, 2024 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-38433353

RESUMEN

The methyl CpG-binding protein-2 (MECP2) gene is located on the Xq28 region. Loss of function mutations or increased copies of MECP2 result in Rett syndrome (RTT) and MECP2 duplication syndrome (MDS), respectively. Individuals with both disorders exhibit overlapping autism symptoms, yet few studies have dissected the differences between these gene dosage sensitive disorders. Further, research examining sensory processing patterns in persons with RTT and MDS is largely absent. Thus, the goal of this study was to analyze and compare sensory processing patterns in persons with RTT and MDS. Towards this goal, caregivers of 50 female individuals with RTT and 122 male individuals with MDS, between 1 and 46 years of age, completed a standardized measure of sensory processing, the Sensory Experiences Questionnaire. Patterns detected in both disorders were compared against each other and against normative values. We found sensory processing abnormalities for both hyper- and hypo-sensitivity in both groups. Interestingly, abnormalities in MDS were more pronounced compared with in RTT, particularly with items concerning hypersensitivity and sensory seeking, but not hyposensitivity. Individuals with MDS also exhibited greater sensory symptoms compared with RTT in the areas of tactile and vestibular sensory processing and for both social and nonsocial stimuli. This study provides a first description of sensory symptoms in individuals with RTT and individuals with MDS. Similar to other neurodevelopmental disorders, a variety of sensory processing abnormalities was found. These findings reveal a first insight into sensory processing abnormalities caused by a dosage sensitive gene and may ultimately help guide therapeutic approaches for these disorders.


Asunto(s)
Síndrome de Rett , Femenino , Humanos , Masculino , Proteína 2 de Unión a Metil-CpG/genética , Mutación , Síndrome de Rett/genética , Síndrome de Rett/fisiopatología , Encuestas y Cuestionarios , Trastornos de la Sensación/etiología , Trastornos de la Sensación/genética , Trastornos de la Sensación/fisiopatología
9.
J Korean Med Sci ; 37(3): e8, 2022 Jan 17.
Artículo en Inglés | MEDLINE | ID: mdl-35040293

RESUMEN

BACKGROUND: A culturally validated Korean version of the PainDETECT Questionnaire (PD-Q) was used to identify neuropathic pain components (NeP) in patients suffering from chronic pain. The purpose of this study was to determine if the Korean PD-Q can be used to subgroup patients with peripheral NeP according to sensory symptom profiles. METHODS: This study included 400 Korean patients with peripheral neuropathic pain diagnosed as probable or definite NeP. The total scores and subscores for each item in PD-Q were transformed into a Z-score for standardization. Hierarchical cluster analysis was performed to identify clusters of subjects by PD-Q scores. RESULTS: The mean total PD-Q score of the study participants was 14.57 ± 6.46. A hierarchical cluster analysis identified 5 clusters with distinct pain characteristic profiles. Cluster 1 had relatively severe burning and tingling sensations. The mean total PD-Q score for cluster 2 was the lowest of the 5 clusters. Cluster 3 tended to be vulnerable to pain in response to cold/heat stimulation. Cluster 4 showed relatively severe pain induced by physical stimuli, such as light touch or slight pressure. Cluster 5 had high scores for all NeP symptoms. CONCLUSION: This study demonstrates the ability of patients to cluster by symptoms using the Korean PD-Q. Subgrouping of peripheral neuropathic pain by sensory symptom profile may be useful in making effective drug treatment decisions.


Asunto(s)
Dimensión del Dolor/instrumentación , Enfermedades del Sistema Nervioso Periférico/complicaciones , Trastornos de la Sensación/etiología , Anciano , Estudios Transversales , Femenino , Humanos , Masculino , Persona de Mediana Edad , Manejo del Dolor/métodos , Manejo del Dolor/estadística & datos numéricos , Dimensión del Dolor/normas , Dimensión del Dolor/estadística & datos numéricos , Enfermedades del Sistema Nervioso Periférico/epidemiología , Enfermedades del Sistema Nervioso Periférico/fisiopatología , República de Corea/epidemiología , Trastornos de la Sensación/epidemiología , Trastornos de la Sensación/fisiopatología , Encuestas y Cuestionarios
10.
Brain Dev ; 44(2): 81-94, 2022 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-34563417

