RESUMEN
Accurate estimation of distortion-free spectra is important but difficult in various applications, especially for spectral computed tomography. Two key problems must be solved to reconstruct the incident spectrum. One is the acquisition of the detector energy response. It can be calculated by Monte Carlo simulation, which requires detailed modeling of the detector system and a high computational power. It can also be acquired by establishing a parametric response model and be calibrated using monochromatic x-ray sources, such as synchrotron sources or radioactive isotopes. However, these monochromatic sources are difficult to obtain. Inspired by x-ray fluorescence (XRF) spectrum modeling, we propose a feasible method to obtain the detector energy response based on an optimized parametric model for CdZnTe or CdTe detectors. The other key problem is the reconstruction of the incident spectrum with the detector response. Directly obtaining an accurate solution from noisy data is difficult because the reconstruction problem is severely ill-posed. Different from the existing spectrum stripping method, a maximum likelihood-expectation maximization iterative algorithm is developed based on the Poisson noise model of the system. Simulation and experiment results show that our method is effective for spectrum reconstruction and markedly increases the accuracy of XRF spectra compared with the spectrum stripping method. The applicability of the proposed method is discussed, and promising results are presented.
Asunto(s)
Cadmio/normas , Telurio/normas , Tomografía Computarizada por Rayos X/normas , Zinc/normas , Algoritmos , Cadmio/efectos de la radiación , Calibración , Fluorescencia , Sincrotrones , Telurio/efectos de la radiación , Tomografía Computarizada por Rayos X/instrumentación , Tomografía Computarizada por Rayos X/métodos , Rayos X , Zinc/efectos de la radiaciónRESUMEN
Fortified rice holds great potential for bringing essential micronutrients to a large part of the world population. The present study quantified the losses of three different micronutrients (vitamin A, iron, zinc) in fortified rice that were produced using three different techniques (hot extrusion, cold extrusion, and coating) and stored at two different environments (25 ± 5 °C at a humidity of 60% and 40 ± 5 °C at a humidity of 75%) for up to one year. Fortified rice premix from the different techniques was mixed with normal rice in a 1:100 ratio. Each sample was analyzed in triplicate. The study confirmed the high stability of iron and zinc during storage while the retention of vitamin A was significantly affected by storage and the type of techniques used to make rice premix. Losses for iron and zinc were typically <10% for any type of rice premix. After 12 months at mild conditions (25 °C and humidity of 60%), losses for vitamin A ranged from 20% for cold extrusion, 30% for hot extruded rice 77% for coated rice premix. At higher temperatures and humidity, losses of vitamin A were 40%-50% for extruded premix and 93% for coated premix after 6 months. We conclude that storage does lead to a major loss of vitamin A and question whether rice is a suitable food vehicle to fortify with vitamin A. For Cambodia, fortification of rice with iron and zinc could be an effective strategy to improve the micronutrient status of the population if no other food vehicles are available.
Asunto(s)
Almacenamiento de Alimentos/métodos , Alimentos Fortificados/análisis , Hierro/análisis , Oryza/química , Vitamina A/análisis , Zinc/análisis , Cambodia , Almacenamiento de Alimentos/normas , Alimentos Fortificados/normas , Humedad/efectos adversos , Hierro/normas , Micronutrientes/análisis , Micronutrientes/normas , Programas Nacionales de Salud/normas , Temperatura , Oligoelementos/análisis , Oligoelementos/normas , Vitamina A/normas , Zinc/normasRESUMEN
Recent years have seen considerable improvement in water quality standards (QS) for metals by taking account of the effect of local water chemistry conditions on their bioavailability. We describe preliminary efforts to further refine water quality standards, by taking account of the composition of the local ecological community (the ultimate protection objective) in addition to bioavailability. Relevance of QS to the local ecological community is critical as it is important to minimise instances where quality classification using QS does not reconcile with a quality classification based on an assessment of the composition of the local ecology (e.g. using benthic macroinvertebrate quality assessment metrics such as River InVertebrate Prediction and Classification System (RIVPACS)), particularly where ecology is assessed to be at good or better status, whilst chemical quality is determined to be failing relevant standards. The alternative approach outlined here describes a method to derive a site-specific species sensitivity distribution (SSD) based on the ecological community which is expected to be present at the site in the absence of anthropogenic pressures (reference conditions). The method combines a conventional laboratory ecotoxicity dataset normalised for bioavailability with field measurements of the response of benthic macroinvertebrate abundance to chemical exposure. Site-specific QSref are then derived from the 5%ile of this SSD. Using this method, site QSref have been derived for zinc in an area impacted by historic mining activities. Application of QSref can result in greater agreement between chemical and ecological metrics of environmental quality compared with the use of either conventional (QScon) or bioavailability-based QS (QSbio). In addition to zinc, the approach is likely to be applicable to other metals and possibly other types of chemical stressors (e.g. pesticides). However, the methodology for deriving site-specific targets requires additional development and validation before they can be robustly applied during surface water classification.
