COVCOG: Immediate and long-term cognitive improvement after cognitive versus emotion management psychoeducation programs - a randomized trial in covid patients with neuropsychological difficulties.

BACKGROUND: Cognitive difficulties are a frequent complaint in long COVID and persist for more than a year post- infection. There is a lack of evidence-based data on effective intervention strategies. Non-pharmacological intervention programs that are used with other neurological populations have not yet been the subject of controlled trials. COVCOG is a multicentric, randomized trial comparing cognitive intervention and a cognitive-behavioural counselling. METHODS/DESIGN: Patients with long covid are selected and recruited at least three months post-infection. Patients are randomised in a 1:1 ratio into the cognitive (neuropsychological psychoeducation) and affective (emotion management with cognitive-behavioural counselling) intervention arms. The inclusion of 130 patients is planned. The cognitive intervention includes psycho-educational modules on fatigue and sleep, attention and working memory, executive functions and long-term memory. The affective intervention includes modules on emotion recognition and communication, uncertainty management and behavioral activation. The main objective is to reduce cognitive complaints 2 months after the intervention. A Follow-up is also planned at 8 months. DISCUSSION: Given the long-term effects of Covid on cognition and the negative effects of cognitive impairment on quality of life and social participation, it is important to determine whether low-dose, non-pharmacological interventions can be effective. The trial will determine which of the usual types of intervention is the most effective. TRIAL REGISTRATION: Clinicaltrials.gov Number: NCT05167266 (21/12/ 2021).

Using 360-degree immersive videos to assess multiple transdiagnostic symptoms: A study focusing on fear of negative evaluation, paranoid thoughts, negative automatic thoughts, and craving.

Over the last 20 years, virtual reality (VR) has gained a great interest for both assessment and treatment of various psychopathologies. However, due to high costs and material specificity, VR remains disadvantageous for clinicians. Adopting a multiple transdiagnostic approach, this study aims at testing the validity of a 360-degree immersive video (360IV) for the assessment of five common psychological symptoms (fear of negative evaluation, paranoid thoughts, negative automatic thoughts, craving for alcohol and for nicotine). A 360IV was constructed in the Darius Café and included actors behaving naturally. One hundred and fifty-eight adults from the general population were assessed in terms of their proneness towards the five symptoms, were then exposed to the 360IV and completed measures for the five state symptoms, four dimensions of presence (place, plausibility, copresence and social presence illusions) and cybersickness. Results revealed that the five symptoms occurred during the immersion and were predicted by the participants' proneness towards these symptoms. The 360IV was also able to elicit various levels of the four dimensions of presence while producing few cybersickness. The present study provides evidence supporting the use of the 360IV as a new accessible, ecological, and standardized tool to assess multiple transdiagnostic symptoms. Supplementary Information: The online version contains supplementary material available at 10.1007/s10055-023-00779-y.

Examining the impact of experiencing auditory verbal hallucinations from a first-person perspective on the degree of empathy and stigmatization in a group of psychology students: A study using 360° immersive videos.

BACKGROUND: Stigmatization toward psychosis is persistent among mental health professionals (MHPs) and negatively impacts the patients' outcomes. One suggested way of reducing stigmatization is to expose MHPs to simulations of psychotic symptoms. This approach has been associated with an increase in empathy, but also with an increase in the desire of social distance. The addition of an empathic task (ET) has been suggested to neutralize this effect on social distance. The present study aims to (1) examine the effect of a remotely administered 360° immersive video (360IV) simulation on empathy and stigma among psychology students and (2) replicate the neutralizing effect of an ET on social distance. Finally, the potential role of immersive properties on changes will also be explored. METHODS: A 360IV simulating auditory hallucinations was constructed in collaboration with patient partners. 121 psychology students were allocated to one of three conditions: (i) exposure to the 360IV, (ii) exposure to the 360IV and to an ET (360IV + ET), and (iii) no exposure (control). Measures of empathy and stigma (stereotypes and social distance) were collected before and after the interventions. RESULTS: An increase of empathy was observed in the 360IV and 360IV + ET conditions compared to the control condition. There was an increase of stereotypes in all conditions and no effect on social distance. CONCLUSIONS: This study confirms the effectiveness of a 360IV simulation intervention in increasing empathy in psychology students but questions its efficacy in reducing stigma.