RESUMEN

BACKGROUND: Atypical sensory behavior disrupts behavioral adaptation in children with autism spectrum disorder (ASD); however, neural correlates of sensory dysfunction using magnetoencephalography (MEG) remain unclear. METHOD: We used MEG to measure the cortical activation elicited by visual (uni)/audiovisual (multisensory) movies in 46 children (7-14 years) were included in final analysis: 13 boys with atypical audiovisual behavior in ASD (AAV+), 10 without this condition, and 23 age-matched typically developing boys. RESULTS: The AAV+ group demonstrated an increase in the cortical activation in the bilateral insula in response to unisensory movies and in the left occipital, right superior temporal sulcus (rSTS), and temporal regions to multisensory movies. These increased responses were correlated with severity of the sensory impairment. Increased theta-low gamma oscillations were observed in the rSTS in AAV+. CONCLUSION: The findings suggest that AAV is attributed to atypical neural networks centered on the rSTS.


Asunto(s)
Percepción Auditiva/fisiología , Trastorno del Espectro Autista/fisiopatología , Ondas Encefálicas/fisiología , Corteza Cerebral/fisiopatología , Trastornos de la Percepción/fisiopatología , Trastornos de la Sensación/fisiopatología , Percepción Visual/fisiología , Adolescente , Niño , Humanos , Magnetoencefalografía , Masculino , Películas Cinematográficas
11.
Headache ; 61(9): 1342-1350, 2021 10.
Artículo en Inglés | MEDLINE | ID: mdl-34669970

RESUMEN

OBJECTIVE: To better characterize differences in interictal sensory experience in adults with migraine and more comprehensively describe the relevance of anxiety to these experiences. BACKGROUND: Evidence suggests that sensitivity to sensory input may not be limited to migraine attacks but continues between them. However, there is a need to better understand whether this is the case across senses, and to clearly distinguish sensory experience from measured sensory threshold, which are not straightforwardly related. Previous literature also indicates a co-occurrence between sensory sensitivity, migraine, and anxiety, but this relationship remains to be fully elucidated. METHODS: The present cross-sectional study used online questionnaires to investigate how self-reported sensory experiences relate to migraine in a large community sample including 117 individuals with probable migraine and 827 without. Mediation analyses were also used to determine whether any relationship between migraine and sensory sensitivity was mediated by anxiety. RESULTS: Significant increases in subjective reports of sensory sensitivity (d = 0.80) and sensory avoidance (d = 0.71) were found in participants with migraine. Anxiety symptoms partially mediated the relationship between subjective sensory sensitivity and migraine. Finally, visual, movement, and auditory subscales were found to provide unique explanatory variance in analyses predicting the incidence of migraine (area under the curve = 0.73, 0.69, 0.62 respectively). CONCLUSION: Subjective sensory sensitivities are present between attacks and across senses in individuals with migraine. Anxiety symptoms are relevant to this relationship; however, sensory sensitivities appear to exist independent of this affective influence. The implications of interictal sensitivities for the daily lives of those with migraine should, therefore, be considered in clinical management wherever appropriate.


Asunto(s)
Ansiedad/fisiopatología , Trastornos Migrañosos/fisiopatología , Trastornos de la Sensación/fisiopatología , Adolescente , Adulto , Anciano , Anciano de 80 o más Años , Estudios Transversales , Modificador del Efecto Epidemiológico , Femenino , Humanos , Masculino , Persona de Mediana Edad , Trastornos Migrañosos/complicaciones , Trastornos de la Sensación/etiología , Adulto Joven
12.
Parkinsonism Relat Disord ; 91: 88-95, 2021 10.
Artículo en Inglés | MEDLINE | ID: mdl-34547654