Asunto(s)
Organismos Acuáticos/metabolismo , Monitoreo del Ambiente/métodos , Contaminantes Químicos del Agua/normas , Zinc/normas , Animales , Ecología , Ambiente , Invertebrados/metabolismo , Metales/análisis , Metales/metabolismo , Metales/normas , Minería , Plaguicidas/análisis , Plaguicidas/metabolismo , Plaguicidas/normas , Ríos/química , Contaminantes Químicos del Agua/análisis , Contaminantes Químicos del Agua/metabolismo , Zinc/análisis , Zinc/metabolismoRESUMEN
A certified reference material (CRM) for trace cadmium and other elements in brown rice flour was developed at the National Metrology Institute of Japan (NMIJ). The CRM was provided as a dry powder after drying and frozen pulverization of fresh brown rice obtained from a Japanese domestic market. Characterization of the property value for each element was carried out exclusively by NMIJ with at least two independent analytical methods, including inductively coupled plasma mass spectrometry (ICP-MS), ICP high-resolution mass spectrometry, isotope-dilution ICP-MS, ICP optical emission spectrometry, and graphite-furnace atomic-absorption spectrometry. Property values were provided for six elements (Mn, Fe, Cu, Zn, As, and Cd). The concentration range of the property values was from 0.280 mg kg(-1) of As to 31.8 mg kg(-1) of Zn. The combined relative standard uncertainties of the property values were estimated by considering the uncertainties of the homogeneity, characterization, difference among analytical methods, dry-mass correction factor, and calibration standard. The range of the relative combined standard uncertainties was from 1.1% of Zn to 1.6% of As.
Asunto(s)
Cadmio/análisis , Harina/análisis , Oryza/química , Arsénico/análisis , Arsénico/normas , Cadmio/normas , Calibración , Cobre/análisis , Cobre/normas , Harina/normas , Hierro/análisis , Hierro/normas , Manganeso/análisis , Manganeso/normas , Espectrometría de Masas , Zinc/análisis , Zinc/normasRESUMEN
The study has been performed on tears of apparently healthy subjects who live and work in urban and rural areas, respectively. After the collection the following elements were investigated: chromium (Cr); arsenic (As); copper (Cu); zinc (Zn); selenium (Se); rubidium (Rb); barium (Ba); lead (Pb) and cobalt (Co). Significantly higher values of As were found in subjects living and working in rural areas as compared to those found in urban area residents (0.290 vs. 0.025; p<0.001). Conversely, Ba and Pb were significantly lower in rural area residents (1.10 vs. 2.50, p=0.027 and 1.70 vs. 1.10, p=0.057, respectively). Our data show that trace elements analysis in tears is possible; further studies could define if it could be a reliable biomarker in persons exposed to high concentration of trace elements due to working or environmental reasons.
