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1.
Phytochemistry ; 224: 114168, 2024 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-38823569

RESUMO

Three previously undescribed highly modified lanostane triterpenoids, ganopyrone A, ganocolossusin I, and ganodermalactone Y, were isolated from the artificially cultivated fruiting bodies of the basidiomycete Ganoderma colossus TBRC-BCC 17711. Ganopyrone A possesses an unprecedented polycyclic carbon skeleton with an α-pyrone ring and C-18/C-23 bond. It showed antimalarial activity against Plasmodium falciparum K1 (multidrug-resistant strain) with an IC50 value of 7.8 µM (positive control: dihydroartemisinin, IC50 1.4 nM), while its cytotoxicity (Vero cells) was much weaker (IC50 103 µM).


Assuntos
Antimaláricos , Carpóforos , Ganoderma , Plasmodium falciparum , Triterpenos , Ganoderma/química , Antimaláricos/farmacologia , Antimaláricos/química , Antimaláricos/isolamento & purificação , Plasmodium falciparum/efeitos dos fármacos , Carpóforos/química , Triterpenos/farmacologia , Triterpenos/química , Triterpenos/isolamento & purificação , Animais , Estrutura Molecular , Células Vero , Chlorocebus aethiops , Lanosterol/análogos & derivados , Lanosterol/farmacologia , Lanosterol/química , Lanosterol/isolamento & purificação , Testes de Sensibilidade Parasitária , Relação Estrutura-Atividade , Relação Dose-Resposta a Droga
2.
Org Biomol Chem ; 21(39): 7944-7953, 2023 10 11.
Artigo em Inglês | MEDLINE | ID: mdl-37740400

RESUMO

Five undescribed polyketide metabolites, oudemansins E (1), M (2), P (3), and Q (4), and 9-methoxystrobilurin I (5), were isolated from cultures of basidiomycete Favolaschia minutissima TBRC-BCC 19434. A γ-lactone derivative (6) of noroudemansin A (8), which was previously reported as a semisynthetic compound, was also isolated. The absolute configuration of the isoprene-derived moiety of the known cometabolite 9-methoxystrobilurin E (9) was determined to be 2'R,6'S by comparison of the experimental and calculated ECD data, which was correlated to the new derivative 1. These compounds exhibited antimalarial activity against Plasmodium falciparum K1 (multidrug-resistant strain). A putative minor natural product, namely 9-methoxystrobilurin P (13), was prepared by semisynthesis, which exhibited significant antimalarial activity (IC50 0.086 µM).


Assuntos
Antimaláricos , Basidiomycota , Antimaláricos/farmacologia , Butadienos , Plasmodium falciparum
3.
Phytochemistry ; 207: 113568, 2023 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-36565946

RESUMO

Seven undescribed compounds, including four naphthoquinone terpenoids (aculeolatins A - D), one rare 2-nitropyrrole terpenoid (nitropyrrolin F), and two hydroxamate siderophores (aculeolamides A and B) and one further undescribed compound (2,5,7-trihydroxy-3,6-dimethylnaphthalene-1,4-dione), together with eleven known compounds (arromycin, phenaziterpene A, nitropyrrolin A, heronapyrroles A and B, salaceyin A, 5,7-dihydroxy-2-isopropylchromone, 1-hydroxyphenazine, 1-methoxyphenazine, 1-acetyl-ß-carboline, and N-(2-phenylethyl) acetamide), were isolated from the cultures of the endophytic Streptomyces aculeolatus MS1-6. The structures of the isolated compounds were determined using NMR spectroscopy and corroborated using chemical modification. These compounds exhibited a broad spectrum of biological activities, including antimalarial (IC50 6.03-9.84 µg/mL), antitubercular (MIC 3.13-6.25 µg/mL), anti-plant pathogenic fungal (MIC 25.0-50.0 µg/mL), and antibacterial (MIC 3.03-50 µg/mL) activities; however, they displayed unremarkable cytotoxicity against cancerous (MCF-7 and NCI-H187) and non-cancerous (Vero) cell lines.


