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Chem Biodivers ; 20(7): e202300390, 2023 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-37293748

RESUMO

Adenosma bracteosum and Vitex negundo are natural sources of methoxylated flavonoids. Little is known about the α-glucosidase inhibition of multi-methoxylated flavonoid derivatives. Eighteen natural flavonoids were isolated from A. bracteosum and V. negundo. Seven halogenated derivatives were synthesized. Their chemical structures were elucidated by extensive NMR analysis and high-resolution mass spectroscopy as well as comparisons in literature. All compounds were evaluated for their α-glucosidase inhibition. Most compounds showed good activity with IC50 values ranging from 16.7 to 421.8 µM. 6,8-Dibromocatechin was the most active compound with an IC50 value of 16.7 µM. A molecular docking study was conducted, indicating that those compounds are potent α-glucosidase inhibitors.


Assuntos
Flavonoides , Vitex , Flavonoides/química , Vitex/química , alfa-Glucosidases/metabolismo , Simulação de Acoplamento Molecular , Espectroscopia de Ressonância Magnética , Inibidores de Glicosídeo Hidrolases/química , Estrutura Molecular
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