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Hypoxia has profound effects on cell physiology, both in normal or pathological settings like cancer. In this study, we asked whether a variant of coverslip-induced hypoxia that recapitulates the conditions found in the tumor microenvironment would elicit similar cellular responses compared to the well established model of cobalt chloride-induced hypoxia. Comparable levels of nuclear HIF-1α were observed after 24â¯h of coverslip-induced hypoxia or cobalt chloride treatment in CAL-27 oral squamous carcinoma cells. However, cellular stress levels assessed by reactive oxygen species production and lipid droplet accumulation were markedly increased in coverslip-induced hypoxia compared to cobalt chloride treatment. Conversely, mitochondrial ATP production sharply decreased after coverslip-induced hypoxia but was preserved in the presence of cobalt chloride. Coverslip-induced hypoxia also had profound effects in nuclear organization, assessed by changes in nuclear dry mass distribution, whereas these effects were much less marked after cobalt chloride treatment. Taken together, our results show that coverslip-induced hypoxia effects on cell physiology and structure are more pronounced than mimetic hypoxia induced by cobalt chloride treatment. Considering also the simplicity of coverslip-induced hypoxia, our results therefore underscore the usefulness of this method to recapitulate in vitro the effects of hypoxic microenvironments encountered by cells in vivo.
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Hipóxia Celular , Núcleo Celular , Cobalto , Cobalto/farmacologia , Humanos , Hipóxia Celular/efeitos dos fármacos , Núcleo Celular/metabolismo , Núcleo Celular/efeitos dos fármacos , Linhagem Celular Tumoral , Subunidade alfa do Fator 1 Induzível por Hipóxia/metabolismo , Mitocôndrias/metabolismo , Mitocôndrias/efeitos dos fármacos , Espécies Reativas de Oxigênio/metabolismoRESUMO
INTRODUCTION: Most neonatal deaths in industrialized countries follow a process of redirection of care. The objectives of this study were to describe how neonates die in a middle-income country, whether there was redirection of care, and the reason for this decision. METHODS: This was a prospective, multicenter, cross-sectional study. Neonates who died in the delivery room or in the neonatal intensive care unit in 97 hospitals over a 6-month period were included. After each neonatal death, one investigator interviewed a member of the healthcare team who had been involved in the end-of-life care process. Perinatal data, conditions that led to death, whether there was redirection of care, and details of the end-of-life process were recorded. RESULTS: Data from 697 neonatal deaths were analyzed, which represent 80% of the total deaths occurring in Argentina in that period. The main causes of death were complications of prematurity (47%) and congenital anomalies (27%). Overall, 32% of neonates died after a process of redirection of care, and this was less frequent in the neonatal intensive care unit (28%) than in the delivery room (70%, p < 0.001). The reasons for withholding/withdrawing care were inevitable death (75%) and severe compromise of expected quality of life (25%). Redirection of care consisted in withholding therapies in 66% and withdrawal in 34%. A diagnosis of a major congenital anomaly increased the odds of redirection of care (OR 5.45; 95% CI: 3.59-8.27). CONCLUSION: Most neonates who die in Argentina do so while receiving full support. Redirection of care mainly follows a condition of inevitable death.
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The transport of intensity equation (TIE) allows to recover the phase of a microscopy sample from differently focused intensity measures along the axial direction of its optical field. In the present work, we propose a cost-effective technique for snapshot phase retrieval with TIE. The optics of a commercially available camera is replaced with a doublet system consisting of a microscope objective and a lenslet array with an extra lens mask attached to it. The system allows to obtain, in real-time and with no mechanical shift of either the sample or the sensor, the in-focus as well as a defocused image of the sample. From these two sub-aperture images, the intensity derivative term in TIE can then be approximated after image rectification. Phase is then retrieved for static as well as dynamic samples over the common view area. Validation experiments are presented.
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In many areas ranging from medical imaging to visual entertainment, 3D information acquisition and display is a key task. In this regard, in multifocus computational imaging, stacks of images of a certain 3D scene are acquired under different focus configurations and are later combined by means of post-capture algorithms based on image formation model in order to synthesize images with novel viewpoints of the scene. Stereoscopic augmented reality devices, through which is possible to simultaneously visualize the three dimensional real world along with overlaid digital stereoscopic image pair, could benefit from the binocular content allowed by multifocus computational imaging. Spatial perception of the displayed stereo pairs can be controlled by synthesizing the desired point of view of each image of the stereo-pair along with their parallax setting. The proposed method has the potential to alleviate the accommodation-convergence conflict and make augmented reality stereoscopic devices less vulnerable to visual fatigue.
