Optimizing chemotherapy treatment outcomes using metaheuristic optimization algorithms: A case study.

BACKGROUND: This study explores the dynamics of a mathematical model, utilizing ordinary differential equations (ODE), to depict the interplay between cancer cells and effector cells under chemotherapy. The stability of the equilibrium points in the model is analysed using the Jacobian matrix and eigenvalues. Additionally, bifurcation analysis is conducted to determine the optimal values for the control parameters. OBJECTIVE: To evaluate the performance of the model and control strategies, benchmarking simulations are performed using the PlatEMO platform. METHODS: The Pure Multi-objective Optimal Control Problem (PMOCP) and the Hybrid Multi-objective Optimal Control Problem (HMOCP) are two different forms of optimal control problems that are solved using revolutionary metaheuristic optimisation algorithms. The utilization of the Hypervolume (HV) performance indicator allows for the comparison of various metaheuristic optimization algorithms in their efficacy for solving the PMOCP and HMOCP. RESULTS: Results indicate that the MOPSO algorithm excels in solving the HMOCP, with M-MOPSO outperforming for PMOCP in HV analysis. CONCLUSION: Despite not directly addressing immediate clinical concerns, these findings indicates that the stability shifts at critical thresholds may impact treatment efficacy.

Entropy optimization and response surface methodology of blood hybrid nanofluid flow through composite stenosis artery with magnetized nanoparticles (Au-Ta) for drug delivery application.

Entropy creation by a blood-hybrid nanofluid flow with gold-tantalum nanoparticles in a tilted cylindrical artery with composite stenosis under the influence of Joule heating, body acceleration, and thermal radiation is the focus of this research. Using the Sisko fluid model, the non-Newtonian behaviour of blood is investigated. The finite difference (FD) approach is used to solve the equations of motion and entropy for a system subject to certain constraints. The optimal heat transfer rate with respect to radiation, Hartmann number, and nanoparticle volume fraction is calculated using a response surface technique and sensitivity analysis. The impacts of significant parameters such as Hartmann number, angle parameter, nanoparticle volume fraction, body acceleration amplitude, radiation, and Reynolds number on the velocity, temperature, entropy generation, flow rate, shear stress of wall, and heat transfer rate are exhibited via the graphs and tables. Present results disclose that the flow rate profile increase by improving the Womersley number and the opposite nature is noticed in nanoparticle volume fraction. The total entropy generation reduces by improving radiation. The Hartmann number expose a positive sensitivity for all level of nanoparticle volume fraction. The sensitivity analysis revealed that the radiation and nanoparticle volume fraction showed a negative sensitivity for all magnetic field levels. It is seen that the presence of hybrid nanoparticles in the bloodstream leads to a more substantial reduction in the axial velocity of blood compared to Sisko blood. An increase in the volume fraction results in a noticeable decrease in the volumetric flow rate in the axial direction, while higher values of infinite shear rate viscosity lead to a significant reduction in the magnitude of the blood flow pattern. The blood temperature exhibits a linear increase with respect to the volume fraction of hybrid nanoparticles. Specifically, utilizing a hybrid nanofluid with a volume fraction of 3% leads to a 2.01316% higher temperature compared to the base fluid (blood). Similarly, a 5% volume fraction corresponds to a temperature increase of 3.45093%.

Dynamics of Rotating Micropolar Fluid over a Stretch Surface: The Case of Linear and Quadratic Convection Significance in Thermal Management.

This article analyzes the significance of linear and quadratic convection on the dynamics of micropolar fluid due to a stretching surface in the presence of magnetic force and a rotational frame. Modern technological implementations have attracted researchers to inquire about non-Newtonian fluids, so the effect of linear and nonlinear convection conditions is accounted for in the dynamics of non-Newtonian fluid. The highly nonlinear governing equations are converted into a system of dimensionless ODEs by using suitable similarity transformations. The bvp4c technique is applied in MATLAB software to obtain a numerical solution. This investigation examines the behavior of various parameters with and without quadratic convection on the micro-rotation, velocity, and temperature profiles via graphical consequences. The velocity profile decreases with a higher input by magnetic and rotating parameters, and fluid velocity is more elevated in the nonlinear convection case. However, the temperature profile shows increasing behavior for these parameters and quadratic convection increases the velocity profile but has an opposite tendency for the temperature distribution. The micro-rotation distribution is augmented for higher magnetic inputs in linear convection but reduces against thermal buoyancy.

Mixed Convection Nanofluid Flow with Heat Source and Chemical Reaction over an Inclined Irregular Surface.

Two-dimensional mixed convection radiative nanofluid flow along with the non-Darcy permeable medium across a wavy inclined surface are observed in the present analysis. The transformation of the plane surface from the wavy irregular surface is executed via coordinate alteration. The fluid flow has been evaluated under the outcomes of heat source, thermal radiation, and chemical reaction rate. The nonlinear system of partial differential equations is simplified into a class of dimensionless set of ordinary differential equations (ODEs) through a similarity framework, where the obtained set of ODEs are further determined by employing the computational technique parametric continuation method (PCM) via MATLAB software. The comparative assessment of the current outcomes with the earlier existing literature studies confirmed that the present findings are quite reliable, and the PCM technique is satisfactory. The effect of appropriate dimensionless flow constraints is studied versus energy, mass, and velocity profiles and listed in the form of tables and figures. It is perceived that the inclination angle and wavy surface assist to improve the flow velocity by lowering the concentration and temperature. The velocity profile enhances with the variation of the inclination angle of the wavy surface, non-Darcian term, and wavy surface term. Furthermore, the rising value of Brownian motion and thermophoresis effect diminishes the heat-transfer rate.