Assuntos
Actinobacteria , Anti-Infecciosos , Antimaláricos , Antimaláricos/química , Anti-Infecciosos/química , Antibacterianos/química , Antituberculosos , Testes de Sensibilidade Microbiana
4.
Nat Prod Res ; 37(1): 24-30, 2023 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-34187248

RESUMO

Two new hydroquinones bearing a 1,3-enyne moiety, pestalotioquinols G and H, together with four known compounds, including pestalotioquinol A, phomonitroester, (R)-4,6,8-trihydroxy-3,4-dihydronaphthalen-1(2H)-one, and scylatone were isolated from the marine fungus Pestalotiopsis diploclisia (BCC 35283). The structures of these compounds were elucidated by analysis of 2D-NMR and HR-MS data. The known pestalotioquinol A displayed antimalarial activity against Plasmodium falciparum K1 with an IC50 value of 19.0 µM, while pestalotioquinol G displayed weak cytotoxic activity against Vero cell lines with an IC50 value of 47.9 µM.


Assuntos
Fungos , Hidroquinonas , Estrutura Molecular , Fungos/química , Pestalotiopsis , Plantas
5.
J Antibiot (Tokyo) ; 75(10): 583-588, 2022 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-35986091

RESUMO

A new benzothioate glycoside metabolite, phitsanoside A, together with its new and known derivatives were isolated from Streptomyces sp. TBRC 11511 collected from sediment of a dry evergreen forest located in Phitsanulok Province, Thailand. The structure elucidation of the new compound was interpreted on the basis of spectroscopic data analysis. The configuration of the sugar moiety was derived based on NOESY nuclear magnetic resonance correlations, a vicinal coupling constant analysis, and the measurement of an optical rotation from the hydrolyzed sugar unit, which was identified as ß-D-glucopyranose. Phitsanoside A did not exhibit antibacterial activity against Bacillus cereus, Mycobacterium tuberculosis or Staphylococcus aureus, but phitsanoside B showed activity against all of them with MIC values of 3.13, 25 and 12.5 µg ml-1, respectively.


Assuntos
Streptomyces , Antibacterianos/química , Glicosídeos/química , Testes de Sensibilidade Microbiana , Estrutura Molecular , Streptomyces/metabolismo , Açúcares , Tailândia
6.
Phytochemistry ; 196: 113075, 2022 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-34974245

RESUMO

In the quest for medicinally active compounds in mushrooms of the genus Ganoderma, eleven undescribed lanostane triterpenoids, including a novel chlorinated derivative, i.e., (20S,24E)-21-chloro-15ß,20,29-trihydroxy-3,7,11-trioxolanosta-8,24-dien-26-oic acid, were isolated from artificially cultivated fruiting bodies of the basidiomycete Ganoderma mbrekobenum. The structures were elucidated on the basis of NMR spectroscopic and mass spectrometry data. The configuration of the C-20 atom in the most abundant 20-hydroxy-lanostane, (20S,24E)-15ß,20,29-trihydroxy-3,7,11-trioxolanosta-8,24-dien-26-oic acid, was established by chemical derivatization, and the absolute configuration of the lanostane skeleton was determined by ECD calculation. Two of the undescribed compounds exhibited moderate antimalarial activity.


Assuntos
Ganoderma , Triterpenos , Carpóforos/química , Ganoderma/química , Estrutura Molecular , Triterpenos/química
7.
J Nat Prod ; 84(11): 2775-2785, 2021 11 26.
Artigo em Inglês | MEDLINE | ID: mdl-34748348

RESUMO

Eight new angucyclic quinones, miaosporones A to H (1-8), along with the previously described metabolites 8-hydroxy-3-methylbenz[a]anthraquinone (9), tetrangulol (10), 5,6-dihydro-1,8-dihydroxy-3-methybenz[a]anthracene-7,12-quinone (11), and SF2315A (12), were isolated from the terrestrial actinomycete Actinomadura miaoliensis TBRC 5172 obtained from sediment collected from the Huai Yang reservoir, Prachuap Khiri Khan Province, Thailand. The relative and absolute configurations of the new compounds were determined from analysis of NMR spectroscopic and X-ray crystallographic data. Miaosporone A exhibited antimalarial activity against Plasmodium falciparum K1 and antibacterial activity against Mycobacterium tuberculosis with respective IC50 values of 2.5 and 2.4 µM and displayed cytotoxic activities against both cancerous (MCF-7 and NCI-H187) and nonmalignant (Vero) cells.