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Introducción: La integración de la investigación científica y la vinculación es clave para la contribución de las universidades a la solución de los problemas de la sociedad mediante la transferencia de conocimientos y la innovación. Objetivo: Caracterizar el proceso de integración entre vinculación e investigación en la carrera de Medicina de UNIANDES. Método: Se realizó una investigación predominantemente cualitativa y descriptiva con la utilización del análisis documental y la entrevista. Se revisaron documentos rectores, lineamientos, y políticas, aplicadas en la carrera de Medicina. Se aplicaron entrevistas a los coordinadores en la carrera para buscar volumen informativo acerca de estas dos actividades y las proyecciones concretas de transversalización. Resultados: Se denotó una debilidad en cuanto a la gestión de la vinculación con la sociedad, ausencia de una visión más amplia de una gestión integral donde no solo se imbrique vinculación con docencia en las prácticas preprofesionales sino en los proyectos integradores y la existencia de la voluntad de los directivos institucionales en gestar desde la investigación una verdadera vinculación universidad-sociedad. Conclusiones: Falta una visión más amplia de la integración entre los tres procesos claves universitarios, se evidencia solo la relación entre docencia y vinculación a partir de las prácticas preprofesionales, dejando fuera la base y génesis que deben ser los proyectos integradores de saberes. En aras del perfeccionamiento de esta integración se deben proponer proyectos de innovación social donde se unan vinculación e investigación, garantizar la publicación de los resultados de los proyectos de innovación social en las revistas internas de UNIANDES y en otras de impacto regional o mundial.
Introduction: The integration of scientific research and linkage is key for the contribution of universities to the solution of society's problems through the transfer of knowledge and innovation. Objective: Characterize the integration process between linkage and research in the UNIANDES Medicine degree. Method: A predominantly qualitative and descriptive research was carried out with the use of documentary analysis and interviews. Governing documents, guidelines, and policies applied in the Medicine career were reviewed. Interviews were carried out with the coordinators in the program to search for volume of information about these two activities and the specific projections of mainstreaming. Results: A weakness was noted in terms of the management of the link with society, absence of a broader vision of comprehensive management where not only linkage with teaching is intertwined in pre-professional practices but also in integrative projects and the existence of will of institutional directors to create a true university-society link through research. Conclusions: A broader vision of the integration between the three key university processes is missing, only the relationship between teaching and connection is evident from pre-professional practices, leaving out the basis and genesis that knowledge-integrating projects should be. In order to perfect this integration, social innovation projects must be proposed where linkage and research come together, guaranteeing the publication of the results of social innovation projects in the internal journals of UNIANDES and in others with regional or global impact.
Introdução: A integração e articulação da investigação científica é fundamental para a contribuição das universidades na solução dos problemas da sociedade através da transferência de conhecimento e inovação. Objetivo: Caracterizar o processo de integração entre vinculação e pesquisa na graduação em Medicina da UNIANDES. Método: Foi realizada uma pesquisa predominantemente qualitativa e descritiva com utilização de análise documental e entrevistas. Foram revisados documentos normativos, diretrizes e políticas aplicadas à carreira de Medicina. Foram realizadas entrevistas com os coordenadores do programa para buscar volume de informações sobre essas duas atividades e as projeções específicas de mainstreaming. Resultados: Constatou-se uma fragilidade na gestão do vínculo com a sociedade, ausência de uma visão mais ampla de uma gestão integral onde não só o vínculo com o ensino esteja entrelaçado nas práticas pré-profissionais, mas também nos projetos integradores e na existência de vontade de instituições diretores para criar um verdadeiro vínculo universidade-sociedade através da pesquisa. Conclusões: Falta uma visão mais ampla da integração entre os três principais processos universitários, apenas a relação entre ensino e conexão é evidente nas práticas pré-profissionais, deixando de fora a base e a gênese que os projetos integradores de conhecimento deveriam ser. Para aperfeiçoar esta integração, devem ser propostos projetos de inovação social onde a articulação e a investigação se unam, garantindo a publicação dos resultados dos projetos de inovação social nas revistas internas da UNIANDES e em outras com impacto regional ou global.