RESUMEN

BACKGROUND: Dual-task is a challenge for Parkinson's disease patients with postural instability and gait disorders (PD-PIGD). OBJECTIVE: This study investigated clinical, cognitive and functional brain correlates of dual-task deficits in PD-PIGD patients using quantitative gait analysis, neuropsychological evaluations and functional MRI (fMRI). METHODS: Twenty-three PD-PIGD patients performed a clinical assessment of gait/balance abilities. Single and dual-task Timed-Up-and-Go tests were monitored using an optoelectronic system to study turning velocity. Patients underwent executive-attentive function evaluation and two fMRI tasks: motor-task (foot anti-phase movements), and dual-task (foot anti-phase movements while counting backwards by threes starting from 100). Twenty-three healthy subjects underwent neuropsychological and fMRI assessments. RESULTS: Dual-task in PD-PIGD patients resulted in worse gait performance, particularly during turning. Performing the dual-task relative to the motor-fMRI task, healthy subjects showed widespread increased recruitment of sensorimotor, cognitive and cerebellar areas and reduced activity of inferior frontal and supramarginal gyri, while PD-PIGD patients showed increased recruitment of inferior frontal gyrus and supplementary motor area and reduced activity of primary motor, supramarginal and caudate areas. Dual-task gait alterations in patients correlated with balance and executive deficits and with altered dual-task fMRI brain activity of frontal areas. CONCLUSIONS: This study suggested the correlation between dual-task gait difficulties, postural instability and executive dysfunction in PD-PIGD patients. FMRI results suggest that an optimized recruitment of motor and cognitive networks is associated with a better dual-task performance in PD-PIGD. Future studies should evaluate the effect of specific gait/balance and dual-task trainings to improve gait parameters and optimize brain functional activity during dual-tasks.


Asunto(s)
Trastornos Neurológicos de la Marcha/fisiopatología , Imagen por Resonancia Magnética , Enfermedad de Parkinson/fisiopatología , Equilibrio Postural , Trastornos de la Sensación/fisiopatología , Anciano , Anciano de 80 o más Años , Atención , Encéfalo/diagnóstico por imagen , Encéfalo/fisiopatología , Estudios de Casos y Controles , Disfunción Cognitiva/diagnóstico por imagen , Disfunción Cognitiva/etiología , Disfunción Cognitiva/fisiopatología , Función Ejecutiva , Femenino , Marcha , Análisis de la Marcha , Trastornos Neurológicos de la Marcha/diagnóstico por imagen , Trastornos Neurológicos de la Marcha/etiología , Humanos , Masculino , Persona de Mediana Edad , Pruebas Neuropsicológicas , Enfermedad de Parkinson/complicaciones , Enfermedad de Parkinson/diagnóstico por imagen , Trastornos de la Sensación/diagnóstico por imagen , Trastornos de la Sensación/etiología , Análisis y Desempeño de Tareas
13.
J Am Geriatr Soc ; 69(12): 3557-3567, 2021 12.
Artículo en Inglés | MEDLINE | ID: mdl-34478566

RESUMEN

BACKGROUND: Vision and hearing impairments often co-exist with dementia, and all are independently associated with limitations in daily activities. Our aim was to examine the association of dual sensory impairment with functional limitations, and further examine the combined estimated association of sensory impairment and dementia with these functional limitations. METHODS: Cross-sectional analysis of the National Health and Aging Trends Study (NHATS), a population-based cohort of Medicare beneficiaries, was performed. Participants were selected from the 2015 round. Survey weighted Poisson regression models adjusted for dementia, demographics, and health status variables examined the association of self-reported dual sensory impairment (no sensory impairment, single sensory impairment, dual sensory impairment) with scores of limitations in mobility, self-care, and household activities. Models were repeated to take into account the combined effects of dual sensory impairment and dementia. RESULTS: Overall, 7124 participants representative of Medicare beneficiaries 65 years or older were included. Of them, 43.9% were 75 years or older and 55.3% were female. Older adults with dual sensory impairment had greater limitations with mobility (prevalence rate ratio [PRR] = 1.45, 95% CI = 1.28-1.63), self-care (PRR = 1.41, 95% CI = 1.25-1.59), and household activities (PRR = 1.54, 95% CI = 1.37-1.72) compared with those without sensory impairment. They also had greater limitations than those with a single sensory impairment across the different activity categories. In models taking into account the combined estimated effect of both sensory impairment and dementia, those with dual sensory impairment and dementia had greater limitations than those without sensory impairment or dementia in each category (mobility: PRR = 1.85, 95% CI = 1.59-2.14, self-care: PRR = 1.86, 95% CI = 1.59-2.18, household: PRR = 2.41, 95% CI = 2.09-2.77). CONCLUSIONS: Older adults with dual sensory impairment had greater functional limitations compared with those without sensory impairment and those with a single sensory impairment. Strategies to improve visual and/or hearing function (e.g., sensory aids, rehabilitation) could potentially help prevent or minimize disability, even among those with dementia.


