Metabolism of 1,8-dihydroxy 3-hydroxy methyl anthraquinone (aloe-emodin) isolated from the leaves of Cassia tora in albino rats.

Cassia tora is a well known plant of India. Aloe-emodin was isolated from the leaves of this plant and its metabolism pattern was studied. The results showed that about 15.4% of the administered aloe-emodin was excreted and the rest was probably bound or metabolized in the system.

Hepatoprotective activity of Cassia fistula leaf extract.

Hepatoprotective activity of the n-heptane extract of Cassia fistula leaves was investigated by inducing hepatotoxicity with paracetamol in rats. The extract at a dose of 400 mg/kg body wt. exhibited orally, significant protective effect by lowering the serum levels of transaminases (SGOT and SGPT), bilirubin and alkaline phosphatase (ALP). The effects produced were comparable to that of a standard hepatoprotective agent.

Evaluation of anti-pyretic potential of Jussiaea suffruticosa L. extract in rats.

A study was carried out to evaluate the anti-pyretic potential of the methanol extract of the aerial part of Jussiaea suffruticosa Linn. (MEJS) on normal body temperature and yeast-induced pyrexia in albino rats. Yeast suspension (10 ml/kg body wt.) increased rectal temperature after 19 hours of subcutaneous injection. The MEJS, at doses of 100, 200 and 300 mg/kg body wt. p.o., showed significant reduction in normal body temperature and yeast-provoked elevated temperature in a dose-dependent manner. The effect also extended up to 5 hours after the drug administration. The anti-pyretic effect of MEJS was comparable to that of paracetamol (150 mg/kg body wt, p.o.), a standard anti-pyretic agent.

Studies on some Pharmacognostical profiles of Leucas lavandulaefolia Rees. (Family Labiatae).

The macroscopic characters of L. lavandulaefolia, physical constant values, behaviour on treatment with different chemical reagents, fluorescence characteristics after treatment with different chemical reagents of the powder of L. Lavandulaefolia were studied to fix some pharmacognostical parameters. Preliminary phytochemical studies and TLC characterization of different extractives has also been performed. These studies will help in future for identifying the plant for further research.

Evaluation of hepatoprotective activity of Cassia fistula leaf extract.

Hepatoprotective activity of the n-heptane extract of Cassia fistula leaves was investigated in rats by inducing hepatotoxicity with carbon tetrachloride:liquid paraffin (1:1). The extract has been shown to possess significant protective effect by lowering the serum levels of transminases (SGOT and SGPT), bilirubin and alkaline phosphatase (ALP). The extract of C. fistula at a dose of 400 mg/kg showed significant hepatoprotective activity which was comparable to that of a standard hepatoprotective agent.

Anti-cholesterolaemic activity of a fraction of azadirachta indica leaf extract on rats.

A fraction of leaf extract isolated from leaves of Azadirachta indica (Meliaceae) was tested for lowering of blood cholesterol level in rats. The extract at a dose of 200 mg/kg i.p. significantly lowered the blood cholesterol level in test animals.

Protective effect of fraction of azadirachta indica leaf extract on carbon tetrachloride induced hepatotoxicity.

The hepatoprotective activity of a fraction of the leaf extract of A.indica against carbon tetrachloride : liquid paraffin (1:1) induced liver damage in rats at doses of 100 mg/kg and 200 mg/kg was evaluated. A significant dose dependent hepatoprotective activity was evidenced by lowering of the elevated levels of glutamate oxaloacetate transaminase (GOT), glutamate pyruvate transaminase (GPT), acid phosphatase (ACP) and alkaline phosphatase (ALP) in the serum of CCl(4) : liquid paraffin (1:1) treated rats.