Assuntos
Povo Asiático/genética , Testes Genéticos , Farmacogenética , Medicina de Precisão , Grupos Raciais/genética , Alopurinol/efeitos adversos , Carbamazepina/efeitos adversos , Antígenos HLA-B/genética , Antígeno HLA-B15/genética , Humanos , Estados Unidos , United States Food and Drug AdministrationAssuntos
Assistência Ambulatorial , Telemedicina , Serviço Hospitalar de Emergência , Hospitais , HumanosRESUMO
Objectives. To examine content of financial assistance polices (FAPs) among US tax-exempt hospitals and determine whether restrictive policies were associated with reduced charity care spending.Methods. Using hospital tax filings with the Internal Revenue Service in 2016 and FAPs obtained from hospital Web sites, we examined characteristics of FAPs and associated expenditures for charity care in a representative sample of 170 tax-exempt hospitals. We identified common eligibility requirements and used them to define restrictiveness of FAPs.Results. FAPs were characterized by various ways to exclude patients, a patchwork of coverage for typical health care services, and wide-ranging discounts. FAP expenditures were lowest among restrictive hospitals in states that expanded Medicaid as part of the Affordable Care Act and highest among nonrestrictive hospitals in nonexpansion states. FAP expenses did not differ by hospital restrictiveness alone.Conclusions. Standardizing common eligibility requirements among FAPs carries potential benefits with regard to optimizing charity care for community benefit and achieving at least some level of equity; however, further policy efforts must account for additional restrictions, charges, and exclusions to be effective.
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Hospitais Públicos/economia , Hospitais Filantrópicos/economia , Cuidados de Saúde não Remunerados/economia , Hospitais Públicos/estatística & dados numéricos , Hospitais Filantrópicos/estatística & dados numéricos , Humanos , Medicaid , Patient Protection and Affordable Care Act , Políticas , Pobreza/economia , Isenção Fiscal , Cuidados de Saúde não Remunerados/estatística & dados numéricos , Estados UnidosAssuntos
Analgésicos/efeitos adversos , Gabapentina/efeitos adversos , Dor/tratamento farmacológico , Pregabalina/efeitos adversos , Analgésicos/uso terapêutico , Dor Crônica/tratamento farmacológico , Uso Indevido de Medicamentos , Gabapentina/uso terapêutico , Humanos , Guias de Prática Clínica como Assunto , Pregabalina/uso terapêuticoRESUMO
Background: The gabapentinoid drugs gabapentin and pregabalin were originally developed as antiseizure drugs but now are prescribed mainly for treatment of pain. For gabapentin, the only pain-related indication approved by the US Food and Drug Administration (FDA) is postherpetic neuralgia. For pregabalin, FDA-approved indications related to pain are limited to postherpetic neuralgia, neuropathic pain associated with diabetic neuropathy or spinal cord injury, and fibromyalgia. Despite these limited indications, gabapentin and pregabalin are widely prescribed off-label for various other pain syndromes. Such use is growing, possibly because clinicians are searching increasingly for alternatives to opioids. Observations: This report summarizes the limited published evidence to support off-label gabapentinoid uses, describes clinical cases in which off-label use is problematic, and notes how review articles and guidelines tend to overstate gabapentinoid effectiveness. Conclusions: Clinicians who prescribe gabapentinoids off-label for pain should be aware of the limited evidence and should acknowledge to patients that potential benefits are uncertain for most off-label uses.
Assuntos
Analgésicos/uso terapêutico , Gabapentina/uso terapêutico , Uso Off-Label , Dor/tratamento farmacológico , Pregabalina/uso terapêutico , Neuropatias Diabéticas/tratamento farmacológico , Aprovação de Drogas , Fibromialgia/tratamento farmacológico , Humanos , Dor Lombar/tratamento farmacológico , Diferença Mínima Clinicamente Importante , Neuralgia/tratamento farmacológico , Neuralgia/etiologia , Neuralgia Pós-Herpética/tratamento farmacológico , Medição da Dor , Radiculopatia/tratamento farmacológico , Ciática/tratamento farmacológico , Traumatismos da Medula Espinal/complicaçõesRESUMO
Iron deficiency anemia is often listed among potential adverse effects of gastric acid-suppressive medications, given that gastric acidity promotes intestinal absorption of nonheme iron. Additionally, the antacid calcium carbonate can inhibit iron absorption. However, there is little direct clinical evidence that proton-pump inhibitors, histamine-2 receptor antagonists, or calcium carbonate cause iron deficiency anemia. Most case reports have had substantial limitations (e.g., minimal follow-up and presence of other causes of iron deficiency), and retrospective cohort studies have lacked sufficient patient-specific detail to make strong causal inferences. We present 2 cases-both with detailed, prospective 10-year follow-up-in which combinations of proton-pump inhibitors, histamine-2 receptor antagonists and calcium carbonate were clearly associated with development of iron deficiency anemia. Overt iron-deficiency anemia is probably uncommon in patients who use acid-modifying medications and who have no other conditions that predispose to iron deficiency. Nevertheless, clinicians should be aware of this potential complication, given widespread use of these agents.
