Blood Vessel Resident Human Stem Cells in Health and Disease.

The vascular wall is comprised of distinct layers controlling angiogenesis, blood flow, vessel anchorage within organs, and cell and molecule transit between blood and tissues. Moreover, some blood vessels are home to essential stem-like cells, a classic example being the existence in the embryo of hemogenic endothelial cells at the origin of definitive hematopoiesis. In recent years, microvascular pericytes and adventitial perivascular cells were observed to include multi-lineage progenitor cells involved not only in organ turnover and regeneration but also in pathologic remodeling, including fibrosis and atherosclerosis. These perivascular mesodermal elements were identified as native forerunners of mesenchymal stem cells. We have presented in this brief review our current knowledge on vessel wall-associated tissue remodeling cells with respect to discriminating phenotypes, functional diversity in health and disease, and potential therapeutic interest.

The Effect of Spirituality on Mood: Mediation by Self-Esteem, Social Support, and Meaning in Life.

Negative correlations between religiosity or spirituality and depression symptoms have been frequently reported, but relatively few empirical studies have investigated the processes that mediate the relationships. This study investigated four theorized mediators in a single model to assess the unique contributions of self-esteem, social support, meaning in life, and positive religious coping to the relationship between religiosity, spirituality, and two markers of depression, positive affect and negative affect. Path analysis was employed to investigate multiple mediation models in a sample of 352 undergraduates. Non-significant paths were removed, and a second independent sample of 316 undergraduates was used to validate the trimmed models. Results indicated that self-esteem mediated the relationships between spirituality and both positive and negative affect. Meaning in life also mediated the relationship between spirituality and positive affect, while social support mediated the relationship between spirituality and negative affect. Positive religious coping did not mediate either relationship, possibly because the samples were not drawn from populations under stress. The relationship between intrinsic religiosity and positive affect was similarly mediated by self-esteem and meaning in life. Religiosity and negative affect were related through the mediators self-esteem and an unexpectedly adverse factor captured by positive religious coping in the models used.