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1.
Clin Exp Allergy ; 42(2): 284-92, 2012 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-22181034

RESUMO

BACKGROUND: Although adrenaline is recommended as first line treatment for anaphylaxis, it is often not utilized. There has been a debate about when adrenaline autoinjectors should be prescribed and how many should be dispensed. OBJECTIVES: To see how many adrenaline autoinjectors were used during anaphylactic reactions and to determine why they were not used in situations where they were clinically indicated. METHODS: Patients were recruited prospectively at 14 paediatric allergy clinics throughout UK. Participants completed a questionnaire covering demographic data, atopic status and details of allergic reactions in the previous year and reasons for using more than one device. RESULTS: A total of 969 patients were recruited of whom 466 (48.1%, 95% CI: 37.9-58.2) had had at least one reaction in the previous year; 245 (25.3%, 95% CI: 16.2-34.4) of these reactions were anaphylaxis. An adrenaline autoinjector was used by 41 (16.7%, 95% CI: 11.7-21.3) participants experiencing anaphylaxis. Thirteen participants received more than one dose of adrenaline, for nine of these a health professional gave at least one. The commonest reasons for using more than one were severe breathing difficulties (40%), lack of improvement with first dose (20%) and miss-firing (13.3%). The commonest reasons for not using adrenaline in anaphylaxis were 'thought adrenaline unnecessary' (54.4%) and 'unsure adrenaline necessary' (19.1%). Many with wheeze did not use their autoinjector. CONCLUSIONS AND CLINICAL RELEVANCE: Adrenaline is used by only a minority of patients experiencing anaphylaxis in the community. Thirteen of the 41 patients with anaphylaxis who used their autoinjector needed another dose of adrenaline. Further research is needed to consider how to best encourage the usage of adrenaline when clinically indicated in anaphylaxis.


Assuntos
Agonistas alfa-Adrenérgicos/administração & dosagem , Anafilaxia/prevenção & controle , Epinefrina/administração & dosagem , Adolescente , Criança , Pré-Escolar , Feminino , Humanos , Injeções Subcutâneas/instrumentação , Injeções Subcutâneas/métodos , Masculino , Estudos Prospectivos , Reino Unido
3.
Eur Respir J ; 34(1): 176-9, 2009 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-19251788

RESUMO

The sensitivity of the Enhanced Tuberculosis Surveillance (ETS) scheme for monitoring tuberculosis in children is unknown. We used the British Paediatric Surveillance Unit (BPSU) reporting scheme to conduct a prospective observational study of tuberculosis in children aged <16 yrs in the UK. Reported cases were then matched with records from the ETS database. A total of 320 cases were reported to the BPSU between January and December 2004. We estimated that there were 557 paediatric cases in England, Wales and Northern Ireland in 2004: 222 (40%) cases reported to both BPSU and ETS, 98 (18%) reported to BPSU but not ETS and 237 (42%) reported to ETS but not BPSU. Children aged <5 yrs were significantly less likely to be reported to ETS compared with older children (p<0.01). There is substantial under-reporting of childhood tuberculosis, especially of children aged <5 yrs. ETS provides a representative picture of the demographics but may miss approximately 20% of cases. This should be taken into account when planning training and resource requirements for tuberculosis. Increased efforts are needed to ensure that all paediatric cases are reported to ETS.


Assuntos
Tuberculose/diagnóstico , Tuberculose/epidemiologia , Adolescente , Antituberculosos/uso terapêutico , Criança , Pré-Escolar , Inglaterra , Inquéritos Epidemiológicos , Humanos , Lactente , Recém-Nascido , Londres , Irlanda do Norte , Vigilância da População/métodos , Informática em Saúde Pública/métodos , País de Gales
4.
Arch Dis Child ; 94(4): 263-7, 2009 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-19052030