Assuntos
Actinomadura/metabolismo , Anti-Infecciosos/isolamento & purificação , Antineoplásicos/isolamento & purificação , Quinolonas/isolamento & purificação , Anti-Infecciosos/farmacologia , Antineoplásicos/farmacologia , Linhagem Celular Tumoral , Humanos , Espectroscopia de Ressonância Magnética , Mycobacterium tuberculosis/efeitos dos fármacos , Plasmodium falciparum/efeitos dos fármacos , Quinolonas/química , Quinolonas/farmacologia
8.
J Nat Prod ; 84(4): 1149-1162, 2021 04 23.
Artigo em Inglês | MEDLINE | ID: mdl-33852304

RESUMO

Thirteen tetrahydroxanthone dimers, atrop-ascherxanthone A (1), ascherxanthones C-G (2-6), and confluxanthones A-G (7-13), were isolated from the entomopathogenic fungus Aschersonia confluens BCC53152. The chemical structures were determined based on analysis of NMR spectroscopic and mass spectrometric data. The absolute configurations of compounds 1 and 7 were confirmed by single-crystal X-ray diffraction experiments, while the configurations of other compounds were assigned based upon evidence from NOESY and NOEDIFF experiments, modified Mosher's method, and ECD spectroscopic data together with biogenetic considerations. Compounds 1, 3-5, 7-11, and 13 showed antimalarial activity against Plasmodium falciparum (K1, multidrug-resistant strain) (IC50 0.6-6.1 µM), antitubercular activity against Mycobacterium tuberculosis H37Ra (MIC 6.3-25.0 µg/mL), and cytotoxicity against NCI-H187 (IC50 0.5-3.5 µM) and Vero (IC50 0.9-6.1 µM) cells. All tested compounds except for compound 9 exhibited cytotoxicity against KB cells (IC50 1.3-9.7 µM).


Assuntos
Antimaláricos/farmacologia , Antituberculosos/farmacologia , Hypocreales/química , Xantonas/farmacologia , Animais , Antimaláricos/isolamento & purificação , Antituberculosos/isolamento & purificação , Chlorocebus aethiops , Células HeLa , Humanos , Estrutura Molecular , Mycobacterium tuberculosis/efeitos dos fármacos , Plasmodium falciparum/efeitos dos fármacos , Tailândia , Células Vero , Xantonas/isolamento & purificação
9.
Nat Prod Res ; 35(3): 392-398, 2021 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-31250661

RESUMO

Two unknown enantiomeric compounds, named (R)- and (S)-taeniolin, along with six known compounds, were isolated from the marine-associated fungus Taeniolella sp. BCC31839. Chemical structures were determined by NMR spectroscopic techniques, and the absolute configurations were confirmed by Mosher application together with CD spectral analyses. Both were inactive for antimicrobial activity against multidrug-resistant malaria parasite (Plasmodium falciparum) and bacteria (Mycobacerium tuberculosis and Bacillus cereus) at maximum tested concentration.


