Assuntos
Hiperpigmentação , Humanos , Estudos Retrospectivos , Feminino , Hiperpigmentação/diagnóstico , Hiperpigmentação/etiologia , Hiperpigmentação/patologia , Masculino , Adulto , Pessoa de Meia-Idade , Doenças da Glândula Tireoide/epidemiologia , Doenças da Glândula Tireoide/diagnóstico , Doenças da Glândula Tireoide/complicações , Adolescente , Adulto Jovem , Glândula Tireoide/patologia , Glândula Tireoide/imunologia , Criança , IdosoRESUMO
Aim: Secretion of proteins into basal tears of Parkinson's disease (PD) patients may be altered by changes in nerve function. Materials & methods: Oligomeric α-SynOligo and total α-SynTotal, CCL-2, DJ-1, LF and MMP-9 were measured in basal tears from 93 PD patients and 82 age- and sex-equivalent healthy controls. Results: α-SynTotal was decreased (p = 0.0043), whereas α-SynOligo (p < 0.0001) and the ratio of α-SynOligo/α-SynTotal (p < 0.0001) were increased in basal tears from PD patients compared with healthy controls. Area under receiver-operating curves of α-SynOligo and α-SynOligo/α-SynTotal contents were 0.70 (95% confidence limits: 0.621-0.774) and 0.72 (95% confidence limits: 0.642-0.792). Conclusion: PD patient basal tears may contain biomarkers that can be assayed noninvasively and inexpensively.