Asunto(s)
Demencia/complicaciones , Demencia/fisiopatología , Limitación de la Movilidad , Trastornos de la Sensación/fisiopatología , Trastornos de la Sensación/psicología , Anciano , Anciano de 80 o más Años , Estudios Transversales , Femenino , Estado Funcional , Humanos , Masculino , Medicare , Afecciones Crónicas Múltiples/psicología , Distribución de Poisson , Prevalencia , Análisis de Regresión , Autoinforme , Estados Unidos
14.
J Laryngol Otol ; 135(10): 926-931, 2021 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-34404495

RESUMEN

OBJECTIVE: This study investigated the characteristics and prognosis of the feeling of ear fullness in patients with unilateral all-frequency sudden sensorineural hearing loss. METHODS: Our study included 56 patients with a diagnosis of unilateral all-frequency sudden sensorineural hearing loss accompanied by a feeling of ear fullness and 48 patients without a feeling of ear fullness. The condition of these patients was prospectively observed. RESULTS: Positive correlations were observed between grading of feeling of ear fullness and hearing loss in patients with a feeling of ear fullness (r = 0.599, p < 0.001). No significant differences were observed in the total effective rate of hearing recovery between patients with and without a feeling of ear fullness after one month of treatment (Z = -0.641, p = 0.521). Eighty-six per cent of patients (48 out of 56) showed complete recovery from the feeling of ear fullness. There was no correlation between feeling of ear fullness recovery and hearing recovery (r = 0.040, p = 0.769). CONCLUSION: The prognosis of feeling of ear fullness is good. There was no correlation between feeling of ear fullness recovery and hearing recovery for all-frequency sudden sensorineural hearing loss patients.


Asunto(s)
Pérdida Auditiva Sensorineural/diagnóstico , Pérdida Auditiva Súbita/diagnóstico , Audición/fisiología , Trastornos de la Sensación/fisiopatología , Adulto , Umbral Auditivo/fisiología , Conducción Ósea/fisiología , Estudios de Casos y Controles , Femenino , Pérdida Auditiva Sensorineural/fisiopatología , Pérdida Auditiva Sensorineural/psicología , Pérdida Auditiva Sensorineural/terapia , Pérdida Auditiva Súbita/fisiopatología , Pérdida Auditiva Súbita/psicología , Pérdida Auditiva Súbita/terapia , Pruebas Auditivas/métodos , Humanos , Masculino , Persona de Mediana Edad , Pronóstico , Estudios Prospectivos , Recuperación de la Función , Trastornos de la Sensación/psicología , Factores de Tiempo
15.
Phys Ther ; 101(10)2021 10 01.
Artículo en Inglés | MEDLINE | ID: mdl-34270771

RESUMEN

OBJECTIVE: The purpose of this study was to assess the static balance of children with sensorineural hearing loss (SNHL) according to the degrees of SNHL and the function of the vestibular system. METHODS: This cross-sectional study was conducted in public schools located in Caruaru, Pernambuco state, Brazil, with 130 children (65 with normal hearing and 65 with SNHL as documented by air and bone conduction audiometry) of both sexes between 7 and 11 years old. Static balance was assessed by a stabilometric analysis using a force platform consisting of the circular area of center-of-pressure displacement of the children evaluated in 3 positions: bipedal support with feet together and parallel (PF), tandem feet (TF), and 1 foot (OF), carried out under 2 sensory conditions each, with eyes open and eyes closed. After balance assessments, the children with SNHL received examinations of auditory and vestibular functions-through audiometry and computerized vectoelectronystagmography, respectively-to compose the groups according to degrees of SNHL and vestibular function. RESULTS: The children with severe and profound SNHL demonstrated more static balance instabilities than the children with normal hearing in 5 positions assessed with eyes open (PF, TF, and OF) and eyes closed (PF and TF). The same phenomenon occurred in children with SNHL and associated vestibular dysfunction in all of the positions assessed with eyes open and eyes closed (PF, TF, and OF). CONCLUSION: The larger the degree of SNHL, the greater the balance instability of the children. The children with SNHL and associated vestibular dysfunction showed the highest balance instabilities in this study. IMPACT: Children with larger degrees of SNHL and associated vestibular dysfunction might require prolonged periods to rehabilitate their balance.


