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1.
JBJS Case Connect ; 14(1)2024 01 01.
Artículo en Inglés | MEDLINE | ID: mdl-38279923

RESUMEN

CASE: An 85-year-old woman was transported to our institution due to difficulty in walking. Preoperative imaging showed spinal cord lesions indicative of spinal cord tumor at the T7-8 level, accompanied by T8 vertebral fracture. Intraoperatively, the spinal lesion was suspected to be an epidural abscess; therefore, the capsule was resected, and the abscess was drained. We added pedicle screw fixation at the T6-10 level. Postoperatively, the spinal cord lesion was definitively diagnosed as spinal epidural tuberculoma. CONCLUSION: Spinal epidural tuberculomas should be considered in the treatment of spinal cord lesions causing paralysis attributed to spinal cord compression.


Asunto(s)
Tornillos Pediculares , Compresión de la Médula Espinal , Enfermedades de la Médula Espinal , Fracturas de la Columna Vertebral , Tuberculoma , Femenino , Humanos , Anciano de 80 o más Años , Fracturas de la Columna Vertebral/complicaciones , Fracturas de la Columna Vertebral/diagnóstico por imagen , Vértebras Torácicas/cirugía , Tuberculoma/complicaciones , Tuberculoma/diagnóstico , Tuberculoma/patología , Compresión de la Médula Espinal/etiología , Tornillos Pediculares/efectos adversos
2.
Ann Clin Microbiol Antimicrob ; 22(1): 69, 2023 Aug 07.
Artículo en Inglés | MEDLINE | ID: mdl-37550721

RESUMEN

BACKGROUND: Central nervous system tuberculosis (CNS TB) is a severe Mycobacterium tuberculosis (MTB) infection. It is unclear whether a patient's immune status alters the clinical manifestations and treatment outcomes of CNS TB. METHODS: Between January 2007-December 2018, chart reviews of CNS TB, including tuberculous meningitis (TBM), tuberculoma/abscess, and TB myelitis, were made. Subjects were categorized as immunodeficient (ID) and non-immunodeficient (NID). RESULTS: Of 310 subjects, 160 (51.6%) were in the ID group-132 (42.6%) had HIV and 28 (9.0%) had another ID, and 150 (48.4%) were in the NID group. The mean age was 43.64 ± 16.76 years, and 188 (60.6%) were male. There were 285 (91.9%) TBM, 16 (5.2%) tuberculoma/abscess, and 9 (2.9%) myelitis cases. The TBM characteristics in the ID group were younger age (p = 0.003), deep subcortical location of tuberculoma (p = 0.030), lower hemoglobin level (p < 0.001), and lower peripheral white blood cell count (p < 0.001). Only HIV individuals with TBM had an infection by multidrug-resistant MTB (p = 0.013). TBM mortality was varied by immune status -HIV 22.8%, other ID 29.6%, and NID 14.8% (p < 0.001). Factors significantly associated with unfavorable outcomes in TBM also differed between the HIV and NID groups. CONCLUSIONS: TBM is the most significant proportion of CNS TB. Some of the clinical characteristics of TBM, such as age, radiographic findings, hematological derangement, and mortality, including factors associated with unfavorable outcomes, differed between ID and non-ID patients.


Asunto(s)
Infecciones por VIH , Mycobacterium tuberculosis , Tuberculoma , Tuberculosis del Sistema Nervioso Central , Tuberculosis Meníngea , Humanos , Masculino , Adulto , Persona de Mediana Edad , Femenino , Estudios Retrospectivos , Absceso , Tuberculosis del Sistema Nervioso Central/diagnóstico , Tuberculosis del Sistema Nervioso Central/complicaciones , Tuberculosis del Sistema Nervioso Central/tratamiento farmacológico , Tuberculosis Meníngea/diagnóstico , Tuberculosis Meníngea/complicaciones , Tuberculosis Meníngea/tratamiento farmacológico , Tuberculoma/complicaciones , Infecciones por VIH/complicaciones
3.
Acta Neurochir (Wien) ; 165(3): 647-650, 2023 03.
Artículo en Inglés | MEDLINE | ID: mdl-36624232

RESUMEN

Cerebrovascular complications of central nervous system tuberculosis (TB) are predictors of poor prognosis and adverse outcomes. These complications are mainly intracranial arterial involvement, with occasional venous involvement. Here, we present a 67-year-old woman with concurrent cerebral infarction and intracranial tuberculoma induced by the carotid plaque complicated by miliary tuberculosis. Mycobacterium tuberculosis was observed on the luminal side of the carotid plaques in pathological specimens. Treatment with anti-TB drugs alone would likely not cure the patient, as M. tuberculosis would continue to disseminate. Endarterectomy could directly remove the embolic source, and a complete cure was achieved.