Insight into the Role of Nanoparticles Shape Factors and Diameter on the Dynamics of Rotating Water-Based Fluid.

This article addresses the dynamic of three-dimensional rotating flow of Maxwell nanofluid across a linearly stretched sheet subject to a water-based fluid containing copper nanoparticles. Nanoparticles are used due to their fascinating features, such as exceptional thermal conductivity, which is crucial in modern nanotechnology and electronics. The primary goal of this comprehensive study is to examine the nanoparticles size and shape factors effect on the base fluid temperature. The mathematical model contains the governing equations in three dimensional partial differential equations form, and these equations transformed into dimensionless ordinary dimensional equations via suitable similarity transformation. The bvp4c technique is harnessed and coded in Matlab script to obtain a numerical solution of the coupled non-linear ordinary differential problem. It is observed that the greater input of rotating, Deborah number, and magnetic parameters caused a decline in the fluid primary and secondary velocities, but the nanoparticles concentration enhanced the fluid temperature. Further, a substantial increment in the nanofluid temperature is achieved for the higher nanoparticle's diameter and shape factors.

Bio-Convection Effects on Prandtl Hybrid Nanofluid Flow with Chemical Reaction and Motile Microorganism over a Stretching Sheet.

This study aims to determine the heat transfer properties of a magnetohydrodynamic Prandtl hybrid nanofluid over a stretched surface in the presence of bioconvection and chemical reaction effects. This article investigates the bio-convection, inclined magnetohydrodynamic, thermal linear radiations, and chemical reaction of hybrid nanofluid across stretching sheets. Also, the results are compared with the nanofluid flow. Moreover, the non-Newtonian fluid named Prandtl fluid is considered. Microfluidics, industry, transportation, the military, and medicine are just a few of the real-world applications of hybrid nanofluids. Due to the nonlinear and convoluted nature of the governing equations for the problem, similarity transformations are used to develop a simplified mathematical model with all differential equations being ordinary and asymmetric. The reduced mathematical model is computationally analyzed using the MATLAB software package's boundary value problem solver, Runge-Kutta-fourth-fifth Fehlberg's order method. When compared to previously published studies, it is observed that the acquired results exhibited a high degree of symmetry and accuracy. The velocity profiles of basic nanofluid and hybrid nanofluid are increased by increasing the Prandtl parameters' values, which is consistent with prior observations. Additionally, the concentration and temperature of simple and hybrid nanofluids increase with the magnetic parameter values.

Numerical Analysis of an Unsteady, Electroviscous, Ternary Hybrid Nanofluid Flow with Chemical Reaction and Activation Energy across Parallel Plates.

Despite the recycling challenges in ionic fluids, they have a significant advantage over traditional solvents. Ionic liquids make it easier to separate the end product and recycle old catalysts, particularly when the reaction media is a two-phase system. In the current analysis, the properties of transient, electroviscous, ternary hybrid nanofluid flow through squeezing parallel infinite plates is reported. The ternary hybrid nanofluid is synthesized by dissolving the titanium dioxide (TiO2), aluminum oxide (Al2O3), and silicon dioxide (SiO2) nanoparticles in the carrier fluid glycol/water. The purpose of the current study is to maximize the energy and mass transfer rate for industrial and engineering applications. The phenomena of fluid flow is studied, with the additional effects of the magnetic field, heat absorption/generation, chemical reaction, and activation energy. The ternary hybrid nanofluid flow is modeled in the form of a system of partial differential equations, which are subsequently simplified to a set of ordinary differential equations through resemblance substitution. The obtained nonlinear set of dimensionless ordinary differential equations is further solved, via the parametric continuation method. For validity purposes, the outcomes are statistically compared to an existing study. The results are physically illustrated through figures and tables. It is noticed that the mass transfer rate accelerates with the rising values of Lewis number, activation energy, and chemical reaction. The velocity and energy transfer rate boost the addition of ternary NPs to the base fluid.

Significance low oscillating magnetic field and Hall current in the nano-ferrofluid flow past a rotating stretchable disk.

The present investigation involves the Hall current effects past a low oscillating stretchable rotating disk with Joule heating and the viscous dissipation impacts on a Ferro-nanofluid flow. The entropy generation analysis is carried out to study the impact of rotational viscosity by applying a low oscillating magnetic field. The model gives the continuity, momentum, temperature, magnetization, and rotational partial differential equations. These equations are transformed into the ODEs and solved by using bvp4c MATLAB. The graphical representation of arising parameters such as effective magnetization and nanoparticle concentration on thermal profile, velocity profile, and rate of disorder along with Bejan number is presented. Drag force and the heat transfer rate are given in the tabular form. It is comprehended that for increasing nanoparticle volume fraction and magnetization parameter, the radial, and tangential velocity reduce while thermal profile surges. The comparison of present results for radial and axial velocity profiles with the existing literature shows approximately the same results.

Heat Transfer and Entropy in a Vertical Porous Plate Subjected to Suction Velocity and MHD.

This article presents an investigation of heat transfer in a porous medium adjacent to a vertical plate. The porous medium is subjected to a magnetohydrodynamic effect and suction velocity. The governing equations are nondepersonalized and converted into ordinary differential equations. The resulting equations are solved with the help of the finite difference method. The impact of various parameters, such as the Prandtl number, Grashof number, permeability parameter, radiation parameter, Eckert number, viscous dissipation parameter, and magnetic parameter, on fluid flow characteristics inside the porous medium is discussed. Entropy generation in the medium is analyzed with respect to various parameters, including the Brinkman number and Reynolds number. It is noted that the velocity profile decreases in magnitude with respect to the Prandtl number, but increases with the radiation parameter. The Eckert number has a marginal effect on the velocity profile. An increased radiation effect leads to a reduced thermal gradient at the hot surface.