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Ren Fail ; 46(2): 2371055, 2024 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-38946159

RESUMO

IgA nephropathy (IgAN) is one of the most common primary glomerulonephritis, and serum Helicobacter pylori (H. pylori) antibody levels are increased in patients with IgA N, but the role of H. pylori infection in the pathogenesis of IgAN is unclear. In this study, we investigated whether there is a causal relationship and reverse causality between IgAN and H. pylori infection by using a bidirectional two-sample Mendelian randomization (MR) analysis. This study was estimated using inverse variance weighted (IVW), MR-Egger and weighted median methods, with the IVW method having the strongest statistical efficacy. Seven common serum H. pylori antibodies were selected as exposure factors for positive MR analysis. The results showed that there was no evidence of a causal relationship between H. pylori infection and IgAN. Reverse MR analysis showed that there was also no evidence that the occurrence of IgAN leads to an increased risk of H. pylori infection.


Assuntos
Glomerulonefrite por IGA , Infecções por Helicobacter , Helicobacter pylori , Análise da Randomização Mendeliana , Humanos , Infecções por Helicobacter/complicações , Glomerulonefrite por IGA/microbiologia , Glomerulonefrite por IGA/genética , Glomerulonefrite por IGA/sangue , Helicobacter pylori/isolamento & purificação , Anticorpos Antibacterianos/sangue , Fatores de Risco
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