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Molecules ; 27(20)2022 Oct 18.
Artigo em Inglês | MEDLINE | ID: mdl-36296620

RESUMO

Imperatorin is a furanocoumarin derivative and an effective ingredient in several Chinese medicinal herbs. It has favorable expectorant, analgesic, and anti-inflammatory effects. In this study, we investigated whether imperatorin has protective effects against Dermatophagoides pteronyssinus (Der p)-induced asthma in mice. Lung and bronchial tissues were histopathologically examined through hematoxylin-eosin staining. The concentrations of immunoglobin E (IgE), IgG1, IgG2a in serum and those of T helper 1 (Th1) and two cytokines and eosinophil-activated chemokines in bronchoalveolar lavage fluid (BALF) were detected using an enzyme immunoassay. Histological examination revealed that imperatorin reduced inflammatory cell infiltration, mucus hypersecretion, and endothelial cell hyperplasia. The examination also indicated that imperatorin could reduce the inflammatory cell count in BALF as well as IgE and IgG1 expression in serum, but IgG2a expression was significantly increased. Imperatorin reduced the production of interleukin (IL)-4, IL-5, and IL-13 by Th2, promoted the production of interferon-γ and IL-12 by Th1, and increased the production of IL-10 in bronchoalveolar lavage fluid. These findings suggest that imperatorin has a considerable anti-inflammatory effect on Der p-induced allergic asthma in mice.


Assuntos
Asma , Furocumarinas , Camundongos , Animais , Dermatophagoides pteronyssinus/metabolismo , Interleucina-13 , Interleucina-10/farmacologia , Camundongos Endogâmicos BALB C , Interferon gama/farmacologia , Expectorantes/farmacologia , Amarelo de Eosina-(YS) , Hematoxilina/farmacologia , Hematoxilina/uso terapêutico , Interleucina-5/farmacologia , Interleucina-5/uso terapêutico , Asma/induzido quimicamente , Asma/tratamento farmacológico , Asma/metabolismo , Furocumarinas/farmacologia , Líquido da Lavagem Broncoalveolar , Citocinas/metabolismo , Imunoglobulina E , Interleucina-12 , Imunoglobulina G , Anti-Inflamatórios/farmacologia , Modelos Animais de Doenças , Células Th2 , Ovalbumina
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