Chikungunya Virus Infection Manifesting as Intermediate Uveitis.

PURPOSE: To describe a case of intermediate uveitis caused by chikungunya virus infection in the Western Hemisphere. METHODS: Case report of a patient diagnosed with chikungunya infection presenting with blurry vision and floaters. RESULTS: Exam revealed a unilateral intermediate uveitis, with an extensive work-up positive for chikungunya virus immunoglobulin M and G titers. The patient responded to oral corticosteroids with signs and symptoms resolving over the course of 3 months' treatment. CONCLUSIONS: While anterior uveitis and retinitis are the most common ocular manifestations of chikungunya infection, we report here a case of chikungunya infection presenting as an intermediate uveitis, responding well to oral corticosteroids. This case demonstrates the varied presentation of chikungunya-related uveitis and highlights its consideration in the differential diagnoses of those who have had preceding systemic viral symptoms and uveitis.

Intermediate uveitis: an unusual presentation of cytomegalovirus intraocular infection in an immunocompetent patient.

We report a case of cytomegalovirus (CMV) intraocular infection in an otherwise healthy 51-year-old patient, presenting atypically as isolated intermediate uveitis without retinitis or retinal vasculitis. The patient had a confirmed CMV infection as a cause of her intraocular inflammation via PCR DNA testing of an aqueous sample. Appropriate oral antiviral therapy was initiated, and resulted in complete resolution of inflammation and improvement in visual acuity. Prophylactic therapy was instituted thereafter.

[Intermediate uveitis due to human T-cell lymphotropic virus type 1]. / Uveítis intermedia por virus linfotropo humano de células T Tipo 1.

CASE REPORT: The case of a 66-year-old woman with intermediate uveitis in both eyes and progressive weakness of lower limbs is reported. A human T-lymphotropic virus type 1 (HTLV-1) infection was detected in the serological study, with the patient being diagnosed with tropical spastic paraparesis and HTLV-1 intermediate uveitis. The patient made good progress with oral steroid treatment. DISCUSSION: The clinical and epidemiological aspects of HTLV-1 infection are discussed. We recommend a serological determination of the virus in intermediate uveitis of unknown origin in people from endemic areas or with neurological symptoms.

Rubella-related intermediate uveitis in pregnancy--a rare presentation.

PURPOSE: To report a rare case of intermediate uveitis following rubella infection in pregnancy. DESIGN: Case report. METHODS: A 35-year-old pregnant woman, at 24 weeks of gestation, presented with sudden floaters and blurring of vision of the left eye. Ocular examination revealed vitritis 1-2+ with no retinal involvement. Rubella serology showed a high IgG titr eof 268 IU/mL. Treatment with periocular steroids (posterior subtenon triamcinalone) injection into the left eye was initiated. RESULTS: Improvement of vision with resolution of the vitritis was seen after 3 weeks. Repeat rubella IgG titer dropped to 20.4 IU/mL. Obstetrics evaluation of the fetus remained normal. CONCLUSIONS: Rubella-related intermediate uveitis is a very rare presentation during pregnancy. It is worthwhile to investigate for rubella infections in pregnant patients complaining of recent onset of visual disturbances. This type of intermediate uveitis can be treated successfully with minimal ocular complications if recognized early.

Uveitis in children with human immunodeficiency virus-associated arthritis.

PURPOSE: To describe the ocular inflammatory manifestations and clinical characteristics of children with Human Immunodeficiency Virus (HIV)-associated arthritis. METHODS: A retrospective review of the charts of children with chronic uveitis and HIV-associated arthritis seen between June 2004 and September 2006 at Inkosi Albert Luthuli Central Hospital, Durban, South Africa. The following data were analyzed: age at presentation, gender, race/ethnicity, rheumatologic problems, uveitic diagnosis, laboratory findings, and ocular complications. RESULTS: Seven black African males with a mean age of 9 years (range, 4 to 13 years) were identified. There were no other significant laboratory findings apart from HIV; all patients were antinuclear antibody negative. Arthritis was polyarticular in 6 patients and pauciarticular in 1. Four patients had intermediate uveitis and 3 patients had nongranulomatous anterior uveitis. Visual acuity ranged from 20/20 to hand movements. Ocular complications included cataract, cystoid macular edema, hypotony, pupillary membranes, band keratopathy, posterior synechiae and optic disk edema. CONCLUSIONS: HIV-associated arthritis and uveitis in children is a clinical syndrome that may be associated with severe sight-threatening intraocular inflammation. Routine eye screening in HIV-positive children, particularly those with arthritis, is warranted to facilitate prompt treatment.