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Introducción: De acuerdo con el avance científico y tecnológico de la sociedad, se van implementando nuevas y mejoradas técnicas en la práctica dental, que están destinadas a ofrecer tratamientos efectivos, más rápidos, conservadores y que reduzcan los niveles de miedo y ansiedad en los pacientes. Objetivo: Interpretar los beneficios de emplear laserterapia en el campo odontológico, mediante una revisión bibliográfica. Métodos: Estudio del nivel exploratorio, auxiliado por la hermenéutica para interpretar la revisión bibliográfica ejecutada. Correspondió al tipo observacional, transversal, descriptivo y retrospectivo. Las búsquedas se efectuaron en las bases de datos: Lilacs, Pubmed, Sciencedirect y se buscaron estudios clínicos aleatorizados. Resultados: Se encontraron 252 artículos, de los cuales fueron seleccionados 7 de acuerdo con los criterios de inclusión y exclusión. Se percibieron resultados favorables sobre el láser en las especialidades de cirugía, endodoncia, periodoncia y patología oral, en comparación con las terapias consideradas como gold standard, lo que demuestra que el uso del láser es mejor o igual de efectivo que los tratamientos convencionales, ya que reduce el nivel de tiempo en las intervenciones, en tratamientos quirúrgicos evita el sangrado y el uso de sutura en algunos casos, además de que bien aceptado para pacientes porque también evita la presencia de dolor al aplicarlo. Conclusiones: Usando láser para intervenciones odontológicas se puede obtener una mejoría o al menos el mismo resultado que aplicando técnicas convencionales, lo que comprueba que es viable su uso(AU)
Introduction: In accordance with the scientific and technological progress of society, new and improved techniques are being implemented in dental practice that are aimed at offering effective, faster, and more conservative treatments that reduce the levels of fear and anxiety in patients. Objective: To interpret the benefits of using laser therapy in the dental field by means of a review of the literature. Methods: This was an exploratory study, aided by hermeneutics to interpret the literature review. It was observational, cross-sectional, descriptive, and retrospective. The searches were carried out in the following databases: Lilacs, Pubmed, Sciencedirect and randomized clinical studies were searched. Results: 252 articles were found, of which 7 were selected according to the inclusion and exclusion criteria. Favorable results were found on laser in the specialties of surgery, endodontics, periodontics, and oral pathology, in comparison with therapies considered as gold standard. thus, demonstrating that the use of laser is better or equally effective than conventional treatments, since it reduces the level of time in interventions, in surgical treatments it avoids bleeding and the use of suture in some cases, besides being well accepted for patients because it also avoids the presence of pain when applying it. Conclusions: Using laser for dental interventions an improvement can be obtained or at least the same result as applying conventional techniques, which proves that its use is feasible (AU)
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Humanos , Terapia a Laser/métodos , Bases de Dados Bibliográficas , Odontologia , HermenêuticaRESUMO
RESUMO Objetivo: Descrever e comparar a estrutura das unidades de terapia intensiva argentinas que responderam ao inquérito de autoavaliação de unidades de terapia intensiva desenvolvido pela Sociedad Argentina de Terapia Intensiva. Métodos: Foi realizado um estudo transversal observacional com uso de um inquérito voluntário online por meio do banco de dados de membros da Sociedad Argentina de Terapia Intensiva e outras publicações em mídias sociais. Foram analisadas as respostas recebidas entre dezembro de 2018 e julho de 2020. Foram utilizados testes não paramétricos e estatística descritiva. Resultados: Foram recebidos 392 inquéritos, sendo 244 considerados para a análise. Eram de unidades de terapia intensiva adulto 77% (187/244), e 23% (57/244) eram de unidades de terapia intensiva pediátrica. A taxa de participação foi de 76%. A amostra incluiu 2.567 leitos de unidades de terapia intensiva (1.981 adulto e 586 pediátrica). Observamos nítida concentração de unidades de terapia intensiva nas regiões Centro e Buenos Aires, Argentina. A mediana de leitos foi de dez (intervalo interquartil 7 - 15). A mediana de monitores multiparamétricos, ventiladores mecânicos e oxímetros de pulso foi de um por leito, sem diferenças regionais ou de tipo de unidade de terapia intensiva (adulto ou pediátrica). Embora nossa amostra tenha evidenciado que as unidades de terapia intensiva pediátrica apresentaram proporção de ventilação mecânica/leito maior do que as unidades de terapia intensiva adulto, esse achado não foi linearmente correlacionado. Conclusão: A Argentina tem concentração notável de leitos de cuidados intensivos e complexidade estrutural superior nas regiões de Buenos Aires e Centro, tanto de unidades de terapia intensiva adulto quanto pediátrica. Além disso, observou-se ausência de dados precisos informados sobre a estrutura e os recursos de unidades de terapia intensiva. São necessárias mais opções de melhoria para alocar os recursos de unidades de terapia intensiva nos níveis institucional e regional.