RESUMO

AIMS: To describe the clinical features, diagnosis and management of children with tuberculosis in the United Kingdom and Republic of Ireland. METHODS: Cases of culture-confirmed and clinically diagnosed tuberculosis were reported to the British Paediatric Surveillance Unit from December 2003 to January 2005. RESULTS: 385 eligible cases were reported. Pulmonary disease was present in 154 (40%) children. Just over half (197, 51%) of children presented clinically and most of the remainder (166, 43%) at contact tracing. A probable source case was identified for 73/197 (36%) of the children presenting clinically. The majority (253, 66%) of children had a microbiological and/or histological investigation, and culture results were available for 240 (62%), of whom 102 (26%) were culture positive. Drug resistance was reported in 15 (0.4%) cases. 44% (128/292) of non-white children did not receive the recommended quadruple drug therapy. Seven children died. Only 57% (217) of children were managed by a paediatric subspecialist in respiratory or infectious diseases or a general paediatrician with a special interest in one of these areas. Fewer than five cases were reported from 119/143 (83%) respondents and 72 of 96 (75%) centres. CONCLUSIONS: Many paediatricians and centres see few children with tuberculosis. This may affect adherence to national guidelines. Managed clinical networks for children with tuberculosis may improve management and should be the standard of care.


Assuntos
Tuberculose , Adolescente , Antituberculosos/uso terapêutico , Criança , Pré-Escolar , Feminino , Humanos , Lactente , Recém-Nascido , Irlanda , Masculino , Estudos Prospectivos , Tuberculose/diagnóstico , Tuberculose/tratamento farmacológico , Tuberculose Pulmonar/diagnóstico , Tuberculose Pulmonar/tratamento farmacológico , Reino Unido
5.
Arch Dis Child ; 91(11): 900-4, 2006 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-16737997

RESUMO

AIMS: To estimate the incidence of active tuberculosis (TB) and study the use of chemoprophylaxis for latent TB in children in Wales, and to identify potential areas for improving prevention and management. METHODS: Active surveillance for TB in children aged 0-15 years from July 1996 to December 2003, using the Welsh Paediatric Surveillance Scheme. RESULTS: A total of 232 children, 102 with active TB (2.3 per 100 000) and 130 with latent TB (2.9 per 100 000), were identified. Nearly half (45%) belonged to ethnic minorities (19% were of black African origin), a much higher proportion than the base population. Pulmonary disease was the most common presentation (47%), including six (9%) children who were sputum smear positive. There were 10 cases of disseminated TB, nearly all in white children under 10 years of age. Less than two thirds of eligible children (27/46, 59%) were known to have received BCG immunisation. The source of infection was an adult household contact in most cases, but was not known in 44 cases, particularly among teenagers. Four community outbreaks occurred during the surveillance period, including three in high schools. CONCLUSION: TB incidence in children in Wales remains low, but the epidemiology is changing with an increasing proportion of cases in black African children. The high proportion of patients with disseminated TB is of particular concern. TB in teenagers was often associated with school outbreaks. Many eligible children do not receive BCG immunisation, indicating further scope for prevention.


Assuntos
Tuberculose/epidemiologia , Adolescente , Antituberculosos/uso terapêutico , População Negra , Criança , Pré-Escolar , Feminino , Humanos , Incidência , Lactente , Recém-Nascido , Masculino , Vigilância da População , Tuberculose/terapia , País de Gales/epidemiologia
6.
Thorax ; 61(3): 247-9, 2006 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-16384882

RESUMO

BACKGROUND: Tuberculosis (TB) is a re-emerging problem, especially in the larger cities of Western Europe. Selective neonatal BCG vaccination is recommended for infants at risk of TB in the UK. Neonatal BCG is safe and effective, with an overall protective value of 75%. This study aimed to assess BCG rates among at risk infants in Cardiff and the Vale of Glamorgan, South Wales in the year 2003. METHODS: A cohort of infants at risk for TB was identified from demographic data stored on a computerised maternity activity database. A manual search of immunisation records determined overall rates and the rates for infants belonging to various ethnic groups. RESULTS: Of 5308 infants born in 2003, 514 (9.6%) were at risk of TB; 423 (82.2%) of these infants were referred postnatally for BCG vaccination and 391 received it. Twenty six of the 41 at risk white British infants missed having a BCG vaccination compared with 47 of 288 Asian infants and seven of 39 black African babies. The rate of BCG vaccination among white British infants was 36.5% compared with 83.6% for Asian infants from the Indian subcontinent (chi(2) = 7.25, p<0.01) and 82% for black African infants (chi(2) = 4.48, p<0.05). CONCLUSIONS: The overall BCG rate among at risk infants in Cardiff was 76% during the study period. The vaccination rate was poor among white British infants compared with other ethnic groups. Enhanced awareness of health professionals to recognise the need for vaccinating certain white children at risk of TB is essential to improve BCG coverage in an increasingly multiethnic population.