Asunto(s)
Pérdida Auditiva Sensorineural/complicaciones , Trastornos de la Destreza Motora/complicaciones , Equilibrio Postural/fisiología , Trastornos de la Sensación/complicaciones , Trastornos de la Sensación/etiología , Enfermedades Vestibulares/complicaciones , Vestíbulo del Laberinto/patología , Estudios de Casos y Controles , Niño , Estudios Transversales , Electronistagmografía , Femenino , Pérdida Auditiva/complicaciones , Pérdida Auditiva Sensorineural/terapia , Humanos , Masculino , Trastornos de la Sensación/diagnóstico , Trastornos de la Sensación/fisiopatología , Enfermedades Vestibulares/diagnóstico , Pruebas de Función Vestibular
16.
Int J Mol Sci ; 22(5)2021 Mar 06.
Artículo en Inglés | MEDLINE | ID: mdl-33800863

RESUMEN

The ability to sense and move within an environment are complex functions necessary for the survival of nearly all species. The spinal cord is both the initial entry site for peripheral information and the final output site for motor response, placing spinal circuits as paramount in mediating sensory responses and coordinating movement. This is partly accomplished through the activation of complex spinal microcircuits that gate afferent signals to filter extraneous stimuli from various sensory modalities and determine which signals are transmitted to higher order structures in the CNS and to spinal motor pathways. A mechanistic understanding of how inhibitory interneurons are organized and employed within the spinal cord will provide potential access points for therapeutics targeting inhibitory deficits underlying various pathologies including sensory and movement disorders. Recent studies using transgenic manipulations, neurochemical profiling, and single-cell transcriptomics have identified distinct populations of inhibitory interneurons which express an array of genetic and/or neurochemical markers that constitute functional microcircuits. In this review, we provide an overview of identified neural components that make up inhibitory microcircuits within the dorsal and ventral spinal cord and highlight the importance of inhibitory control of sensorimotor pathways at the spinal level.


Asunto(s)
Vías Aferentes/fisiología , Interneuronas/fisiología , Movimiento/fisiología , Inhibición Neural/fisiología , Sensación/fisiología , Filtrado Sensorial/fisiología , Médula Espinal/citología , Animales , Células del Asta Anterior/química , Células del Asta Anterior/clasificación , Células del Asta Anterior/fisiología , Humanos , Interneuronas/química , Interneuronas/clasificación , Modelos Neurológicos , Neuronas Motoras/fisiología , Trastornos del Movimiento/fisiopatología , Fibras Nerviosas/fisiología , Proteínas del Tejido Nervioso/análisis , Neuropéptidos/análisis , Células del Asta Posterior/química , Células del Asta Posterior/clasificación , Trastornos de la Sensación/fisiopatología , Células Receptoras Sensoriales/fisiología , Médula Espinal/fisiología , Sinapsis/fisiología
17.
J Stroke Cerebrovasc Dis ; 30(6): 105750, 2021 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-33812174

RESUMEN

OBJECTIVE: Vertebral artery compression of the medulla is a rare vascular finding that causes a variety of clinical presentations, from asymptomatic to neurological disability. This article presents the largest literature review to date on medullary compression of the vertebral arteries. METHODS: An English literature search was performed using the PubMed database and the keywords vertebral artery tortuosity, vertebral artery compression, and medullary compression. RESULTS: A comprehensive literature search yielded 68 patients (57% male) with medullary compression by an intracranial vertebral artery (ICVA). The left side of the medulla was compressed in 44, the right side in 19, and bilateral in 7. The most common clinical symptom was weakness - 26 patients (36%) - 6 had quadriparesis and 6 had hemiparesis. 21 patients reported imbalance; 12 various sensory symptoms; 4 patients were asymptomatic. CONCLUSIONS: Understanding the anatomy of the vasculature can help mitigate future debilitating stroke symptoms. Concrete guidelines for revascularization surgery in symptomatic patients may also be effective. Future studies are needed to further clarify the prevalence, natural history, vascular etiology, and treatment of this condition, including asymptomatic patients and the likelihood that they will develop further neurological signs and disability.