Asunto(s)
Tuberculoma Intracraneal , Tuberculoma , Tuberculosis Miliar , Femenino , Humanos , Anciano , Tuberculoma Intracraneal/complicaciones , Tuberculoma Intracraneal/tratamiento farmacológico , Tuberculosis Miliar/complicaciones , Tuberculosis Miliar/tratamiento farmacológico , Antituberculosos/uso terapéutico , Infarto Cerebral , Tuberculoma/complicaciones , Tuberculoma/tratamiento farmacológico
4.
Eur J Ophthalmol ; 33(1): NP15-NP18, 2023 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-34420419

RESUMEN

The diagnosis of OTB (Ocular tuberculosis) is usually difficult to make. Definitive diagnosis requires the identification of M. tuberculosis organisms in ocular tissues or fluids, but samples are often difficult to obtain, and biopsy may be hard to justify. We describe a 50-years-old Maghreb male, who presented a multifocal choroiditis associated with a choroidal tuberculoma on the left eye. Based on positive QuantiFERON-TB-Gold test and suggestive clinical and radiographic findings, a diagnosis of presumed ocular tuberculosis was made. Serial swept-source optical coherence tomography (SS-OCT) and widefield fundus retinographies during subsequent follow-up visits demonstrated the characterization of the atypical tuberculosis presentation and allowed the assessment of response to antitubercular therapy and oral steroids.


Asunto(s)
Coroiditis , Tuberculoma , Tuberculosis Ocular , Humanos , Masculino , Persona de Mediana Edad , Tuberculosis Ocular/diagnóstico , Tuberculosis Ocular/tratamiento farmacológico , Tuberculosis Ocular/complicaciones , Coroiditis Multifocal/complicaciones , Coroiditis Multifocal/tratamiento farmacológico , Coroiditis Multifocal/patología , Coroides/patología , Técnicas de Diagnóstico Oftalmológico , Antituberculosos/uso terapéutico , Tuberculoma/diagnóstico , Tuberculoma/tratamiento farmacológico , Tuberculoma/complicaciones , Coroiditis/diagnóstico , Coroiditis/tratamiento farmacológico , Coroiditis/complicaciones , Tomografía de Coherencia Óptica/métodos , Angiografía con Fluoresceína/métodos
5.
Arq Bras Oftalmol ; 86(2): 164-167, 2023.
Artículo en Inglés | MEDLINE | ID: mdl-35170661

RESUMEN

Interstitial keratitis is an inflammation of the corneal stroma without epithelium or endothelium involvement. The underlying causes are mostly infectious or immune mediated. Brazil has one of the highest incidence rates of tuberculosis in the world. Tuberculosis is considered one of the causes of interstitial keratitis. Malnutrition and anemia are risk factors of the disseminated disease. This is a case report of a 10-year-old child who presented with decreased visual acuity and a clinical diagnosis of bilateral interstitial keratitis and sclero-uveitis. The patient had been treated with topical steroids with partial improvement. Examinations revealed severe iron deficiency anemia, negative serologies for human immunodeficiency virus and syphilis, positivity for cytomegalovirus- and herpes simplex-specific IgG, and purified protein derivative of 17 mm. During the follow-up, the patient presented with tonic-clonic seizures, and magnetic resonance imaging findings suggested a central nervous system tuberculoma. Interstitial keratitis improvement was observed after specific tuberculosis treatment. This is the first case report describing the association of interstitial keratitis and central nervous system tuberculoma.


Asunto(s)
Queratitis Herpética , Queratitis , Tuberculoma , Tuberculosis , Niño , Humanos , Queratitis/tratamiento farmacológico , Tuberculosis/complicaciones , Tuberculosis/patología , Sustancia Propia/patología , Tuberculoma/complicaciones , Tuberculoma/patología , Encéfalo , Queratitis Herpética/complicaciones , Queratitis Herpética/tratamiento farmacológico , Queratitis Herpética/patología
6.
Comput Math Methods Med ; 2022: 5666067, 2022.
Artículo en Inglés | MEDLINE | ID: mdl-36065379