Assuntos
Antibacterianos/farmacologia , Antimaláricos/farmacologia , Cromonas/química , Fungos Mitospóricos/química , Animais , Antibacterianos/química , Antimaláricos/química , Antineoplásicos/química , Antineoplásicos/farmacologia , Bacillus cereus/efeitos dos fármacos , Chlorocebus aethiops , Cromonas/farmacologia , Dicroísmo Circular , Avaliação Pré-Clínica de Medicamentos , Humanos , Células MCF-7 , Espectroscopia de Ressonância Magnética , Fungos Mitospóricos/isolamento & purificação , Estrutura Molecular , Mycobacterium tuberculosis/efeitos dos fármacos , Plasmodium falciparum/efeitos dos fármacos , Células Vero
10.
J Antibiot (Tokyo) ; 73(10): 702-710, 2020 10.
Artigo em Inglês | MEDLINE | ID: mdl-32733078

RESUMO

Ten previously undescribed lanostane-type triterpenoids (1-10), together with 15 known lanostanes, were isolated from artificially cultivated fruiting bodies of the basidiomycete Ganoderma sp. BCC 21329. The structures were elucidated on the basis of NMR spectroscopic and mass spectrometry data and by application of the modified Mosher's method. Compounds 1, 3, 5, and 7 showed moderate antimalarial activity (IC50 3.8-7.6 µg ml-1).


Assuntos
Antimaláricos/isolamento & purificação , Carpóforos/química , Ganoderma/química , Triterpenos/isolamento & purificação , Antimaláricos/química , Antimaláricos/farmacologia , Espectroscopia de Ressonância Magnética , Estrutura Molecular , Plasmodium falciparum/efeitos dos fármacos , Relação Estrutura-Atividade , Triterpenos/química , Triterpenos/farmacologia
11.
Fitoterapia ; 144: 104606, 2020 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-32376482

RESUMO

Six new compounds [ascherlactones A (1) and B (2), ascherchromanone A (3), phenethyl 4'-O-methylglucoside (8), 4'-O-methylpleoside (10), and 4'-O-methyltorachrysone 8-O-glucoside (11)] and one naturally new compound [4'-O-methyl-ß-d-benzylglucoside (9)] together with fourteen known compounds, including paecilodepsipeptides A (5), B (7), and D (4), conoideocrellide A (6), eugenin (12), 5-hydroxy-2,3-dimethyl-7-methoxychromone (13), (S)-1-phenyl-1,2-ethanediol (14), (2S)-l-3-phenyllactic acid (15), papuline [or (2S)-l-3-phenyllactic acid methyl ester, 16], 2'-epi terpendole A (17), terpendoles C (18) and D (19), cholic acid, and zeorin were isolated from the entomopathogenic fungus Aschersonia confluens BCC53152. Their chemical structures were elucidated on the basis of NMR spectroscopic and mass spectrometric analyses. The absolute configurations were determined by using the evidence from NOESY correlations, chemical means, optical rotation values together with comparison of ECD spectroscopic data with the calculated ECD spectra. The plausible biosynthetic pathway of compounds 1-3 was also proposed. Moreover, antimicrobial activity such as antimalarial, antitubercular, antifungal, and antibacterial activities and cytotoxicity against cancerous (MCF-7, KB, and NCI-H187) and non-cancerous (Vero) cells of the isolated compounds were evaluated.


Assuntos
Cromonas/farmacologia , Glucosídeos/farmacologia , Hypocreales/química , Animais , Antibacterianos/isolamento & purificação , Antibacterianos/farmacologia , Antimaláricos/isolamento & purificação , Antimaláricos/farmacologia , Antineoplásicos/isolamento & purificação , Chlorocebus aethiops , Cromonas/isolamento & purificação , Glucosídeos/isolamento & purificação , Hemípteros/microbiologia , Humanos , Células MCF-7 , Estrutura Molecular , Tailândia , Células Vero
12.
J Nat Prod ; 83(4): 905-917, 2020 04 24.
Artigo em Inglês | MEDLINE | ID: mdl-32193929