ABSTRACT Objective: To describe and compare the structure of Argentinean intensive care units that completed the "self-assessment survey of intensive care units" developed by the Sociedad Argentina de Terapia Intensiva. Methods: An observational crosssectional study was conducted using an online voluntary survey through the Sociedad Argentina de Terapia Intensiva member database and other social media postings. Answers received between December 2018 and July 2020 were analyzed. Descriptive statistics and nonparametric tests were used. Results: A total of 392 surveys were received, and 244 were considered for the analysis. Seventy-seven percent (187/244) belonged to adult intensive care units, and 23% (57/244) belonged to pediatric intensive care units. The overall completion rate was 76%. The sample included 2,567 ICU beds (adult: 1,981; pediatric: 586). We observed a clear concentration of intensive care units in the Central and Buenos Aires regions of Argentina. The median number of beds was 10 (interquartile range 7 - 15). The median numbers of multiparameter monitors, mechanical ventilators, and pulse oximeters were 1 per bed with no regional or intensive care unit type differences (adult versus pediatric). Although our sample showed that the pediatric intensive care units had a higher mechanical ventilation/bed ratio than the adult intensive care units, this finding was not linearly correlated. Conclusion: Argentina has a notable concentration of critical care beds and better structural complexity in the Buenos Aires and Centro regions for both adult and pediatric intensive care units. In addition, a lack of accurate data reported from the intensive care unit structure and resources was observed. Further improvement opportunities are required to allocate intensive care unit resources at the institutional and regional levels.
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Introducción. El objetivo de este estudio fue analizar recursos disponibles, guías utilizadas y preparación para la atención de neonatos en maternidades de Argentina durante la pandemia de COVID-19.Método. Estudio transversal mediante una encuesta enviada a equipos médicos y de enfermería. En mayo de 2020, se contactaron instituciones de más de 500 nacimientos anuales en la Argentina, el 58 % del sector público.Resultados. Respondieron 104/147 instituciones (el 71 %). Todas contaban con guías para la atención durante la pandemia, y un 93 % refirió haber recibido capacitación para su uso. No autorizaban la presencia de acompañante en el parto el 26 % de instituciones privadas y el 60 % de las públicas (p < 0,01). El 87 % recomendaba ligadura oportuna del cordón, el 62 % promovía internación conjunta en neonatos asintomáticos, un 70 % recomendaba la puesta al pecho con medidas de protección, y el 23 %, leche materna mediante biberón. El 94 % restringía el ingreso de familiares a Neonatología.Las dificultades incluyeron imposibilidad de contar con habitaciones individuales para neonatos sintomáticos y potencial limitación del personal de salud y equipos de protección personal.Conclusiones. Todas las instituciones conocen las guías nacionales para enfrentar la pandemia. La mayoría cuenta con recursos para respetar las medidas de protección recomendadas. Existe incertidumbre sobre si, ante un aumento significativo en el número de casos, serán suficientes los elementos de protección personal, el personal y el espacio físico disponible en los distintos centros
Introduction. The objective of this study was to analyze available resources, guidelines in use, and preparedness to care for newborn infants at maternity centers in Argentina during the COVID-19 pandemic.Method. Cross-sectional study based on a survey administered to medical and nursing staff. In May 2020, Argentine facilities with more than 500 annual births were contacted; 58 % of these were from the public sector.Results. In total, 104/147 facilities answered (71 %). All had guidelines for care during the pandemic, and 93 % indicated they had been trained on how to use them. A companion was not allowed during childbirth in 26 % of private facilities and in 60 % of public ones (p < 0.01). Deferred cord clamping was recommended in 87 %; rooming-in with asymptomatic newborns was promoted in 62 %; breastfeeding using protective measures was recommended in 70 %; and breast milk using a bottle, in 23 %. In 94 %, family visiting in the Neonatology Unit was restricted.Difficulties included the unavailability of individual rooms for symptomatic newborn infants and a potential shortage of health care staff and personal protective equipment.Conclusions. All facilities are aware of the national guidelines to fight the pandemic. Most have the resources to comply with the recommended protective measures. There is uncertainty as to whether personal protective equipment, staff, and physical space available at the different facilities would be enough if cases increased significantly