Assuntos
Vacina BCG , Imunização/estatística & dados numéricos , Aceitação pelo Paciente de Cuidados de Saúde/etnologia , Tuberculose/prevenção & controle , África/etnologia , Ásia/etnologia , Estudos de Coortes , Humanos , Lactente , Fatores de Risco , Tuberculose/etnologia , País de Gales/epidemiologia , População Branca/etnologia
10.
BJOG ; 109(8): 905-8, 2002 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-12197370

RESUMO

OBJECTIVE: To determine the vitamin D status of pregnant women from non-European ethnic minorities in South Wales. DESIGN: Prospective study. SETTING: Llandough Hospital, Cardiff, South Wales. SAMPLE: One hundred and sixty pregnant women from a non-European ethnic minority population in South Wales. METHODS: Biochemical screening of vitamin D status was carried out at the first antenatal visit. Women found to be deficient in vitamin D were subsequently supplemented and vitamin D status was rechecked at delivery. MAIN OUTCOME MEASURE: Vitamin D status at delivery. RESULTS: Eighty of 160 women had a vitamin D level below 8 ng/mL at their first antenatal visit and were treated with oral vitamin D. Factors that could influence vitamin D status such as religion, fluency in English and dressing habits did not appear to have any effect, although a higher proportion of women who had lived in Britain for longer than three years had subnormal vitamin D levels. In 58 of those checked at delivery, the mean plasma vitamin D level increased from 6 to 11 ng/mL although the mean parathyroid hormone level was unchanged. CONCLUSION: In view of the high incidence of subnormal vitamin D levels in women from ethnic minorities, we recommend biochemical screening of these women in early pregnancy, with subsequent supplementation where indicated.


Assuntos
Etnicidade , Complicações na Gravidez/etnologia , Deficiência de Vitamina D/etnologia , África/etnologia , Ásia/etnologia , Feminino , Humanos , Oriente Médio/etnologia , Gravidez , Estudos Prospectivos , País de Gales/epidemiologia , Índias Ocidentais/etnologia
12.
Arch Dis Child ; 78(4): 349-53, 1998 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-9623399

RESUMO

OBJECTIVES: To describe the epidemiology of childhood tuberculosis in Wales and to assess the standard of management of patients with tuberculosis. DESIGN: Retrospective study of data retrieved from case notes and review of radiographs of all identified patients. SUBJECTS: Forty eight cases of tuberculosis and 10 of tuberculosis chemoprophylaxis in children under 15 years of age, in Wales, between January 1986 and December 1992. MAIN OUTCOME MEASURES: Management of childhood tuberculosis in Wales compared with the published recommendations of the Joint Tuberculosis Committee of the British Thoracic Society. RESULTS: Documentation was poor in most of the 48 cases of tuberculosis and only 31 (65%) were formally notified. One third of patients were asymptomatic and were detected by contact tracing; only eight (17%) were culture positive. Only 20% of patients from ethnic minorities had previously been immunised with BCG. Management and chemotherapy varied widely. Few patients were managed jointly by paediatricians and chest doctors. Only 10% completed treatment with a recommended chemotherapy regimen. In 37% of patients treatment was inadequate, and in the remainder either the choice of drugs or the duration of treatment was inappropriate. No patient died, nor had any relapsed by June 1995. CONCLUSIONS: Very few cases of childhood tuberculosis were managed according to the recommendations of the British Thoracic Society.


Assuntos
Padrões de Prática Médica , Tuberculose/tratamento farmacológico , Adolescente , Criança , Pré-Escolar , Notificação de Doenças , Feminino , Humanos , Incidência , Lactente , Masculino , Pediatria , Pneumologia , Estudos Retrospectivos , Escarro/microbiologia , Teste Tuberculínico , Tuberculose/diagnóstico , Tuberculose/epidemiologia , País de Gales/epidemiologia
13.
Arch Dis Child ; 75(4): 342-3, 1996 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-8984925

RESUMO

A child presented with ischaemic episodes of his left leg from the age of 2 months. He was found to have raised anticardiolipin antibodies so was started on low dose aspirin. At a three year follow up he was asymptomatic with a normal anticardiolipin antibody level while taking aspirin daily, probably for life.