RESUMO

Fourteen new compounds, oudemansins 1-4, oudemansinols 5-7, favolasins 8-10, favolasinin (12), polyketides 13-15, and (R,E)-2,4-dimethyl-5-phenyl-4-pentene-2,3-diol (16), together with nine known compounds were isolated from the basidiomycete fungus Favolaschia sp. BCC 18686. Two new compounds, favolasin E (11) and 9-oxostrobilurin E (17), were isolated from the closely related organism Favolaschia calocera BCC 36684 along with nine ß-methoxyacrylate-type derivatives. Compounds in the class of oudemansins and strobilurins exhibited moderate to strong antimalarial activity with relatively low cytotoxicity against Vero cells (African green monkey kidney fibroblasts). Potent antimalarial activity was demonstrated for 9-methoxystrobilurins G, K, and E (IC50 values 0.061, 0.089, and 0.14 µM, respectively). The structure-activity relationships (SAR) for antimalarial activity is proposed on the basis of the activity of the new and several known ß-methoxyacrylate derivatives in combination with the data from previously isolated compounds. Furthermore, several compounds showed specific cytotoxicity against NCI-187 cells (human small-cell lung cancer), although the SAR was different from that for antimalarial activity.


Assuntos
Agaricales/química , Antimaláricos/química , Antimaláricos/farmacologia , Policetídeos/química , Policetídeos/farmacologia , Estrobilurinas/química , Estrobilurinas/farmacologia , Acrilatos/química , Acrilatos/farmacologia , Animais , Antibióticos Antineoplásicos/farmacologia , Linhagem Celular Tumoral , Chlorocebus aethiops , Ensaios de Seleção de Medicamentos Antitumorais , Fermentação , Humanos , Espectroscopia de Ressonância Magnética , Estrutura Molecular , Plasmodium falciparum/efeitos dos fármacos , Espectrometria de Massas por Ionização por Electrospray , Relação Estrutura-Atividade , Células Vero
13.
Phytochemistry ; 170: 112225, 2020 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-31855780

RESUMO

Sixteen previously undescribed lanostane-type triterpenoids (1-16), together with fourteen known compounds, were isolated from cultivated fruiting bodies of the basidiomycete Ganoderma casuarinicola, a recently described species. The structures were elucidated on the basis of NMR spectroscopic and mass spectrometry data. Two of these compounds, 9 and 10, showed antimalarial activity with IC50 values of 9.7 and 9.2 µg/ml, respectively.


Assuntos
Antimaláricos/farmacologia , Antituberculosos/farmacologia , Ganoderma/química , Lanosterol/farmacologia , Malária/tratamento farmacológico , Compostos Fitoquímicos/farmacologia , Triterpenos/farmacologia , Animais , Antimaláricos/química , Antimaláricos/metabolismo , Antituberculosos/química , Antituberculosos/metabolismo , Sobrevivência Celular/efeitos dos fármacos , Chlorocebus aethiops , Relação Dose-Resposta a Droga , Carpóforos/química , Carpóforos/metabolismo , Ganoderma/metabolismo , Lanosterol/análogos & derivados , Lanosterol/química , Lanosterol/metabolismo , Testes de Sensibilidade Microbiana , Conformação Molecular , Mycobacterium tuberculosis/efeitos dos fármacos , Compostos Fitoquímicos/química , Compostos Fitoquímicos/metabolismo , Triterpenos/química , Triterpenos/metabolismo , Células Vero , Madeira/química , Madeira/metabolismo
14.
Nat Prod Res ; 34(9): 1233-1237, 2020 May.
Artigo em Inglês | MEDLINE | ID: mdl-30663349

RESUMO

Four xanthones (1‒4) and a known compound, mansonone D (5), were isolated from the lignicolous freshwater fungus BCC 28210 (family, Chaetosphaeriaceae). The structures of these compounds were elucidated by extensive spectroscopic analysis. Among the isolated metabolites, compound 2 and the known mansonone D (5) displayed antimalarial activity against Plasmodium falciparum K1 with IC50 values of 7.75 and 0.55 µg/mL, respectively. Compound 4 displayed antibacterial activity against Bacillus cereus with an MIC value of 6.25 µg/mL.