RESUMEN

Objective: To compare the clinical efficacy and adverse drug reactions of four different schemes in the treatment of pleural tuberculoma. Methods: A total of 120 patients with pleural tuberculoma admitted to the Tuberculosis Department of our hospital from January 2018 to January 2021 were selected as the research subjects. According to different treatment methods, the patients were divided into four groups, with 30 cases in each group. They were as follows: group A received classical HRZE regimen, group B received HRZE+pleural injection, group C received HZE+rifabutin, and group D received HZE+rifabutin+pleural injection. All patients were treated intensively for 3 months and then consolidated treatment for 6 months according to the patient's condition. The absorption of lesions in the four groups at different time was compared, and the occurrences of adverse drug reactions and treatment outcomes during treatment were recorded. Results: After 3 months of treatment, compared with groups A, B, and C, the number of significantly absorbed cases and effective cases in group D increased, while the number of invalid cases decreased. However, there was no statistical significance in the absorption of lesions between the four groups (χ 2 = 8.272, P = 0.507). In addition, pairwise comparison showed no significant difference in the absorption of lesions (P > 0.05). After 9 months of treatment, there was no significant difference in the absorption of lesions among the four groups (χ 2 = 8.795, P = 0.185), but the absorption of lesions in group D was significantly better than that in group A (P < 0.05). During treatment, the incidence of adverse reactions in the four groups was significantly different (χ 2 = 8.779, P = 0.032). Pairwise comparison showed that the incidence of adverse reactions in groups C and D was significantly lower than that in group A (P < 0.05). The total treatment course of group A was 9-16 months, and 10 cases (33.33%) still had residual lesions or pleural thickening at the end of treatment. The total course of treatment in group B was 9-12 months, and 7 cases (23.33%) still had residual lesions or pleural thickening at the end of the course of treatment. The total treatment course of group C was 9-16 months, and 8 cases (26.67%) still had residual lesions or pleural thickening at the end of treatment. The total course of treatment in group D was 9-12months, and there were still 2 cases of residual lesions (6.67%) at the end of the course. Conclusions: HZE+rifabutin+pleural injection against tuberculosis therapy has a significant clinical efficacy in the treatment of pleural tuberculoma, which can more effectively improve the clinical symptoms of patients, improve the efficacy, and reduce complications, with a good prognosis, worthy of clinical promotion.


Asunto(s)
Efectos Colaterales y Reacciones Adversas Relacionados con Medicamentos , Pleuresia , Tuberculoma , Tuberculosis Pleural , Progresión de la Enfermedad , Humanos , Pleuresia/complicaciones , Rifabutina/uso terapéutico , Tuberculoma/complicaciones , Tuberculoma/tratamiento farmacológico , Tuberculoma/patología , Tuberculosis Pleural/complicaciones , Tuberculosis Pleural/tratamiento farmacológico , Tuberculosis Pleural/patología
7.
Am J Trop Med Hyg ; 107(4): 833-840, 2022 10 12.
Artículo en Inglés | MEDLINE | ID: mdl-36037862

RESUMEN

Inflammatory granulomas (neurocysticercosis [NCC] and tuberculomas) are important causes of seizures in children and adults in the developing world. Although several studies have explored seizure characteristics individually in patients with either NCC or tuberculoma, none has compared the seizure recurrence rate between them. This study included patients aged 5 to 18 years with viable parenchymal NCC or tuberculomas who had completed regular follow-up of at least 12 months at a tertiary institute in India. Their baseline seizure and electroencephalographic characteristics, antiseizure medications (ASMs), and breakthrough seizure rates at 12, 24, and 52 weeks were noted. A total of 103 and 54 patients with active NCC and tuberculomas respectively were included. The number of patients who had at least one breakthrough seizure at 12, 24, and 52 weeks in both groups was comparable (P = 0.32, 0.27, and 0.13), and the vast majority were controlled on monotherapy (98% cases in each group). The proportion of patients who required an increase in the dose or change of ASMs or polytherapy, the proportion of children who had status epilepticus at or before 12 months, abnormal electroencephalogram at 12 months, and calcified and active granuloma in neuroimaging at 12 months were also comparable between the two groups (P > 0.05 for all). The number of patients who had ASM-related adverse events and discontinued ASM due to serious adverse events was comparable between both groups, except for hepatotoxicity in the tuberculoma group. The predictors for breakthrough seizures that were found to be statistically significant in the NCC group were the presence of perilesional edema in the baseline magnetic resonance imaging (P = 0.02) and more than five active granulomas (P = 0.01); predictors in the tuberculoma group were the presence of severe perilesional edema causing midline shift in the baseline magnetic resonance imaging (P = 0.01) and more than five active granulomas (P = 0.04). The recurrence rates of breakthrough seizures over the next 12 months in newly detected cases of active NCC and tuberculomas were comparable.


