Nanoribbon Yarn with Versatile Inorganic Materials.

Nanomaterial-based yarns have been actively developed owing to their advantageous features, namely, high surface-area-to-volume ratios, flexibility, and unusual material characteristics such as anisotropy in electrical/thermal conductivity. The superior properties of the nanomaterials can be directly imparted and scaled-up to macro-sized structures. However, most nanomaterial-based yarns have thus far, been fabricated with only organic materials such as polymers, graphene, and carbon nanotubes. This paper presents a novel fabrication method for fully inorganic nanoribbon yarn, expanding its applicability by bundling highly aligned and suspended nanoribbons made from various inorganic materials (e.g., Au, Pd, Ni, Al, Pt, WO3, SnO2, NiO, In2O3, and CuO). The process involves depositing the target inorganic material on a nanoline mold, followed by suspension through plasma etching of the nanoline mold, and twisting using a custom-built yarning machine. Nanoribbon yarn structures of various functional inorganic materials are utilized for chemical sensors (Pd-based H2 and metal oxides (MOx)-based green gas sensors) and green energy transducers (water splitting electrodes/triboelectric nanogenerators). This method is expected to provide a comprehensive fabrication strategy for versatile inorganic nanomaterials-based yarns.

Highly Sensitive Soft Pressure Sensors for Wearable Applications Based on Composite Films with Curved 3D Carbon Nanotube Structures.

Soft pressure sensors based on 3D microstructures exhibit high sensitivity in the low-pressure range, which is crucial for various wearable and soft touch applications. However, it is still a challenge to manufacture soft pressure sensors with sufficient sensitivity under small mechanical stimuli for wearable applications. This work presents a novel strategy for extremely sensitive pressure sensors based on the composite film with local changes in curved 3D carbon nanotube (CNT) structure via expandable microspheres. The sensitivity is significantly enhanced by the synergetic effects of heterogeneous contact of the microdome structure and changes of percolation network within the curved 3D CNT structure. The finite-element method simulation is used to comprehend the relationships between the sensitivity and mechanical/electrical behavior of microdome structure under the applied pressure. The sensor shows an excellent sensitivity (571.64 kPa-1 ) with fast response time (85 ms), great repeatability, and long-term stability. Using the developed sensor, a wireless wearable health monitoring system to avoid carpel tunnel syndrome is built, and a multi-array pressure sensor for realizing a variety of movements in real-time is demonstrated.

Correction: A wearable colorimetric sweat pH sensor-based smart textile for health state diagnosis.

Correction for 'A wearable colorimetric sweat pH sensor-based smart textile for health state diagnosis' by Ji-Hwan Ha et al., Mater. Horiz., 2023, 10, 4163-4171, https://doi.org/10.1039/d3mh00340j.

A Leakage Prediction Model for Sealing Performance Assessment of EPDM O-Rings under Irradiation Conditions.

In this work, a model for predicting the leakage rate was developed to investigate the effect of irradiation on the sealing performance of ethylene propylene diene monomer (EPDM) O-rings. The model is based on a mesoscopic interfacial gap flow simulation and accurately predicts the sealing performance of irradiated and non-irradiated materials by utilizing the gap height as an indicator in a mechanical simulation of the O-ring under operating conditions. A comparison with vacuum test results indicates that the model is a good predictor of leak initiation. The positive pressure leakage of the O-rings was investigated numerically. The results show the following. The sealing performance of the non-irradiated O-ring is much better than that of the irradiated one. The sealing performance is the worst at 0. 713 MGy and the best at 1.43 MGy, and the seal is maintained at an absorbed dose of 3.55 MGy. A theoretical analysis of the non-monotonic variation using the proposed model shows that the leakage behavior of the O-rings depends not only on the material properties but also on the roughness and prestressing properties. Finally, a method was proposed to classify the sealing performance, using the maximum allowable leakage rate as an indicator.

A wearable colorimetric sweat pH sensor-based smart textile for health state diagnosis.