Assuntos
Antibacterianos/isolamento & purificação , Antimaláricos/isolamento & purificação , Ascomicetos/química , Xantonas/isolamento & purificação , Antibacterianos/química , Antimaláricos/química , Ascomicetos/metabolismo , Bacillus cereus/efeitos dos fármacos , Água Doce/microbiologia , Concentração Inibidora 50 , Testes de Sensibilidade Microbiana , Estrutura Molecular , Naftoquinonas/isolamento & purificação , Extratos Vegetais/isolamento & purificação , Plasmodium falciparum/efeitos dos fármacos , Xantonas/química , Xantonas/farmacologia
15.
J Nat Prod ; 82(5): 1165-1176, 2019 05 24.
Artigo em Inglês | MEDLINE | ID: mdl-30983350

RESUMO

Thirty-one highly modified lanostanes (1-31), together with 19 known compounds (32-50), were isolated from fruiting bodies of the wood-rot basidiomycete Tomophagus sp. The structures were elucidated by analyses of HRMS and NMR spectroscopic data. The present work demonstrates the high structural diversity of modified lanostane triterpenoids from Tomophagus. This paper also discusses structural revisions of several known derivatives. Some of the isolated compounds exhibited moderate antimalarial activity against Plasmodium falciparum K1 (IC50 5.1-19 µM).


Assuntos
Basidiomycota/química , Carpóforos/química , Triterpenos/isolamento & purificação , Lanosterol/isolamento & purificação , Espectroscopia de Ressonância Magnética , Plasmodium falciparum/efeitos dos fármacos , Triterpenos/química , Triterpenos/farmacologia
16.
Nat Prod Res ; 32(9): 1044-1049, 2018 May.
Artigo em Inglês | MEDLINE | ID: mdl-28931319

RESUMO

A new lanostane triterpene (1), together with three known compounds (2-4), were isolated from cultivated fruiting bodies of the basidiomycete Ganoderma australe. The structure was elucidated on the basis of NMR spectroscopic and mass spectrometry data. The olefinic geometry of methyl australate (2) was revised from 20(22)Z to 20(22)E. These compounds (1-4) were different from the lanostanes isolated from mycelial cultures of the same strain source.


Assuntos
Antibacterianos/farmacologia , Carpóforos/química , Ganoderma/química , Triterpenos/química , Antibacterianos/química , Avaliação Pré-Clínica de Medicamentos/métodos , Espectroscopia de Ressonância Magnética , Testes de Sensibilidade Microbiana , Estrutura Molecular , Espectrometria de Massas por Ionização por Electrospray , Triterpenos/farmacologia
17.
Res Microbiol ; 167(4): 290-298, 2016 May.
Artigo em Inglês | MEDLINE | ID: mdl-26809052

RESUMO

An endophytic actinomycete strain BCC72023 was isolated from rice (Oryza sativa L.) and identified as the genus Streptomyces, based on phenotypic, chemotaxonomic and 16S rRNA gene sequence analyses. The strain showed 99.80% similarity compared with Streptomyces samsunensis M1463(T). Chemical investigation led to the isolation of three macrolides, efomycins M (1), G (2) and oxohygrolidin (3), along with two polyethers, abierixin (4) and 29-O-methylabierixin (5). To our knowledge, this is the first report of efomycin M being isolated from a natural source. The compounds were identified using spectroscopic techniques and comparison with previously published data. All compounds exhibited antimalarial activity against the Plasmodium falciparum, K-1 strain, a multidrug-resistant strain, with IC50 values in a range of 1.40-5.23 µg/ml. In addition, these compounds were evaluated for biological activity against Mycobacterium tuberculosis, Bacillus cereus, Colletotrichum gloeosporioides and Colletotrichum capsici, as well as cytotoxicity against both cancerous (MCF-7, KB, NCI-H187) and non-cancerous (Vero) cells.