Using 360° immersive videos to assess paranoia in a non-clinical population.

Introduction: For the past two decades, virtual reality (VR) has proven to be an innovative approach for the assessment of state paranoia. However, the use of VR remains costly, and avatars are still far from realistic in terms of facial and bodily expressions. The present study aimed to test the validity of three 360° immersive videos (360IVs) as an accessible and realistic alternative for the assessment of non-clinical state paranoia.Method: Three 360IVs were created (a Lift, a Library and a Bar) and included actors behaving naturally. One hundred and fifty healthy students were assessed in terms of their proneness towards trait paranoia, were then exposed to one of the three 360IVs, and finally completed measures of state paranoia, sense of presence and cybersickness.Results: Results revealed the presence of various interpretations about the actor's attitudes in the three 360IVs. Also, paranoid thoughts were predicted by proneness towards trait paranoia in two out of the three 360IVs. Furthermore, moderate levels of sense of presence and low levels of cybersickness were observed for each 360IV.Conclusion: The present study provides evidence in favour of the use of 360IVs as a new accessible, realistic, and standardised tool to assess state paranoia in non-clinical samples.

Psychometric investigation of the French version of the Aberrant Salience Inventory (ASI): differentiating patients with psychosis, patients with other psychiatric diagnoses and non-clinical participants.

During the prodromal phase of psychosis, individuals may experience an aberrant attribution of salience to irrelevant stimuli. The concept of aberrant salience has been hypothesized to be a central mechanism in the emergence and maintenance of psychosis. The 29-item Aberrant Salience Inventory (ASI) was designed to measure five aspects of aberrant salience. The aim of this study was to investigate the psychometric properties of the French version of the ASI comparing patients with psychosis, patients with other diagnosis and healthy, non-clinical participants. The French-language ASI was adapted using the back-translation procedure. Two hundred and eighty-two participants issued from the general population and 150 psychiatric patients were evaluated. Internal validity was assessed using a two-parameter logistic item response model. Reliability was estimated using a test-retest procedure. Convergent validity was estimated using correlations between the ASI scores and several other scales. Sensitivity was evaluated by comparing the scores of participants with a diagnosis of psychosis, patients with other diagnoses and the general population. The best model distinguished three factors: Enhanced Interpretation and Emotionality, Sharpening of Senses and Heightened Cognition. Reliability and convergent validity estimates were good in both groups. The Sharpening of Senses factor was able to discriminate between patients and the general population. Only the Heightened Cognition factor was able to discriminate patients with psychosis from the other psychiatric patients. The ASI is a valid and reliable tool to study not only the aberrant salience phenomenon in patients with psychosis, but also with other diagnoses and within the general population.

Idiographic analyses of motivation and related processes in participants with schizophrenia following a therapeutic intervention for negative symptoms.

BACKGROUND: Motivational negative symptoms hinder quality of life and daily functioning of individuals with schizophrenia spectrum disorders. A recently developed intervention, Switch, has shown promising effects on negative symptoms and functional outcomes. Switch targets multiple cognitive, emotional and behavioural processes associated with motivation and goal directed behaviours. We aimed to investigate its effects on motivation and associated processes in a naturalistic setting, and to explore the dynamics between the processes. METHODS: We used a single case approach (n = 3), with a pre-post and follow-up assessment design, which also included ambulatory assessments (experience sampling method, ESM; and step count). We computed autoregressive lag 1 models to evaluate the effects of the intervention on daily motivation levels and related processes, descriptive pie-charts, and vector autoregressive modelling to reveal the dynamics of the processes over time. RESULTS: The intervention was beneficial for each participant according to traditional evaluations of motivational negative symptoms, apathy, daily functioning and quality of life. The effects on the ESM variables revealed distinct outcomes for each individual. The dynamics between the various processes differed between participants, and fluctuated within participants (when comparing baseline, intervention phase, and follow-up). CONCLUSIONS: This study used an innovative approach to look at the effectiveness of an intervention. The intervention seems to lead to meaningful improvements in motivational negative symptoms and functional outcomes. The mechanisms of change need to be further investigated. TRIAL REGISTRATION NUMBER: ClinicalTrials.gov, NCT04325100 . Registered 27 March 27, 2020 -retrospectively registered. REPORTING: Guidelines from the Transparent Reporting of Evaluations with Non-randomized Designs (TREND) statement were followed.