Sweat pH is an important indicator for diagnosing disease states, such as cystic fibrosis. However, conventional pH sensors are composed of large brittle mechanical parts and need additional instruments to read signals. These pH sensors have limitations for practical wearable applications. In this study, we propose wearable colorimetric sweat pH sensors based on curcumin and thermoplastic-polyurethane (C-TPU) electrospun-fibers to diagnose disease states by sweat pH monitoring. This sensor aids in pH monitoring by changing color in response to chemical structure variation from enol to di-keto form via H-atom separation. Its chemical structure variation changes the visible color due to light absorbance and reflectance changes. Furthermore, it can rapidly and sensitively detect sweat pH due to its superior permeability and wettability. By O2 plasma activation and thermal pressing, this colorimetric pH sensor can be easily attached to various fabric substrates such as swaddling and patient clothing via surface modification and mechanical interlocking of C-TPU. Furthermore, the diagnosable clothing is durable and reusable enough to neutral washing conditions due to the reversible pH colorimetric sensing performance by restoring the enol form of curcumin. This study contributes to the development of smart diagnostic clothing for cystic fibrosis patients who require continuous sweat pH monitoring.

Nanotransfer-on-Things: From Rigid to Stretchable Nanophotonic Devices.

The growing demand for nanophotonic devices has driven the advancement of nanotransfer printing (nTP) technology. Currently, the scope of nTP is limited to certain materials and substrates owing to the temperature, pressure, and chemical bonding requirements. In this study, we developed a universal nTP technique utilizing covalent bonding-based adhesives to improve the adhesion between the target material and substrate. Additionally, the technique employed plasma-based selective etching to weaken the adhesion between the mold and target material, thereby enabling the reliable modulation of the relative adhesion forces, regardless of the material or substrate. The technique was evaluated by printing four optical materials on nine substrates, including rigid, flexible, and stretchable substrates. Finally, its applicability was demonstrated by fabricating a ring hologram, a flexible plasmonic color filter, and extraordinary optical transmission-based strain sensors. The high accuracy and reliability of the proposed nTP method were verified by the performance of nanophotonic devices that closely matched numerical simulation results.

Nanoscale three-dimensional fabrication based on mechanically guided assembly.

The growing demand for complex three-dimensional (3D) micro-/nanostructures has inspired the development of the corresponding manufacturing techniques. Among these techniques, 3D fabrication based on mechanically guided assembly offers the advantages of broad material compatibility, high designability, and structural reversibility under strain but is not applicable for nanoscale device printing because of the bottleneck at nanofabrication and design technique. Herein, a configuration-designable nanoscale 3D fabrication is suggested through a robust nanotransfer methodology and design of substrate's mechanical characteristics. Covalent bonding-based two-dimensional nanotransfer allowing for nanostructure printing on elastomer substrates is used to address fabrication problems, while the feasibility of configuration design through the modulation of substrate's mechanical characteristics is examined using analytical calculations and numerical simulations, allowing printing of various 3D nanostructures. The printed nanostructures exhibit strain-independent electrical properties and are therefore used to fabricate stretchable H2 and NO2 sensors with high performances stable under external strains of 30%.

Biocompatible Nanotransfer Printing Based on Water Bridge Formation in Hyaluronic Acid and Its Application to Smart Contact Lenses.

Many conventional micropatterning and nanopatterning techniques employ toxic chemicals, rendering them nonbiocompatible and unsuited for biodevice production. Herein the formation of water bridges on the surface of hyaluronic acid (HA) films is exploited to develop a transfer-based nanopatterning method applicable to diverse structures and materials. The HA film surface, made deformable via water bridge generation, is brought into contact with a functional material and subjected to thermal treatment, which results in film shrinkage, allowing a robust pattern transfer. The proposed biocompatible method, which avoids the use of extra chemicals, enables the transfer of nanoscale, microscale, and thin-film structures as well as functional materials such as metals and metal oxides. A nanopatterned HA film is transferred onto a moisture-containing contact lens to fabricate smart contact lenses with unique optical characteristics of rationally designed optical nanopatterns. These lenses demonstrated binocular parallax-induced stereoscopy via nanoline array polarization and acted as cutoff filters, with nanodot arrays, capable of treating Irlen syndrome.

Ultra-Wide Range Pressure Sensor Based on a Microstructured Conductive Nanocomposite for Wearable Workout Monitoring.