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Humanos , Masculino , Feminino , Recém-Nascido , Adulto , Pessoa de Meia-Idade , Estratégias de Saúde , Infecções por Coronavirus , Preparação em Desastres , Equipe de Assistência ao Paciente , Argentina , Medidas de Segurança , Estudos Transversais , Inquéritos e Questionários , Equipamento de Proteção Individual , Maternidades , NeonatologiaRESUMO
Introducción. A nivel mundial, hay una tendencia ascendente en nacimientos prematuros y cesáreas. El objetivo fue describir edad gestacional (EG), vía de parto, distribución en días y horarios, y relación entre la vía de parto y el momento del nacimiento en dos instituciones privadas.Población y métodos. Estudio prospectivo, transversal, analítico.Resultados. Se incluyeron los 1500 nacidos vivos entre 9-2017 y 8-2018 (1465 embarazadas). El 99,4 % fueron embarazos controlados; el 66,8 % terminaron por cesárea. La causa fue cesárea previa en el 36,4 %, falta de progresión y descenso en el 18,9 % y elección materna en el 9,2 %. El peso promedio al nacer fue de 3232 g ± 561,1 g y la mediana de EG, 39 semanas (rango 38-40) por fecha de última menstruación. El 88,2 % fueron nacidos de término y, de los prematuros, el 76,1 % fueron pretérminos tardíos. Los nacidos de término temprano tuvieron mayor índice de cesáreas (p < 0,001). Los nacimientos por cesárea en días hábiles fueron 849/1201 (el 74,5 %) y, en los días de fin de semana y feriados, 173/299 (el 57,9 %, p < 0,001). Se encontró una relación estadísticamente significativa entre el horario de nacimiento y la realización de cesárea.Conclusiones. La mediana de EG fue 39 semanas. La cesárea fue la vía de nacimiento más frecuente. Los nacimientos se produjeron, predominantemente, de lunes a viernes entre las 8 y las 21 h. El 82,9 % de los nacimientos por cesárea ocurrieron en días de semana laborables
Introduction. There is a worldwide growing trend of preterm births and C-sections. Our objective was to describe gestational age (GA), mode of delivery, day and time distribution, and the relation between the mode of delivery and the time of birth in two private facilities.Population and methods. Prospective, cross-sectional, analytical study.Results. A total of 1500 live newborn infants were included between September 2017 and August 2018 (1465 pregnant women). Of these, 99.4 % had received antenatal care; 66.8 % of pregnancies ended via C-section. The reason was a previous C-section in 36.4 %, lack of progression and descent in 18.9 %, and maternal choice in 9.2 %. The average birth weight was 3232 g ± 561.1 g and the median GA was 39 weeks (range: 38-40) based on the date of the last menstrual period; 88.2 % were term births and, among preterm births, 76.1 % corresponded to late preterm babies. Early term births showed a higher rate of C-sections (p < 0.001). There were 849/1201 (74.5 %) C-sections on weekdays and 173/299 (57.9 %, p < 0.001) on weekends and holidays. A statistically significant relation was observed between the time of birth and the performance of a C-section.Conclusions. The median GA was 39 weeks. C-sections were the most common mode of delivery. Births occurred predominantly Mondays through Fridays between 8 a.m. and 9 p.m.; 82.9 % of C-sections took place on weekdays.
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Humanos , Masculino , Feminino , Gravidez , Recém-Nascido , Cesárea , Idade Gestacional , Fatores de Tempo , Recém-Nascido Prematuro , Estudos Transversais , Estudos Prospectivos , PartoRESUMO
Introducción: el desarrollo de la educación superior en el contexto mundial impone nuevos retos a sus instituciones. Se necesita contribuir a solucionar los problemas y demandas de la sociedad. Objetivo: evaluar la pertinencia del programa de maestría en Gerencia de Salud de la Universidad Regional Autónoma de los Andes. Métodos: se realizó una investigación mixta con énfasis en elementos cualitativos, exploratoria de corte transversal en el período de mayo a junio de 2016. Se emplearon los métodos analítico-sintético, inductivo-deductivo, histórico-lógico y sistémico para conformar el estado del arte sobre la pertinencia de la formación de postrado. Se revisó la relación de las políticas de desarrollo de Ecuador con los objetivos de la maestría, y se aplicó una encuesta a 203 profesionales de las ciencias médicas seleccionados de manera no probabilística. Resultados: se evidenció que el programa tributa directamente al cumplimiento de las políticas y lineamientos de desarrollo de Ecuador así como con los objetivos estratégicos del Ministerio de Salud Pública. Los resultados de la encuesta demostraron que existe una demanda en esta área de formación y un interés de los profesionales por acceder a la maestría para su desarrollo profesional. Conclusiones: el procedimiento propuesto permitió evaluar la pertinencia de la maestría de Gerencia de Salud e incluye elementos no antes tratados en la literatura internacional relacionados con la contribución del programa a la solución de las principales necesidades de la salud pública ecuatoriana(AU)