Asunto(s)
Neurocisticercosis , Tuberculoma , Adulto , Anticonvulsivantes/uso terapéutico , Niño , Edema , Granuloma , Humanos , India/epidemiología , Neurocisticercosis/complicaciones , Neurocisticercosis/diagnóstico por imagen , Neurocisticercosis/tratamiento farmacológico , Recurrencia , Convulsiones/tratamiento farmacológico , Convulsiones/etiología , Tuberculoma/complicaciones
8.
Clin Neurol Neurosurg ; 210: 106989, 2021 11.
Artículo en Inglés | MEDLINE | ID: mdl-34700277

RESUMEN

Tuberculoma of medulla oblongata is a rare manifestation of central nervous system tuberculosis (CNS TB), which may manifest as intractable singultus as the initial symptom. It is almost impossible to obtain definite diagnosis through biopsy consider its location. Immediate thorough diagnostic workup is needed, and empirical treatment should be started. We report a case of medulla oblongata tuberculoma in an HIV-negative 38-year-old man with intractable singultus as one of the early symptoms. He was treated empirically with anti-tuberculosis therapy and his symptoms subsided within 2 weeks.


Asunto(s)
Hipo/diagnóstico por imagen , Hipo/etiología , Bulbo Raquídeo/diagnóstico por imagen , Tuberculoma/complicaciones , Tuberculoma/diagnóstico por imagen , Adulto , Antituberculosos/farmacología , Antituberculosos/uso terapéutico , Hipo/tratamiento farmacológico , Humanos , Masculino , Tuberculoma/tratamiento farmacológico
9.
Turk Neurosurg ; 31(4): 658-660, 2021.
Artículo en Inglés | MEDLINE | ID: mdl-34169986

RESUMEN

To present a young immunocompetent patient with a fourth ventricle tuberculoma without pulmonary tuberculosis. A previously healthy young male patient presented with a history of headache, nausea, and blurred vision. Neuroimaging revealed a mass present in the fourth ventricle. The lesion was successfully resected. Histological and microbiological findings suggested the presence of a tuberculoma. Tuberculomas can be found in the posterior fossa in adults. This infectious pathology should not be forsaken when considering the differential diagnosis for infratentorial masses.


Asunto(s)
Cuarto Ventrículo/microbiología , Tuberculoma/diagnóstico , Tuberculosis del Sistema Nervioso Central/diagnóstico , Adulto , Antibióticos Antituberculosos/uso terapéutico , Diagnóstico Diferencial , Cuarto Ventrículo/patología , Cefalea/diagnóstico , Cefalea/tratamiento farmacológico , Cefalea/etiología , Humanos , Imagen por Resonancia Magnética/métodos , Masculino , Neuroimagen , Tuberculoma/complicaciones , Tuberculoma/tratamiento farmacológico , Tuberculoma/patología , Tuberculosis del Sistema Nervioso Central/tratamiento farmacológico
11.
Pan Afr Med J ; 36: 147, 2020.
Artículo en Francés | MEDLINE | ID: mdl-32874411

RESUMEN

Ocular manifestations of tuberculosis are non-specific and polymorphic as they can affect all the tunics of the eye and cause severe visual loss in the absence of early and appropriate treatment. We here report 2 casesof pseudotumoral ocular tuberculosis with favorable outcome under antibacillary treatment; the first patient recently had had spontaneous burst of the eyeball with exit of a burgeoning fleshy and suppurative mass measuring 10cm/6cm, the second patient had granuloma of the ciliary body mimicking melanoma; then we here discuss the clinical and therapeutic particularities of this disease.


Asunto(s)
Antituberculosos/uso terapéutico , Tuberculoma/tratamiento farmacológico , Tuberculosis Ocular/tratamiento farmacológico , Adulto , Cuerpo Ciliar/patología , Diagnóstico Diferencial , Granuloma/diagnóstico , Granuloma/tratamiento farmacológico , Humanos , Masculino , Melanoma/diagnóstico , Persona de Mediana Edad , Marruecos , Resultado del Tratamiento , Tuberculoma/complicaciones , Tuberculoma/diagnóstico , Tuberculosis Ocular/complicaciones , Tuberculosis Ocular/diagnóstico , Neoplasias de la Úvea/diagnóstico , Uveítis/diagnóstico , Uveítis/tratamiento farmacológico , Uveítis/etiología
12.
Ann Thorac Surg ; 109(2): e109-e111, 2020 02.
Artículo en Inglés | MEDLINE | ID: mdl-31301274

RESUMEN

A patient with main pulmonary artery mass may have severe symptoms and warrants urgent surgical management, whereas in a stable patient with a diagnosis amenable to medical treatment, medical management should be started while monitoring the size of the lesion. We report a case in which the patient experienced severe right heart dysfunction due to obstruction of the main pulmonary artery, diagnosed as a probable thrombus, and the patient was taken for urgent surgical excision, later diagnosed as tuberculoma on histopathologic examination.


