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1.
Nat Biotechnol ; 2024 Apr 15.
Artigo em Inglês | MEDLINE | ID: mdl-38622344

RESUMO

Citizen science video games are designed primarily for users already inclined to contribute to science, which severely limits their accessibility for an estimated community of 3 billion gamers worldwide. We created Borderlands Science (BLS), a citizen science activity that is seamlessly integrated within a popular commercial video game played by tens of millions of gamers. This integration is facilitated by a novel game-first design of citizen science games, in which the game design aspect has the highest priority, and a suitable task is then mapped to the game design. BLS crowdsources a multiple alignment task of 1 million 16S ribosomal RNA sequences obtained from human microbiome studies. Since its initial release on 7 April 2020, over 4 million players have solved more than 135 million science puzzles, a task unsolvable by a single individual. Leveraging these results, we show that our multiple sequence alignment simultaneously improves microbial phylogeny estimations and UniFrac effect sizes compared to state-of-the-art computational methods. This achievement demonstrates that hyper-gamified scientific tasks attract massive crowds of contributors and offers invaluable resources to the scientific community.

2.
Sci Rep ; 13(1): 1772, 2023 01 31.
Artigo em Inglês | MEDLINE | ID: mdl-36720921

RESUMO

We present a methodology to develop the integrated toxicity and climate change risk assessment of Europe based facilities, industries and regions. There is an increasingly important need for large scale sustainability measurement solutions for company reporting with high granularity. In this paper we measure key aspects of Sustainable Development Goals in terms of human, cancer and non-cancer toxicity, ecotoxicity together with global warming impact potentials from point source pollutant releases of more than 10,000 companies and their 33,000 facilities in Europe from 2001 to 2017, by using the European Pollutant Release and Transfer Register. For our assessment, we deploy a scientific consensus model, USEtox for characterizing human and ecotoxicological impacts of chemicals and the global warming potential values from the Intergovernmental Panel on Climate Change. We discuss water and air emissions of dozens of pollutants in urban, rural, coastal and inland areas. Companies in the electricity production sector are estimated to have the largest human toxicity impact potential (46% of total) and the largest global warming impact potential (50%), while companies in the sewerage sector have the largest ecotoxicity impact potential (50%). In the overall economy, the correlation between facilities' global warming and toxicity impact potentials is positive, however, not very strong. Therefore, we argue that carbon footprint of industrial organizations can be only used as a climate change risk indicator, but not as an overall environmental performance indicator. We confirm impact potentials of major pollutants in previous research papers (Hg accounting for 76% of the total human toxicity and Zn accounting for 68% of total ecotoxicity), although we draw the attention to the limitations of USEtox in case of metals. From 2001 to 2017 total human toxicity dropped by 28%, although the downward trend reversed in 2016. Ecotoxicity and global warming impact potentials remained unchanged in the same period. Finally, we show that the European pollutant release monitoring data quality could be further improved, as only three quarters of the toxic releases are measured in the Member States of the European Union, and a high share of toxic pollutant releases are only estimated in some countries. Of the measured or calculated toxic releases, only one third is reported according to the most robust CEN/ISO standards and about one fifth according to the least preferred other methods, like engineering judgements.


Assuntos
Poluentes Ambientais , Aquecimento Global , Humanos , Mudança Climática , Pegada de Carbono , Instalações Industriais e de Manufatura
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