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Anemia Ferropriva/induzido quimicamente , Carbonato de Cálcio/efeitos adversos , Antagonistas dos Receptores H2 da Histamina/efeitos adversos , Inibidores da Bomba de Prótons/efeitos adversos , Idoso , Humanos , Masculino , Pessoa de Meia-Idade , Estudos ProspectivosRESUMO
For nearly three decades, clinicians and bioethicists have debated about use of the term futile to describe end-of-life medical interventions that clinicians believe are no longer warranted. In clinical practice, the term is most often invoked when a family of a dying or permanently unconscious patient insists upon such interventions, despite the medical team's belief or recommendation that they be withheld or withdrawn. This essay argues that each of the commonly used terms for these interventions (futile, inappropriate, and nonbeneficial) captures an important, different, and complementary facet of these conflicts in end-of-life medical care. Rather than continuing to debate which term is best, clinicians and bioethicists should direct their attention to the professional ethics of end-of-life care and the clinical and organizational factors that create or contribute to these so-called "futility cases."
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Assistência Terminal , Ética Médica , Ética Profissional , Humanos , Futilidade MédicaAssuntos
Aminas/uso terapêutico , Analgésicos/uso terapêutico , Dor Crônica/tratamento farmacológico , Ácidos Cicloexanocarboxílicos/uso terapêutico , Neuralgia/tratamento farmacológico , Uso Off-Label/estatística & dados numéricos , Pregabalina/uso terapêutico , Ácido gama-Aminobutírico/uso terapêutico , Aprovação de Drogas , Uso de Medicamentos , Gabapentina , Humanos , Prescrição Inadequada , Estados Unidos , United States Food and Drug AdministrationRESUMO
OBJECTIVE AND IMPORTANCE: Sickle cell trait is widely known to be associated with splenic infarction at high altitudes. Although textbooks and reviews imply that this complication does not occur at low altitudes, we encountered such a case and identified several previous cases in the literature. CLINICAL PRESENTATION: An 18-year-old woman with sickle cell trait who resided near sea level presented with left upper quadrant abdominal pain and was found to have multiple splenic infarcts. She was otherwise well, with no comorbidities that would predispose to hypoxemia or vascular injury. A review of the literature revealed 12 previously published cases of low-altitude splenic infarction in patients with sickle trait; 7 of those patients had comorbidities that likely predisposed to splenic infarction. INTERVENTION: None. CONCLUSION: Spontaneous splenic infarction can occur in patients with sickle trait who live at low altitudes. It is unclear whether this complication is rare, or whether it is relatively common but under-recognized.
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Altitude , Traço Falciforme/complicações , Infarto do Baço/etiologia , Adolescente , Feminino , Humanos , Traço Falciforme/diagnóstico , Infarto do Baço/diagnóstico , Tomografia Computadorizada por Raios XRESUMO
Carotid ultrasonography is performed frequently to identify carotid stenosis in patients with no history of carotid-territory cerebrovascular ischemia. The premises of such testing are that the potential benefit of endarterectomy or stenting exceeds the potential harm in patients with asymptomatic stenosis and that discovery of asymptomatic stenosis may trigger beneficial changes in lifestyle or medical management that otherwise would not have occurred. However, given low contemporary rates of stroke in medically managed patients with asymptomatic carotid stenosis, invasive carotid procedures cannot be justified in this population. Moreover, among patients at increased cardiovascular risk, there is no evidence that carotid imaging motivates behavioral change or improves risk stratification beyond consideration of conventional risk factors. In this focused review, we address topics that should help health care professionals advise patients who inquire about carotid screening and patients in whom asymptomatic carotid stenosis has already been identified. We conclude that there is currently no role for carotid imaging in patients without a history of carotid-territory stroke or transient ischemic attack.
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Doenças Assintomáticas , Estenose das Carótidas/diagnóstico por imagem , Ponte de Artéria Coronária , Endarterectomia das Carótidas , Comportamentos Relacionados com a Saúde , Acidente Vascular Cerebral/prevenção & controle , Procedimentos Desnecessários , Idoso , Estenose das Carótidas/complicações , Estenose das Carótidas/cirurgia , Tontura/diagnóstico por imagem , Feminino , Humanos , Ataque Isquêmico Transitório/prevenção & controle , Programas de Rastreamento , Estudos Multicêntricos como Assunto , Guias de Prática Clínica como Assunto , Ensaios Clínicos Controlados Aleatórios como Assunto , Medição de Risco , Fatores de Risco , Acidente Vascular Cerebral/etiologia , Síncope/diagnóstico por imagem , UltrassonografiaRESUMO
INTRODUCTION: Long-acting beta agonists and inhaled corticosteroids combination products (LABA-ICS) are widely used in the treatment of asthma. However, there appears to be little data on their cardiovascular safety. The purpose of this study was to conduct a systematic review of the available studies and trials on the cardiovascular safety of LABA-ICS in adults with asthma. METHODS: Two independent reviewers screened citations from PubMed and National Clinical Trials registry to identify studies and trials on the cardiovascular effects of LABA-ICS in patients with asthma. RESULTS: A total of 15 studies (with 17 cohorts on LABA-ICS to compare with a comparator or placebo) with 5,440 total study participants met the inclusion criteria. Two studies on budesonide-formoterol and one on fluticasone-salmeterol reported treatment emergent cardiovascular adverse events, all of which were dysrhythmias. For comparison, the pooled estimate of the Peto odds ratio (0.72; 95 % confidence interval [CI] 0.17-3; p = 0.65) and the summary risk ratio (0.77; 95 % CI 0.26-2.3; p = 0.64) indicated a nonsignificant difference between LABA-ICS and comparator/placebo groups. CONCLUSIONS: Our systematic review found that few studies and trials reported treatment emergent cardiovascular adverse events with LABA-ICS. However, the Peto odds ratio and risk ratio for these outcomes was statistically nonsignificant. This suggests that LABA-ICS products may have a safe cardiovascular profile in asthma patients.