Asunto(s)
Arteria Pulmonar/diagnóstico por imagen , Estenosis de Arteria Pulmonar/etiología , Tuberculoma/complicaciones , Tuberculosis Cardiovascular/complicaciones , Procedimientos Quirúrgicos Vasculares/métodos , Adolescente , Diagnóstico Diferencial , Ecocardiografía , Humanos , Masculino , Arteria Pulmonar/cirugía , Estenosis de Arteria Pulmonar/diagnóstico , Estenosis de Arteria Pulmonar/cirugía , Tuberculoma/diagnóstico , Tuberculoma/cirugía , Tuberculosis Cardiovascular/diagnóstico , Tuberculosis Cardiovascular/cirugía
13.
Photodiagnosis Photodyn Ther ; 29: 101580, 2020 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-31629876

RESUMEN

Choroidal granuloma is rarely seen as the first sign of tuberculosis(TB). Here we report a case of a 34-year old male with a choroidal mass which was associated with serous retinal detachment on EDI-OCT and the "contact sign" between the neurosensory retina and the retinal pigment epithelium. We analysed the macular microvascular features of tuberculoma with Optical Coherence Tomography Angiography(OCTA). After 3 months of antituberculosis treatment, we observed the shrinkage of granuloma with permanent changes of macular microvasculature in deep capillary plexus and choriocapillaris. In conclusion, OCT-A may provide useful information about the retinal microvascular involvement in patients with choroidal tuberculoma.


Asunto(s)
Coroides/diagnóstico por imagen , Coroides/microbiología , Tomografía de Coherencia Óptica/métodos , Tuberculoma/diagnóstico , Tuberculosis/diagnóstico , Adulto , Humanos , Masculino , Imagen Multimodal , Desprendimiento de Retina/complicaciones , Tuberculoma/complicaciones , Tuberculoma/diagnóstico por imagen , Tuberculosis/patología
15.
Chest ; 156(2): e51-e55, 2019 08.
Artículo en Inglés | MEDLINE | ID: mdl-31395269

RESUMEN

CASE PRESENTATION: A 22-year-old woman was admitted to our department for fever of unknown origin. The patient reported intermittent fever and nonspecific abdominal pain for several years. Six months before admission she started complaining of palpitations and exertional dyspnea. She had no weight loss, chest pain, headache, or joint complaints. Medical history was unremarkable. She did not consume tobacco, alcohol, or illicit drugs. The patient was from Malia. She had lived in France for 4 years and did not report recent travel.


Asunto(s)
Arritmias Cardíacas/etiología , Fiebre/etiología , Pericarditis Tuberculosa/diagnóstico , Tuberculoma/diagnóstico , Arritmias Cardíacas/diagnóstico por imagen , Femenino , Fiebre/diagnóstico por imagen , Francia , Humanos , Imagen por Resonancia Magnética , Pericarditis Tuberculosa/complicaciones , Tomografía Computarizada por Tomografía de Emisión de Positrones , Tuberculoma/complicaciones , Adulto Joven
16.
Saudi J Kidney Dis Transpl ; 29(3): 719-722, 2018.
Artículo en Inglés | MEDLINE | ID: mdl-29970752

RESUMEN

A paradoxical reaction during anti-tuberculosis (anti-TB) therapy is commonly reported in patients with human immunodeficiency virus (HIV). However, a similar reaction to anti-TB therapy can also occur in patients without HIV, especially in patients who have undergone solid organ transplantation. A 65-year-old woman who underwent kidney transplantation six months prior presented to our emergency room with progressive paraparesis. She had been diagnosed with drug-susceptible miliary TB and had undergone two weeks of treatment with anti-TB medication. Magnetic resonance imaging showed a spinal intramedullary mass and multiple intracranial nodules. The etiology of the lesions was confirmed as Mycobacterium tuberculosis. We report a paradoxical reaction of spinal intramedullary and multiple intracranial tuberculomas in a patient with miliary TB who had received appropriate treatment for more than two weeks.


