[A case of myomectomy for infertility and a following twin pregnancy associated with hyperthyroidism]. / Considerazioni su un caso di miomectomia per infertilità e successiva gravidanza gemellare associata ad ipertiroidismo.

The authors describe an infertility case caused by a posterior wall subendometrial fibromyoma of the uterus and treated by traditional transcavitary myomectomy dwelling upon details of the operative technique. The following pregnancy is complicated by twin gestation, hyperthyroidism and preterm delivery. Fetuses were born by caesarean section one in good condition, the other affected by myelomeningocele with good prognosis. Clinical pictures emerged during pregnancy are discussed, in particular the therapy of hyperthyroidism, beta 2-adrenoceptor stimulants drugs, diagnosis and multifactorial genesis of fetal malformation.

[Biologic action of promestriene on the genital tract of the castrated rat]. / Attività biologica del promestriene sul tratto genitale della ratta castrata.

The study assessed the activity of promestrien administered by a local vaginal route in 16 rats castrated 60 days previously. The dose used was 5 mg per day for 10 days. Following treatment, animals were sacrificed and histological analyses revealed a remarkable proliferation of the vaginal epithelium, inhibition and restored trophism of the strome, whereas no estrogen stimulus was observed at the level of uterine mucous. This confirms the exclusively local action of promestrien which does not provoke undesirable side effects on other segments of the genital tract, and allows the therapeutic use of the hormone in different gynaecological pathologies.