Switch, a new intervention that targets motivational negative symptoms in people with schizophrenia: An uncontrolled pilot study.

OBJECTIVE: People diagnosed with schizophrenia experience difficulties in their daily life, which is best explained by motivational negative symptoms. This study explores the feasibility, acceptability, and efficacy of Switch, a new multifactorial intervention that targets motivational deficits. METHOD: Eight participants with schizophrenia or schizoaffective disorder followed around 30 individual sessions of Switch over 12 months. Participants and their informants were interviewed at baseline (T0), at 6 months (T1), at the end of the intervention (T2), and at 6 months follow-up (T3). RESULTS: T0-T1 paired sample t tests showed large improvements on motivational deficits, general negative symptoms, and apathy and functional outcomes (both as rated by informants). At T2 and T3, moderate to large improvements were maintained. Switch was well accepted by participants. CONCLUSIONS: This preliminary investigation provides evidence that Switch may be a feasible, acceptable, and effective intervention specifically designed to target motivational deficits and improve daily functioning.

Testing a model of auditory hallucinations: the role of negative emotions and cognitive resources.

Introduction: Models of auditory hallucinations (AH) state that AH arise through an interaction between negative emotions and limited available cognitive resources. However, this hypothesis has never been directly tested. Methods: A two-by-two factorial design was used to examine the effect of emotions (neutral VS negative) and available cognitive resources (high VS low) on the elicitation of false alarms in an auditory signal detection paradigm. One hundred and seventy four healthy participants were assigned to one of the four experimental conditions. While participants were listening to white noise, their emotional state was manipulated using affective pictures and the level of available cognitive resources was manipulated using a visual N-back task. Results: Results revealed significant interaction effects between emotions and cognitive resources on the number of false alarms. In particular, participants with fewer available cognitive resources and at the same time who were in a negative emotional state, tended to hear significantly more false alarms. In addition, the degree of certitude was significantly correlated with a higher degree of hallucination proneness. Conclusions: Such results are in agreement with models of AH and they provide new data for the understanding of the emotional and cognitive mechanisms that underpin AH.

Source flexibility in schizophrenia: specificity and role in auditory hallucinations.

INTRODUCTION: One important aspect of human cognition relies on the ability to bias attention towards stimulus-independent and stimulus-oriented thoughts and to switch between these states - or source flexibility. This mechanism has received very little attention in the literature, and in particular in schizophrenia. Moreover, there is good reason to believe that this mechanism could also be implicated in hallucinations, but this hypothesis has never been examined. Thus, the aim of the present study was, for the first time in the literature, to explore source flexibility abilities in schizophrenia and their potential relations with auditory hallucinations. METHODS: Forty persons diagnosed with schizophrenia and 26 healthy controls were evaluated with tasks assessing source flexibility, cognitive flexibility and processing speed. Patients were also assessed with a measure of hallucinations and delusions. RESULTS: Results revealed that persons diagnosed with schizophrenia presented a poorer performance than healthy controls for source flexibility. Moreover, results demonstrated that source flexibility performance could not be explained by a more general impairment of processing speed or buy difficulties in cognitive flexibility. Finally, source flexibility was found to be related to hallucinations. CONCLUSIONS: Source flexibility plays an important role in schizophrenia and in particular is a cognitive mechanism involved in hallucinations.