Effects of cerestat and NBQX on functional and morphological outcomes in rat focal cerebral ischemia.

This study investigated the ability of NBQX, an AMPA receptor antagonist, and cerestat, a NMDA receptor antagonist, to counteract neurological deficits and morphological damage induced by permanent occlusion of the left middle cerebral artery (MCAO model) in the rat. NBQX (3, 10, and 30 mg/kg, ip) injected at 10, 60, and 120 min postocclusion did not reduce the volume of infarct in the MCAO model of cerebral ischemia and had marginal effects on sensory dysfunctions (vibrissae stimulation and body proprioception) and no effects on motor dysfunctions (forelimb flexion and footfault test). Conversely, cerestat (0.3, 1, and 3 mg/kg, sc) injected at 10 and 120 min postocclusion significantly reduced the ischemic volume at the dose of 1 mg/kg, and, at the same dose, significantly attenuated behavioural deficits in the body proprioception and in the forelimb flexion tests.

[Epidemiological situation in the region of Lombardy of reportable infectious deseases (1973). Comparison with the preceding years (1971 and 1972)]. / Situazione epidemiologica nella regione Lombardia delle malattie infettive soggette a denuncia (anno 1973). Confronto con gli anni precedenti (1971 e 1972)

The AA. acting as members of Regional Health Assessor in Lombardy, have exposed the data of infectious diseases declared in comparison with the data of other Regions and also with data of the single provinces. Useful indications shall be offered to the operators of public health and also to the responsible persons of the local Administrations.