RESUMO
The objective was to study antibiotics prescribing in Cotonou health care centres. This prospective study was conducted in two phases. The first consisted in collecting antibiotics prescriptions. In a second phase, the prescriptions were submitted to 4 experts who assessed the correctness of the prescribing. Out of the 588 prescriptions that could be analysed, 173 (29.4%) were correct The quality of the prescribing seems to depend only on the pathology but not on the nature of the basic training of the prescriber
Assuntos
Antibacterianos/uso terapêutico , Prescrições de Medicamentos/estatística & dados numéricos , Benin , Prescrições de Medicamentos/normas , Humanos , Garantia da Qualidade dos Cuidados de SaúdeRESUMO
From June 1983 to January 1994, 22 adult patients with severe Listeria monocytogenes meningoencephalitis were observed in our Intensive Care Unit. Listeria monocytogenes was obtained in culture in cerebrospinal fluid or blood for every patient. Seven patients were treated with the combination ampicillin-aminoglycoside (group A) and 15 patients with the combination ampicillin (or amoxicillin)-cotrimoxazole (group A + C). Risk factors and gravity scores were similar in both groups. Failure of the 'gold standard' regimen (group A) was significantly higher (57%) compared to group A + C (6.7%) (P < 0.05). Mortality related to L. monocytogenes was 23.5% in group A compared to 6.7% in group A + C. Morbidity was reduced in group A + C (13.3%) compared to group A (60%) (P = 0.15). This unique study seems to demonstrate that amoxicillin-cotrimoxazole should be the most appropriate therapeutic regimen for Listeria meningoencephalitis.