Asunto(s)
Encefalopatías/etiología , Bulbo Raquídeo/fisiopatología , Malformaciones Vasculares/complicaciones , Arteria Vertebral/anomalías , Adulto , Anciano , Anciano de 80 o más Años , Encefalopatías/diagnóstico por imagen , Encefalopatías/fisiopatología , Femenino , Humanos , Masculino , Bulbo Raquídeo/diagnóstico por imagen , Persona de Mediana Edad , Paresia/etiología , Paresia/fisiopatología , Equilibrio Postural , Pronóstico , Cuadriplejía/etiología , Cuadriplejía/fisiopatología , Trastornos de la Sensación/etiología , Trastornos de la Sensación/fisiopatología , Malformaciones Vasculares/diagnóstico por imagen , Malformaciones Vasculares/fisiopatología , Arteria Vertebral/diagnóstico por imagen , Arteria Vertebral/fisiopatología , Adulto Joven
18.
Res Sports Med ; 29(4): 406-416, 2021.
Artículo en Inglés | MEDLINE | ID: mdl-33779438

RESUMEN

This study investigated the effects of a 16-week Tai Chi (TC) intervention on cutaneous sensitivity and proprioception among older adults with and without sensory loss. Thirty-six older adults were divided into sensory loss and control groups, and they underwent a 16-week TC intervention. Significant interactions were detected in heel cutaneous sensitivity (p = 0.046, F = 4.419) and knee flexion (p = 0.043, F = 4.580), extension (p = 0.027, F = 5.529) and ankle plantar-flexion proprioception (p = 0.037, F = 4.860). The post hoc test indicated that in the sensory loss group, heel cutaneous sensitivity threshold (p = 0.034) and knee flexion (p = 0.004), extension (p = 0.002) and ankle plantar-flexion (p = 0.023) proprioception threshold decreased at week 17, whereas in the control group, knee flexion (p = 0.029) proprioception threshold decreased at week 17. TC intervention improved cutaneous sensitivity at more sites and proprioception in more joints among the older adults with sensory loss. TC intervention is a good option for older adults to exercise, and it is more effective among older adults with sensory loss.


Asunto(s)
Propiocepción/fisiología , Trastornos de la Sensación/fisiopatología , Trastornos de la Sensación/terapia , Taichi Chuan/métodos , Accidentes por Caídas/prevención & control , Anciano , Anciano de 80 o más Años , Humanos , Extremidad Inferior , Masculino , Persona de Mediana Edad
19.
J Neuroinflammation ; 18(1): 77, 2021 Mar 22.
Artículo en Inglés | MEDLINE | ID: mdl-33752705

RESUMEN

BACKGROUND: While the etiology remains elusive, macrophages and T cells in peripheral nerves are considered as effector cells mediating autoimmune peripheral neuropathy (APN), such as Guillain-Barre syndrome. By recognizing both pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs) signals, TLRs play a central role in the initiation of both innate and adaptive immune responses. In this study, we aimed to understand the involvement of TLR4 in the pathogenesis of APN and explore the potential of TLR4 as a drug target for therapeutic use. METHODS: APN was induced by a partial ligation on one of the sciatic nerves in B7.2 (L31) transgenic mice which possess a predisposed inflammatory background. APN pathology and neurological function were evaluated on the other non-injured sciatic nerve. RESULTS: TLR4 and its endogenous ligand HMGB1 were highly expressed in L31 mice, in circulating immune cells and in peripheral nerves. Enhanced TLR4 signaling was blocked with TAK 242, a selective TLR4 inhibitor, before and after disease onset. Intraperitoneal administration of TAK 242 not only inhibited monocyte, macrophage and CD8+ T cell activation, but also reduced the release of pro-inflammatory cytokines. TAK 242 protected mice from severe myelin and axonal loss, resulting in a remarkable improvement in mouse motor and sensory functions. TAK 242 was effective in alleviating the disease in both preventive and reversal paradigms. CONCLUSION: The study identified the critical contribution of TLR4-mediated macrophage activation in disease course and provided strong evidence to support TLR4 as a useful drug target for treating inflammatory autoimmune neuropathy.


