RESUMO
Folliculosebaceous cystic hamartoma (FSCH) is a rare cutaneous hamartoma composed of dilated folliculosebaceous units associated with mesenchymal elements. Two cases of FSCH with typical histopathological features are reported. Patient 1 was a 60-year-old man presented with a normal skin-coloured asymptomatic nodule on his scalp. Patient 2 was a 70-year-old man with an asymptomatic nodule on his right auricle that had persisted for the previous 15 years. In all, 34 cases of FSCH have been reported in the English literature. Clinically, the lesions are asymptomatic, usually rubbery to firm in consistency, and usually occur on or above the neck (> 90%). Most lesions do not exceed 25 mm in diameter (> 90%). Histopathologically, FSCH shares several similar features to sebaceous trichofolliculoma, but it is usually possible to differentiate these two tumours.
Assuntos
Hamartoma/patologia , Dermatopatias/patologia , Idoso , Cistos/patologia , Orelha Externa/patologia , Humanos , Masculino , Pessoa de Meia-Idade , Couro Cabeludo/patologiaRESUMO
We report a 12-year-old boy with nonHallopeau-Siemens recessive dystrophic epidermolysis bullosa (nHS-RDEB) who developed two skin lesions of squamous cell carcinoma (SCC) on the left foot. The incidence of SCC in nHS-RDEB is much lower than in the HS-RDEB subtype. Furthermore, this boy is the youngest among 92 previously described patients with DEB to develop SCC. This study emphasizes the importance of vigilance in monitoring the possible development of SCC in DEB patients regardless of age or clinical severity.
Assuntos
Carcinoma de Células Escamosas/complicações , Epidermólise Bolhosa Simples/complicações , Doenças do Pé/complicações , Neoplasias Cutâneas/complicações , Idade de Início , Carcinoma de Células Escamosas/genética , Carcinoma de Células Escamosas/patologia , Criança , Códon sem Sentido , Colágeno Tipo VII/genética , Epidermólise Bolhosa Simples/genética , Epidermólise Bolhosa Simples/patologia , Doenças do Pé/genética , Doenças do Pé/patologia , Humanos , Masculino , Mutação de Sentido Incorreto , Neoplasias Cutâneas/genética , Neoplasias Cutâneas/patologiaAssuntos
Carcinoma de Células Escamosas/complicações , Neoplasias de Cabeça e Pescoço/complicações , Ictiose Lamelar/complicações , Neoplasias Cutâneas/complicações , Adulto , Carcinoma de Células Escamosas/patologia , Neoplasias de Cabeça e Pescoço/patologia , Humanos , Ictiose Lamelar/patologia , Masculino , Fenótipo , Neoplasias Cutâneas/patologiaAssuntos
Unhas Malformadas/cirurgia , Fenóis/uso terapêutico , Adulto , Idoso , Feminino , Humanos , Masculino , Fenóis/administração & dosagemRESUMO
We investigated the production of the major pollen allergen [Cry j I] of Japanese cedar (Cj) in the course of male flower bud development. We found that most of the pollen was at the tetrad stage in early September, and they developed to the mature stage in mid-October (1987) or early November (1988). Large amounts of Cry j I seemed to be extractable to ABS solution from the mature stage pollen but not from the pollen at other stages, that is, the tetrad and immature stages. Mature pollen could be ruptured with ammonium bicarbonate buffer, but tetrad and immature pollen could not. By immunofluorescent technique, antigen Cry j I was detected in the pollen only at the mature stage of Cj pollen development. Therefore, we think that Cry j I is produced at the time of pollen maturation.