Introduction: the development of higher education in the global context imposes new challenges to such institutions. It is necessary to contribute to solve the problems and demands of society. Objective: to assess the relevance of the Master's degree program in Health Management of the Autonomous Regional University of the Andes. Methods: amixed research, cross-sectional and exploratory, was carried out with emphasis on qualitative elements, in the period from May to June 2016. Analytical-synthetic, inductive-deductive, historical-logical and systemic methods were used to make up the state-of-the-art about the relevance of postgraduate training. The relationship was reviewed between development policies in Ecuador and the objectives of the master's degree, and a survey was applied to 203 selected non-probabilistic medical science professionals. Results: the program was evidenced to contribute directly with the fulfillment of the development policies and guidelines in Ecuador, as well as with the strategic objectives of the Ministry of Public Health. The results of the survey showed that there is a demand in this area of training and an interest of professionals to access the master's degree for their professional development. Conclusions: the proposed procedure allowed to assess the relevance of the master's degree in Health Management and includes elements not previously discussed in the international literature and related to the contribution of the program to the solution of the main needs of the Ecuadorian public health(AU)
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Humanos , Administração de Serviços de Saúde , Currículo , Educação de Pós-Graduação em Medicina , Estudos Transversais , EquadorRESUMO
Objetivos. Evaluar la aceptabilidad y factibilidad de una intervención basada en salud móvil, para la adopción de estilos de vida saludables en personas prehipertensas que viven en zonas urbanas de bajos recursos en Argentina, Guatemala y Perú. Materiales y métodos. Se reclutaron prehipertensos entre 30 a 60 años para un estudio piloto. La intervención incluyó dos llamadas de consejería realizadas por una nutricionista, seguidas de un mensaje de texto customizado semanal. Una plataforma basada en Internet ofreció el soporte para la implementación de la intervención. Utilizando entrevistas semiestructuradas se evaluó el alcance y la aceptabilidad de esta intervención en los participantes, y la facilidad de uso en las nutricionistas. Resultados. Se logró contactar a 43 de los 45 participantes (95%). El número promedio de llamadas para contactar a un sujeto fue de dos, con un rango de 1-9 llamadas. Dos participantes pudieron ser contactados en su teléfono celular y cinco no recibieron una exposición completa a la intervención. Basados en las entrevistas semiestructuradas, los resultados mostraron una buena aceptabilidad a la intervención en los participantes. Las nutricionistas percibieron a la plataforma como amigable y de fácil manejo. Las barreras para ofrecer esta intervención se relacionaron con dificultades para obtener una señal de telefonía celular adecuada. Conclusiones. Dada la alta penetración de la telefonía celular en países en desarrollo, se concluye que una intervención basada en salud móvil es factible y aceptable para ofrecer una intervención orientada a la modificación del estilo de vida en prehipertensos o personas de alto riesgo de enfermedades crónicas.
Objectives. To evaluate the acceptability and feasibility of an intervention based on mobile health, for the adoption of healthy lifestyles in prehypertensive people living in low-income urban areas in Argentina, Guatemala and Peru. Materials and methods. Prehypertensive people aged 30-60 years were recruited for a pilot study. The intervention included two counseling calls made by a nutritionist followed by a weekly customized text message. An internet-based platform offered support for the implementation of the intervention. Using semi-structured interviews, we evaluated the reach and acceptability of the intervention in the participants and ease of use for the nutritionists. Results. It was possible to contact 43 of the 45 participants (95%). The average number of calls to contact a subject was two, with a range of 1-9 calls. Two participants could not be reached on their cell phone; five did not receive complete exposure to the intervention. Based on semi-structured interviews, the results showed good acceptability for the intervention by the participants. Nutritionists perceived the platform as friendly and easy to use. Barriers to deliver this intervention were related to difficulties in obtaining an adequate cellular signal. Conclusions. Given the high penetration of mobile phones in developing countries, it is concluded that it is feasible and acceptable to offer a mobile health based intervention oriented towards lifestyle modification in people with prehypertension or high risk of chronic disease intervention.
