Synthesis of (2-chloroquinolin-3-yl)-1,3,4-thiadiazole-2-carboxamides.

(2-Chloroquinolin-3-yl)-1,3,4-thiadiazole-2-carboxamides were synthesized from hydrazones obtained via the reaction of 3-formyl-2-chloroquinoline with oxamic acid thiohydrazides.

[Placental mesenchymal dysplasia]. / Mezenkhimal'naia displaziia platsenty.

OBJECTIVE: To carry out a clinical and morphological analysis of 6 cases of placental mesenchymal dysplasia (PMD) that is not associated with Beckwith-Wiedemann syndrome. MATERIAL AND METHODS: Medical records, placental macroscopic and microscopic changes, histochemical (MSB staining) and immunohistochemical studies of placental tissue with antibodies against p57, CD34, smooth muscle actin, desmin, and Ki-67 were analyzed. RESULTS: Vascular anomalies in the chorionic plate and stem villi, the increased size and edema of the stem villi during normal formation of the terminal branches of the villous tree, the lack of proliferation of villous trophoblast were the typical signs of PMD and were noted in all cases. Comparison of the results of ultrasonography with the morphological pattern of the disease suggested that there were ultrasound signs that were typical of PMD. The characteristics of the course and outcomes of pregnancy in PMD were given. The features of morphological changes in the presence of PMD concurrent with preeclampsia were found. Significant variability in p57 expression in PMD was shown and variants of changes given. There were no substantial features of the expression of desmin and smooth muscle actin in PMD. CONCLUSION: MDP has typical morphological and ultrasound signs. The significant variability in the levels of chorionic gonadotropin and alpha-fetoprotein and in the expression of p57 does not allow their use in the differential diagnosis of PMD. The high incidence of thrombotic events in the intervillous space and fetal vessels, as well as intrauterine growth restriction, intrauterine hypoxia, and an impaired neonatal adaptation period in PMD should be taken into account when determining the management tactics for female patients and newborns.

[The significance of the material of vascular catheters in the development of thrombotic complications in cava catheterization]. / Znachenie materiala sosudistykh kateterov v razvitii tromboticheskikh oslozhenii pri kavokateterizatsii.

Based on 210 cases of putting polyurethane catheters through the subclavian vein the authors substantiate the significance of the catheter material for the development of the most frequent complications. In addition to the absence of clinically diagnosed thrombotic complications, the advantages of this material were confirmed in US investigation of tributaries of the vena cava superior in 27 patients with polyurethane cava catheters staying in the same position during 3 weeks. In all the patients there were no signs of a reaction of a central veins to the catheter.

[Characteristics of the state of the prostacyclin-thromboxane system in newborn infants after acute and chronic intrauterine hypoxia]. / Osobennosti sostoianiia prostatsiklin-tromboksanovoi sistemy u novorozhdennykh detei, perenesshikh ostruiu i khronicheskuiu vnutriutrobnuiu gipoksiiu.

Specific features of the prostacyclin-thromboxane system of 122 newborns with perinatal hypoxia of varying severity were detected in the course of the early neonatal period. Differences in the content of thromboxane and prostacyclin and their ratio in newborns' blood were revealed, which depended on the type of previous hypoxia and severity of adaptation disorders. The most manifest and stubborn shifts were observed in the babies with a history of grave chronic intrauterine hypoxia. The detected regularities help differentiate the therapy of the newborns with consideration for the type and severity of hypoxia.

[The functional characteristics of the prostacyclin-thromboxane system in newborn infants with a history of acute and chronic intrauterine hypoxia]. / Osobennosti sostoianiia protsatsiklin-tromboksanovoi sistemy u novorozhdennykh detei, perenesshikh ostruiu i khronicheskuiu vnutriutrobnuiu gipoksiiu.

Specific features of the prostacyclin-thromboxan system were revealed in 122 newborns with perinatal hypoxia of various severity in the course of the early neonatal period. Differences in blood prostacyclin and thromboxan levels and their ratio were revealed in newborns who suffered different forms of hypoxia and adaptation disturbances of varying severity. The most pronounced and stubborn changes were characteristic of infants with a history of grave chronic intrauterine hypoxia.

[Preoperative preparation for abdominal delivery of pregnant women with fetal distress]. / Podgotovka k abdominal'nomu rodorazresheniiu beremennykh so stradaniem ploda.

A complex of the methods currently available for examining the fetoplacental system was used in 36 patients with severe extragenital and obstetric abnormalities, which allowed the authors to diagnose fetal affections such as hypoxia, hormonal dysfunction of the fetoplacental system before abdominal delivery. The employment of differential drug preparation for cesarean section with due regard to the severity of the fetus' status, maturity and the pattern of an obstetric and extragenital abnormality enhanced the adaptabilities of the fetus and improved perinatal parameters in cesarean section.