Assuntos
Síndrome Antifosfolipídica/complicações , Extremidades/irrigação sanguínea , Isquemia/etiologia , Doença Aguda , Anticorpos Anticardiolipina/sangue , Síndrome Antifosfolipídica/sangue , Síndrome Antifosfolipídica/tratamento farmacológico , Aspirina/uso terapêutico , Pré-Escolar , Humanos , Isquemia/tratamento farmacológico , Masculino , Inibidores da Agregação Plaquetária/uso terapêutico
14.
J Clin Pharm Ther ; 20(3): 165-6, 1995 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-7593378

RESUMO

Twelve patients with cystic fibrosis received 12 courses of intravenous antibiotics, each over 10-14 days, both with and without the use of an extended-life disposable filter. The design of the trial was to replace the Venflon cannulae as they became non-patent and inserting a filter on alternate occasions. Thus each patient acted as her/his own control. Comparison of times during which cannulae remained patent showed a 50% improvement with use of a filter for 4 patients and no change for 7 patients. There was no significant difference associated with the use of a filter for the group as a whole but our small sample size excludes modest improvements.


Assuntos
Antibacterianos/administração & dosagem , Cateterismo Periférico/métodos , Fibrose Cística/tratamento farmacológico , Filtração/instrumentação , Adolescente , Adulto , Criança , Estudos Cross-Over , Feminino , Humanos , Injeções Intravenosas , Masculino
15.
Br J Nutr ; 73(6): 881-7, 1995 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-7632669

RESUMO

Vitamin D status of Asian mothers in Cardiff was investigated during early pregnancy and at the time of the birth of their babies, using serum parathyroid hormone (PTH). Median values in Asian (n 32) and Caucasian (n 63) mothers in early pregnancy were 1.56 and 0.81 pmol/l respectively. PTH levels from a separate sample of nineteen Asian and twenty-five Caucasian mothers at the time of birth were 3.0 and 2.20 pmol/l respectively. Altogether twelve Asian and two Caucasian women had elevated PTH. All Asian women who had high PTH values also had a very low serum 25-hydroxycholecalciferol level (25OHD). All samples were taken from women with no significant medical history and normal obstetric history. These findings suggest that subclinical vitamin D deficiency is still a cause for concern in Asian women. More active measures need to be taken to implement current recommendations to improve their vitamin D intake in pregnancy.


Assuntos
Complicações na Gravidez/etnologia , Deficiência de Vitamina D/etnologia , Ásia/etnologia , Calcifediol/sangue , Feminino , Humanos , Estado Nutricional , Hormônio Paratireóideo/sangue , Gravidez , Vitamina D/sangue , Deficiência de Vitamina D/sangue , País de Gales
16.
Med Educ ; 28(2): 132-5, 1994 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-8208179

RESUMO

Most teaching of child health in Cardiff takes place in block attachments of 8 weeks. There is an introductory seminar of 2 days followed by a 6-week clinical attachment in a district general hospital in Wales, and then a revision period of one week designed to help students formalize and structure their basic knowledge and to clarify aspects of child health which they may have had difficulty in understanding. The revision programme has to take into account: the short time available, the small number of teaching staff, the most relevant basic knowledge and active participation by the student. This paper describes how this week has been improved through the use of student-initiated revision (SIR). The students' appraisal of this revision and in particular SIR is presented.


Assuntos
Proteção da Criança , Educação de Graduação em Medicina , Ensino/métodos , Criança , Avaliação Educacional , Humanos , Programas de Autoavaliação , País de Gales
17.
Br J Dermatol ; 129(1): 86-8, 1993 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-8369215

RESUMO

We describe transepidermal water loss (TEWL) measurements in a collodion baby suffering from severe hypernatraemic dehydration and hypothermia, who required intravenous fluid therapy in a special incubator. The TEWL values 4 days after birth were abnormally high compared with normal infants of the same age. The TEWL measurements returned towards normal within the first month, in parallel with the improvement of both the skin signs and the electrolyte and fluid balance.