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Humanos , Masculino , Adulto , Feminino , Pessoa de Meia-Idade , Avaliação da Tecnologia Biomédica , Hipertensão , Informática Médica , Argentina , Guatemala , PeruRESUMO
Introducción. El índice pediátrico de mortalidad 2 (Pediatric Index of Mortality 2; PIM2, por sus siglas en inglés) es uno de los puntajes más utilizados para la predicción de la mortalidad en pacientes ingresados en las Unidades de Cuidados Intensivos Pediátricos (UCIP) argentinas. El objetivo de este estudio fue validar el puntaje PIM2 en las UCIP integrantes del Programa de Calidad de Atención de la Sociedad Argentina de Terapia Intensiva. Población y métodos. Estudio multicéntrico, prospectivo, observacional, de corte transversal. Se incluyeron todos los pacientes de entre 1 mes y 16 años de edad, ingresados en las UCIP participantes entre el 01-01-2009 y el 31-122009. Se evaluó la discriminación y calibración del puntaje PIM2 en toda la población y en diferentes subgrupos (riesgo de mortalidad, edad, diagnósticos de ingreso). Resultados. Se incluyeron 2832 pacientes. El PIM2 predijo 246 muertes; sin embargo, fallecieron 297 pacientes (p <0,01). La razón de mortalidad estandarizada fue 1,20 (IC 95%: 1,01-1,43). El área bajo la curva ROC fue 0,84 (IC 95%: 0,82-0,86). Se detectaron diferencias estadísticamente significativas entre las muertes observadas y las predichas para toda la población y en los distintos intervalos de riesgo (χ² 71,02; df 8; p <0,001). También se detectaron diferencias estadísticamente significativas entre las muertes observadas y esperadas en los pacientes adolescentes (37/22, p= 0,03) y en aquellos ingresados con patología respiratoria (105/81, p= 0,03). Conclusiones. El puntaje PIM2 permite diferenciar adecuadamente los pacientes que sobreviven de aquellos que fallecen. Sin embargo, subvalora el riesgo de muerte en forma global, especialmente en los pacientes adolescentes y en aquellos ingresados por causa respiratoria. Es fundamental considerar estas diferencias al interpretar los resultados.
Introduction. The Pediatric Index of Mortality 2 (PIM2) is one of the most commonly used scoring systems to predict mortality in patients admitted to pediatric intensive care units (PICU) in Argentina. The objective of this study was to validate the PIM2 score in PICUs participating in the Quality of Care Program promoted by the Argentine Society of Intensive Care.Population and Methods. Multicenter, prospective, observational, cross-sectional study.All patients between 1 month and 16 years old admitted to participating PICUs between January 1st, 2009 and December 31st, 2009 were included. The discrimination and calibration of the PIM2 score were assessed in the entire population and in different subgroups (risk of mortality, age, diagnoses on admission).Results. Two thousand, eight hundred and thirty-two patients were included. PIM2 predicted 246 deaths; however, 297 patients died (p < 0.01). The standardized mortality ratio was 1.20 (95% confidence interval [CI]: 1.01-1.43). The area under the ROC curve was 0.84 (95% CI: 0.82-0.86). Statistically significant differences were detected between the observed and the predicted mortality for the entire population and for the different risk intervals (χ²: 71.02, df: 8, p < 0.001). Statistically significant differences were also found between observed and predicted mortality in adolescent patients (37/22, p = 0.03) and in those hospitalized due to respiratory disease (105/81, p = 0.03).Conclusions. The PIM2 score adequately discriminates survivors from non-survivors. However, it underscores the overall risk of death, especially in adolescent patients and those hospitalized due to respiratory disease. It is critical to take such differences into account when interpreting results.
Assuntos
Humanos , Lactente , Pré-Escolar , Criança , Adolescente , Pediatria , Índice de Gravidade de Doença , Unidades de Terapia Intensiva Pediátrica , Mortalidade , BenchmarkingRESUMO
OBJETIVOS: a) determinar la prevalencia de la enfermedadde Chagas en la población total y en menores de 15 años en Bajo de Veliz; b) identificar y tratar a la población infantil infectada; y c) evaluar la adherencia, reacciones adversas y efectividad del tratamiento. MÉTODO: geo-referencia y visita domiciliaria para obtención de muestras de sangre venosa para diagnóstico con técnicas de hemaglutinación indirecta y ensayo inmunoenzimático. Los casos diagnosticados se trataron con benznidazol 5 mg/kg/día durante 60 días y se controlaron con examen clínico y electrocardiograma cada 15 días y examen bioquímico a los 30 y 45 días intratratamiento y a los 30 días postratamiento. Se roció conpiretroides las viviendas de los pacientes tratados. RESULTADOS:la prevalencia fue de 21,18% en población general y de 12,5% en menores de 15 años. Se realizó tratamiento a los cinco niñosdiagnosticados (100%) y los efectos adversos fueron: vómitos (1),leucopenia (1) y elevación de la fosfatasa alcalina (5). La serologíacontinuó positiva en todos los casos hasta la finalización del estudio.CONCLUSIONES: se verificó una marcada prevalencia de Chagas en Bajo de Veliz, la que en niños fue seis veces superior al 1,82% determinado oficialmente en 2001 en áreas rurales endémicas.La adherencia al tratamiento fue óptima. Las reacciones adversas que se presentaron fueron leucopenia, considerada de rara aparición; y notable elevación de la enzima fosfatasa alcalinahepática, sin antecedentes en la bibliográfica. No se pudo certificarla curación de los pacientes tratados. Se implementaron medidas de control vectorial aunque sin lograr participación comunitaria.