Asunto(s)
Exposición a Riesgos Ambientales/normas , Contaminantes Ambientales/análisis , Lágrimas/química , Oligoelementos/análisis , Arsénico/análisis , Arsénico/normas , Cromo/análisis , Cromo/normas , Cobalto/análisis , Cobalto/normas , Cobre/análisis , Cobre/normas , Exposición a Riesgos Ambientales/análisis , Exposición a Riesgos Ambientales/estadística & datos numéricos , Contaminantes Ambientales/normas , Humanos , Valores de Referencia , Selenio/análisis , Selenio/normas , Oligoelementos/normas , Zinc/análisis , Zinc/normasRESUMEN
The United States Environmental Protection Agency's (U.S. EPA) current ambient water quality criteria (AWQC) for zinc in freshwater are hardness-based and were last updated in 1995. The acute and chronic freshwater toxicity databases have since expanded substantially and the U.S. EPA's minimum phylogenetic diversity requirements for chronic zinc toxicity are now met (an acute:chronic ratio was previously required). Additionally, several acute and chronic biotic ligand models (BLMs) for zinc have since been developed and validated for freshwater organisms. Using the expanded toxicity database and existing BLMs, we developed a unified zinc BLM that could efficiently predict both acute and chronic toxicity over a wide range of zinc bioavailabilities. The unified BLM, developed by objectively averaging the biotic ligand binding constants for zinc (Zn(2+)) and competing cations (Ca(2+), Mg(2+), Na(+), H(+)) from existing BLMs, performed better in predicting toxicity to a diverse set of organisms than any individual existing BLM. Performance of the unified BLM was further improved by optimizing the biotic ligand binding constant for the ZnOH(+) species. The updated freshwater zinc toxicity database and unified BLM were then used to estimate the fifth percentiles of the acute and chronic species sensitivity distributions following the U.S. EPA guidelines for AWQC development.
Asunto(s)
Agua Dulce/química , Contaminantes Químicos del Agua/análisis , Calidad del Agua/normas , Zinc/análisis , Animales , Guías como Asunto , Estados Unidos , United States Environmental Protection Agency , Contaminantes Químicos del Agua/normas , Contaminantes Químicos del Agua/toxicidad , Zinc/normas , Zinc/toxicidadRESUMEN
Diurnal fluctuations of metals have been observed in the South Tyne river catchment, UK, in both upland tributaries and major river reaches. Zinc exhibits the most pronounced cyclicity, with concentrations increasing during the night to a maximum near 05:00 before decreasing during the day. This trend is the inverse of pH and temperature observations, which are thought to be the predominant drivers behind the cyclicity. Photosynthetic reactions of biomass and algae alter the pH within the river systems, therefore promoting hydrous metal oxide precipitation during the daylight which consequently allows divalent cations including zinc to sorb onto them. This mechanism may be supported by direct uptake of zinc by algae and other biogeochemical reactions which combine to create large differences in zinc concentrations; during base flow zinc concentrations increased by 326% from the minima over 48 hours. Maximum concentrations are not being captured during routine water quality analysis resulting in inaccurate and misleading EQS results and total flux estimations, for example the annual total zinc flux in a small tributary increases from 17 to 76 tonnes/year when routine grab sample data are supplemented with 24-hour sampling results.
Asunto(s)
Ríos/química , Contaminantes Químicos del Agua/análisis , Zinc/análisis , Arsénico/análisis , Concentración de Iones de Hidrógeno , Metales/análisis , Temperatura , Factores de Tiempo , Reino Unido , Contaminantes Químicos del Agua/normas , Calidad del Agua , Zinc/normasRESUMEN
In recent years, due to concerns on the potential effects of zinc on aquatic biota, zinc is receiving particular attention from regulatory agencies. A comprehensive exposure and risk assessment of zinc in Japanese surface waters was conducted to provide a scientific basis for developing realistic risk reduction measures for zinc. Emissions from corrosion contribute approximately 37% of the total zinc emissions to surface water in Japan. The zinc concentration distributions estimated using 12 years of monitoring data from 2075 sites by a maximum likelihood method indicated that the mean concentrations have gradually declined. The threshold concentrations (HC5 and PHC5) derived from organism- and population-level species sensitivity distributions were estimated to be 27 and 107 microg/L for total zinc, respectively. The risk characterization identified that during 1991-2002, 14.5-26.8% of the monitoring sites likely exceeded the HC5, whereas only 0.7-3.5% likely exceeded the PHC5. Evaluation of the effect of stormwater runoff to zinc concentrations in a river showed that zinc concentrations in river water increased significantly from roadway drainage flowing into the river. The cost-effectiveness analyses demonstrated that enforcement of the zinc national effluent standard may be effective at a certain level for public water areas in Japan; however, the degree of the effectiveness is highly dependent on the characteristics (e.g., sources and background) of the watersheds. An emissions and exposure assessment along with cost-effectiveness analysis is crucial for developing realistic and appropriate ecological risk management of zinc. The zinc RAD in Japan illustrated that in any "state-of-the science" method used, some degree of ecological risk from zinc can be observed in some Japanese water environments. On the other hand, zinc is a beneficial material for human industrial activities. Because zinc is an element, its role in industrial activities would be difficult to be substituted by other metals with less toxicity. In addition to improving science-based risk assessment methodologies which often focus on the toxicological perspectives, it is important to develop a more robust framework considering a trade-off between a damage in ecosystem and a benefit in human activities. Zinc can be a role model for it.