Asunto(s)
Enfermedades Autoinmunes/fisiopatología , Trastornos del Movimiento/fisiopatología , Enfermedades del Sistema Nervioso Periférico/fisiopatología , Trastornos de la Sensación/fisiopatología , Receptor Toll-Like 4/genética , Animales , Enfermedades Autoinmunes/prevención & control , Enfermedades Autoinmunes/psicología , Linfocitos T CD8-positivos/efectos de los fármacos , Femenino , Proteína HMGB1/metabolismo , Macrófagos/efectos de los fármacos , Masculino , Ratones , Ratones Endogámicos C57BL , Ratones Transgénicos , Monocitos/efectos de los fármacos , Trastornos del Movimiento/prevención & control , Trastornos del Movimiento/psicología , Enfermedades del Sistema Nervioso Periférico/psicología , Nervio Ciático/lesiones , Trastornos de la Sensación/prevención & control , Trastornos de la Sensación/psicología , Transducción de Señal , Sulfonamidas/farmacología , Receptor Toll-Like 4/antagonistas & inhibidores
20.
J Stroke Cerebrovasc Dis ; 30(5): 105680, 2021 May.
Artículo en Inglés | MEDLINE | ID: mdl-33652344

RESUMEN

INTRODUCTION: Body lateropulsion (BLP) is seen in neurological lesions involving the pathways responsible for body position and verticality. We report a case of isolated body lateropulsion (iBLP) as the presentation of lateral medullary infarction and conducted a systematic literature review. METHODS: MEDLINE and EMBASE databases were searched up to December 3, 2020. INCLUSION CRITERIA: age ≥ 18, presence of BLP, confirmed stroke on imaging. EXCLUSION CRITERIA: age < 18, qualitative reviews, studies with inadequate patient data. Statistical analysis was performed using IBM® SPSS® Statistics 20. RESULTS: A 64-year-old man presented with acute-onset iBLP. Brain MRI demonstrated acute infarction in the right caudolateral medulla. His symptoms progressed with ipsilateral Horner syndrome over the next 24 hours and contralateral hemisensory loss 10 days later. Repeat MRI showed an increase in infarct size. BLP resolved partially at discharge. Systematic review: 418 abstracts were screened; 59 studies were selected reporting 103 patients. Thirty-three patients had iBLP (32%). BLP was ipsilateral to stroke in 70 (68%) and contralateral in 32 (32%). The most common stroke locations were medulla (n = 63, 59%), pons (n = 16, 15%), and cerebellum (n = 16, 15%). Four strokes were cortical, 3 frontal and 1 temporoparietal (3%). The most common etiology was large-artery atherosclerosis (LAA) in 20 patients (32%), followed by small-vessel occlusion in 12 (19%). Seventeen (27%) had large-vessel occlusion (LVO), 12 involving the vertebral artery. Sixty (98%) had some degree of resolution of BLP; complete in 41 (70%). Median time-to-resolution was 14 days (IQR 10-21). There was no relationship between time-to-resolution and age, sex, side of BLP or side of stroke. CONCLUSION: BLP was commonly seen with medullary infarction and was the isolated finding in one-third. LAA and LVO were the most common etiologies. Recovery of BLP was early and complete in most cases.


Asunto(s)
Infartos del Tronco Encefálico/complicaciones , Equilibrio Postural , Trastornos de la Sensación/etiología , Infartos del Tronco Encefálico/diagnóstico por imagen , Infartos del Tronco Encefálico/fisiopatología , Imagen de Difusión por Resonancia Magnética , Síndrome de Horner/etiología , Síndrome de Horner/fisiopatología , Humanos , Masculino , Persona de Mediana Edad , Trastornos de la Sensación/diagnóstico , Trastornos de la Sensación/fisiopatología
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