["Structure-anti-arrhythmic activity" relationship of N-phenilacetamide derivatives and amides of aromatic carbonic acids].

Using the computer system SARD-21 (Structure Activity Relationship & Design) structural features of high- and low-effective anti-arrhythmic agents have been recognized and the influence of these features on the anti-arrhythmic properties has been evaluated. This information has been used for generation of the model for prediction of anti-arrhythmic effectiveness of pharmaceutical preparations with the 82%-level of recognition by two methods. The recognized structural parameters may be successfully used for design of new highly effective anti-arrhythmic drugs, and also for modification of structures of known anti-arrhythmic drugs for the increase of effectiveness of their anti-arrhythmic action.

[Nonsteroidal anti-inflammatory drugs. Declaration I. A study of interrelation "structure--the effectiveness of anti-inflammatory action"].

Using the computer system SARD-21 (Structure Activity Relationship & Design) the structural features typical for high- and low- effective nonsteroid anti-inflammatory drugs (NSAIDs) were analyzed. This information has been used for the model for prediction of anti-inflammatory effectiveness of medicines with 76% and 81% level of recognition by two methods. New data can be used for creating new highly effective NSAIDs, and for increasing effectiveness of already known components.

[Electrophoretic mobility and oxidizing status of rat blood erythrocytes at scald trauma]. / Elektroforeticheskaia podvizhnost' i okislitelnyl status eritrotsitov krys pri ozhoge.

On model of scald trauma the correlation of electrophoretic mobility of rat blood erythrocytes with intensity of lipid oxidation of erythrocyte membranes and with activity of catalase were studied. It is shown that in dynamics of scald disease development the erythrocyte mobility decreases, the velocity of oxidizing ability of their lipids increases and the protective action of blood antioxidation system is blocked. It is found that there is a close dependence between the level of oxidative processes and electrogenic properties of erythrocytes at the height of manifestation of scald toxaemia. A conclusion was made that the oppressing influence of increasing lipid oxidizing ability a on electrokinetic potential of erythrocytes is of a threshold nature and is realized through change in the membranes' state of these cells.