Conventional flexible pressure sensors are not suitable for high-pressure applications due to their low saturation pressure. In this study, an ultra-wide range pressure sensor is designed based on the optimized microstructure of the polyimide/carbon nanotubes (PI/CNT) nanocomposite film. The sensing range of the pressure sensor is expanded by adopting polyimide (PI) with a high elastic modulus as a matrix material and its sensitivity is improved through functional sensing film with tip-flattened microdome arrays. As a result, the pressure sensor can measure a wide pressure range (≈ 0-3000 kPa) and possesses the sensitivity of ≈ 5.66 × 10-3 -0.23 × 10-3 kPa-1 with high reliability and durability up to 1000 cycles. The proposed sensor is integrated into the hand and foot pressure monitoring systems for workout monitoring. The representative values of the pressure distribution in the hands and feet during the powerlifting are acquired and analyzed through Pearson's correlation coefficient (PCC). The analyzed results suggest that the pressure sensor can provide useful real-time information for healthcare and sports performance monitoring.

Microdome-Induced Strain Localization for Biaxial Strain Decoupling toward Stretchable and Wearable Human Motion Detection.

Soft strain sensors have attracted significant attention in wearable human motion monitoring applications. However, there is still a huge challenge for decoupled measurement of multidirectional strains. In this study, we have developed a biaxial and stretchable strain sensor based on a carbon nanotube (CNT) film and a microdome array (MA)-patterned elastomeric substrate. The MA structures lead to generating localized and directional microcracks of CNT films within the intended regions under tensile strain. This mechanism allows a single sensing layer to act as a strain sensor capable of decoupling the biaxial strains into axial and transverse terms. The ratio of resistance change between two perpendicular axes is about 960% under an x-directional strain of 30%, demonstrating the biaxial decoupling capability. Also, the proposed strain sensor shows high stretchability and excellent long-term reliability under a cyclic loading test. Finally, wearable devices integrated with the strain sensor have been successfully utilized to monitor various human motions of the wrist, elbow, knee, and fingers by measuring joint bending and skin elongation.

Microscale Biosensor Array Based on Flexible Polymeric Platform toward Lab-on-a-Needle: Real-Time Multiparameter Biomedical Assays on Curved Needle Surfaces.

In vivo sensing of various physical/chemical parameters is gaining increased attention for early prediction and management of various diseases. However, there are major limitations on the fabrication method of multiparameter needle-based in vivo sensing devices, particularly concerning the uniformity between sensors. To address these challenges, we developed a microscale biosensor array for the measurement of electrical conductivity, pH, glucose, and lactate concentrations on a flexible polymeric polyimide platform with electrodeposited electrochemically active layers. The biosensor array was then transferred to a medical needle toward multiparametric in vivo sensing. The flexibility of the sensor platform allowed an easy integration to the curved surface (φ = 1.2 mm) of the needle. Furthermore, the electrodeposition process was used to localize various active materials for corresponding electrochemical sensors on the microscale electrodes with a high precision (patterning area = 150 µm × 2 mm). The biosensor array-modified needle was aimed to discriminate cancer from normal tissues by providing real-time discrimination of glucose, lactate concentration, pH, and electrical conductivity changes associated with the cancer-specific metabolic processes. The sensor performance was thus evaluated using solution samples, covering the physiological concentrations for cancer discrimination. Finally, the possibility of in vivo electrochemical biosensing during needle insertion was confirmed by utilizing the needle in a hydrogel phantom that mimicked the normal and cancer microenvironments.

Synergetic Effect of Porous Elastomer and Percolation of Carbon Nanotube Filler toward High Performance Capacitive Pressure Sensors.

Wearable pressure sensors have been attracting great attention for a variety of practical applications, including electronic skin, smart textiles, and healthcare devices. However, it is still challenging to realize wearable pressure sensors with sufficient sensitivity and low hysteresis under small mechanical stimuli. Herein, we introduce simple, cost-effective, and sensitive capacitive pressure sensor based on porous Ecoflex-multiwalled carbon nanotube composite (PEMC) structures, which leads to enhancing the sensitivity (6.42 and 1.72 kPa-1 in a range of 0-2 and 2-10 kPa, respectively) due to a synergetic effect of the porous elastomer and percolation of carbon nanotube fillers. The PEMC structure shows excellent mechanical deformability and compliance for an effective integration with practical wearable devices. Also, the PEMC-based pressure sensor shows not only the long-term stability, low-hysteresis, and fast response under dynamic loading but also the high robustness against temperature and humidity changes. Finally, we demonstrate a prosthetic robot finger integrated with a PEMC-based pressure sensor and an actuator as well as a healthcare wristband capable of continuously monitoring blood pressure and heart rate.

