Physiological and functional impact of an unsupervised but supported exercise programme for claudicants.

OBJECTIVES: To evaluate an unsupervised home-based exercise programme for physiological, functional, and quality of life impact in patients with symptomatic peripheral arterial disease. DESIGN: Prospective cohort with exercise intervention. MATERIALS: Human performance laboratory with non-invasive haemodynamic assessment facilities. METHODS: Forty-seven patients with symptomatic peripheral arterial disease (mean age 67.6+/-7 years, 33 males) participated in an unsupervised home-based exercise programme. Heart rate (HR), ankle brachial blood pressure index (ABPI), leg blood flow (BF), and blood lactate were measured before and after a graded treadmill walk at baseline and after the 12-week exercise programme. Maximum walking distance (MWD) during the treadmill walk was measured at baseline and 12 weeks. Exercise compliance, functional parameters, and quality of life (VascuQoL) were assessed by questionnaire. RESULTS: MWD, leg BF, and VascuQoL scores increased significantly, while resting HR, exercise HR, and end of walk rate-pressure-product (RPP) decreased significantly after 12 weeks. Exercise compliance was significantly correlated with increase in MWD (r=0.89, p<0.001) and QOL score improvement (r=0.61, p<0.001). CONCLUSIONS: This supported but unsupervised exercise programme generated improvements in walking distance and leg blood flow without detectable increases in cardiorespiratory work. Exercise compliance is related to MWD and VascuQoL score in a dose-response manner.

The diagnostic value of light reflection rheology for suspected deep vein thrombosis: a five-and-a-half year single centre experience.

OBJECTIVES: Previous studies evaluating light reflection rheology (LRR) in the preliminary diagnosis of suspected deep vein thrombosis (DVT) have been based on limited patient numbers. The objective of this study was to demonstrate the diagnostic value of LRR in this setting for a large patient series. METHODS: A retrospective study was carried out using prospectively collected data over a five-and-a-half year period. During the study period, 3342 limbs were assessed with LLR in 3105 patients referred with suspected DVT (both inpatients and outpatients). RESULTS: In total, 2396 (71.7%) of all the LRR tests carried out yielded an abnormal result. Of the remaining 946 (28.3%) with a normal result, 204 went on to have a duplex scan due to a high clinical index of suspicion, and 14 DVTs were identified on duplex scanning. Of the remaining 742 patients with a normal LRR result who were not scanned, six re-presented within three months with a confirmed DVT, and one with a confirmed pulmonary embolus (PE). These results yield a negative predictive value of 97.8%, a sensitivity of 96.4% with a three-month post-test thromboembolism incidence of 0.9%. Use of LRR allowed duplex scanning to be avoided for 22.2% of referrals. CONCLUSIONS: Despite the increasing use of D-dimers and clinical probability scoring in the preliminary investigation of thromboembolic events, LRR remains a viable alternative in safely risk-stratifying patients with suspected DVT.

Cross-sectional survey of beta-blockers use in primary and secondary care for patients with arterial disease.

Beta-blockers reduce mortality in ischaemic heart disease and, when given perioperatively, in vascular surgery. We investigated the use of and attitudes towards beta-blockers by British vascular surgeons and primary care physicians (GPs). We performed a cross-sectional postal survey by questionnaire sent to 367 GPs and 397 members of the Vascular Surgical Society. Specific questions related to beta-blockers use and indications. Two hundred and thirty-four GPs, 95 full-time vascular surgeons (VS) and 137 general surgeons (GS) with a vascular interest responded. Thirty-eight percent of VS and 16% of GS often or always used perioperative beta-blockade (p<0.001). Common indications were ischaemic heart disease (39.2%), hypertension (30.6%), arrhythmia (16.3%) and myocardial protection (6.9%). Sixty-eight percent of VS and 42% of GS would prescribe beta-blockers to patients with occlusive arterial disease (p < 0.001). Common indications were ischaemic heart disease (39.6%), hypertension (29.2%) and arrhythmia (13.3%). Of those who would not prescribe beta-blockers in occlusive arterial disease, 65% felt that beta-blockers were contraindicated in this condition. GPs widely regarded occlusive arterial disease as a contraindication to beta-blockade. Beta-blockers are underused by GPs and GS especially, perhaps because of a perceived risk of side effects in patients with occlusive arterial disease. Further evidence is needed on the effect of beta-blockade on quality of life of patients with arterial disease.

Exercise training for claudicants: changes in blood flow, cardiorespiratory status, metabolic functions, blood rheology and lipid profile.

