RESUMO
Microcrystalline cellulose (MCC) is one of the most important functional excipient in Pharmaceutical industries. A renewable biomass from Ensete glaucum (Roxb.) was investigated as a potential source of a novel functional MCC. MCC was prepared by a simple, dilute acid hydrolysis and characterized through FTIR, DSC, XRD, along with micromeritic studies. Functional properties such as packing, rearrangement, consolidation and compactibility of the prepared MCC were also evaluated in view of its application as drug delivery biomaterial. Results suggest that the prepared MCC exhibit properties comparable to commercially available standard MCC. From Kawakita and Heckel plots, it was observed that the new MCC consolidates better than the standard MCC. Disintegration efficiency test also indicates that the novel MCC functions as a better tablet disintegrant to the standard MCC indicating the potential of Ensete glaucum (Roxb.) as a green resource for preparation of the low cost, functional and sustainable carbohydrate polymer.
Assuntos
Materiais Biocompatíveis/química , Celulose/química , Portadores de Fármacos/química , Excipientes/química , Musa/química , Materiais Biocompatíveis/isolamento & purificação , Biomassa , Celulose/isolamento & purificação , Portadores de Fármacos/isolamento & purificação , Excipientes/isolamento & purificação , Química Verde/métodos , Porosidade , Comprimidos/química , Resistência à Tração , ViscosidadeRESUMO
The objective of the present work is to study the physicochemical and functional properties of taro starch (Colocasia esculenta) and to further modify the starch by treating with citric acid to obtain a novel functional material. DSC, FTIR and SEM studies were performed along with physicochemical analysis. The disintegrant efficiency ratio and dissolution efficiency were determined on paracetamol tablets prepared by wet granulation taking the starch as a binder-disintegrant. The moisture content and ash values of taro and citrate taro starches were about 13% and 0.5% respectively. The average particle size of taro starch was found to be 1.53⯵m and citration was not found to cause significant changes in the particle size. Results from disintegration efficiency study showed that both the taro and citrate modified taro starch showed tablet disintegrant property and even performed better than the standard corn starch. The reduced disintegration time was also found to enhance dissolution of the model drug from the tablet.
