RESUMO
We studied the effect of the carbonic anhydrase inhibitor methazolamide in 25 patients with essential tremor (ET) in a double-blind, placebo-controlled trial. Tremor assessment included patient self-reporting of functional disability, clinical rating of motor tasks and tremor severity, and accelerometric measurements. There was no significant difference between methazolamide and placebo in any of the assessments. Side effects, paresthesias, sedation, headaches, and gastrointestinal symptoms were common. Only two patients elected to remain on the drug after the study. Methazolamide has only limited efficacy in the treatment of essential tremor.
Assuntos
Metazolamida/uso terapêutico , Tremor/tratamento farmacológico , Análise de Variância , Método Duplo-Cego , Feminino , Mãos , Humanos , Masculino , Metazolamida/efeitos adversos , Pessoa de Meia-Idade , Atividade Motora , Tremor/etiologia , Tremor/fisiopatologiaRESUMO
Tremor may be seen not only in association with Parkinson's disease but also as an idiopathic disorder or in association with a variety of neurologic diseases. Our knowledge of these associations and of effective treatments for various types of tremor has increased.
Assuntos
Exame Neurológico , Doença de Parkinson/fisiopatologia , Tremor/fisiopatologia , Cerebelo/fisiopatologia , Humanos , Neurônios Motores/fisiologia , Núcleo Olivar/fisiopatologiaRESUMO
Differential diagnosis of Parkinson's disease should cover not only the classic disorder described by James Parkinson in 1817 (paralysis agitans) but also numerous other idiopathic and secondary disorders that have varying degrees of parkinsonian features. Because treatment options can vary greatly among mimicking disorders and differ from those effective for Parkinson's disease, a prompt, accurate diagnosis is essential. Physicians can distinguish between these often-overlapping disorders by differentiating primary from secondary parkinsonism and by classifying primary syndromes into disorders with prominent tremor and those without.
Assuntos
Doença de Parkinson/diagnóstico , Diagnóstico Diferencial , Humanos , Doença de Parkinson/etiologia , Doença de Parkinson Secundária/diagnóstico , Fatores de Tempo , Tremor/diagnóstico , Tremor/etiologiaRESUMO
UNLABELLED: Screening laboratory tests for thyroid disease often include serum levels for thyroxine (T4), thyrotropic hormone (TSH), and triiodothyronine resin binding (T3) as a measure of T4 binding to serum. A neural network using the above values as input was unable to converge during training to identify an output diagnoses of six common thyroid functional states. When binding protein (TBG) data were supplied the network readily converged. Since thyroxine binding can be roughly estimated from a relationship between T4 and T3, a virtual input node reflecting the binding was calculated from each T4/T3 input set and used as additional input. With this addition, the system trained easily and accurately diagnosed from the training set. CONCLUSION: 1) Quantitative laboratory data can be used in input neurodes in a diagnostic network 2) Training and diagnostic accuracy for the network is more efficient using the virtual TBG neurode than by either omitting TBG data or using actual TBG values.