OBJECTIVES: a) to determine the prevalence of Chagas disease in the general population and children under15 in Bajo de Veliz; b) to identify infected children to manage specific treatment; andc) to assess their adherence, adverse reactions and effectiveness. METHOD: geo-reference and home, visits to venous blood sampling. Indirect hemagglutinationand immunoenzymatic assays were used. Pediatric patients were controlled with clinical and electrocardiographyexams. They were treated with benznidazole 5 mg/kg/dayduring 60 days. Clinical controls were performed fortnightly and biochemical at 30 and 45 days during treatment and 30days after treatment. Houses were sprinkled with pyrethroid.RESULTS: the prevalence was 21.18% in general population and 12.5% in children under 15. The five children diagnosed were treated (100%). Adverse effects were: vomiting (1), leukopenia (1) and elevation of alkaline phosphatase (5).Serology continued positive in all cases until the completion of the study. CONCLUSIONS: we found a sharp prevalence of Chagas in Bajo de Veliz. In children the prevalence was six times greater than 1.82% officially established in 2001 for endemic areas. Adherence to treatment was optimal. Adverse reactions were leukopenia, considered of rare appearance;and remarkable elevation of the enzyme liver, with no previous bibliographic reference. We could not certify healing intreated patients. Vector control measures were implementedbut community participation was not reached.
Assuntos
Pré-Escolar , Criança , Adolescente , Técnicas de Laboratório Clínico , Doença de Chagas/diagnóstico , Doença de Chagas/terapia , Saneamento de Residências , Testes Sorológicos , Controle de Vetores de DoençasRESUMO
Las bases de datos constituyen una importante herramienta en la gestión de un servicio. Para ello es indispensable que el registro se realice en tiempo real, permitiendo un monitoreo efectivo de la situación, con intervenciones oportunas que admitan modificar situaciones que compremeten la calidad de atención de un servicio.
Assuntos
Pediatria , Unidades de Terapia Intensiva Pediátrica , Gestão da Informação , Registros Eletrônicos de Saúde , Gestão da Informação em SaúdeRESUMO
Se analiza la experiencia acumulada en eclampsia en los últimos 8 años. Sobre un total de 80.194 partos, hubo 81 pacientes, que presentaron eclampsia, lo que da una incidencia de 1 por mil. El 84,6 por ciento ocurrió en primíparas; el 45,7 por ciento de las pacientes eran menores de 20 años. El 61,7 por ciento presentó las convulsiones durante la gestación, el 22,2 por ciento durante el trabajo de parto y el 16,1 por ciento durante las primeras 24 horas postparto. Hubo 11 pacientes que convulsionaron a pesar de encontrarse en ese momento con terapia de sulfato de Mg. Un 21,3 por ciento de pacientes, presentó convulsiones con cifras tensionales iguales o menores de 140/100 mmHg. En el 25,9 por ciento las cifras de proteinuria eran normales. El 75,3 por ciento de las gestaciones se resolvió mediante operación cesárea, siendo la principal indicación las malas condiciones cervicales. La morbilidad neonatal más frecuente fue el RCIU y el distress respiratorio. La mortalidad perinatal fue de 13,2 por ciento. Hubo 3 muertes maternas 3,7 por ciento
Assuntos
Humanos , Feminino , Gravidez , Adolescente , Adulto , Eclampsia/epidemiologia , Peso ao Nascer , Estudos de Casos e Controles , Cesárea/estatística & dados numéricos , Técnicas de Laboratório Clínico/estatística & dados numéricos , Doenças do Recém-Nascido , Sulfato de Magnésio/uso terapêutico , Mortalidade Materna , Mortalidade Perinatal , ProteinúriaRESUMO
En este estudio se analizan 14 mujeres embarazadas trasplantadas renales, con control y resolución de su embarazo en nuestro Servicio. Cinco de ellas con más de un embarazo. El promedio de latencia al inicio de la gestación es de 39,3 meses. En relación a la PA, el 73 por ciento presentaba cifras en rango aceptable previo al embarazo y el 28 por ciento evoluciona en el puerperio con PA sobre 140/90. En los casos en que el embarazo se prolonga pasado el primer trimestre, se produjo un 93 por ciento de éxito, hubo 41 por ciento prematuros, 38 por ciento RCIU y 10 por ciento abortos. La resolución del embarazo fue por cesárea en un 83 por ciento