RESUMO
This study investigated the ability of NBQX, an AMPA receptor antagonist, and cerestat, a NMDA receptor antagonist, to counteract neurological deficits and morphological damage induced by permanent occlusion of the left middle cerebral artery (MCAO model) in the rat. NBQX (3, 10, and 30 mg/kg, ip) injected at 10, 60, and 120 min postocclusion did not reduce the volume of infarct in the MCAO model of cerebral ischemia and had marginal effects on sensory dysfunctions (vibrissae stimulation and body proprioception) and no effects on motor dysfunctions (forelimb flexion and footfault test). Conversely, cerestat (0.3, 1, and 3 mg/kg, sc) injected at 10 and 120 min postocclusion significantly reduced the ischemic volume at the dose of 1 mg/kg, and, at the same dose, significantly attenuated behavioural deficits in the body proprioception and in the forelimb flexion tests.
Assuntos
Antagonistas de Aminoácidos Excitatórios/farmacologia , Guanidinas/farmacologia , Ataque Isquêmico Transitório/patologia , Ataque Isquêmico Transitório/psicologia , Fármacos Neuroprotetores/farmacologia , Quinoxalinas/farmacologia , Animais , Comportamento Animal/efeitos dos fármacos , Encéfalo/patologia , Infarto Cerebral/patologia , Membro Anterior/fisiologia , Masculino , Artéria Cerebral Média/fisiologia , Estimulação Física , Propriocepção/efeitos dos fármacos , Desempenho Psicomotor/efeitos dos fármacos , Ratos , Ratos Endogâmicos F344 , Vibrissas/fisiologiaAssuntos
Coeficiente de Natalidade , Serviços de Saúde da Criança , Mortalidade Infantil , Serviços de Saúde Materna , Mortalidade Materna , Aborto Espontâneo/epidemiologia , Adolescente , Adulto , Criança , Pré-Escolar , Feminino , Morte Fetal , Humanos , Lactente , Recém-Nascido , Itália , Masculino , GravidezRESUMO
The AA. acting as members of Regional Health Assessor in Lombardy, have exposed the data of infectious diseases declared in comparison with the data of other Regions and also with data of the single provinces. Useful indications shall be offered to the operators of public health and also to the responsible persons of the local Administrations.