Asunto(s)
Exposición a Riesgos Ambientales/análisis , Agua Dulce/química , Contaminantes Químicos del Agua/análisis , Zinc/análisis , Análisis Costo-Beneficio , Exposición a Riesgos Ambientales/normas , Monitoreo del Ambiente , Japón , Medición de Riesgo , Gestión de Riesgos/economía , Contaminantes Químicos del Agua/normas , Contaminantes Químicos del Agua/toxicidad , Contaminación Química del Agua/prevención & control , Zinc/normas , Zinc/toxicidadRESUMEN
In Japan, the Environmental Quality Standard for zinc, established in 2003, was the first standard for the protection of aquatic species. To achieve this environmental criterion, the National Effluent Standard was lowered from 5 mgL(-1) to 2 mgL(-1) in 2006. However, some industries were permitted to apply a provisional effluent standard until 2011, when the provisional standard will revert to the national standard. Therefore, discussion about the environmental management of and countermeasures for the risk of zinc continues in Japan. The aim of this paper is to present the current status of the risk of zinc. Using long-term monitoring data for zinc from more than 3000 monitoring sites in Japan, both freshwater and marine, we found that the geometric mean concentration of zinc at freshwater sites was about 10.8 microgL(-1) and that the annual mean concentrations have been generally decreasing. We identified sites where zinc concentrations were high, and we also identified the most likely sources of zinc responsible for the high concentrations. The ecological risk of zinc was estimated at the conventional individual level and at the population level. Individual-level risk was detected at about 20% of freshwater sites, and population-level risk at about 2%. The risks were lower in more recent years; however, they remain at unacceptable levels. Our results show the necessity of risk reduction strategies. We propose a new approach for risk management and countermeasures that consider both individual- and population-level risks.
Asunto(s)
Contaminantes Químicos del Agua/análisis , Contaminación Química del Agua/estadística & datos numéricos , Zinc/análisis , Exposición a Riesgos Ambientales/análisis , Exposición a Riesgos Ambientales/normas , Monitoreo del Ambiente , Japón , Medición de Riesgo , Contaminantes Químicos del Agua/normas , Zinc/normasRESUMEN
New environmental standards for protecting aquatic organisms for zinc (e.g., 0.03 mg/L) in surface waters were set in Japan in 2003. Although wastewater effluent might be one of the major pathways of zinc to public water bodies in Japan, current status of concentration of zinc in wastewater effluent was not clear due to higher detection limits (e.g., 0.5 mg/L) than the level required by the new regulations. This study aims at assessing current status of zinc in wastewater effluent in Japan to revise wastewater effluent standards for protecting aquatic organisms. Survey of zinc in wastewater treatment plants (WWTPs) was carried out in Japan in 2005, setting the detection limits at least 0.01 mg/L. The results of the survey suggested the difficulty to remove zinc (especially dissolved zinc) with conventional activated sludge treatment if concentration of zinc in influent was relatively low. And it was suggested that high concentration of dissolved zinc might be derived from some industries discharging high concentration of zinc. The concentration of zinc in wastewater influent without industrial discharges was about 0.1 mg/L which might be lower than that in wastewater from industries discharging high concentration of zinc. Finally, effluent standards for point sources including WWTPs to public water bodies were set at 2 mg/L in 2006. Based on the results of the survey that it was difficult to remove dissolved zinc discharged from industries at WWTPs, the effluent standards from industries to sewerage were set at the same value of the effluent standards from WWTPs to public water bodies.