Asunto(s)
Trasplante de Riñón/efectos adversos , Tuberculoma , Tuberculosis del Sistema Nervioso Central , Anciano , Antituberculosos/uso terapéutico , Encéfalo/diagnóstico por imagen , Encéfalo/patología , Femenino , Humanos , Imagen por Resonancia Magnética , Radiografía Torácica , Columna Vertebral/diagnóstico por imagen , Columna Vertebral/patología , Tuberculoma/complicaciones , Tuberculoma/diagnóstico por imagen , Tuberculoma/tratamiento farmacológico , Tuberculosis del Sistema Nervioso Central/complicaciones , Tuberculosis del Sistema Nervioso Central/diagnóstico por imagen , Tuberculosis del Sistema Nervioso Central/tratamiento farmacológico , Tuberculosis Miliar/complicaciones , Tuberculosis Miliar/tratamiento farmacológico
17.
J Coll Physicians Surg Pak ; 28(6): S97-S98, 2018 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-29866234

RESUMEN

Tuberculosis rarely involves the hypothalamo-pituitary region and constitutes only 1% of the lesions involving the sellar and/or suprasellar region. Coleman and Meredith first reported pituitary tuberculosis in 1940, and only a handful of cases have been reported ever since. It may manifest as a chiasmal syndrome due to compression of the optic chiasm or as hypopituitarism due to pituitary destruction. It has a characteristic radiological appearance and can mimic a pituitary adenoma. Diagnostic procedures, such as trans-sphenoidal biopsy, are crucial for accurate diagnosis. We report a case of a 32-year male, who presented with complaints of headache and decreased visual acuity for the past 6 months. Eye examination revealed bitemporal hemianopsia. Brain MRI scan showed a mass in the sella with features suggestive of pituitary adenoma. Transcranial resection of the mass was performed; histopathology of the excised mass proved it to be a pituitary tuberculoma.


Asunto(s)
Cefalea/etiología , Hipopituitarismo/etiología , Imagen por Resonancia Magnética/métodos , Quiasma Óptico/diagnóstico por imagen , Enfermedades de la Hipófisis/diagnóstico por imagen , Hipófisis/diagnóstico por imagen , Tuberculoma/diagnóstico por imagen , Adulto , Antituberculosos/uso terapéutico , Craneotomía , Terapia de Reemplazo de Hormonas , Humanos , Hipopituitarismo/terapia , Masculino , Quiasma Óptico/irrigación sanguínea , Enfermedades de la Hipófisis/complicaciones , Hipófisis/cirugía , Tuberculoma/complicaciones , Tuberculoma/tratamiento farmacológico , Tuberculoma/cirugía , Trastornos de la Visión/etiología
20.
Ocul Immunol Inflamm ; 26(2): 239-241, 2018.
Artículo en Inglés | MEDLINE | ID: mdl-27541084

RESUMEN

The authors present a 36-year-old female with pulmonary tuberculosis who developed a choroidal tuberculoma in the left eye. The choroidal tuberculoma successfully resolved with visual gain following oral anti-tubercular and oral steroid therapy leaving behind a chorioretinal scar. One year after the completion of anti-tubercular treatment, she developed visual loss due to the development of a secondary choroidal neovascular membrane at the fovea. This was treated successfully with one intravitreal injection of bevacizumab in the left eye. The fovea remained free of fluid until the last follow-up 10 months after the intravitreal injection. Intravitreal bevacizumab may be an effective modality for treating secondary choroidal neovascular membranes that may form at the edge of a healed choroidal tuberculoma.


Asunto(s)
Inhibidores de la Angiogénesis/uso terapéutico , Bevacizumab/uso terapéutico , Neovascularización Coroidal/tratamiento farmacológico , Tuberculoma/complicaciones , Tuberculosis Ocular/complicaciones , Adulto , Neovascularización Coroidal/diagnóstico por imagen , Neovascularización Coroidal/etiología , Neovascularización Coroidal/fisiopatología , Femenino , Humanos , Inyecciones Intravítreas , Líquido Subretiniano , Tomografía de Coherencia Óptica , Tuberculoma/diagnóstico por imagen , Tuberculosis Ocular/diagnóstico por imagen , Tuberculosis Pulmonar/complicaciones , Factor A de Crecimiento Endotelial Vascular/antagonistas & inhibidores , Agudeza Visual/fisiología
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