Wearable Strain Sensors Using Light Transmittance Change of Carbon Nanotube-Embedded Elastomers with Microcracks.

A number of flexible and stretchable strain sensors based on piezoresistive and capacitive principles have been recently developed. However, piezoresistive sensors suffer from poor long-term stability and considerable hysteresis of signals. On the other hand, capacitive sensors exhibit limited sensitivity and strong electromagnetic interference from the neighboring environment. In order to resolve these problems, a novel stretchable strain sensor based on the modulation of optical transmittance of carbon nanotube (CNT)-embedded Ecoflex is introduced in this paper. Within the film of multiwalled CNTs embedded in the Ecoflex substrate, the microcracks are propagated under tensile strain, changing the optical transmittance of the film. The proposed sensor exhibits good stretchability (ε ≈ 400%), high linearity (R2 > 0.98) in the strain range of ε = 0-100%, excellent stability, high sensitivity (gauge factor ≈ 30), and small hysteresis (∼1.8%). The sensor was utilized to detect the bending of the finger and wrist for the control of a robot arm. Furthermore, the applications of this sensor to the real-time posture monitoring of the neck and to the detection of subtle human motions were demonstrated.

Biopsy needle integrated with multi-modal physical/chemical sensor array.

A biopsy needle integrated with a multi-modal physical/chemical sensor array for electrical conductivity, pH, and glucose concentration measurement was developed. A flexible device with an electrical conductivity sensor, a pH sensor, and a glucose sensor was fabricated on a flexible polyimide substrate with thickness less than 20 µm. Then, the sensor was directly integrated onto the surface of biopsy needle by attaching with a pressure sensitive adhesive. The performance factors of the sensor were examined, showing that it could properly measure the parameters in the ranges of human body conditions (conductivity = 0.0265 S/m - 1.027 S/m, pH = 6.6-7.4, and glucose concentration = 2 mM-13 mM). The capabilities of dual-modal and multi-modal sensing were demonstrated by tests with a liver cancer mimicking hydrogel phantom, a solution sample, and porcine liver tissue with exchanged parameters by perfusion of the phosphate buffer saline. Based on these results, we expect that the biopsy needle integrated with the multi-modal sensor array could help to increase the accuracy of the image-guided biopsy process by providing the information of tissue types at the needle tip.

Printed fabric heater based on Ag nanowire/carbon nanotube composites.

The increasing demand for smart fabrics has inspired extensive research in the field of nanomaterial-based wearable heaters. However, existing stretchable heaters employ polymer substrates, and hence require additional substrate-fabric bonding that can result in high thermal contact resistance. Moreover, currently used stretchable fabric heaters suffer from high sheet resistance and require complex fabrication processes. In addition, conventional fabrication methods do not allow for patternability, thus hindering the fabrication of wearable heaters with diverse designs. Herein, we propose an improved spray coating method well suited for the preparation of patternable heaters on commercial fabrics, combining the structural stability of carbon nanotubes with the high electrical conductivity of Ag nanowires to fabricate a stretchable fabric heater with excellent mechanical (stretchability ≈ 50%) and electrical (sheet resistance ≈ 22 Ω sq-1) properties. The fabricated wearable heater reaches typical operating temperatures of 35 °C-55 °C at a low driving voltage of 3-5 V with a proper surface power density of 26.6-72.2 [Formula: see text] (heater area: [Formula: see text]) and maintains a stable heating temperature for more than 30 h. This heater shows a stable performance even when folded or rolled, thus being well suited for the practical wearable applications.

Comparison of Accuracy of One-Use Methods for Calculating Fractional Flow Reserve by Intravascular Optical Coherence Tomography to That Determined by the Pressure-Wire Method.