Asunto(s)
Organismos Acuáticos , Conservación de los Recursos Naturales , Eliminación de Residuos Líquidos/normas , Contaminantes Químicos del Agua/normas , Zinc/normas , Animales , Monitoreo del Ambiente , Japón , Eliminación de Residuos Líquidos/métodos , Contaminantes Químicos del Agua/análisis , Zinc/análisisRESUMEN
Environmental quality standards are an important tool for assessing the chemical quality of water bodies under the Water Framework Directive. However, there must be confidence in assessments of any failure to avoid disproportionate investment in unnecessary risk reduction. Metals present a number of unique challenges for environmental regulators in that they are naturally occurring and their ecotoxicology is driven, in part, by the physico-chemical conditions of the water body in which they are present. This paper describes the use of a tiered approach that could be adopted to assess compliance with any future environmental quality standards for metals under the Water Framework Directive. Through this approach, the use of background concentrations is considered and also bioavailability via the use of biotic ligand models. This assessment is based on an analysis of routine Environment Agency chemical monitoring data combined with biological indices to support results of the approach. Using copper and zinc as examples, it is shown that it is important to take account of background concentrations and the bioavailability of metals, otherwise the risk of impact from metals may be significantly overestimated. The approach presented here provides a methodology by which regulators and the regulated community may implement surface water standards for metals under the Water Framework Directive.
Asunto(s)
Cobre/normas , Monitoreo del Ambiente/métodos , Contaminantes Químicos del Agua/normas , Contaminación del Agua/prevención & control , Abastecimiento de Agua/normas , Zinc/normas , Cobre/análisis , Unión Europea , Estándares de Referencia , Medición de Riesgo/métodos , Medición de Riesgo/normas , Contaminantes Químicos del Agua/análisis , Abastecimiento de Agua/análisis , Zinc/análisisAsunto(s)
Bovinos/metabolismo , Contaminantes Ambientales/análisis , Zinc/análisis , Animales , Monitoreo del Ambiente , Contaminantes Ambientales/metabolismo , Contaminantes Ambientales/normas , Femenino , Riñón/química , Hígado/química , Metalurgia , Músculos/química , Miocardio/química , Eslovaquia , Zinc/metabolismo , Zinc/normasRESUMEN
Copper, mercury, and zinc levels were determined in muscle and liver (N = 163) of seven fish species caught in coastal waters off Montevideo and Piriapolis (control site): Odontesthes spp., Mugil platanus, Micropogonias furnieri, Urophycis brasiliensis, Cynoscion guatucupa, Menticirrhus americanus, and Mustelus schmitti. The local population commonly uses these species for consumption. Heavy metal concentrations determined in this study were generally below those obtained for fish caught in Argentinean and Brazilian coastal waters, with some exceptions in the case of mercury and zinc. Based on copper, mercury, and zinc levels in muscle tissue, we conclude that the fish studied here are acceptable for human consumption. Nevertheless, it is recommended not to consume the fish liver (up to 466 microg Zn g(-1) dry weight in liver) nor large specimens of the investigated species. Regional programs involving the neighboring countries should be established to assess the fisheries resources and potential risks for human health.
Asunto(s)
Cobre/análisis , Peces/metabolismo , Contaminación de Alimentos/análisis , Mercurio/análisis , Contaminantes Químicos del Agua/análisis , Zinc/análisis , Animales , Cobre/metabolismo , Cobre/normas , Monitoreo del Ambiente , Contaminación de Alimentos/estadística & datos numéricos , Sedimentos Geológicos/análisis , Hígado/química , Mercurio/metabolismo , Mercurio/normas , Músculos/química , Agua de Mar/análisis , Uruguay , Contaminantes Químicos del Agua/metabolismo , Contaminantes Químicos del Agua/normas , Zinc/metabolismo , Zinc/normasRESUMEN
The heavy metal zinc is an element of natural origin. Adverse effects of chemicals on soil ecosystems depend on the soil type. Therefore, soil type-specific variation in natural background concentration and toxicity data should be taken into account in the derivation of environmental quality standards for zinc. In this paper, a methodology is presented, taking the specific features of natural occurrence and soil type into account by deriving soil type-specific background concentrations as well as soil type-specific maximum permissible additions (MPAs) for zinc in Dutch soil. The strategy used to perform a soil type-specific risk assessment for zinc consisted of 6 steps: identification of soil types, determination of characteristic background concentrations, selection of characteristic organisms, determination of no-observed-effect concentrations (NOECs), and derivations of the MPA and the maximum permissible concentration (MPC). Differences in background concentrations between different Dutch soil types were up to a factor of 7.5, whereas the MPA between the soil types varied by up to a factor of 3. This resulted in MPCs for the 3 predominant soil types that vary from 44 mg/kg dry weight (dry wt) to 208 mg/kg dry wt. Although large differences in MPC were observed, the uncertainties in background concentrations hinder setting more accurate environmental quality standards for zinc. Additional measurements on remote background concentrations of zinc in Dutch soil are needed to reduce the uncertainties in the calculated MPCs. The risk assessment approach discussed here is widely applicable to naturally occurring and anthropogenic substances.
