1.
Org Biomol Chem
; 15(3): 564-569, 2017 Jan 18.
Artigo
em Inglês
| MEDLINE
| ID: mdl-27991631
RESUMO
The synthesis of a new contrast agent based on a ß-cyclodextrin scaffold and bearing a flexible lipophilic spacer arm on its secondary face is reported. Intermolecular host-guest inclusion complexes were known to undergo an enhancement of the contrast imaging. We extend this concept to intramolecular complexation. Inter- and intramolecular interactions are compared by NMR spectroscopy, circular dichroism and magnetic resonance imaging using hydrocinnamic acid and adamantane carboxylic acid as external guests. This positive variation of the observed relaxivity is a key element of new strategies aiming at developing smart molecular MRI probes.
Assuntos
Imageamento por Ressonância Magnética , beta-Ciclodextrinas/síntese química , Modelos Moleculares , Estrutura Molecular , beta-Ciclodextrinas/química
2.
Rapid Commun Mass Spectrom
; 18(6): 729-32, 2004.
Artigo
em Inglês
| MEDLINE
| ID: mdl-15052587