Assuntos
Anti-Infecciosos/análise , Produtos Biológicos/análise , Endófitos/química , Oryza/microbiologia , Streptomyces/química , Antineoplásicos/análise , Técnicas de Tipagem Bacteriana , Análise por Conglomerados , DNA Bacteriano/química , DNA Bacteriano/genética , DNA Ribossômico/química , DNA Ribossômico/genética , Filogenia , RNA Ribossômico 16S/genética , Análise de Sequência de DNA , Análise Espectral , Streptomyces/classificação , Streptomyces/genética , Streptomyces/isolamento & purificação
18.
J Antibiot (Tokyo) ; 66(6): 305-9, 2013 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-23549355

RESUMO

Three new angucyclinones, saccharosporones A, B and C, together with (+)-ochromycinone, (+)-rubiginone B2, tetrangulol methyl ether and fujianmycin A, were obtained from fermentation of the terrestrial actinomycete of the genus Saccharopolyspora BCC 21906 isolated from a soil collected in Chanthaburi Province, Thailand. Structures of the new compounds and their relative configurations were assigned by NMR spectral data interpretation. Saccharosporones A and B exhibited antimalarial activity against Plasmodium falciparum K1 with IC50 values of 4.1 and 3.9 µM. Both metabolites also possessed cytotoxic activities against cancer cell lines (KB, MCF-7 and NCI-H187) and nonmalignant Vero cell, while saccharosporone C only showed cytotoxic activity against NCI-H187.


Assuntos
Antraquinonas/isolamento & purificação , Antibióticos Antineoplásicos/isolamento & purificação , Antimaláricos/isolamento & purificação , Saccharopolyspora/química , Microbiologia do Solo , Animais , Antraquinonas/química , Antraquinonas/farmacologia , Antibacterianos/química , Antibacterianos/isolamento & purificação , Antibacterianos/farmacologia , Antibióticos Antineoplásicos/química , Antibióticos Antineoplásicos/farmacologia , Antifúngicos/química , Antifúngicos/isolamento & purificação , Antifúngicos/farmacologia , Antimaláricos/química , Antimaláricos/farmacologia , Bacillus cereus/efeitos dos fármacos , Benzo(a)Antracenos/isolamento & purificação , Benzo(a)Antracenos/farmacologia , Candida albicans/efeitos dos fármacos , Chlorocebus aethiops , Fermentação , Humanos , Concentração Inibidora 50 , Células KB , Células MCF-7 , Espectroscopia de Ressonância Magnética , Testes de Sensibilidade Microbiana , Conformação Molecular , Mycobacterium tuberculosis/efeitos dos fármacos , Plasmodium falciparum/efeitos dos fármacos , Tailândia , Células Vero
20.
J Nat Prod ; 73(4): 759-62, 2010 Apr 23.
Artigo em Inglês | MEDLINE | ID: mdl-20329738

RESUMO

Two strobilurins, 9-methoxystrobilurin B (1) and 9-methoxystrobilurin G (2), two monochlorinated 2,3-dihydro-1-benzoxepin derivatives, 3 and 4a, and butenolide 5, together with four known compounds, strobilurin B, 9-methoxystrobilurin A, and oudemansins A and B, were isolated from culture BCC 18689 of the fungus Favolaschia tonkinensis. 9-Methoxystrobilurins A, B (1), and G (2) and oudemansins A and B exhibited antimalarial, antifungal, and cytotoxic activities, while compounds 3, 4a, and 5 displayed only cytotoxic activity.


Assuntos
Basidiomycota/química , Citotoxinas/isolamento & purificação , Citotoxinas/farmacologia , Ácidos Graxos Insaturados/isolamento & purificação , Ácidos Graxos Insaturados/farmacologia , Metacrilatos/isolamento & purificação , 4-Butirolactona/análogos & derivados , 4-Butirolactona/química , 4-Butirolactona/isolamento & purificação , Animais , Antifúngicos/isolamento & purificação , Antifúngicos/farmacologia , Antimaláricos/farmacologia , Benzoxepinas/química , Benzoxepinas/isolamento & purificação , Candida albicans/efeitos dos fármacos , Chlorocebus aethiops , Citotoxinas/química , Ensaios de Seleção de Medicamentos Antitumorais , Ácidos Graxos Insaturados/química , Feminino , Humanos , Células KB , Metacrilatos/química , Metacrilatos/farmacologia , Testes de Sensibilidade Microbiana , Estrutura Molecular , Plasmodium falciparum/efeitos dos fármacos , Pirazóis , Pirimidinas , Estrobilurinas , Tailândia , Células Vero
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