Asunto(s)
Contaminantes del Suelo/normas , Suelo , Zinc/normas , Animales , Monitoreo del Ambiente , Países Bajos , Nivel sin Efectos Adversos Observados , Valores de Referencia , Medición de RiesgoRESUMEN
This study demonstrates the anti-Staphylococcus aureus properties of stainless steel surfaces coated with zeolite containing 2.5% silver and 14% zinc ions. Stainless steel panels with and without the heavy-metal-containing coatings were inoculated with S. aureus and incubated at room temperature. Survival of S. aureus was significantly reduced by the silver/zinc coatings within 1 h. Many hospital surfaces could be constructed of stainless steel with silver/zinc zeolite coatings. Such measures may reduce rates of hospital-acquired S. aureus infection.
Asunto(s)
Antibacterianos/normas , Cerámica/normas , Contaminación de Equipos/prevención & control , Plata/normas , Acero Inoxidable , Staphylococcus aureus/crecimiento & desarrollo , Zeolitas/normas , Zinc/normas , Recuento de Colonia Microbiana , Microbiología Ambiental , Humanos , Control de Infecciones/métodos , Control de Infecciones/normas , PolvosRESUMEN
Diet as a key factor in determining genomic stability is more important than previously imagined because we now know that it impacts on all relevant pathways, namely exposure to dietary carcinogens, activation/detoxification of carcinogens, DNA repair, DNA synthesis and apoptosis. Current recommended dietary allowances for vitamins and minerals are based largely on the prevention of diseases of deficiency such as scurvy in the case of vitamin C. Because diseases of development, degenerative disease and aging itself are partly caused by damage to DNA it seems logical that we should focus better our attention on defining optimal requirements of key minerals and vitamins for preventing damage to both nuclear and mitochondrial DNA. To date, our knowledge on optimal micronutrient levels for genomic stability is scanty and disorganised. However, there is already sufficient evidence to suggest that marginal deficiencies in folate, vitamin B12, niacin and zinc impact significantly on spontaneous chromosome damage rate. The recent data for folate and vitamin B12 in humans with respect to micronucleus formation in blood and epithelial cells provide compelling evidence of the important role of these micronutrients in maintenance of genome integrity and the need to revise current RDAs for these micronutrients based on minimisation of DNA damage. Appropriately designed in vitro studies and in vivo placebo controlled trials with dose responses using a complementary array of DNA damage biomarkers are required to define recommended dietary allowances for genomic stability. Furthermore these studies would have to be targeted to individuals with common genetic polymorphisms that alter the bioavailability of specific micronutrients and the affinity of specific key enzymes involved in DNA metabolism for their micronutrient co-factor. That there is a need for an international collaborative effort to establish RDAs for genomic stability is self-evident.