OBJECTIVE: Exercise training improves the walking distance of claudicants. The aim of this study was to investigate factors associated with the improvement in the maximum walking distance (MWD) in respect to cardiovascular, respiratory and metabolic adaptations. METHODS: Forty claudicants were studied. Common femoral artery blood flow (BF), heart rate (HR), oxygen consumption (VO(2)), respiratory exchange ratio (RER), lactate levels, blood rheology and lipid profiles were measured. Tests were repeated after 3 months of exercise training. RESULTS: Fifteen patients did not complete the exercise program. For patients who did complete the program, MWD improved by 82%. A significant reduction in HR and VO(2)during exercise was demonstrated. No significant changes occurred in BF or RER. Although MWD increased significantly, there was no increase in recovery VO(2)(oxygen debt). A significant reduction in post-exercise lactate levels occurred. Blood rheology was unchanged, but an improvement in HDL levels was noted. CONCLUSIONS: Many claudicants could not complete an exercise program, mainly due to osteoarthritis. Exercise training improved exercise tolerance significantly without any increase in BF. The HR and oxygen cost of similar exercise was reduced. An improved MWD did not correlate with a higher oxygen debt or lactate load. Favourable changes in lipid profiles occurred.

Exercise training and peripheral vascular disease.

BACKGROUND: Conservative management is advocated as a treatment of choice for patients with intermittent claudication. This is a review of the mechanisms behind the improvement following an exercise rehabilitation programme. METHODS: All Medline articles from the National Library of Medicine, USA containing the text words 'claudication' or 'peripheral vascular disease' and 'exercise' were reviewed. Cross-referencing from relevant articles was carried out. RESULTS AND CONCLUSION: The poor physical status of a patient with intermittent claudication is not solely due to a reduction in blood flow to the lower limbs; associated factors, such as metabolic inefficiency, poor cardiorespiratory reserve and exercise-induced inflammation contribute. An exercise programme frequently improves both the physical aspect and quality of life, and the success of such exercise is multifactorial. An increase in the blood flow to the lower extremity is uncommon. Other factors, such as a redistribution of blood flow, changes in oxidative capacity of the skeletal muscles and greater utilization of oxygen, occur and the associated metabolic dysfunction of the skeletal muscles is rectified. Following exercise training, blood rheology improves and exercise-induced inflammation is ameliorated; cardiorespiratory status also benefits and the oxygen cost of exercise decreases.

Value of a surgical high-dependency unit.

BACKGROUND: A minority of hospitals in the UK have a high-dependency unit (HDU). One reason for this is a lack of evidence supporting its benefit. This study sought to compare the outcomes of patients undergoing major abdominal surgery with regard to HDU utilization. METHODS: Data were collected prospectively from two groups of patients over 10 months. Patients in the no-HDU group underwent major abdominal surgery in a hospital without an HDU and returned to a general surgical ward. The other group was managed initially in an HDU. Data collected included Physiological and Operative Severity Score for enUmeration of Mortality and morbidity (POSSUM) scores, complications, deaths and length of stay. RESULTS: Physiological and operative scores as calculated on the RAJIS POSSUM software were similar in both groups. The HDU group comprised 121 patients. Sixty-four developed a complication whereas 58.81 were expected to, giving an observed : expected (O : E) ratio of 1.09. Sixteen deaths occurred and 14.54 were expected (O : E ratio 1.10). Some 50 per cent stayed in hospital longer than was predicted. The no-HDU group comprised 71 patients. Fifty-nine developed a complication compared with 33.82 expected (O : E ratio 1.74). Ten deaths occurred, whereas 8.88 were expected, giving an O : E ratio of 1.13. Some 63 per cent stayed longer than predicted. The O : E ratios for morbidity were significantly different (P < 0.0005). The complications that occurred more frequently in the absence of an HDU were chest infection, arrhythmias and hypotension. CONCLUSION: Postoperative management on an HDU was associated with fewer cardiorespiratory complications. There was no difference in mortality rate but there was a trend towards shorter hospital stay.

The effect of pregnancy on the lower-limb venous system of women with varicose veins.

OBJECTIVES: to assess the effect of pregnancy on the lower-limb venous system of women with varicose veins. Design a longitudinal prospective study of 11 pregnant women, with varicose vein disease. METHODS: eleven pregnant women with varicose veins were recruited as part of a larger study. Veins were assessed in both lower limbs using colour-flow duplex scanning at a 75 degrees head-up tilt. The diameter and velocity and duration of reflux were measured in each vein at 12, 20, 26, 34, 38 weeks gestation and 6 weeks postpartum. RESULTS: eleven women had reflux and varicose veins demonstrated at first scan. All veins dilated with increasing gestation. This was maximal in the superficial system, reaching significance (p

Serial colour flow duplex scanning of the veins of the lower limb throughout pregnancy.