Although the identification of the hemodynamic significance of coronary lesions becomes important for revascularization strategy, the potential role of 3-dimensional high-resolution intracoronary optical coherence tomography (OCT) for predicting functional significance of coronary lesions remains unclear. We assessed the diagnostic performance of 2 computational approaches for deriving fractional flow reserve (FFR) from intravascular OCT images. We developed 2 methods to derive FFR-OCT by AFD (FFR-OCTAFD) and FFR-OCT by CFD (FFR-OCTCFD). Among 217 eligible patients between 2011 and 2014, 104 were included for data analysis (9 for derivation, 95 for validation). Luminal geometries from 3-dimensional OCT were used for both FFR-OCTAFD and FFR-OCTCFD calculations. The analytical fluid dynamics method calculated FFR from the blood flow resistance estimated using Poiseuille's law. For computational fluid dynamics, we numerically solved the Navier-Stokes equation in a steady-state flow with the distal porous media model for the capillary vessels. We examined the diagnostic performance of FFR-OCTAFD and FFR-OCTCFD compared with the pressure-wire measured FFR. The accuracy, sensitivity, specificity, PPV, and NPV were 86%, 65%, 94%, 81%, and 88% for FFR-OCTAFD and 86%, 73%, 91%, 76%, and 90% for FFR-OCTCFD. The area under the curve of the receiver-operating characteristic curve was 0.88 for FFR-OCTAFD and 0.86 for FFR-OCTCFD. FFR-OCTAFD and FFR-OCTCFD showed a strong linear correlation with the measured FFR (r = 0.631; p <0.001, r = 0.655; p <0.001, respectively). FFR derived from high-resolution volumetric OCT images showed high diagnostic performance for the detection of coronary ischemia. In conclusion, OCT-derived FFR may be useful for guiding the management of coronary artery disease.

[Clinicopathologic and immunophenotypic analysis of myeloid sarcoma].

OBJECTIVE: To study the clinicopathologic features of myeloid sarcoma and to evaluate the role of immunohistochemical study in diagnosis of this entity. METHODS: Eighty-two cases of myeloid sarcoma were retrieved from the archives of Department of Pathology, West China Hospital of Sichuan University during the period from January, 1990 to February, 2005. The morphologic features were reviewed and classified according to the 2001 WHO classification for hematopoietic and lymphoid tissue tumors. Immunohistochemical study using a panel of 11 antibodies was performed on 73 cases. The survival data were collected and analyzed by SPSS 10.0. RESULTS: The median age of patients was 35.5 years. The male-to-female ratio was 1.4:1. The sites of occurrence included lymph node (43.1%), skin (16.7%), nose (7.8%), soft tissue (7.8%) and bone (6.9%). Fifty-one cases (62.2%) represented myeloid sarcoma associated with an underlying myeloproliferative disorder and 25 cases (30.5%) represented solitary myeloid sarcoma. As for the morphology, 79 cases (96.3%) were granulocytic sarcoma, including 41 cases (51.9%) blastic type, 25 cases (31.6%) immature type and 13 cases (16.5%) differentiated type. The other 3 cases (3.7%) were monoblastic sarcoma. Immature eosinophils were found in 51 cases (64.6%) of granulocytic sarcoma, among which 13 cases (31.7%) were of blastic type. Immunohistochemical study showed that 95.9% cases (70/73) were positive for myeloperoxidase, 95.5% (63/66) for lysozyme, 95.2% (60/63) for CD68 (KP1), 90.8% (59/65) for leukocyte common antigen, 85.7% (54/63) for CD43, 77.8% (49/63) for CD117, 58.7% (37/63) for CD99, 54.0% (34/63) for CD15, 22.2% (14/63) for CD34, and 4.7% (3/64) for CD68 (PG-M1). Proliferation index, as demonstrated by Ki-67 positivity, was 0.49+/-0.22. Follow-up data was obtained in 59 of the 82 patients. The two- and five-year survival rates were 36.1% and 17.3% respectively. No significant prognostic factors were found in the survival analysis. CONCLUSIONS: Myeloid sarcoma may precede, develop in a background of myeloproliferative disorder or even after remission of the disease. The presence of immature eosinophils is an important morphologic clue and immunohistochemical study plays an essential role in arriving at a correct diagnosis. Immunopositivity for myeloperoxidase is specific for granulocytic differentiation, while CD68 (PG-M1)-positivity suggests monocytic differentiation. Detailed clinicopathologic correlation is also helpful.