Asunto(s)
Daño del ADN/efectos de los fármacos , Enfermedades Carenciales/prevención & control , Dieta/normas , Micronutrientes/farmacología , Política Nutricional , Daño del ADN/fisiología , ADN Mitocondrial/efectos de los fármacos , Ácido Fólico/farmacología , Ácido Fólico/normas , Genoma Humano , Humanos , Micronúcleos con Defecto Cromosómico/efectos de los fármacos , Micronutrientes/fisiología , Micronutrientes/normas , Niacina/farmacología , Niacina/normas , Necesidades Nutricionales , Estados Unidos , Vitamina B 12/farmacología , Vitamina B 12/normas , Zinc/farmacología , Zinc/normasAsunto(s)
Política Nutricional , Adulto , Preescolar , Proteínas en la Dieta/normas , Ingestión de Energía , Femenino , Humanos , Indonesia , Lactante , Yodo/normas , Hierro de la Dieta/normas , Masculino , Embarazo , Vitamina A/normas , Zinc/normasRESUMEN
The zinc and selenium levels of 40 surgical patients were monitored pre- and post-TPN. The initial selenium level was low normal, and the initial zinc level was also low. Both selenium and zinc are potent antioxidants involved in cellular defense against free radicals. Surgical patients are at risk for selenium and zinc deficiencies secondary to both increased needs and losses. TPN blood work protocols should include monitoring of selenium and zinc with supplementation of the nutrient solutions, as required.
Asunto(s)
Nutrición Parenteral Total/normas , Selenio/sangre , Procedimientos Quirúrgicos Operativos , Zinc/sangre , Adulto , Anciano , Humanos , Persona de Mediana Edad , Estado Nutricional , Prealbúmina/análisis , Valores de Referencia , Selenio/administración & dosificación , Selenio/normas , Espectrofotometría Atómica , Zinc/administración & dosificación , Zinc/normasRESUMEN
Anthropological pollutions falling in the soil by different routes evolve multitude unfavourable consequences for human being and health. The present publication considers a laboratory survey on the influence of lead, copper and zinc by their combined presence in soil onto soil autocleaning ability. The results from the experiments will serve the goals of complex hygiene standards of these three soil pollutants. A number of micro-organisms, relating to soil as an ecological compartment, are tested by two hygienic microbiological methods. The results from experiments point out as maximum permissible concentration (MPC) the following combination of concentrations within the range of the microbiological index: lead--54 mg/kg, copper--90 mg/kg, zinc--165 mg/kg. Concentrations over the above-mentioned have an oppressive effect on saprophytic microflora in higher rate than the observed impact of pathogenic micro-organisms. In conditions of MPC higher than the reached ones the autocleaning ability of the soil is threatened and thus a basis with unfavourable epidemiological indicators is established.
Asunto(s)
Cobre/toxicidad , Plomo/toxicidad , Microbiología del Suelo , Contaminantes del Suelo/toxicidad , Zinc/toxicidad , Cobre/normas , Relación Dosis-Respuesta a Droga , Ecología , Plomo/normas , Concentración Máxima Admisible , Pruebas de Sensibilidad Microbiana/métodos , Pruebas de Sensibilidad Microbiana/estadística & datos numéricos , Contaminantes del Suelo/normas , Zinc/normasRESUMEN
Oral submucous fibrosis (OSF) is an oral precancerous condition characterized by symptoms such as intolerance to spicy food, altered salivation, progressive difficulty in opening the mouth, and signs like vesiculation, ulceration, blanching, rigidity, and stiffening of the oral mucosa and depapillation and altered mobility of the tongue. It is seen mostly among people of Indian subcontinent origin. The major structural change is extensive fibroelastic scarring of the lamina propria and deeper connective tissues. A combination of micronutrients (vitamins A, B complex, C, D, and E) and minerals (iron, calcium, copper, zinc, magnesium, and others) was evaluated for its efficacy in controlling the symptoms and signs of OSF in 117 compliant subjects in Karachi, Pakistan, in a single-arm preliminary study. The subjects received supplementation for one to three years. Significant improvement in symptoms, notably intolerance to spicy food, burning sensation, and mouth opening, was observed at exit. The interincisor distance deteriorated in 11 subjects (10%) at exit; it was stable in 56 subjects (49%) and improved in 48 (41%). The mean interincisor distance was 19.1 +/- 10.8 (SD) mm at exit compared with 16.2 +/- 7.5 mm at baseline. A significant proportion of concomitant lesions like leukoplakia also regressed at exit. The major outcome from this study was a beneficial clinical response in subjects with OSF to multiple micronutrient intervention, which justifies its further evaluation in well-designed randomized controlled trials in other settings in South Asia.