OBJECTIVE: To examine changes in diameter and reflux in normal veins of the lower limb throughout pregnancy. METHODS: Fifty-seven women were recruited into the study and 43 completed the full assessment to six weeks postpartum. Thirteen had pre-existing venous disease and are reported elsewhere. The veins were assessed in both lower limbs using colour flow duplex scanning. This was performed at a 75 degree tilt measuring vein diameter and the presence or absence of reflux. Measurements were made at 12, 20, 26, 34, 38 weeks of gestation and 6 weeks postpartum. RESULTS: No new reflux developed in any of the veins studied. In the superficial system the maximum change was seen in the long saphenous vein at 34 weeks, on the left side the vein diameter failed to return to baseline size. Significant change also occurred in the superficial femoral vein. Dilatation of the deep veins of the calf was observed being greater in the left posterior tibial and the left peroneal at the mid-calf point. CONCLUSION: Colour flow duplex scanning is an acceptable method of assessing the lower limb veins in pregnancy. Maximum diameter changes were seen in the long saphenous vein and in the deep veins at mid-calf. No new reflux developed during the gestation period in veins which were previously normal.

Risk scoring in surgical patients.

BACKGROUND: A large number of scoring systems for assessing a patient's risk of complications or death has been developed over recent years. This is a review of those that are of relevance to general surgeons. METHODS: A Medline literature search was performed to identify all articles concerning 'severity of illness', 'morbidity', 'mortality' and 'postoperative complications' in the field of surgery from 1966 to 1997. Further searches were performed to find papers about specific identified scoring systems, and relevant articles from the reference lists of these were also sought. RESULTS AND CONCLUSION: The advantages of an accurate assessment of a patient's risk include, on an individual level, the opportunity to give a more accurate prognosis and choose the most appropriate treatment. If the risk of an adverse outcome is known for a group of patients, the actual outcome can be compared with the predicted outcome, and comparison can be made between groups in different surgical units for the purposes of audit or research. The Physiological and Operative Severity Score for enUmeration of Mortality and morbidity (POSSUM) is the most appropriate of the currently available scores for general surgical practice.

Use of a general surgical high dependency unit in a district general hospital: the first 10 years.

The high dependency unit (HDU) is a facility that is an essential component of any surgical unit. This paper reviews the development of a general surgical HDU managed by surgeons over a decade, with analysis of activity from 1991 to 1996. The general surgical workload has increased during the 10-year period, and the case-mix has become richer by an increase in vascular surgery. The HDU provides essential post-operative care to major surgical patients and minimizes the cancellation of aortic operations without placing an extra burden on the intensive care services. The HDU centralises sick patients, facilitating their care, and provides a learning environment for trainee surgeons.

Carotid endarterectomy in the U.K. and Ireland: audit of 30-day outcome. The Audit Committee for the Vascular Surgical Society.

OBJECTIVES AND DESIGN: A prospective study of 709 patients undergoing carotid surgery in the U.K. and Ireland was performed to evaluate the performance of vascular surgeons. MATERIALS AND METHODS: Fifty-nine surgeons (range 2-39 cases each) were sampled and all patients undergoing surgery over a 6-month period (1 March 1994-31 August 1994) were included in the study. Indications for surgery were TIA (35.9%), AF (23.3%), CVA (21.4%) and "others" (19.6%). RESULTS: Mean ipsilateral stenosis was 82% (30%-99%). Thirty-one percent of patients had preoperative neurological consults. Shunts were used in 67.6%, tacking sutures in 40.1%, drains in 71.9% and patches in 54.4% of cases. At 30 days there were nine (1.3%) deaths (four cardiac, three neurological). There were 15 ipsilateral postoperative CVAs (2.1%); 19% of patients had one or more complication, usually minor. Statistical analysis showed no independent risk factor for CVA other than seniority of the surgeon. CONCLUSIONS: A combined stroke/death rate of 3% for the series was obtained at 30 days for all cases. This large, validated study suggests that members of the Vascular Society of G.B. and Ireland currently have a very low morbidity/mortality rate for performing carotid surgery. Continued audit is required to ensure that this quality of service does not deteriorate.

The Stresst'er ergometer as an alternative to treadmill testing in patients with claudication.

OBJECTIVES: To compare a new pedal ergometer (the Stresst'er) with conventional treadmill examination in patients with leg pain on exercise. DESIGN: Patients presenting with claudication were assessed by standard treadmill test and by the new device in two District General Hospitals. METHODS: Ninety-four subjects were studied. Symptoms induced by both types of exercise were compared. Distance walked on the treadmill was compared to the number of pumps using the Stresst'er. The percentage change in ankle systolic pressure produced by the two tests was compared. RESULTS: Subjective symptoms induced by the tests were similar. Distance walked did correlate with pumps on the ergometer, as did change in systolic pressure. Analysis of a subgroup of 41 cases with receiver operator curve (ROC) tests showed that the new device is sensitive and specific. CONCLUSION: This new device is comparable with treadmill testing, but being easier to use, may have a place in the vascular clinic.