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Mol Biol Rep ; 51(1): 677, 2024 May 25.
Artigo em Inglês | MEDLINE | ID: mdl-38796641

RESUMO

BACKGROUND: One of the main causes of diabetic nephropathy is oxidative stress induced by hyperglycemia. Apelin inhibits insulin secretion. Besides, renal expression of TGF-ß is increased in diabetes mellitus (DM). The preventive effect of quercetin (Q) against renal functional disorders and tissue damage developed by DM in rats was assessed. METHODS: Forty male Wistar rats were grouped into normal control (NC), normal + quercetin (NQ: quercetin, 50 mg/kg/day by gavage), diabetic control (DC: streptozotocin, 65 mg/kg, i.p.), diabetic + quercetin pretreatment (D + Qpre), and diabetic + quercetin post-treatment (D + Qpost). All samples (24-hour urine, plasma, pancreatic, and renal tissues) were obtained at the terminal of the experiment. RESULTS: Compared to NC and NQ groups, DM ended in elevated plasma and glucose levels, decreased plasma insulin level, kidney dysfunction, augmented levels of malondialdehyde, decreased level of reduced glutathione, reduced enzymatic activities of superoxide dismutase and catalase, elevated gene expression levels of apelin and TGF-ß, also renal and pancreatic histological damages. Quercetin administration diminished entire the changes. However, the measure of improvement in the D + Qpre group was higher than that of the D + Qpost group. CONCLUSION: Quercetin prevents renal dysfunction induced by DM, which might be related to the diminution of lipid peroxidation, strengthening of antioxidant systems, and prevention of the apelin/ TGF-ß signaling pathway.


Assuntos
Apelina , Diabetes Mellitus Experimental , Nefropatias Diabéticas , Rim , Estresse Oxidativo , Quercetina , Ratos Wistar , Fator de Crescimento Transformador beta , Animais , Quercetina/farmacologia , Ratos , Masculino , Fator de Crescimento Transformador beta/metabolismo , Diabetes Mellitus Experimental/metabolismo , Diabetes Mellitus Experimental/tratamento farmacológico , Rim/efeitos dos fármacos , Rim/metabolismo , Rim/patologia , Nefropatias Diabéticas/metabolismo , Nefropatias Diabéticas/prevenção & controle , Nefropatias Diabéticas/tratamento farmacológico , Apelina/metabolismo , Estresse Oxidativo/efeitos dos fármacos , Glicemia/metabolismo , Glicemia/efeitos dos fármacos , Antioxidantes/farmacologia , Antioxidantes/metabolismo , Insulina/metabolismo , Insulina/sangue , Diabetes Mellitus Tipo 1/metabolismo , Regulação da Expressão Gênica/efeitos dos fármacos
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