Assuntos
Desidratação/etiologia , Hipernatremia/etiologia , Dermatopatias/congênito , Perda Insensível de Água/fisiologia , Desidratação/fisiopatologia , Feminino , Humanos , Hipernatremia/fisiopatologia , Recém-Nascido , Pele/patologia , Pele/fisiopatologia , Dermatopatias/patologia , Dermatopatias/fisiopatologia , Equilíbrio Hidroeletrolítico/fisiologia
18.
Clin Chim Acta ; 204(1-3): 279-90, 1991 Dec 31.
Artigo em Inglês | MEDLINE | ID: mdl-1819470

RESUMO

Vitamin E status was assessed in 22 patients with cystic fibrosis and 9 controls by measuring concentrations of the vitamin, vitamin E:lipid ratios and peroxide-induced haemolysis in plasma and erythrocytes. For a given concentration of plasma or erythrocyte alpha-tocopherol, erythrocytes of patients with cystic fibrosis were more susceptible to peroxide-induced haemolysis than controls. This susceptibility should be countered by supplementation with vitamin E to maintain higher than normal concentrations of circulating alpha-tocopherol-greater than 4.8 mmol alpha-tocopherol/mol cholesterol.


Assuntos
Fibrose Cística/sangue , Hemólise/efeitos dos fármacos , Peróxidos/farmacologia , Vitamina E/sangue , Adolescente , Ácido Araquidônico/sangue , Criança , Pré-Escolar , Colesterol/sangue , Fibrose Cística/tratamento farmacológico , Eritrócitos/efeitos dos fármacos , Eritrócitos/metabolismo , Feminino , Humanos , Ácido Linoleico , Ácidos Linoleicos/sangue , Lipídeos/sangue , Masculino , Triglicerídeos/sangue , Vitamina E/administração & dosagem , Vitamina E/uso terapêutico
19.
Arch Dis Child ; 66(6): 727-8, 1991 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-2053798

RESUMO

Fatty infiltration of the liver at postmortem examination has been recommended as a criterion for selection of infants who have died suddenly and unexpectedly for further biochemical investigation for disorders of fatty acid oxidation. We describe a boy with medium chain acyl CoA dehydrogenase deficiency who died four months after diagnosis and in whom only minimal hepatic fatty infiltration was found.


Assuntos
Acil-CoA Desidrogenases/deficiência , Fígado Gorduroso/patologia , Fígado/patologia , Carboidratos da Dieta/uso terapêutico , Epilepsia/etiologia , Humanos , Lactente , Masculino
20.
Arch Dis Child ; 66(1 Spec No): 29-33, 1991 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-1996888

RESUMO

Screening of the newborn for cystic fibrosis by measurement of immunoreactive trypsin has been undertaken on alternate weeks in Wales and the West Midlands for five years since 1985 to evaluate the possible clinical benefits of early diagnosis. Patients detected by screening and those diagnosed by clinical symptoms alone were assessed annually for differences in clinical, anthropometric, and biochemical variables. Fifty eight infants not considered to be at risk of cystic fibrosis (they did not present with meconium ileus and do not have a sibling with cystic fibrosis) have been detected by screening and they have been compared with 44 children who were diagnosed clinically. This latter group includes nine children whose screening was negative but who were recognised subsequently to have cystic fibrosis. The mean age at diagnosis of the screened group was significantly lower than that of the group diagnosed clinically. Excluding admissions for diagnostic tests for cystic fibrosis, the screened group spent a significantly shorter time in hospital during the first year of life. The results of all other comparisons made between the screened group and those diagnosed clinically were similar up to the age of 4 years.


Assuntos
Fibrose Cística/diagnóstico , Triagem Neonatal/métodos , Estatura , Peso Corporal , Pré-Escolar , Fibrose Cística/sangue , Fibrose Cística/epidemiologia , Inglaterra/epidemiologia , Seguimentos , Humanos , Incidência , Lactente , Recém-Nascido , Tripsina/sangue , País de Gales/epidemiologia
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