RESUMO
AIM: The purpose of the study was to analyze the potential capacity of a dietary supplement, based on gamma linolenic acid, vitamin E, vitamin C, beta-carotene, coenzyme Q10 and Vitis Vitifera, to reduce side effects, in particular the dry skin, erythema and desquamation, due to treatment with oral isotretinoin, and evaluate the ability of the product to increase adherence to therapy in patients with acne. METHODS: Forty-eight patients with nodular acne (32 females and 16 males) were randomly divided into 2 groups: 24 received isotretinoin therapy (20-30 mg/day) for 6 months associated to dietary supplement (twice a day), while the other 24 patients received only isotretinoin (20-30 mg/day) for 6 months. For all patients the degree of acne severity, through GAGS (Global Acne Grading System), the sebum production by Sebutape, the hydration by Corneometer and the erythema by Mexameter, were measured. We have also evaluated the adherence to treatment, asking to patients how many days a week they follow the therapy. RESULTS: Patients treated with dietary supplement had lower side effects, with a less degree of erythema and dryness, and greater degree of hydration; a greater adherence to therapy was also reported. CONCLUSION: Thanks to antioxidant and moisturizing properties, the dietary supplement containing gamma linolenic acid, vitamin E, vitamin C, betacarotene, coenzyme Q10 and Vitis Vitifera, can be considered a useful supplement in the treatment and prevention of dry skin associated with the use of oral isotretinoin.
Assuntos
Acne Vulgar/tratamento farmacológico , Fármacos Dermatológicos/administração & dosagem , Fármacos Dermatológicos/efeitos adversos , Suplementos Nutricionais , Eritema/prevenção & controle , Isotretinoína/administração & dosagem , Isotretinoína/efeitos adversos , Pele/efeitos dos fármacos , Acne Vulgar/diagnóstico , Administração Oral , Adolescente , Adulto , Ácido Ascórbico/uso terapêutico , Relação Dose-Resposta a Droga , Eritema/induzido quimicamente , Feminino , Humanos , Itália , Masculino , Índice de Gravidade de Doença , Resultado do Tratamento , Ubiquinona/análogos & derivados , Ubiquinona/uso terapêutico , Vitamina E/uso terapêutico , Vitaminas/uso terapêutico , Vitis , beta Caroteno/uso terapêutico , Ácido gama-Linolênico/uso terapêuticoRESUMO
The generalized form of lichen nitidus (LN) with oral and nail changes is extremely rare in childhood. We report a 10-year-old boy with generalized LN associated with oral involvement and onychodystrophy. Oral lesions showed yellowish papules on the gums. The nails had longitudinal striations and pits on the finger-nails, and transversal ridging of the big toes was found. Cutaneous and mucosal lesions as well as onychodystrophy spontaneously cleared within 8 months.
Assuntos
Líquen Nítido/complicações , Doenças da Unha/complicações , Estomatite/complicações , Criança , Diagnóstico Diferencial , Humanos , Líquen Nítido/diagnóstico , Líquen Nítido/patologia , Masculino , Mucosa Bucal/patologia , Doenças da Unha/diagnóstico , Doenças da Unha/patologia , Remissão Espontânea , Estomatite/diagnóstico , Estomatite/patologiaAssuntos
Dedos , Dermatoses da Mão/patologia , Adulto , Feminino , Humanos , Ceratose/patologia , Pele/patologiaAssuntos
Onicomicose/epidemiologia , Adolescente , Adulto , Idoso , Feminino , Humanos , Itália , Masculino , Pessoa de Meia-Idade , Onicomicose/microbiologiaRESUMO
A patient with lichen planopilaris with peculiar leukonychia is described. The histologic findings from examination of the nail biopsy specimen are discussed.
Assuntos
Líquen Plano/complicações , Doenças da Unha/complicações , Humanos , Líquen Plano/patologia , Masculino , Pessoa de Meia-Idade , Doenças da Unha/patologiaRESUMO
An unusual case of nail involvement in dermatomyositis in which complete loss of several toenails was the only cutaneous sign of the disease is reported for its clinical interest.
Assuntos
Dermatomiosite/complicações , Doenças da Unha/etiologia , Dermatomiosite/patologia , Feminino , Humanos , Pessoa de Meia-Idade , Doenças da Unha/patologia , Dedos do PéAssuntos
Líquen Plano/patologia , Doenças da Unha/patologia , Unhas/patologia , Biópsia , Feminino , Humanos , Pessoa de Meia-IdadeRESUMO
We report the results of a controlled trial on 119 patients affected by patchy alopecia areata involving less than 40% of the scalp. The statistical analysis showed no differences between the results obtained using squaric acid dibutylester, diphencyprone, minoxidil, and placebo in the treatment of this form of alopecia.
Assuntos
Alopecia em Áreas/tratamento farmacológico , Adolescente , Adulto , Fatores Etários , Idoso , Criança , Pré-Escolar , Ensaios Clínicos como Assunto , Ciclobutanos/uso terapêutico , Ciclopropanos/uso terapêutico , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Minoxidil/uso terapêutico , PlacebosRESUMO
Electroretinography (ERG) and electro-oculography (EOG) were performed in 98 patients affected by alopecia areata (AA) free from ophthalmologic disorders, and in 40 healthy subjects, in order to evaluate whether or not the retinal pigment epithelium of AA patients shows bioelectrical changes. ERG was normal. EOG, on the contrary, showed a significantly depressed mean value in the AA patient group. Furthermore, depressed EOG occurred more frequently in patients affected by alopecia totalis or universalis as compared with multiple patchy alopecia. These findings prompt the authors to believe that the melanocytes may play a prominent part in the pathogenesis of AA.
