1.
Bioorg Med Chem Lett
; 9(24): 3459-64, 1999 Dec 20.
Artigo
em Inglês
| MEDLINE
| ID: mdl-10617091
RESUMO
A series of novel FXa inhibitors 2a-m and 3a-f was discovered that feature heterocyclic carboxamides tethered to a d-diaminobutyric acid sidechain. These neutral amide derivatives serve as novel P3 d-arginine mimics. Pyrazine carboxamide scaffolds afforded the most potent FXa inhibitors (e.g., 2b IC50 = 4.6 nM). The synthesis and biological activity of two focused libraries are reported.